Multi-pronged inhibition of airway hyper-responsiveness and inflammation by lipoxin A4

Nature Medicine

Volumn 8, Issue 9, 2002, Pages 1018-1023

  Levy, Bruce D ^a   De Sanctis, George T ^a   Devchand, Pallavi R ^a   Kim, Eugene ^a   Ackerman, Kate ^a   Schmidt, Birgitta A ^a   Szczeklik, Wojciech ^a   Drazen, Jeffrey M ^a   Serhan, Charles N ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LIPOXIN A;

AIRWAY DYNAMICS; AIRWAY OBSTRUCTION; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTHMA; CELL INFILTRATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; INHIBITION KINETICS; LEUKOCYTE COUNT; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; PROTEIN SYNTHESIS; PROVOCATION TEST; REGULATORY MECHANISM; SENSITIZATION; SUPERNATANT;

ANIMALS; ASTHMA; BRONCHIAL HYPERREACTIVITY; BRONCHITIS; CHEMOKINES, CC; EOSINOPHILS; HYDROXYEICOSATETRAENOIC ACIDS; INTERLEUKIN-13; INTERLEUKIN-5; LEUKOTRIENES; LIPOXINS; MALE; METHACHOLINE CHLORIDE; MICE; MICE, INBRED BALB C; MICE, TRANSGENIC; PROSTAGLANDINS; RECEPTORS, CELL SURFACE; RECEPTORS, FORMYL PEPTIDE; RECEPTORS, LIPOXIN;

ANIMALIA; MURINAE;

EID: 0036734152     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/nm748     Document Type: Article

References (36)

1. Role of leukotrienes in bronchial hyperresponsiveness and cellular responses in airways
2. Asthma. From bronchoconstriction to airways inflammation and remodeling
3. Predominant TH2-like bronchoalveolar T-lymphocyte population in atopic asthma
4. Cytokines in symptomatic asthma airways
5. From studies of biochemical mechanisms to novel biological mediators: Prostaglandin endoperoxides, thromboxanes and leukotrienes
6. Treatment of asthma with drugs modifying the leukotriene pathway
7. Lipid mediator networks in cell signaling: Update and impact of cytokines
8. Lipoxins: Revelations on resolution
9. Lipid mediator class switching during acute inflammation: Signals in resolution
10. Identification of lipoxin A4 and its relationship to the sulfidopeptide leukotrienes C4, D 4, and E4 in the bronchoalveolar lavage fluids obtained from patients with selected pulmonary diseases
11. Lipoxin A4 antagonizes cellular and in vivo actions of leukotriene D4 in rat glomerular mesangial cells: Evidence for competition at a common receptor
12. 4 and regulation of vascular and inflammatory responses
13. Aspirin-triggered 15-epi-lipoxin A4 (LXA4) and LXA4 stable analogues are potent inhibitors of acute inflammation: Evidence for anti-inflammatory receptors
14. Interleukin-8 receptor modulates IgE production and B-cell expansion and trafficking in allergen-induced pulmonary inflammation
15. Contribution of nitric oxide synthases 1, 2, and 3 to airway hyperresponsiveness and inflammation in a murine model of asthma
16. Local and systemic delivery of a stable aspirin-triggered lipoxin prevents neutrophil recruitment in vivo
17. The epidemic of allergy and asthma
18. Heterogeneity of therapeutic responses in asthma
19. Effects of recombinant human interleukin-12 on eosinophils, airway hyper-responsiveness, and the late asthmatic response
20. Effects of an interleukin-5 blocking monoclonal antibody on eosinophils, airway hyper-responsiveness, and the late asthmatic response
21. The effects of lipoxin A4 on airway responses in asthmatic subjects
22. 4 and related compounds in smooth muscle preparations and on the microcirculation in vivo
23. The Th2 lymphocyte products IL-4 and IL- 13 rapidly induce airway hyperresponsiveness through direct effects on resident airway cells
24. Direct effects of interleukin- 13 on signaling pathways for physiological responses in cultured human airway smooth muscle cells
25. IL-5 increases expression of 5lipoxygenase-activating protein and translocates 5-lipoxygenase to the nucleus in human blood eosinophils
26. Cysteinyl-leukotrienes partly mediate eotaxin-induced bronchial hyperresponsiveness and eosinophilia in IL-5 transgenic mice
27. Leukotrienes as mediators of airway obstruction
28. The fibrinolytic receptor for urokinase activates the G-protein-coupled chemotactic receptor FPRL1/LXA4R
29. Effects of lipoxin A4 on chemotaxis and degranulation of human eosinophils stimulated by platelet-activating factor and Nformyl-L-methionyl-L-leucyl-L-phenylalanine
30. 4 block allergen-induced eosinophil trafficking
31. 4 accelerate resolution of allergic edema in Angiostrongylus costaricensis-infected rats: Relationship with concurrent eosinophilia
32. Lipoxin-mediated inhibition of IL-12 production by DCs: A mechanism for regulation of microbial immunity
33. Aspirin-tolerant asthmatics generate more lipoxins than aspirin-intolerant asthmatics
34. Cutting edge: Lipoxins rapidly stimulate nonphlogistic phagocytosis of apoptotic neutrophils by monocyte-derived macrophages
35. 4 receptor transgenic mice reveal novel protective roles for lipoxins and aspirin-triggered lipoxins in reperfusion
36. Eosinophils generate brominating oxidants in allergen-induced asthma