Increased frequency of cells secreting interleukin-6 and interleukin-10 in peripheral blood of patients with primary Sjögren's Syndrome

Scandinavian Journal of Immunology

Volumn 49, Issue 5, 1999, Pages 533-538

  Halse, A K ^a,d   Tengner P ^a,b   Wahren Herlenius, M ^b   Haga, H J ^c   Jonsson, R ^a  

^a UNIVERSITY OF BERGEN   (Norway)

^b KAROLINSKA INSTITUTE   (Sweden)

^c HAUKELAND UNIVERSITY HOSPITAL   (Norway)

^d Broegelmann Research Laboratory   (Norway)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 6;

ADULT; AGED; ANTIBODY PRODUCTION; ARTICLE; B LYMPHOCYTE ACTIVATION; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE RELEASE; DISEASE ACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HELPER CELL; HUMAN; HUMAN CELL; MALE; MONONUCLEAR CELL; PRIORITY JOURNAL; QUANTITATIVE ASSAY; SJOEGREN SYNDROME;

ADULT; AGED; ANTIBODIES, ANTINUCLEAR; AUTOANTIGENS; FEMALE; HUMANS; INTERLEUKIN-10; INTERLEUKIN-6; LEUKOCYTE COUNT; LEUKOCYTES, MONONUCLEAR; MIDDLE AGED; RIBONUCLEOPROTEINS; RNA, SMALL CYTOPLASMIC; SJOGREN'S SYNDROME;

EID: 0033017601     PISSN: 03009475     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-3083.1999.00533.x     Document Type: Article

References (34)

1. Tan EM. Antinuclear antibodies: diagnostic markers for autoimmune diseases and probes for cell biology. Adv Immunol 1989;44:93-106.
2. Vitali C, Bombardieri S, Moutsopoulos HM et al. Preliminary criteria for the classification of Sjögren's syndrome. Arthritis Rheum 1993;36:340-7.
3. Wolin SL, Steitz JA. The Ro small cytoplasmic ribonucleoproteins: identification of the antigenic protein and its binding site on the Ro RNAs. Proc Natl Acad Sci USA 1984;81:1996-2000.
4. Ben-Chetrit E, Chan EKL, Sullivan KF, Tan EM. A 52-kD protein is a novel component of the SS-A/Ro antigenic particle. J Exp Med 1988;167:1560-71.
5. Price EJ, Venables PJW. The etiopathogenesis of Sjögren's syndrome. Semin Arthritis Rheum 1995;25:117-33.
6. Mosmann TR, Sad S. The expanding universe of T-cell subsets: Th1, Th2 and more. Immunol Today 1996;17:138-46.
7. Llorente L, Richaud-Patin Y, Fior R et al. In vivo production of interleukin-10 by non-T cells in rheumatoid arthritis, Sjögren's syndrome, and systemic lupus erythematosus. Arthritis Rheum 1994;37:1647-55.
8. Gajewski TF, Schell SR, Nau G, Fitch FW. Regulation of T-cell activation: differences among T-cell subsets. Immunol Rev 1989; 111:79-110.
9. H2 responses. Immunol Today 1991;12:49-53.
10. Powrie F, Coffman RL. Cytokine regulation of T-cell function: potential for therapeutic intervention. Immunol Today 1993;14: 270-4.
11. Fox RI, Kang H-I, Ando D, Abrams J, Pisa E. Cytokine mRNA expression in salivary gland biopsies of Sjögren's syndrome. J Immunol 1994;152:5532-9.
12. Ohyama Y, Nakamura S, Matsuzaki G et al. Cytokine messenger RNA expression in the labial salivary glands of patients with Sjögren's syndrome. Arthritis Rheum 1996;39:1376-84.
13. Rowe D, Griffiths M, Stewart J, Novick D, Beverley PCL, Isenberg DA. HLA class I and II, interferon, interleukin 2, and the interleukin 2 receptor expression on labial biopsy specimens from patients with Sjögren's syndrome. Ann Rheum Dis 1987;46:580-6.
14. Czerkinsky C, Andersson G, Ekre H-P, Nilsson L-Å, Klareskog L, Ouchterlony Ö. Reverse ELISPOT assay for clonal analysis of cytokine production. I. Enumeration of gamma-interferon-secreting cells. J Immunol Methods 1988;110:29-36.
15. Thorsby E, Bratlie A. A rapid method for preparation of pure lymphocyte suspensions. In: Terasaki PI., ed. Histocompatibility Testing. Copenhagen: Munksgaard, 1970:655-6.
16. Ting A, Morris PJ. A technique for lymphocyte preparation from stored heparinized blood. Vox Sang 1971;20:561-3.
17. Blange I, Ringertz NR, Pettersson I. Identification of antigenic regions of the human 52kD Ro/SS-A protein recognized by patient sera. J Autoimmun 1994;7:263-74.
18. Wahren M, Rudén U, Andersson B, Ringertz NR, Pettersson I. Identification of antigenic regions of the human Ro 60 kDa protein using recombinant antigen and synthetic peptides. J Autoimmun 1992;5:319-32.
19. Nyman U, Ringertz NR, Pettersson I. Demonstration of an amino terminal La epitope recognized by human anti-La sera. Immunol Lett 1989;22:65-72.
20. Hagiwara E, Gourley MF, Lee S, Klinman DM. Disease severity in patients with systemic lupus erythematosus correlates with an increased ratio of interleukin-10: interferon-γ-secreting cells in the peripheral blood. Arthritis Rheum 1996;39:379-85.
21. Hagiwara E, Pando J, Ishigatsubo Y, Klinman DM. Altered frequency of type 1 cytokine secreting cells in the peripheral blood of patients with primary Sjögren's syndrome. J Rheumatol 1998;25: 89-93.
22. Grisius MM, Bermudez DK, Fox PC. Salivary and serum interleukin 6 in primary Sjögren's syndrome. J Rheumatol 1997;24:1089-91.
23. Yoshizaki K, Kuritani T, Kishimoto T. Interleukin-6 in autoimmune disorders. Semin Immunol 1992;4:155-66.
24. Rousset F, Garcia E, Defrance T et al. Interleukin 10 is a potent growth and differentiation factor for activated human B lymphocytes. Proc Natl Acad Sci USA 1992;89:1890-3.
25. 2-microglobulin, and the interleukin 2 receptor in Sjögren's syndrome. Clin Immunol Immunopathol 1987;45:235-43.
26. Hedfors E, Lindahl G. Variation of MHC class I and II antigen expression in relation to lymphocytic infiltrates and interferon-γ positive cells. J Rheumatol 1990;17:743-50.
27. Brookes SM, Price EJ, Venables PJW, Maini RN. Interferon-gamma and epithelial cell activation in Sjögren's syndrome. Br J Rheumatol 1995;34:226-31.
28. Namekawa T, Kuroda K, Kato T et al. Identification of Ro (SSA) 52 kDa reactive T cells in labial salivary glands from patients with Sjögren's syndrome. J Rheumatol 1995;22:2092-9.
29. Halse A-K, Wahren M, Jonsson R. Peripheral blood in Sjögren's syndrome does not contain increased levels of T lymphocytes reactive with the recombinant Ro/SS-A 52 kD and La/SS-B 48 kD autoantigens. Autoimmunity 1996;23:25-34.
30. Baboonian C, Venables PJW, Booth J, Williams DG, Roffe LM, Maini RN. Virus infection induces redistribution and membrane localization of the nuclear antigen La (SS-B): a possible mechanism for autoimmunity. Clin Exp Immunol 1989;78:454-9.
31. Bachmann M, Althoff H, Tröster H, Selenka C, Falke D, Müller WEG. Translocation of the nuclear autoantigen La to the cell surface of herpes simplex virus type I infected cells. Autoimmunity 1992;12: 37-45.
32. de Wilde PCM, Kater L, Bodeutsch C, van den Hoogen FHJ, van de Putte LBA, van Venrooij WJ. Aberrant expression pattern of the SS-B/La antigen in the labial salivary glands of patients with Sjögren's syndrome. Arthritis Rheum 1996;39:783-91.
33. Tengnér P, Halse A-K, Haga H-J, Jonsson R, Wahren-Herlenius M. Detection of anti-Ro/SS-A and anti-La/SS-B autoantibody producing cells in salivary glands from patients with Sjögren's syndrome. Arthritis Rheum 1998;41:2238-48.
34. Halse A-K, Harley JB, Kroneld U, Jonsson R. Ro/SS-A reactive B lymphocytes in salivary glands and peripheral blood of patients with Sjögren's syndrome. Clin Exp Immunol 1999;115:203-7.