Novel 3-Oxa Lipoxin A4 Analogues with Enhanced Chemical and Metabolic Stability Have Anti-inflammatory Activity in Vivo

Journal of Medicinal Chemistry

Volumn 47, Issue 8, 2004, Pages 2157-2165

  Guilford, William J ^a   Bauman, John G ^a   Skuballa, Werner ^b   Bauer, Shawn ^a   Wei, Guo Ping ^a   Davey, David ^a   Schaefer, Caralee ^a   Mallari, Cornell ^a   Terkelsen, Jennifer ^a   Tseng, Jih Lie ^a   Shen, Jun ^a   Subramanyam, Babu ^a   Schottelius, Arndt J ^b   Parkinson, John F ^a  

^a BAYER AG   (Germany)

^b BAYER PHARMA AG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

16 (4 FLUOROPHENOXY) 3 OXA 5,6,15 TRIHYDROXY 7,9,11,13 HEXADECATETRAENOIC ACID; 16 (4 FLUOROPHENOXY) 3 OXA 5,6,15 TRIHYDROXY 7,9,13 HEXADECATRIENOIC ACID; 3 OXALIPOXIN A4; 3 OXATETRAENE; 3 OXATRIEN 11 YNE; ANTIINFLAMMATORY AGENT; DRUG METABOLITE; ICOSANOID; LIPOXIN A; METHYL 16 (4 FLUOROPHENOXY) 5,6,15 TRIHYDROXY 7,9,11,13 HEXADECATETRAENOATE; UNCLASSIFIED DRUG; ZK 819; ZK 994;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG EFFICACY; DRUG METABOLISM; DRUG STABILITY; DRUG STRUCTURE; IMMUNOMODULATION; IN VIVO STUDY; INFLAMMATION; MALE; MOUSE; NONHUMAN; STRUCTURE ANALYSIS;

ACUTE DISEASE; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CALCIMYCIN; DERMATITIS, CONTACT; DRUG STABILITY; IONOPHORES; LIPOXINS; MALE; MICE; MICE, INBRED BALB C; OXIDATION-REDUCTION; PHENYL ETHERS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 11144355135     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm030569l     Document Type: Article

References (30)

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