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Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 8, 2012, Pages 2843-2849

Discovery of novel and potent heterocyclic carboxylic acid derivatives as protein tyrosine phosphatase 1B inhibitors

(16) Basu, Sujay a,b Prasad, Uppuleti Viplava b Barawkar, Dinesh A a De, Siddhartha a Palle, Venkata P a Menon, Suraj a Patel, Meena a Thorat, Sachin a Singh, Umesh P a Sarma, Koushik Das a Waman, Yogesh a Niranjan, Sanjay a Pathade, Vishal a Gaur, Ashwani a Reddy, Satyanarayana a Ansari, Shariq a

a Advinus Therapeutics Private Limited Bangalore (India)

b ANDHRA UNIVERSITY (India)

Author keywords

Carboxylic acid; Diabetes; Heterocycle; Metabolic stability; Protein tyrosine phosphatase 1B

Indexed keywords

CARBOXYLIC ACID DERIVATIVE; PROTEIN TYROSINE PHOSPHATASE 1B INHIBITOR;

ANIMAL EXPERIMENT; ARTICLE; DRUG ACTIVITY; DRUG BIOAVAILABILITY; DRUG PENETRATION; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; MALE; MOUSE; NONHUMAN; STRUCTURE ACTIVITY RELATION;

ADMINISTRATION, ORAL; ANIMALS; CARBOXYLIC ACIDS; ENZYME ACTIVATION; ENZYME INHIBITORS; HETEROCYCLIC COMPOUNDS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; MALE; MICE; MICE, INBRED C57BL; PROTEIN TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 1; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84859444421 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2012.02.070 Document Type: Article

Times cited : (25)

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