Revisiting glitazars: Thiophene substituted oxazole containing α-ethoxy phenylpropanoic acid derivatives as highly potent PPARα/γ dual agonists devoid of adverse effects in rodents

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 10, 2011, Pages 3103-3109

  Raval, Preeti ^a,b   Jain, Mukul ^a   Goswami, Amitgiri ^a   Basu, Sujay ^a   Gite, Archana ^a   Godha, Atul ^a   Pingali, Harikishore ^a   Raval, Saurin ^a   Giri, Suresh ^a   Suthar, Dinesh ^a   Shah, Maanan ^a   Patel, Pankaj ^a  

^a ZYDUS RESEARCH CENTRE   (India)

^b M S UNIVERSITY OF BARODA   (India)

Author keywords

Metabolic syndrome; Oxazole; PPAR dual agonist; Type 2 diabetes

Indexed keywords

[2 METHYL 4 [4 METHYL 2 (4 TRIFLUOROMETHYLPHENYL) 5 THIAZOLYLMETHYLTHIO]PHENOXY]ACETIC ACID; ALPHA ALKOXY PHENYLPROPANOIC ACID; ANTIDIABETIC AGENT; ANTILIPEMIC AGENT; OXAZOLE DERIVATIVE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA AGONIST; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA AGONIST; PIRINIXIC ACID; PROPIONIC ACID DERIVATIVE; ROSIGLITAZONE; THIOPHENE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG EFFICACY; DRUG HALF LIFE; DRUG SAFETY; DRUG SYNTHESIS; FEMALE; MALE; MAXIMUM PLASMA CONCENTRATION; MOUSE; NONHUMAN; RAT; TIME TO MAXIMUM PLASMA CONCENTRATION;

ADMINISTRATION, ORAL; ANIMALS; CELL LINE; DOSE-RESPONSE RELATIONSHIP, DRUG; HYPOGLYCEMIC AGENTS; INHIBITORY CONCENTRATION 50; MICE; MOLECULAR STRUCTURE; OXAZOLES; PHENYLPROPIONATES; PPAR ALPHA; PPAR GAMMA; PROTEIN BINDING; RATS; RATS, WISTAR; THIAZOLIDINEDIONES; THIOPHENES;

RODENTIA;

EID: 79955569015     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.03.020     Document Type: Article

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