Discovery of a highly orally bioavailable c-5-[6-(4-Methanesulfonyloxyphenyl)hexyl]-2-methyl-1,3-dioxane-r-2-carbo xylic acid as a potent hypoglycemic and hypolipidemic agent

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 20, 2008, Pages 5586-5590

  Pingali, Harikishore ^a,b   Jain, Mukul ^a   Shah, Shailesh ^b   Basu, Sujay ^a   Makadia, Pankaj ^a   Goswami, Amitgiri ^a   Zaware, Pandurang ^a   Patil, Pravin ^a   Godha, Atul ^a   Giri, Suresh ^a   Goel, Ashish ^a   Patel, Megha ^a   Patel, Harilal ^a   Patel, Pankaj ^a  

^a ZYDUS RESEARCH CENTRE   (India)

^b M S UNIVERSITY OF BARODA   (India)

Author keywords

1,3 Dioxane 2 carboxylic acid; Metabolic disorders; PPAR agonist; Type 2 diabetes

Indexed keywords

1,3 DIOXANE 2 CARBOXYLIC ACID DERIVATIVE; 1,3 DIOXANE DERIVATIVE; ANTIDIABETIC AGENT; C 5 [6 (4 METHANESULFONYLOXYPHENYL)HEXYL] 2 METHYL 1,3 DIOXANE 2 CARBOXYLIC ACID; CHOLESTEROL; GLUCOSE; NS 220; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA AGONIST; TESAGLITAZAR; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG POTENCY; HYPOLIPEMIA; LIPID BLOOD LEVEL; LIPOPHILICITY; MALE; MOUSE; NONHUMAN; RAT; SUBSTITUTION REACTION;

ANIMALS; ANTILIPEMIC AGENTS; CARBOXYLIC ACIDS; DIABETES MELLITUS, TYPE 2; DIOXANES; HUMANS; HYPOGLYCEMIC AGENTS; LIPIDS; MESYLATES; MICE; MODELS, CHEMICAL; PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS; PPAR ALPHA; PPAR GAMMA; RATS; RATS, WISTAR; TRANSCRIPTIONAL ACTIVATION;

ANIMALIA;

EID: 53449091837     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.08.112     Document Type: Article

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