메뉴 건너뛰기




Volumn 30, Issue 1, 2004, Pages 7-12

Clinical interest of PPARs ligands: Particular benefit in type 2 diabetes and metabolic syndrome

Author keywords

Diabetes; Fibrate; Glitazone; Metabolic syndrome; PPAR

Indexed keywords

2,4 THIAZOLIDINEDIONE DERIVATIVE; ANTILIPEMIC AGENT; CELL ADHESION MOLECULE; ENDOTHELIN 1; FATTY ACID; FIBRIC ACID DERIVATIVE; GLUCOSE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INSULIN; LIPID; LOW DENSITY LIPOPROTEIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; METALLOPROTEINASE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR AGONIST; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PIOGLITAZONE; PROTEIN; SMALL DENSE LOW DENSITY LIPOPROTEIN; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

EID: 1842454746     PISSN: 12623636     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1262-3636(07)70083-6     Document Type: Review
Times cited : (92)

References (51)
  • 1
    • 0033305213 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptors: Nuclear control of metabolism
    • Desvergne B, Wahli W. Peroxisome proliferator-activated receptors: nuclear control of metabolism. Endocr Rev, 1999, 20, 649-88.
    • (1999) Endocr Rev , vol.20 , pp. 649-688
    • Desvergne, B.1    Wahli, W.2
  • 2
    • 0029994543 scopus 로고    scopus 로고
    • Role of the peroxisome proliferator-activated receptor (PPAR) in mediating the effects of fibrates and fatty acids on gene expression
    • Schoonjans K, Staels B, Auwerx J. Role of the peroxisome proliferator-activated receptor (PPAR) in mediating the effects of fibrates and fatty acids on gene expression. J Lipid Res, 1996, 37, 907-25.
    • (1996) J Lipid Res , vol.37 , pp. 907-925
    • Schoonjans, K.1    Staels, B.2    Auwerx, J.3
  • 4
    • 0035924635 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor-alpha activation and high-density lipoprotein metabolism
    • Fruchart JC. Peroxisome proliferator-activated receptor-alpha activation and high-density lipoprotein metabolism. Am J Cardiol, 2001, 88, 24N-29N.
    • (2001) Am J Cardiol , vol.88
    • Fruchart, J.C.1
  • 5
    • 0029144018 scopus 로고
    • Induction of the acylcoenzyme A synthetase gene by fibrates and fatty acids is mediated by a peroxisome proliferator response element in the C promoter
    • Schoonjans K, Watanabe M, Suzuki H, et al. Induction of the acylcoenzyme A synthetase gene by fibrates and fatty acids is mediated by a peroxisome proliferator response element in the C promoter. J Biol Chem, 1995, 270, 19269-76.
    • (1995) J Biol Chem , vol.270 , pp. 19269-19276
    • Schoonjans, K.1    Watanabe, M.2    Suzuki, H.3
  • 6
    • 0032813808 scopus 로고    scopus 로고
    • Mutations in ABC1 in Tangier disease and familial high-density lipoprotein deficiency
    • Brooks-Wilson A, Marcil M, Clee SM, et al. Mutations in ABC1 in Tangier disease and familial high-density lipoprotein deficiency. Nat Genet, 1999, 22, 336-45.
    • (1999) Nat Genet , vol.22 , pp. 336-345
    • Brooks-Wilson, A.1    Marcil, M.2    Clee, S.M.3
  • 7
    • 0032813809 scopus 로고    scopus 로고
    • The gene encoding ATP-binding cassette transporter 1 is mutated in Tangier disease
    • Bodzioch M, Orso E, Klucken J, et al. The gene encoding ATP-binding cassette transporter 1 is mutated in Tangier disease. Nat Genet, 1999, 22, 347-51.
    • (1999) Nat Genet , vol.22 , pp. 347-351
    • Bodzioch, M.1    Orso, E.2    Klucken, J.3
  • 8
    • 0035138625 scopus 로고    scopus 로고
    • PPAR-α and PPAR-γ activators induce cholesterol removal from human macrophage foam cells through stimulation of the ABC-1 pathway
    • Chinetti G, Lestavel S, Bocher V, AT, et al. PPAR-α and PPAR-γ activators induce cholesterol removal from human macrophage foam cells through stimulation of the ABC-1 pathway. Nat Med, 2001, 7, 53-8.
    • (2001) Nat Med , vol.7 , pp. 53-58
    • Chinetti, G.1    Lestavel, S.2    Bocher, V.3
  • 9
    • 0034705071 scopus 로고    scopus 로고
    • CLA-1/SR-BI is expressed in atherosclerotic lesion macrophages and regulated by activators of peroxisome proliferator-activated receptors
    • Chinetti G, Gbaguidi FG, Griglio S, et al. CLA-1/SR-BI is expressed in atherosclerotic lesion macrophages and regulated by activators of peroxisome proliferator-activated receptors. Circulation, 2000, 23, 101, 2411-7.
    • (2000) Circulation , vol.23 , pp. 2411-2417
    • Chinetti, G.1    Gbaguidi, F.G.2    Griglio, S.3
  • 10
    • 0023726344 scopus 로고
    • Lipid alterations and decline in the incidence of coronary heart disease in the Helsinki Heart Study
    • Manninen V, Elo MO, Frick MH, et al. Lipid alterations and decline in the incidence of coronary heart disease in the Helsinki Heart Study. JAMA, 1988, 260, 641-51.
    • (1988) JAMA , vol.260 , pp. 641-651
    • Manninen, V.1    Elo, M.O.2    Frick, M.H.3
  • 11
    • 0027285331 scopus 로고
    • Ciprofibrate therapy normalises the atherogenic low-density lipoprotein subspecies profile in combined hyperlipidemia
    • Bruckert E, Dejager S, Chapman MJ. Ciprofibrate therapy normalises the atherogenic low-density lipoprotein subspecies profile in combined hyperlipidemia. Atherosclerosis, 1993, 100, 91-102.
    • (1993) Atherosclerosis , vol.100 , pp. 91-102
    • Bruckert, E.1    Dejager, S.2    Chapman, M.J.3
  • 12
    • 0033520304 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor activators inhibit thrombin-induced endothelin-1 production in human vascular endothelial cells by inhibiting the activator protein-1 signaling pathway
    • Delerive P, Martin-Nizard F, Chinetti G, et al. Peroxisome proliferator-activated receptor activators inhibit thrombin-induced endothelin-1 production in human vascular endothelial cells by inhibiting the activator protein-1 signaling pathway. Circ Res, 1999, 85, 394-402.
    • (1999) Circ Res , vol.85 , pp. 394-402
    • Delerive, P.1    Martin-Nizard, F.2    Chinetti, G.3
  • 13
    • 0031813989 scopus 로고    scopus 로고
    • Effects of fenofibrate on plasma cytokine concentrations in patients with atherosclerosis and hyperlipoproteinemia IIb
    • Madej A, Okopien B, Kowalski J, et al. Effects of fenofibrate on plasma cytokine concentrations in patients with atherosclerosis and hyperlipoproteinemia IIb Int J Clin Pharmacol Ther, 1998, 36, 345-9.
    • (1998) Int J Clin Pharmacol Ther , vol.36 , pp. 345-349
    • Madej, A.1    Okopien, B.2    Kowalski, J.3
  • 14
    • 0032565868 scopus 로고    scopus 로고
    • Activation of human aortic smooth-muscle cells is inhibited by PPARalpha but not by PPAR-gamma activators
    • Staels B, Koenig W, Habib A, et al. Activation of human aortic smooth-muscle cells is inhibited by PPARalpha but not by PPAR-gamma activators. Nature, 1998, 393, 790-3.
    • (1998) Nature , vol.393 , pp. 790-793
    • Staels, B.1    Koenig, W.2    Habib, A.3
  • 15
    • 0031888958 scopus 로고    scopus 로고
    • PPAR-gamma agonists inhibit production of monocyte inflammatory cytokines
    • Jiang C, Ting AT, Seed B. PPAR-gamma agonists inhibit production of monocyte inflammatory cytokines. Nature, 1998,391, 82-6.
    • (1998) Nature , vol.391 , pp. 82-86
    • Jiang, C.1    Ting, A.T.2    Seed, B.3
  • 16
    • 0032816777 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor-alpha activators regulate genes governing lipoprotein metabolism, vascular inflammation and atherosclerosis
    • Fruchart JC, Duriez P, Staels B. Peroxisome proliferator-activated receptor-alpha activators regulate genes governing lipoprotein metabolism, vascular inflammation and atherosclerosis. Curr Opin Lipidol, 1999, 10, 245-57.
    • (1999) Curr Opin Lipidol , vol.10 , pp. 245-257
    • Fruchart, J.C.1    Duriez, P.2    Staels, B.3
  • 17
    • 0035895326 scopus 로고    scopus 로고
    • PPARalpha Activators Inhibit Tissue Factor Expression and Activity in Human Monocytes
    • Marx N, Mackman N, Schonbeck U, et al. PPARalpha Activators Inhibit Tissue Factor Expression and Activity in Human Monocytes. Circulation, 2001, 103, 213-9.
    • (2001) Circulation , vol.103 , pp. 213-219
    • Marx, N.1    Mackman, N.2    Schonbeck, U.3
  • 18
    • 0032076207 scopus 로고    scopus 로고
    • Effects of two different fibric acid derivatives on lipoproteins, cholesteryl ester transfer, fibrinogen, plasminogen activator inhibitor and paraoxonase activity in type 2b hyperlipoproteinaemia
    • Durrington PN, Mackness MI, Bhatnagar D, et al. Effects of two different fibric acid derivatives on lipoproteins, cholesteryl ester transfer, fibrinogen, plasminogen activator inhibitor and paraoxonase activity in type 2b hyperlipoproteinaemia. Atherosclerosis, 1998, 138, 217-25.
    • (1998) Atherosclerosis , vol.138 , pp. 217-225
    • Durrington, P.N.1    Mackness, M.I.2    Bhatnagar, D.3
  • 19
    • 0035204047 scopus 로고    scopus 로고
    • Effects of fibrates on plasma prothrombotic activity in patients with type 2b dyslipidemia
    • Okopien B, Cwalina L, Lebek M, et al. Effects of fibrates on plasma prothrombotic activity in patients with type 2b dyslipidemia. Int J Clin Pharmacol Ther, 2001, 39, 551-7.
    • (2001) Int J Clin Pharmacol Ther , vol.39 , pp. 551-557
    • Okopien, B.1    Cwalina, L.2    Lebek, M.3
  • 20
    • 0033134791 scopus 로고    scopus 로고
    • Fibrates suppress fibrinogen gene expression in rodents via activation of the peroxisome proliferator-activated receptor-alpha
    • Kockx M, Gervois PP, Poulain P, et al. Fibrates suppress fibrinogen gene expression in rodents via activation of the peroxisome proliferator-activated receptor-alpha Blood, 1999, 93, 2991-8.
    • (1999) Blood , vol.93 , pp. 2991-2998
    • Kockx, M.1    Gervois, P.P.2    Poulain, P.3
  • 21
    • 0023232216 scopus 로고
    • Helsinki Heart Study: Primary-prevention trial with gemfibrozil in middle-aged men with dyslipidemia. Safety of treatment, changes in risk factors, and incidence of coronary heart disease
    • Frick MH, Elo O, Haapa K, et al. Helsinki Heart Study: primary-prevention trial with gemfibrozil in middle-aged men with dyslipidemia. Safety of treatment, changes in risk factors, and incidence of coronary heart disease. N Engl J Med, 1987, 317, 1237-45.
    • (1987) N Engl J Med , vol.317 , pp. 1237-1245
    • Frick, M.H.1    Elo, O.2    Haapa, K.3
  • 22
    • 0026597808 scopus 로고
    • Joint effects of serum triglyceride and LDL cholesterol and HDL cholesterol concentrations on coronary heart disease risk in the Helsinki Heart Study. Implications for treatment
    • Manninen V, Tenkanen L, Koskinen P, et al. Joint effects of serum triglyceride and LDL cholesterol and HDL cholesterol concentrations on coronary heart disease risk in the Helsinki Heart Study. Implications for treatment. Circulation, 1992, 85, 37-45.
    • (1992) Circulation , vol.85 , pp. 37-45
    • Manninen, V.1    Tenkanen, L.2    Koskinen, P.3
  • 23
    • 0033527030 scopus 로고    scopus 로고
    • Gemfibrozil for the secondary prevention of coronary heart disease in men with low levels of high-density lipoprotein cholesterol
    • Veterans Affairs High-Density Lipoprotein Cholesterol Intervention Trial Study Group
    • Rubins HB, Robins SJ, Collins D, et al. Gemfibrozil for the secondary prevention of coronary heart disease in men with low levels of high-density lipoprotein cholesterol. Veterans Affairs High-Density Lipoprotein Cholesterol Intervention Trial Study Group. N Engl J Med, 1999, 341, 410-8.
    • (1999) N Engl J Med , vol.341 , pp. 410-418
    • Rubins, H.B.1    Robins, S.J.2    Collins, D.3
  • 24
    • 0036072223 scopus 로고    scopus 로고
    • Effect of pioglitazone on abdominal fat distribution and insulin sensitivity in type 2 diabetic patients
    • Miyazaki Y, Mahankali A, Matsuda M, et al. Effect of pioglitazone on abdominal fat distribution and insulin sensitivity in type 2 diabetic patients. J Clin Endocrinol Metab, 2002, 87, 2784-91.
    • (2002) J Clin Endocrinol Metab , vol.87 , pp. 2784-2791
    • Miyazaki, Y.1    Mahankali, A.2    Matsuda, M.3
  • 25
    • 0742267552 scopus 로고    scopus 로고
    • Effects of Metformin and Rosiglitazone Monotherapy on Insulin-Mediated Hepatic Glucose Uptake and Their Relation to Visceral Fat in Type 2 Diabetes
    • Iozzo P, Hallsten K, Oikonen V, et al. Effects of Metformin and Rosiglitazone Monotherapy on Insulin-Mediated Hepatic Glucose Uptake and Their Relation to Visceral Fat in Type 2 Diabetes. Diabetes Care, 2003, 26, 2069-74.
    • (2003) Diabetes Care , vol.26 , pp. 2069-2074
    • Iozzo, P.1    Hallsten, K.2    Oikonen, V.3
  • 26
    • 0033754530 scopus 로고    scopus 로고
    • Pioglitazone hydrochloride monotherapy improves glycemic control in the treatment of patients with type 2 diabetes: A 6-month randomized placebo-controlled dose-response study
    • The Pioglitazone 001 Study Group
    • Aronoff S, Rosenblatt S, Braithwaite S, Egan JW, Mathisen AL, Schneider RL. Pioglitazone hydrochloride monotherapy improves glycemic control in the treatment of patients with type 2 diabetes: a 6-month randomized placebo-controlled dose-response study. The Pioglitazone 001 Study Group. Diabetes Care, 2000, 23, 1605-11.
    • (2000) Diabetes Care , vol.23 , pp. 1605-1611
    • Aronoff, S.1    Rosenblatt, S.2    Braithwaite, S.3    Egan, J.W.4    Mathisen, A.L.5    Schneider, R.L.6
  • 27
    • 0035140430 scopus 로고    scopus 로고
    • Rosiglitazone monotherapy is effective in patients with type 2 diabetes
    • Rosiglitazone Clinical Trials Study Group
    • Lebovitz HE, Dole JF, Patwardhan R, Rappaport EB, Freed MI. Rosiglitazone Clinical Trials Study Group. Rosiglitazone monotherapy is effective in patients with type 2 diabetes. J Clin Endocrinol Metab, 2001, 86, 280-8.
    • (2001) J Clin Endocrinol Metab , vol.86 , pp. 280-288
    • Lebovitz, H.E.1    Dole, J.F.2    Patwardhan, R.3    Rappaport, E.B.4    Freed, M.I.5
  • 28
    • 0033975057 scopus 로고    scopus 로고
    • Addition of low-dose rosiglitazone to sulphonylurea therapy improves glycaemic control in Type 2 diabetic patients
    • Wolffenbuttel BH, Gomis R, Squatrito S, Jones NP, Patwardhan RN. Addition of low-dose rosiglitazone to sulphonylurea therapy improves glycaemic control in Type 2 diabetic patients. Diabet Med, 2000, 17, 40-7.
    • (2000) Diabet Med , vol.17 , pp. 40-47
    • Wolffenbuttel, B.H.1    Gomis, R.2    Squatrito, S.3    Jones, N.P.4    Patwardhan, R.N.5
  • 29
    • 0034933056 scopus 로고    scopus 로고
    • Pioglitazone hydrochloride in combination with sulfonylurea therapy improves glycemic control in patients with type 2 diabetes mellitus: A randomized, placebo-controlled study
    • Kipnes MS, Krosnick A, Rendell MS, Egan JW, Mathisen AL, Schneider RL. Pioglitazone hydrochloride in combination with sulfonylurea therapy improves glycemic control in patients with type 2 diabetes mellitus: a randomized, placebo-controlled study. Am J Med, 2001, 111, 10-7.
    • (2001) Am J Med , vol.111 , pp. 10-17
    • Kipnes, M.S.1    Krosnick, A.2    Rendell, M.S.3    Egan, J.W.4    Mathisen, A.L.5    Schneider, R.L.6
  • 30
    • 0034607438 scopus 로고    scopus 로고
    • Effect of metformin and rosiglitazone combination therapy in patients with type 2 diabetes mellitus: A randomized controlled trial
    • Fonseca V, Rosenstock J, Patwardhan R, Salzman A. Effect of metformin and rosiglitazone combination therapy in patients with type 2 diabetes mellitus: a randomized controlled trial. JAMA, 2000, 283, 1695-702.
    • (2000) JAMA , vol.283 , pp. 1695-1702
    • Fonseca, V.1    Rosenstock, J.2    Patwardhan, R.3    Salzman, A.4
  • 31
    • 0034531195 scopus 로고    scopus 로고
    • Pioglitazone hydrochloride in combination with metformin in the treatment of type 2 diabetes mellitus: A randomized, placebo-controlled study
    • Einhorn D, Rendell MS, Rosenzweig J, et al. Pioglitazone hydrochloride in combination with metformin in the treatment of type 2 diabetes mellitus: a randomized, placebo-controlled study. Clin Ther, 2000, 22, 1395-1409.
    • (2000) Clin Ther , vol.22 , pp. 1395-1409
    • Einhorn, D.1    Rendell, M.S.2    Rosenzweig, J.3
  • 32
    • 0036095647 scopus 로고    scopus 로고
    • Oral antidiabetics and lipids
    • Vergès B. Oral antidiabetics and lipids. Ann Endocrinol, 2002, 63, 1S45-1S50.
    • (2002) Ann Endocrinol , vol.63
    • Vergès, B.1
  • 33
    • 0000396919 scopus 로고    scopus 로고
    • Rosiglitazone favorably affects LDL-C and HDL-C heterogeneity in type 2 diabetes
    • Brunzell J, Cohen BR, Kreider M, et al. Rosiglitazone favorably affects LDL-C and HDL-C heterogeneity in type 2 diabetes. Diabetes, 2001, 50, A141.
    • (2001) Diabetes , vol.50
    • Brunzell, J.1    Cohen, B.R.2    Kreider, M.3
  • 34
    • 0001093228 scopus 로고    scopus 로고
    • Differing effects of thiazolidinediones in LDL subfractions
    • Ovalle B, Bell DSH. Differing effects of thiazolidinediones in LDL subfractions. Diabetes, 2001, 51, A457.
    • (2001) Diabetes , vol.51
    • Ovalle, B.1    Bell, D.S.H.2
  • 35
    • 0037630676 scopus 로고    scopus 로고
    • Pioglitazone reduces atherogenic dense low density lipoprotein (LDL) particles in patients with type 2 diabetes mellitus
    • Winkler K, Friedrich I, Baumstark MW, Wieland H, März W. Pioglitazone reduces atherogenic dense low density lipoprotein (LDL) particles in patients with type 2 diabetes mellitus. B J Diabetes Vasc Dis, 2002, 2, 143-8.
    • (2002) B J Diabetes Vasc Dis , vol.2 , pp. 143-148
    • Winkler, K.1    Friedrich, I.2    Baumstark, M.W.3    Wieland, H.4    März, W.5
  • 36
    • 0034726705 scopus 로고    scopus 로고
    • Repression of TNF-alpha-induced E-selectin expression by PPAR activators: Involvement of transcriptional repressor LRF-1/ATF3
    • Nawa T, Nawa MT, Cai Y, et al. Repression of TNF-alpha-induced E-selectin expression by PPAR activators: involvement of transcriptional repressor LRF-1/ATF3. Biochem Biophys Res Commun, 2000, 275, 406-11.
    • (2000) Biochem Biophys Res Commun , vol.275 , pp. 406-411
    • Nawa, T.1    Nawa, M.T.2    Cai, Y.3
  • 37
    • 0033594810 scopus 로고    scopus 로고
    • PPARalpha activators inhibit cytokine-induced vascular cell adhesion molecule-1 expression in human endothelial cells
    • Marx N, Sukhova GK, Collins T, Libby P, Plutzky J. PPARalpha activators inhibit cytokine-induced vascular cell adhesion molecule-1 expression in human endothelial cells. Circulation, 1999, 99, 3125-31.
    • (1999) Circulation , vol.99 , pp. 3125-3131
    • Marx, N.1    Sukhova, G.K.2    Collins, T.3    Libby, P.4    Plutzky, J.5
  • 38
    • 0032988209 scopus 로고    scopus 로고
    • Thiazolidinedione inhibits the production of monocyte chemoattractant protein-1 in cytokine-treated human vascular endothelial cells
    • Murao K, Imachi H, Momoi A, et al. Thiazolidinedione inhibits the production of monocyte chemoattractant protein-1 in cytokine-treated human vascular endothelial cells. FEBS Lett, 1999, 454, 27-30.
    • (1999) FEBS Lett , vol.454 , pp. 27-30
    • Murao, K.1    Imachi, H.2    Momoi, A.3
  • 39
    • 0344333464 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor gamma activators inhibit gene expression and migration in human vascular smooth muscle cells
    • Marx N, Schonbeck U, Lazar MA, Libby P, Plutzky J. Peroxisome proliferator-activated receptor gamma activators inhibit gene expression and migration in human vascular smooth muscle cells. Circ Res, 1998, 83, 1097-103.
    • (1998) Circ Res , vol.83 , pp. 1097-1103
    • Marx, N.1    Schonbeck, U.2    Lazar, M.A.3    Libby, P.4    Plutzky, J.5
  • 40
    • 0034696412 scopus 로고    scopus 로고
    • Expression and function of PPARgamma in rat and human vascular smooth muscle cells
    • Law RE, Goetze S, Xi XP, et al. Expression and function of PPARgamma in rat and human vascular smooth muscle cells. Circulation, 2000, 101, 1311-8.
    • (2000) Circulation , vol.101 , pp. 1311-1318
    • Law, R.E.1    Goetze, S.2    Xi, X.P.3
  • 41
    • 0031870652 scopus 로고    scopus 로고
    • Macrophages in human atheroma contain PPARgamma: Differentiation-dependent peroxisomal proliferator-activated receptor gamma(PPARgamma) expression and reduction of MMP-9 activity through PPARgamma activation in mononuclear phagocytes in vitro
    • Marx N, Sukhova G, Murphy C, Libby P, Plutzky J. Macrophages in human atheroma contain PPARgamma: differentiation-dependent peroxisomal proliferator-activated receptor gamma(PPARgamma) expression and reduction of MMP-9 activity through PPARgamma activation in mononuclear phagocytes in vitro. Am J Pathol, 1998, 153, 17-23.
    • (1998) Am J Pathol , vol.153 , pp. 17-23
    • Marx, N.1    Sukhova, G.2    Murphy, C.3    Libby, P.4    Plutzky, J.5
  • 42
    • 0037324289 scopus 로고    scopus 로고
    • Antidiabetic PPAR gamma-activator rosiglitazone reduces MMP-9 serum levels in type 2 diabetic patients with coronary artery disease
    • Marx N, Froehlich J, Siam L, et al. Antidiabetic PPAR gamma-activator rosiglitazone reduces MMP-9 serum levels in type 2 diabetic patients with coronary artery disease. Arterioscler Thromb Vasc Biol, 2003, 23, 283-8.
    • (2003) Arterioscler Thromb Vasc Biol , vol.23 , pp. 283-288
    • Marx, N.1    Froehlich, J.2    Siam, L.3
  • 43
    • 0033608242 scopus 로고    scopus 로고
    • Thiazolidinediones suppress endothelin-1 secretion from bovine vascular endothelial cells: A new possible role of PPARgamma on vascular endothelial function
    • Satoh H, Tsukamoto K, Hashimoto Y, et al. Thiazolidinediones suppress endothelin-1 secretion from bovine vascular endothelial cells: a new possible role of PPARgamma on vascular endothelial function. Biochem Biophys Res Commun, 1999, 254, 757-63.
    • (1999) Biochem Biophys Res Commun , vol.254 , pp. 757-763
    • Satoh, H.1    Tsukamoto, K.2    Hashimoto, Y.3
  • 44
    • 0033669212 scopus 로고    scopus 로고
    • Comparative effects of pioglitazone, glibenclamide, and voglibose on urinary endothelin-1 and albumin excretion in diabetes patients
    • Nakamura T, Ushiyama C, Shimada N, Hayashi K, Ebihara I, Koide H. Comparative effects of pioglitazone, glibenclamide, and voglibose on urinary endothelin-1 and albumin excretion in diabetes patients. J Diabetes Complications, 2000, 14,250-4.
    • (2000) J Diabetes Complications , vol.14 , pp. 250-254
    • Nakamura, T.1    Ushiyama, C.2    Shimada, N.3    Hayashi, K.4    Ebihara, I.5    Koide, H.6
  • 45
    • 0031888958 scopus 로고    scopus 로고
    • PPAR-gamma agonists inhibit production of monocyte inflammatory cytokines
    • Jiang C, Ting AT, Seed B. PPAR-gamma agonists inhibit production of monocyte inflammatory cytokines. Nature, 1998, 391, 82-6.
    • (1998) Nature , vol.391 , pp. 82-86
    • Jiang, C.1    Ting, A.T.2    Seed, B.3
  • 46
    • 0032737858 scopus 로고    scopus 로고
    • The peroxisome proliferator-activated receptor (PPARgamma) as a regulator of monocyte/macrophage function
    • Ricote M, Huang JT, Welch JS, Glass CK. The peroxisome proliferator-activated receptor (PPARgamma) as a regulator of monocyte/macrophage function. J Leukoc Biol, 1999, 66, 733-9.
    • (1999) J Leukoc Biol , vol.66 , pp. 733-739
    • Ricote, M.1    Huang, J.T.2    Welch, J.S.3    Glass, C.K.4
  • 47
    • 0034741076 scopus 로고    scopus 로고
    • PPARgamma ligands inhibit TNF-alpha-induced LOX-1 expression in cultured endothelial cells
    • Chiba Y, Ogita T, Ando K, Fujita T. PPARgamma ligands inhibit TNF-alpha-induced LOX-1 expression in cultured endothelial cells. Biochem Biophys Res Commun, 2001,286,541-6.
    • (2001) Biochem Biophys Res Commun , vol.286 , pp. 541-546
    • Chiba, Y.1    Ogita, T.2    Ando, K.3    Fujita, T.4
  • 48
    • 0035093258 scopus 로고    scopus 로고
    • Troglitazone inhibits formation of early atherosclerotic lesions in diabetic and nondiabetic low density lipoprotein receptor-deficient mice
    • Collins AR, Meehan WP, Kintscher U, et al. Troglitazone inhibits formation of early atherosclerotic lesions in diabetic and nondiabetic low density lipoprotein receptor-deficient mice. Arterioscler Thromb Vasc Biol, 2001, 21, 365-71.
    • (2001) Arterioscler Thromb Vasc Biol , vol.21 , pp. 365-371
    • Collins, A.R.1    Meehan, W.P.2    Kintscher, U.3
  • 49
    • 0033822852 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor gamma ligands and atherosclerosis: Ending the heartache
    • Rosen ED, Spiegelman BM. Peroxisome proliferator-activated receptor gamma ligands and atherosclerosis: ending the heartache. J Clin Invest, 2000, 106, 629-31.
    • (2000) J Clin Invest , vol.106 , pp. 629-631
    • Rosen, E.D.1    Spiegelman, B.M.2
  • 50
    • 0036314839 scopus 로고    scopus 로고
    • Ligands of the peroxisome proliferator-activated receptors (PPAR-gamma and PPAR-alpha) reduce myocardial infarct size
    • Wayman NS, Hattori Y, McDonald MC, et al. Ligands of the peroxisome proliferator-activated receptors (PPAR-gamma and PPAR-alpha) reduce myocardial infarct size. FASEB J, 2002, 16, 1027-40.
    • (2002) FASEB J , vol.16 , pp. 1027-1040
    • Wayman, N.S.1    Hattori, Y.2    McDonald, M.C.3
  • 51
    • 0034920087 scopus 로고    scopus 로고
    • Rapid communication: Inhibitory effect of pioglitazone on carotid arterial wall thickness in type 2 diabetes
    • Koshiyama H, Shimono D, Kuwamura N, Minamikawa J, Nakamura Y. Rapid communication: inhibitory effect of pioglitazone on carotid arterial wall thickness in type 2 diabetes. J Clin Endocrinol Metab, 2001, 86, 3452-6.
    • (2001) J Clin Endocrinol Metab , vol.86 , pp. 3452-3456
    • Koshiyama, H.1    Shimono, D.2    Kuwamura, N.3    Minamikawa, J.4    Nakamura, Y.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.