Novel 6-N-arylcarboxamidopyrazolo[4,3-d]pyrimidin-7-one derivatives as potential anti-cancer agents

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 5, 2010, Pages 1630-1633

  Devegowda, Vani N ^a,b   Kim, Jung Hyun ^a   Han, Ki Cheol ^a   Yang, Eun Gyeong ^a,b   Choo, Hyunah ^a   Pae, Ae Nim ^a,b   Nam, Ghilsoo ^a   Choi, Kyung Il ^a,b  

^a Korea Institute of Science and Technology   (South Korea)

^b University of Science and Technology (UST)   (South Korea)

Author keywords

6 N Arylcarboxamidopyrazolo 4,3 d pyrimidin 7 one; Anticancer activity; Structure activity relationship

Indexed keywords

3,5,6 TRISUBSTITUTED PYRAZOLO[4,3 D]PYRIMIDIN 7 ONE DERIVATIVE; 6 N ARYLCARBOXAMIDOPYRAZOLO[4,3 D]PYRIMIDIN 7 ONE DERIVATIVE; ANTINEOPLASTIC AGENT; PYRIMIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; COLON CANCER; DRUG INHIBITION; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IN VITRO STUDY; MALE; PROSTATE CANCER; STRUCTURE ACTIVITY RELATION;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; PROTEIN-SERINE-THREONINE KINASES; PYRAZOLES; PYRIMIDINES; PYRIMIDINONES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 76649107345     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.01.029     Document Type: Article

References (28)

1. Gibbs J.B. Science 287 (2000) 1969
2. Varmus H. Science 312 (2006) 1162
3. Ochi H., and Miyasaka T. Chem. Pharm. Bull. 31 (1983) 1228
4. Skipper H.E., Robins R.K., and Thompson J.R. Proc. Soc. Exp. Biol. Med. 89 (1955) 594
5. Rotella D.P. Nat. Rev. Drug Disc. 1 (2002) 674
6. Allerton C.M.N., Barber C.G., Beaumont K.C., Brown D.G., Cole S.M., Ellis D., Lane C.A.L., Maw G.N., Mount N.M., Rawson D.J., Robinson C.M., Street S.D.A., and Summerhill N.W. J. Med. Chem. 49 (2006) 3581
7. Bell, A. S.; Brown, D.; Terrett, N. K. Eur. Patent 463756, 1991.
8. Salem E.A., Kendirci M., and Hellstrom W.J. Curr. Opin. Invest. Drugs 7 (2006) 661
9. Carter A.J., Ballard S.A., and Naylor A.M. J. Urol. 160 (1998) 242
10. Doherty, P. C.; Place, V. A.; Smith W. L. US 6037346, 2000.
11. Blokland A., Schreiber R., and Prickaerts J. Curr. Pharm. Des. 12 (2006) 2511
12. Ratajczyk, J. D.; Stein, R. G.; Swett, L. R. US 3939161, 1976.
13. Dykes, G. J.; Fletcher, S. R.; Menet, C. J. M.; Merayo, N. M.; Schmitt, B. A.; US 20080242661 A1, 2008.
14. Stehlik J., and Movsesian M.A. Expert Opin. Invest. Drugs 15 (2006) 733
15. Shin, J. H.; Ahn, G. J.; Kang, K. K.; Ahn, B. O.; Yoo, M. H. WO 2008153282 A1, 2008.
16. Hamilton, H. W. US 4666908, 1987.
17. Lindell S.D., Moloney B.A., Hewitt B.D., Earnhaw C.G., Philip P.J., and Dancer J.E. Bioorg. Med. Chem. Lett. 9 (1999) 1985
18. Zhu B., and Strada S.J. Curr. Top. Med. Chem. 7 (2007) 437
19. Sanghvi Y.S., Larson S.B., Smee D.F., Revankar G.R., and Robins R.K. Nucleosides Nucleotides 10 (1991) 1417
20. Gonzalez M., Rodriguez Z., Tolon B., Rodriguez J.C., Velez H., Valdes B., Lopez M.A., and Fini A. Il Farmaco 58 (2003) 409
21. Majid T., Hopkins C.R., Pedgrift B., and Collar N. Tetrahedron Lett. 45 (2004) 2137
22. Lee J.G., Choi K.I., Koh H.Y., Kim Y., Kang Y., and Cho Y.S. Synthesis 1 (2001) 81
23. Bartulewicz D., Anchim T., Dabrowska M., and Nowaczek K.M. Il Farmaco 59 (2004) 211
24. Fischer D.S., Allan G.M., Bubert C., Vicker N., Smith A., Tutill H.J., Purohit A., Wood L., Packham G., Mahon M.F., Reed M.J., and Potter B.V.L. J. Med. Chem. 48 (2005) 5749
25. Hale K.J., and Lazarides L. Chem. Commun. (2002) 1832
26. El-Abadelah M.M., Sabri S.S., Khanfar M.A., and Yasin H.A. J. Heterocycl. Chem. 39 (2002) 1055
27. ++H].
28. 50.