Anti-inflammatory activity of bark of Dioscorea batatas DECNE through the inhibition of iNOS and COX-2 expressions in RAW264.7 cells via NF-κB and ERK1/2 inactivation

Food and Chemical Toxicology

Volumn 48, Issue 11, 2010, Pages 3073-3079

  Jin, Meihua ^a   Suh, Seok Jong ^a   Yang, Ju Hye ^a   Lu, Yue ^a   Kim, Su Jeong ^a   Kwon, Soonyoul ^b   Jo, Tae Hyung ^c   Kim, Jin Wan ^c   Park, Young In ^d   Ahn, Ghe Whan ^e   Lee, Chong Kil ^e   Kim, Cheorl Ho ^f   Son, Jong Keun ^a   Son, Kun Ho ^b   Chang, Hyeun Wook ^a  

^a Yeungnam University   (South Korea)

^b Andong National University   (South Korea)

^c Namyang Inc   (South Korea)

^d Korea University   (South Korea)

^e Chungbuk National University   (South Korea)

^f Sungkyunkwan University   (South Korea)

Author keywords

COX 2; Dioscorea batatas; ERK1 2; INOS; Lipopolysaccharide; NF B

Indexed keywords

ALCOHOL; CYCLOOXYGENASE 2; DIOSCOREA BATATAS EXTRACT; DNA; ESCHERICHIA COLI LIPOPOLYSACCHARIDE; I KAPPA B; I KAPPA B ALPHA; I KAPPA B KINASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; NITRIC OXIDE; PLANT EXTRACT; PROSTAGLANDIN E2; TRANSCRIPTION FACTOR RELA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BARK; CONCENTRATION RESPONSE; CONTROLLED STUDY; DIOSCOREA BATATAS; DIOSCOREACEAE; DOWN REGULATION; ENZYME ACTIVATION; ENZYME INACTIVATION; ENZYME INHIBITION; GENE ACTIVITY; IC 50; MOUSE; NONHUMAN; PROSTAGLANDIN SYNTHESIS; PROTEIN DEGRADATION; PROTEIN DNA BINDING; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; REPORTER GENE; SOLVENT EXTRACTION;

ANIMALS; CELL LINE; CELL SURVIVAL; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITORS; DINOPROSTONE; DIOSCOREA; DOSE-RESPONSE RELATIONSHIP, DRUG; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; LIPOPOLYSACCHARIDES; MACROPHAGES; MICE; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; NF-KAPPA B; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; PHOSPHORYLATION; PLANT BARK; PLANT EXTRACTS;

DIOSCOREA POLYSTACHYA;

EID: 77957355681     PISSN: 02786915     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.fct.2010.07.048     Document Type: Article

References (35)

1. Adelizzi R.A. COX-1 and COX-2 in health and disease. J. Am. Osteopath. Assoc. 1999, 99:S7-12.
2. An S.J., Pae H.O., Oh G.S., Choi B.M., Jeong S., Jang S.I., Oh H., Kwon T.O., Song C.E., Chung H.T. Inhibition of TNF-alpha, IL-1beta, and IL-6 productions and NF-kappa B activation in lipopolysaccharide-activated RAW 264.7 macrophages by catalposide, an iridoid glycoside isolated from Catalpa ovata G. Don (Bignoniaceae). Int. Immunopharmacol. 2002, 2:1173-1181.
3. Baeuerle P.A. IkappaB-NF-kappaB structures: at the interface of inflammation control. Cell 1998, 95:729-731.
4. Chen B.C., Chen Y.H., Lin W.W. Involvement of p38 mitogen-activated protein kinase in lipopolysaccharide-induced iNOS and COX-2 expression in J774 macrophages. Immunology 1999, 97:124-129.
5. Ghosh S., Karin M. Missing pieces in the NF-κB puzzle. Cell 2002, 109:S81-S96.
6. 2: Involvements of Cyclooxygenase (COX)-1 and COX-2 in human and rat systems. J. Pharmacol. Exp. Ther. 2002, 303:1001-1006.
7. Guha M., Mackman N. LPS induction of gene expression in human monocytes. Cell Signal 2001, 13:85-94.
8. Henkel T., Machleidt T., Alkalay I., Kronke M., Ben-Neriah Y., Baeuerle P.A. Rapid proteolysis of I kappa B-alpha is necessary for activation of transcription factor NF-kappa B. Nature 1993, 365:182-185.
9. Hou W.C., Lee M.H., Chen H.J., Liang W.L., Han C.H., Liu Y.W., Lin Y.H. Antioxidant activities of dioscorin, the storage protein of yam (Dioscorea batatas Decne) tuber. J. Agric. Food Chem. 2001, 49:4956-4960.
10. Hou W.C., Hsu F.L., Lee M.H. Yam (Dioscorea batatas) tuber mucilage exhibited antioxidant activities in Vitro. Planta Med. 2002, 68:1072-1076.
11. Hur G.Y., Park H.J., Kim H.A., Ye Y.M., Park H.S. Identification of Dioscorea Batatas (Sanyak) Allergen as an Inhalant and Oral Allergen. J. Korean Med. Sci. 2008, 23:72-76.
12. Kim S.H., Jeong H., Kim Y.K., Cho S.H., Min K.U., Kim Y.Y. IgE-mediated occupational asthma induced by herbal medicine, Banha (Pinellia ternata). Clin. Exp. Allergy 2001, 31:779-781.
13. Korhonen R., Lahti A., Kankaanranta H., Moilanen E. Nitric oxide production and signaling in inflammation. Curr. Drug Targets: Inflammation Allergy 2005, 4:471-479.
14. Kroncke K.D., Fehsel K., Kolb-Bachofen V. Inducible nitric oxide synthase in human diseases. Clin. Exp. Immunol. 1998, 113:147-156.
15. Laskin D.L., Pendino K.J. Macrophages and inflammatory mediators in tissue injury. Annu. Rev. Pharmacol. Toxicol. 1995, 35:655-677.
16. Lee S.J., Lim K.T. Inhibitory effect of 30-kDa phytoglycoprotein on expression of TNF-alpha and COX-2 via activation of PKCalpha and ERK 1/2 in LPS-stimulated RAW 264.7 cells. Mol. Cell Biochem. 2008, 317:151-159.
17. Lee S.K., Cho H.K., Cho S.H., Kim S.S., Nahm D.H., Park H.S. Occupational asthma and rhinitis caused by multiple herbal agents in a pharmacist. Ann. Allergy Asthma Immunol. 2001, 86:469-474.
18. Lee C.L., Wang J.J., Kuo S.L., Pan T.M. Monascus fermentation of dioscorea for increasing the production of cholesterol-lowering agent monacolin K and antiinflammation agent-monascin. Appl. Microbiol. Biotechnol. 2006, 72:1254-1262.
19. Lee J.Y., Lee Y.D., Bahn J.W., Park H.S. A case of occupational asthma and rhinitis caused by Sanyak and Korean ginseng dusts. Allergy 2006, 61:392-393.
20. Lee H.Y., Jung D.Y., Ha H., Son K.H., Jeon S.J., Kim C. Induction of growth hormone release by dioscin from Dioscorea batatas DECNE. J. Biochem. Mol. Biol. 2007, 40:1016-1020.
21. Liu Z., Fan Y., Wang Y., Han C., Pan Y., Huang H., Ye Y., Luo L., Yin Z. Dipyrithione inhibits lipopolysaccharide-induced iNOS and COX-2 up-regulation in macrophages and protects against endotoxic shock in mice. FEBS Lett. 2008, 582:1643-1650.
22. Moon S.K., Cha B.Y., Kim C.H. ERK1/2 mediates TNF-α-induced matrix metalloproteinase-9 expression in human vascular smooth muscle cells via the regulation of NF-κB and AP-1: involvement of the ras dependent pathway. J. Cell. Physiol. 2004, 198:417-427.
23. Moon S.K., Kim H.M., Lee Y.C., Kim C.H. Disialoganglioside (GD3) synthase gene expression suppresses vascular smooth muscle cell responses via inhibition of ERK1/2 phosphorylation, cell cycle progression, and matrix metalloproteinase-9 expression. J. Biol. Chem. 2004, 279:33063-33070.
24. Nathan C., Xie Q.W. Nitric oxide synthases: roles, tolls and controls. Cell 1994, 78:915-918.
25. O'Banion M.K., Winn V.D., Young D.A. CDNA cloning and functional activity of a glucocorticoid-regulated inflammatory cyclooxygenase. Proc. Natl. Acad. Sci. USA 1992, 89:4888-4892.
26. Oh M.H., Houghton P.J., Whang W.K., Cho J.H. Screening of Korean herbal medicines used to improve cognitive function for anti-cholinesterase activity. Phytomedicine 2004, 11:544-548.
27. Ohshima H., Bartsch H. Chronic infections and inflammatory processes as cancer risk factors: possible role of nitric oxide in carcinogenesis. Mutat. Res. 1994, 305:253-264.
28. Park H.S., Kim M.J., Moon H.B. Occupational asthma caused by two herb materials, Dioscorea batatas and Pinellia ternata. Clin. Exp. Allergy 1994, 24:575-581.
29. Rajapakse N., Kim M.M., Mendis E., Kim S.K. Inhibition of inducible nitric oxide synthase and cyclooxygenase-2 in lipopolysaccharide-stimulated RAW264.7 cells by carboxybutyrylated glucosamine takes place via down-regulation of mitogen-activated protein kinase-mediated nuclear factor-kappaB signaling. Immunology 2008, 123:348-357.
30. Rhee J.W., Lee K.W., Kim D., Lee Y., Jeon O.H., Kwon H.J., Kim D.S. NF-kappaB-dependent regulation of matrix metalloproteinase-9 gene expression by lipopolysaccharide in a macrophage cell line RAW 264.7. J. Biochem. Mol. Biol. 2007, 40:88-94.
31. Schreck R., Meier B., Männel D.N., Dröge W., Baeuerle P.A. Dithiocarbamates as potent inhibitors of nuclear factor kappa B activation in intact cells. J. Exp. Med. 1992, 175:1181-1194.
32. 2, and tumor necrosis factor-alpha production from murine macrophage RAW 264.7 cells. Biol. Pharm. Bull. 2004, 27:538-543.
33. Tak P.P., Firestein G.S. NF-kB: a key role in inflammatory diseases. J. Clin. Invest. 2001, 107:7-11.
34. Woo C.H., Lim J.H., Kim J.H. Lipopolysaccharide induces matrix metalloproteinase-9 expression via a mitochondrial reactive oxygen species-p38 kinase-activator protein-1 pathway in Raw 264.7 cells. J. Immunol. 2004, 173:6973-6980.
35. Yoon W.J., Ham Y.M., Yoo B.S., Moon J.Y., Koh J., Hyun C.G. Oenothera laciniata inhibits lipopolysaccharide induced production of nitric oxide, prostaglandin E2, and proinflammatory cytokines in RAW264.7 macrophages. J. Biosci. Bioeng. 2009, 107:429-438.