Anti-invasive and anti-adhesive activities of a recombinant disintegrin, r-viridistatin 2, derived from the Prairie rattlesnake (Crotalus viridis viridis)

Toxicon

Volumn 60, Issue 1, 2012, Pages 31-39

  Lucena, Sara E ^a   Jia, Ying ^a   Soto, Julio G ^b   Parral, Jessica ^c   Cantu, Esteban ^a   Brannon, Jeremy ^a   Lardner, Kristina ^c   Ramos, Carla J ^b   Seoane, Agustin I ^b   Sánchez, Elda E ^a  

^a TEXAS A AND M UNIVERSITY KINGSVILLE   (United States)

^b SAN JOSE STATE UNIVERSITY   (United States)

^c Del Mar College   (United States)

Author keywords

Anti metastatic activity; Cancer cell lines; Crotalus viridis viridis; Disintegrin; Recombinant snake toxins

Indexed keywords

ANTINEOPLASTIC AGENT; UNCLASSIFIED DRUG; VIRIDISTATIN 2;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; BASEMENT MEMBRANE; CANCER CELL CULTURE; CANCER INVASION; CELL ADHESION; CELL INVASION; CONTROLLED STUDY; DRUG MECHANISM; HUMAN; HUMAN CELL; LUNG METASTASIS; MELANOMA; METASTASIS INHIBITION; MIGRATION INHIBITION; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; THROMBOCYTE AGGREGATION INHIBITION;

AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; CELL ADHESION; CELL LINE, TUMOR; CROTALID VENOMS; CROTALUS; DISINTEGRINS; DNA PRIMERS; DNA, COMPLEMENTARY; HUMANS; MICE; MOLECULAR SEQUENCE DATA; NEOPLASM INVASIVENESS; PLATELET AGGREGATION INHIBITORS; RECOMBINANT PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID;

CROTALUS VIRIDIS VIRIDIS; MURINAE; MUS;

EID: 84859383536     PISSN: 00410101     EISSN: 18793150     Source Type: Journal    
DOI: 10.1016/j.toxicon.2012.03.011     Document Type: Article

References (51)

1. Aokage K., Ishii G., Ohtaki Y., Yamaguchi Y., Hishida T., Yoshida J., Nishimura M., Nagai K., Ochiai A. Dynamic molecular changes associated with epithelial-mesenchymal transition and subsequent mesenchymal-epithelial transition in the early phase of metastatic tumor formation. Int. J. Cancer 2011, 128:1585-1595.
2. Basanta A.M., Chapman C., Dorsey J.F., Rengan R., Hahn S.M. A glimpse of the future: where will new combinations of diagnosis and therapies take us?. Cancer J. 2011, 17:190-194.
3. Belkin A.M., Stepp M.A. Integrins as receptors for laminins. Microsc. Res. Tech. 2000, 51:280-301.
4. Brooks S.A., Lomax-Browne H.J., Carter T.M., Kinch C.E., Hall D.M.S. Molecular interactions in cancer cell metastasis. Acta Histochem. 2010, 112:3-25.
5. Calvete J.J., Marcinkiewicz C., Monleón D., Esteve V., Celda B., Juárez P., Sanz L. Snake venom disintegrins: evolution of structure and function. Toxicon 2005, 45:1063-1074.
6. Desiniotis A., Kyprianou N. Significance of talin in cancer progression and metastasis. Int. Rev. Cell Mol. Biol. 2011, 289:117-147.
7. Doley R., Kini R.M. Protein complexes in snake venom. Cell Mol. Life Sci. 2009, 66:2851-2871.
8. Felding-Habermann B., O'Toole T.E., Smith J.W., Fransvea E., Ruggeri Z.M., Ginsberg M.H., Hughes P.E., Pampori N., Shattil S.J., Saven A., Mueller B.M. Integrin activation controls metastasis in human breast cancer. Proc. Natl. Acad. Sci. USA 2001, 98:1853-1858.
9. Galán J.A., Sánchez E.E., Rodríguez-Acosta A., Soto J.G., Bashir S., McLane M.A., Paquette-Straub C., Pérez J.C. Inhibition of lung tumor colonization and cell migration with the disintegrin crotatroxin 2 isolated from the venom of Crotalus atrox. Toxicon 2008, 51:1186-1196.
10. Geiger T.R., Peeper D.S. Metastasis mechanisms. Biochim. Biophys. Acta 2009, 2:293-308.
11. Gueron G., De Siervi A., Vazquez E. Key questions in metastasis: new insights in molecular pathways and therapeutic implications. Curr. Pharm. Biotechnol. 2011, 12:1-14.
12. Higuchi D.A., Almeida M.C., Barros C.C., Sanchez E.F., Pesquero P.R., Lang E.A.S., Samaan M., Araujo R.C., Pesquero J.B., Pesquero J.L. Leucurogin, a new recombinant disintegrin cloned form Bothrops leucurus (white-tailed-jararaca) with potent activity upon platelet aggregation and tumor growth. Toxicon 2011, 58:123-129.
13. Janik M.E., Litynska A., Vereecken P. Cell migration-The role of integrin glycosylation. Boichim. Biophys. Acta 2010, 1800:545-555.
14. Kang I.C., Lee Y.D., Kim D.S. A novel disintegrin salmosin inhibits tumor angiogenesis. Cancer Res. 1999, 59:3754-3760.
15. Kim S.H., Turnbull J., Guimond S. Extracellular matrix and cell signaling: the dynamic cooperation of integrin, proteoglycan and growth factor receptor. J. Endocrinol. 2011, 209:139-151.
16. Limam I., Bazaa A., Srairi-Abid N., Taboubi S., Jebali J., Zouari-Kessentini R., Kallech-Ziri O., Mejdoub H., Hammami A., El Ayeb M., Luis J., Marrakchi N. Leberagin-C, a disintegrin-like/cysteine-rich protein from Macrovipera lebetina transmediterranea venom, inhibits alphavbeta3 integrin-mediated cell adhesion. Matrix Biol. 2010, 29:117-126.
17. Lucena S., Sanchez E.E., Perez J.C. Anti-metastatic activity of the recombinant disintegrin, r-mojastin-1, from the Mohave rattlesnake. Toxicon 2011, 5:794-802.
18. Markland F.S. Snake venoms and the hemostatic system. Toxicon 1998, 36:1749-1800.
19. McLane M.A., Sánchez E.E., Wong A., Paquette-Straub C., Pérez J.C. Disintegrins. Curr. Drug Targets-Cardiovasc. Haematol. Dis. 2004, 4:327-355.
20. McLane M.A., Zhang X., Tian J., Zelinskas C., Srivastava A., Hensley B., Paquette-Straub C. Scratching below the surface: wounding healing and alanine mutagenesis provide unique insights into interactions between eristostatin, platelets and melanoma cells. Pathophysiol. Haemost. Thromb. 2005, 34:164-168.
21. Minea R., Swenson S., Costa F., Chen T., Markland F.S. Development of a novel recombinant disintegrin, Contortrostatin, as a effective anti-tumor and anti-angiogenic agent. Pathophysiol. Haemost. Thromb. 2005, 34:177-183.
22. Minea R., Helchowski C.M., Zidovetzki S.J., Costa F.K., Swenson S., Markland F.S. Vicrostatin-An anti-invasive multi-integrin targeting chimeric disintegrin with tumor anti-angiogenic and pro-apoptotic activities. PLoS ONE 2010, 5(6):e10929.
23. Minea R., Helchowski C., Rubino B., Brodmann K., Swenson S., Markland F. Development of a chimeric recombinant disintegrin as a cost-effective anti-cancer agent with promising translational potential. Toxicon 2012, 59:472-486.
24. Mizejewski G.J. Role of integrins in cancer: survey of expression patterns. Proc. Soc. Exp. Biol. Med. 1999, 2:124-138.
25. Molloy T., Van 't Veer L. Recent advances in metastasis research. Curr. Opin. Genet. Dev. 2008, 18:35-41.
26. Navin N., Hicks J. Future medical applications of single-cell sequencing in cancer. Genome Med. 2011, 3:51.
27. Oliva I.B., Coelho R.M., Barcellos G.G., Saldanha-Gama R., Wermelinger L.S., Marcinkiewicz C., Benedeta Z.R., Barja-Fidalgo C. Effect of RGD-disintegrins on melanoma cell growth and metastasis: involvement of the actin cytoskeleton, FAK and c-Fos. Toxicon 2007, 15:1053-1063.
28. Patarroyo M., Tryggvason K., Virtanen I. Laminin isoforms in tumor invasion, angiogenesis and metastasis. Semin. Cancer Biol. 2002, 12:197-207.
29. Peinado H., Lavotshkin S., Lyden D. The secreted factors responsible for pre-metastatic niche formation: old sayings and new thoughts. Semin. Cancer Biol. 2011, 21:139-146.
30. 3 blocking disintegrin containing the RGD motive, DisBa-01, inhibits bFGF-induced angiogenesis and melanoma metastasis. Clin. Exp. Metastasis 2008, 25:53-64.
31. Rathinam R., Alahari S.K. Important role of integrins in the cancer biology. Cancer Metastasis Rev. 2010, 29:223-237.
32. Sajevic T., Leonardi A., Krizaj I. Haemostatically active proteins in snake venoms. Toxicon 2011, 57:627-645.
33. Sánchez E.E., Rodriguez A.A., Palomar R., Lucena S.E., Bashir S., Soto J.G., Pérez J.C. Colombistatin: a disintegrin isolated from the venom of the South American snake (Bothrops colombiensis) that effectively inhibits platelet aggregation and SK-MEL-28 cell adhesion. Arch. Toxicol. 2009, 83:27-327.
34. Sánchez E.E., Lucena S.E., Reyes S., Soto J.G., Cantu E., Lopez-Johnston J.C., Guerrero B., Salazar A.M., Rodríguez-Acosta A., Galán J.A., Tao W.A., Pérez J.C. Cloning, expression, and hemostatic activities of a disintegrin, r-mojastin 1, from the Mohave rattlesnake (Crotalus scutulatus scutulatus). Thromb. Res. 2010, 126:211-219.
35. Scarborough R.M., Rose J.W., Naughton M.A., Phillips D.R., Nannizzi L., Arfsten A., Campbell A.M., Charo I.F. Characterization of the integrin specificities of disintegrins isolated from American pit viper venoms. J. Biol. Chem. 1993, 268:1058-1065.
36. Schägger H., von Jagow G. Tricine-sodium dodecyl sulfate-polyacrylamide gel electrophoresis for the separation of proteins in the range of 1 to 100 kDa. Anal. Biochem. 1987, 166:368-379.
37. 1 integrin-mediated cell adhesion, migration and proliferation. Braz. J. Med. Biol. Res. 2005, 38:1505-1511.
38. Seoane A.I., Tran V.L., Sánchez E.E., White S.A., Choi J.L., Gaytan B., Chavez N., Reyes S.R., Ramos C.J., Tran L.H., Lucena S.E., Sugarek M., Perez J.C., Mandal S.A., Ghorab S., Rodriguez-Acosta A., Fung B.K., Soto J.G. The mojastin mutant Moj-DM induces apoptosis of the human melanoma SK-MEL-28, but not the mutant Moj-NN nor the non-mutated recombinant Moj-WN. Toxicon 2010, 56:391-401.
39. Siegel R., Ward E., Brawley O., Jemal A. Cancer statistics, 2011. CA: Cancer J. Clin. 2011, 61:212-236.
40. Soszka T., Knudsen K.A., Bevigilia L., Rossi C., Poggi A., Niewiarowski S. Inhibition of murine melanoma cell-matrix adhesion and experimental metastasis by albolabrin, and RGD-containing peptide isolated from the venom of Trimeresurus albolabris. Exp. Cell Res. 1991, 196:6-12.
41. Soto J.G., White S.A., Reyes S.R., Regalado R., Sanchez E.E., Perez J.P. Molecular evolution of PIII-SVMP and RGD disintegrin genes from the genus Crotalus. Gene 2006, 389:66-72.
42. Taherian A., Li X., Liu Y., Haas T.A. Differences in integrin expression and signaling within human breast cancer cells. BMC Cancer 2011, 11:293.
43. Teklemariam T., Seoane A.I., Ramos C.J., Sánchez E.E., Lucena S.E., Perez J.C., Mandal S.A., Soto J.G. Functional analysis of a recombinant PIII-SVMP, GST-acocostatin; an apoptotic inducer of HUVEC and HeLa, but not SK-MEL-28 cells. Toxicon 2011, 57:646-656.
44. Tian J., Paquette-Straub C., Sage E., Funk S.E., Patel V., Galileo D., McLane M.A. Inhibition of melanoma cell motility by the snake venom disintegrin eristostatin. Toxicon 2007, 49:899-908.
45. Wang H., Fu W., Im J.H., Zhou Z., Santoro S.A., Iyer V., DiPersio C.M., Yu Q.C., Quaranta V., Al-Mehdi A., Muschel R.J. Tumor cell alpha3beta1 integrin and vascular laminin-5 mediate pulmonary arrest and metastasis. J. Cell Biol. 2004, 164:935-941.
46. v Integrins mediate adhesion and migration of breast carcinoma cell lines. Clin. Exp. Metastasis 1998, 16:50-61.
47. Yang R., Tang C., Chuang W., Huang T., Peng H., Huang T., Fu W. Inhibition of tumor formation by snake venom disintegrin. Toxicon 2005, 45:661-669.
48. Yeh C.H., Peng H.C., Huang T.F. Accutin, a new disintegrin, inhibits angiogenesis in vitro and in vivo by acting as integrin alphavbeta3 antagonist and inducing apoptosis. Blood 1998, 92:3268-3276.
49. Yeh C.H., Peng H.C., Yang R.S., Huang T.F. Rhodostomin, a snake venom disintegrin, inhibits angiogenesis elicited by basic fibroblast growth factor and suppresses tumor growth by a selective alpha(v)beta(3) blockade of endothelial cells. Mol. Pharmacol. 2001, 59:1333-1342.
50. Jia Y., Pérez J.C. Molecular cloning and characterization of cDNAs encoding metalloproteinases from snake venom glands. Toxicon 2010, 55:462-469.
51. Zhou Q., Nakada M.T., Brooks P.C., Swenson S.D., Ritter M.R., Argounova S., Arnold C., Markland F.S. Contortrostatin, a homodimeric disintegrin, binds to integrin αvβ5. Biochem. Biophys. Res. Commun. 2000, 267:350-355.