Colombistatin: A disintegrin isolated from the venom of the South American snake (bothrops colombiensis) that effectively inhibits platelet aggregation and SK-Mel-28 cell adhesion

Archives of Toxicology

Volumn 83, Issue 3, 2009, Pages 271-279

  Sánchez, Elda E ^a,b   Rodríguez Acosta, Alexis ^b   Palomar, Rene ^a   Lucena, Sara E ^a   Bashir, Sajid ^a   Soto, Julio G ^c   Pérez, John C ^a  

^a TEXAS A AND M UNIVERSITY KINGSVILLE   (United States)

^b UNIVERSIDAD CENTRAL DE VENEZUELA   (Venezuela)

^c SAN JOSE STATE UNIVERSITY   (United States)

Author keywords

Bothrops colombiensis; Cell migration; Disintegrin,Venom,Mapanare; Platelet aggregation; SK Mel 28; T24 cells

Indexed keywords

COLOMBISTATIN; DISINTEGRIN; FIBRONECTIN; SNAKE VENOM; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL; CELL ADHESION; CELL INTERACTION; CELL MIGRATION; CONTROLLED STUDY; DRUG ACTIVITY; DRUG ISOLATION; DRUG PURIFICATION; ENVENOMATION; GEL PERMEATION CHROMATOGRAPHY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; MELANOMA CELL; NONHUMAN; PRIORITY JOURNAL; REVERSED PHASE LIQUID CHROMATOGRAPHY; SIGNAL TRANSDUCTION; SNAKE; SOUTH AMERICA; TANDEM MASS SPECTROMETRY; THROMBOCYTE AGGREGATION INHIBITION;

AMINO ACID SEQUENCE; ANIMALS; BOTHROPS; CELL ADHESION; CELL LINE, TUMOR; CELL MOVEMENT; CONSERVED SEQUENCE; CROTALID VENOMS; DISINTEGRINS; DOSE-RESPONSE RELATIONSHIP, DRUG; FIBRONECTINS; MELANOCYTES; MELANOMA; MOLECULAR SEQUENCE DATA; MOLECULAR WEIGHT; PLATELET AGGREGATION; PLATELET AGGREGATION INHIBITORS; SEQUENCE HOMOLOGY, AMINO ACID; SKIN NEOPLASMS; SNAKE VENOMS; SOUTH AMERICA;

ATRACTASPIDIDAE; BOTHROPS COLOMBIENSIS; COLUBRIDAE; ELAPIDAE; VIPERIDAE;

EID: 62349084228     PISSN: 03405761     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00204-008-0358-y     Document Type: Article

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