Leucurogin, a new recombinant disintegrin cloned from Bothrops leucurus (white-tailed-jararaca) with potent activity upon platelet aggregation and tumor growth

Toxicon

Volumn 58, Issue 1, 2011, Pages 123-129

  Higuchi, D A ^a,b   Almeida, M C ^a,b   Barros, C C ^a   Sanchez, E F ^c   Pesquero, P R ^b   Lang, E A S ^b   Samaan, M ^b   Araujo, R C ^d   Pesquero, J B ^d   Pesquero, J L ^e  

^a UNIVERSIDADE DE MOGI DAS CRUZES   (Brazil)

^b Proteobras Desenvolvimento Biotecnológico Ltda   (Brazil)

^c FUNDAÇÃO EZEQUIEL DIAS   (Brazil)

^d FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

^e FEDERAL UNIVERSITY OF MINAS GERAIS   (Brazil)

Author keywords

Bothrops leucurus; Disintegrins; Platelet aggregation; Tumor growth

Indexed keywords

ADENOSINE DIPHOSPHATE; ANTICOAGULANT AGENT; ANTINEOPLASTIC AGENT; ARACHIDONIC ACID; BATROXOBIN; LEUCUROGIN; RECOMBINANT PROTEIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANION EXCHANGE CHROMATOGRAPHY; ANTIANGIOGENIC ACTIVITY; ANTIBODY SPECIFICITY; ARTICLE; BIOLOGICAL ACTIVITY; BOTHROPS LEUCURUS; CANCER INHIBITION; CONTROLLED STUDY; DOSE RESPONSE; DRUG DOSE COMPARISON; EHRLICH ASCITES TUMOR; HUMAN; HUMAN CELL; IC 50; MALE; MOLECULAR CLONING; MOLECULAR WEIGHT; MOUSE; NONHUMAN; PICHIA PASTORIS; PRIORITY JOURNAL; PROTEIN PURIFICATION; SNAKE; THROMBOCYTE AGGREGATION INHIBITION; WESTERN BLOTTING;

AMINO ACID SEQUENCE; ANGIOGENESIS INHIBITORS; ANIMALS; BOTHROPS; CARCINOMA, EHRLICH TUMOR; CLONING, MOLECULAR; CROTALID VENOMS; DISINTEGRINS; MALE; METALLOENDOPEPTIDASES; MICE; MOLECULAR SEQUENCE DATA; NEOVASCULARIZATION, PHYSIOLOGIC; PLATELET AGGREGATION; PLATELET AGGREGATION INHIBITORS; RECOMBINANT PROTEINS; SEQUENCE ALIGNMENT;

BOTHROPS JARARACA; BOTHROPS LEUCURUS; MUS;

EID: 79959378789     PISSN: 00410101     EISSN: 18793150     Source Type: Journal    
DOI: 10.1016/j.toxicon.2011.05.013     Document Type: Article

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