-
1
-
-
20544455330
-
Bevacizumab (Avastin), a humanized anti-VEGF monoclonal antibody for cancer therapy
-
Ferrara N, Hillan KJ, Novotny W (2005) Bevacizumab (Avastin), a humanized anti-VEGF monoclonal antibody for cancer therapy. Biochem Biophys Res Commun 333: 328-335.
-
(2005)
Biochem Biophys Res Commun
, vol.333
, pp. 328-335
-
-
Ferrara, N.1
Hillan, K.J.2
Novotny, W.3
-
2
-
-
27144449009
-
Monoclonal antibody therapy of cancer
-
Adams GP, Weiner LM (2005) Monoclonal antibody therapy of cancer. Nat Biotechnol 23: 1147-1157.
-
(2005)
Nat Biotechnol
, vol.23
, pp. 1147-1157
-
-
Adams, G.P.1
Weiner, L.M.2
-
3
-
-
65649131585
-
Multitarget drugs: The present and the future of cancer therapy
-
Petrelli A, Valabrega G (2009) Multitarget drugs: the present and the future of cancer therapy. Expert Opin Pharmacother 10: 589-600.
-
(2009)
Expert Opin Pharmacother
, vol.10
, pp. 589-600
-
-
Petrelli, A.1
Valabrega, G.2
-
4
-
-
33747855481
-
Comparing antibody and small-molecule therapies for cancer
-
Imai K, Takaoka A (2006) Comparing antibody and small-molecule therapies for cancer. Nat Rev Cancer 6: 714-727.
-
(2006)
Nat Rev Cancer
, vol.6
, pp. 714-727
-
-
Imai, K.1
Takaoka, A.2
-
5
-
-
0034614637
-
The hallmarks of cancer
-
Hanahan D, Weinberg RA (2000) The hallmarks of cancer. Cell 100: 57-70.
-
(2000)
Cell
, vol.100
, pp. 57-70
-
-
Hanahan, D.1
Weinberg, R.A.2
-
6
-
-
0036488589
-
Role of integrins in cell invasion and migration
-
Hood JD, Cheresh DA (2002) Role of integrins in cell invasion and migration. Nat Rev Cancer 2: 91-100.
-
(2002)
Nat Rev Cancer
, vol.2
, pp. 91-100
-
-
Hood, J.D.1
Cheresh, D.A.2
-
7
-
-
0344845001
-
Tissue architecture: The ultimate regulator of breast epithelial function
-
Bissell MJ, Rizki A, Mian IS (2003) Tissue architecture: the ultimate regulator of breast epithelial function. Curr Opin Cell Biol 15: 753-762.
-
(2003)
Curr Opin Cell Biol
, vol.15
, pp. 753-762
-
-
Bissell, M.J.1
Rizki, A.2
Mian, I.S.3
-
8
-
-
0032721665
-
Role of integrins in cancer: Survey of expression patterns
-
Mizejewski GJ (1999) Role of integrins in cancer: survey of expression patterns. Proc Soc Exp Biol Med 222: 124-138.
-
(1999)
Proc Soc Exp Biol Med
, vol.222
, pp. 124-138
-
-
Mizejewski, G.J.1
-
9
-
-
70350574674
-
An integrin alpha(v)beta(3)-c-Src oncogenic unit promotes anchorage-independence and tumor progression
-
Desgrosellier JS, Barnes LA, Shields DJ, Huang M, Lau SK, et al. (2009) An integrin alpha(v)beta(3)-c-Src oncogenic unit promotes anchorage-independence and tumor progression. Nat Med 15: 1163-1169.
-
(2009)
Nat Med
, vol.15
, pp. 1163-1169
-
-
Desgrosellier, J.S.1
Barnes, L.A.2
Shields, D.J.3
Huang, M.4
Lau, S.K.5
-
10
-
-
0036152857
-
Enhanced pathological angiogenesis in mice lacking beta3 integrin or beta3 and beta5 integrins
-
Reynolds LE, Wyder L, Lively JC, Taverna D, Robinson SD, et al. (2002) Enhanced pathological angiogenesis in mice lacking beta3 integrin or beta3 and beta5 integrins. Nature Medicine 8: 27-34.
-
(2002)
Nature Medicine
, vol.8
, pp. 27-34
-
-
Reynolds, L.E.1
Wyder, L.2
Lively, J.C.3
Taverna, D.4
Robinson, S.D.5
-
11
-
-
10744223801
-
Physiological levels of tumstatin, a fragment of collagen IV alpha3 chain, are generated by MMP-9 proteolysis and suppress angiogenesis via alphavbeta3 integrin
-
Hamano Y, Zeisberg M, Sugimoto H, Lively JC, Maeshima Y, et al. (2003) Physiological levels of tumstatin, a fragment of collagen IV alpha3 chain, are generated by MMP-9 proteolysis and suppress angiogenesis via alphavbeta3 integrin. Cancer Cell 3: 589-601.
-
(2003)
Cancer Cell
, vol.3
, pp. 589-601
-
-
Hamano, Y.1
Zeisberg, M.2
Sugimoto, H.3
Lively, J.C.4
Maeshima, Y.5
-
12
-
-
33344461837
-
Integrins and angiogenesis: A sticky business
-
Serini G, Valdembri D, Bussolino F (2006) Integrins and angiogenesis: a sticky business. Exp Cell Res 312: 651-658.
-
(2006)
Exp Cell Res
, vol.312
, pp. 651-658
-
-
Serini, G.1
Valdembri, D.2
Bussolino, F.3
-
13
-
-
40549105078
-
Integrin affinity modulation in angiogenesis
-
Mahabeleshwar GH, Chen J, Feng W, Somanath PR, Razorenova OV, et al. (2008) Integrin affinity modulation in angiogenesis. Cell Cycle 7: 335-347.
-
(2008)
Cell Cycle
, vol.7
, pp. 335-347
-
-
Mahabeleshwar, G.H.1
Chen, J.2
Feng, W.3
Somanath, P.R.4
Razorenova, O.V.5
-
14
-
-
33947732977
-
Angiogenesis: An organizing principle for drug discovery?
-
Folkman J (2007) Angiogenesis: an organizing principle for drug discovery? Nat Rev Drug Discov 6: 273-286.
-
(2007)
Nat Rev Drug Discov
, vol.6
, pp. 273-286
-
-
Folkman, J.1
-
15
-
-
36248976197
-
Alpha-v integrins as therapeutic targets in oncology
-
Nemeth JA, Nakada MT, Trikha M, Lang Z, Gordon MS, et al. (2007) Alpha-v integrins as therapeutic targets in oncology. Cancer Invest 25: 632-646.
-
(2007)
Cancer Invest
, vol.25
, pp. 632-646
-
-
Nemeth, J.A.1
Nakada, M.T.2
Trikha, M.3
Lang, Z.4
Gordon, M.S.5
-
17
-
-
11844301388
-
Matrix revolutions: ''tails'' of basement-membrane components with angiostatic functions
-
Bix G, Iozzo RV (2005) Matrix revolutions: ''tails'' of basement-membrane components with angiostatic functions. Trends Cell Biol 15: 52-60.
-
(2005)
Trends Cell Biol
, vol.15
, pp. 52-60
-
-
Bix, G.1
Iozzo, R.V.2
-
18
-
-
0037446897
-
Human tumstatin and human endostatin exhibit distinct antiangiogenic activities mediated by alphavbeta3 and alpha5beta1 integrins
-
Sudhakar A, Sugimoto H, Yang C, Lively J, Zeisberg M, et al. (2003) Human tumstatin and human endostatin exhibit distinct antiangiogenic activities mediated by alphavbeta3 and alpha5beta1 integrins. Proc Natl Acad SciUSA 100: 4766-4771.
-
(2003)
Proc Natl Acad SciUSA
, vol.100
, pp. 4766-4771
-
-
Sudhakar, A.1
Sugimoto, H.2
Yang, C.3
Lively, J.4
Zeisberg, M.5
-
19
-
-
0025096297
-
Disintegrins: A family of integrin inhibitory proteins from viper venoms
-
Gould RJ, Polokoff MA, Friedman PA, Huang TF, Holt JC, et al. (1990) Disintegrins: a family of integrin inhibitory proteins from viper venoms. Proc Soc Exp Biol Med 195: 168-171.
-
(1990)
Proc Soc Exp Biol Med
, vol.195
, pp. 168-171
-
-
Gould, R.J.1
Polokoff, M.A.2
Friedman, P.A.3
Huang, T.F.4
Holt, J.C.5
-
21
-
-
0035742610
-
Viper venom components affecting angiogenesis
-
Huang TF, Yeh CH, Wu WB (2001) Viper venom components affecting angiogenesis. Haemostasis 31: 192-206.
-
(2001)
Haemostasis
, vol.31
, pp. 192-206
-
-
Huang, T.F.1
Yeh, C.H.2
Wu, W.B.3
-
22
-
-
4444329286
-
Intravenous liposomal delivery of the snake venom disintegrin contortrostatin limits breast cancer progression
-
Swenson S, Costa F, Minea R, Sherwin RP, Ernst W, et al. (2004) Intravenous liposomal delivery of the snake venom disintegrin contortrostatin limits breast cancer progression. Mol Cancer Ther 3: 499-511.
-
(2004)
Mol Cancer Ther
, vol.3
, pp. 499-511
-
-
Swenson, S.1
Costa, F.2
Minea, R.3
Sherwin, R.P.4
Ernst, W.5
-
23
-
-
0025786742
-
Three-dimensional structure of echistatin, the smallest active RGD protein
-
Saudek V, Atkinson RA, Pelton JT (1991) Three-dimensional structure of echistatin, the smallest active RGD protein. Biochemistry 30: 7369-7372.
-
(1991)
Biochemistry
, vol.30
, pp. 7369-7372
-
-
Saudek, V.1
Atkinson, R.A.2
Pelton, J.T.3
-
24
-
-
41949088550
-
Structure of acostatin, a dimeric disintegrin from Southern copperhead (Agkistrodon contortrix contortrix), at 1.7 A resolution
-
Moiseeva N, Bau R, Swenson SD, Markland FS, Jr., Choe JY, et al. (2008) Structure of acostatin, a dimeric disintegrin from Southern copperhead (Agkistrodon contortrix contortrix), at 1.7 A resolution. Acta Crystallogr D Biol Crystallogr 64: 466-470.
-
(2008)
Acta Crystallogr D Biol Crystallogr
, vol.64
, pp. 466-470
-
-
Moiseeva, N.1
Bau, R.2
Swenson, S.D.3
Markland Jr., F.S.4
Choe, J.Y.5
-
25
-
-
0031695498
-
Viper venom disintegrins and related molecules
-
McLane MA, Marcinkiewicz C, Vijay-Kumar S, Wierzbicka-Patynowski I, Niewiarowski S (1998) Viper venom disintegrins and related molecules. Proc Soc Exp Biol Med 219: 109-119.
-
(1998)
Proc Soc Exp Biol Med
, vol.219
, pp. 109-119
-
-
McLane, M.A.1
Marcinkiewicz, C.2
Vijay-Kumar, S.3
Wierzbicka-Patynowski, I.4
Niewiarowski, S.5
-
26
-
-
0027954377
-
Purification and characterization of platelet aggregation inhibitors from snake venoms
-
Trikha M, Rote WE, Manley PJ, Lucchesi BR, Markland FS (1994) Purification and characterization of platelet aggregation inhibitors from snake venoms. Thromb Res 73: 39-52.
-
(1994)
Thromb Res
, vol.73
, pp. 39-52
-
-
Trikha, M.1
Rote, W.E.2
Manley, P.J.3
Lucchesi, B.R.4
Markland, F.S.5
-
27
-
-
0001278780
-
Contortrostatin, a dimeric disintegrin from Agkistrodon contortrix contortrix, inhibits angiogenesis
-
Zhou Q, Nakada MT, Arnold C, Markland FS (1999) Contortrostatin, a dimeric disintegrin from Agkistrodon contortrix contortrix, inhibits angiogenesis. Angiogenesis 3: 259-269.
-
(1999)
Angiogenesis
, vol.3
, pp. 259-269
-
-
Zhou, Q.1
Nakada, M.T.2
Arnold, C.3
Markland, F.S.4
-
28
-
-
0028111866
-
Contortrostatin, a snake venom disintegrin, inhibits beta1 integrin-mediated human metastatic melanoma cell adhesion and blocks experimental metastasis
-
Trikha M, De Clerck YA, Markland FS (1994) Contortrostatin, a snake venom disintegrin, inhibits beta1 integrin-mediated human metastatic melanoma cell adhesion and blocks experimental metastasis. Cancer Res 54: 4993-4998.
-
(1994)
Cancer Res
, vol.54
, pp. 4993-4998
-
-
Trikha, M.1
de Clerck, Y.A.2
Markland, F.S.3
-
29
-
-
0034614597
-
Contortrostatin, a homodimeric disintegrin, binds to integrin alphavbeta5
-
Zhou Q, Nakada MT, Brooks PC, Swenson SD, Ritter MR, et al. (2000) Contortrostatin, a homodimeric disintegrin, binds to integrin alphavbeta5. Biochem Biophys Res Commun 267: 350-355.
-
(2000)
Biochem Biophys Res Commun
, vol.267
, pp. 350-355
-
-
Zhou, Q.1
Nakada, M.T.2
Brooks, P.C.3
Swenson, S.D.4
Ritter, M.R.5
-
30
-
-
33646794420
-
Development of a novel recombinant disintegrin, contortrostatin, as an effective anti-tumor and anti-angiogenic agent
-
Minea R, Swenson S, Costa F, Chen TC, Markland FS (2005) Development of a novel recombinant disintegrin, contortrostatin, as an effective anti-tumor and anti-angiogenic agent. Pathophysiol Haemost Thromb 34: 177-183.
-
(2005)
Pathophysiol Haemost Thromb
, vol.34
, pp. 177-183
-
-
Minea, R.1
Swenson, S.2
Costa, F.3
Chen, T.C.4
Markland, F.S.5
-
31
-
-
61649113720
-
Endogenous inhibitors of angiogenesis: A historical review
-
Ribatti D (2009) Endogenous inhibitors of angiogenesis: a historical review. Leuk Res 33: 638-644.
-
(2009)
Leuk Res
, vol.33
, pp. 638-644
-
-
Ribatti, D.1
-
32
-
-
0036531963
-
Endostatin regulates endothelial cell adhesion and cytoskeletal organization
-
Dixelius J, Cross M, Matsumoto T, Sasaki T, Timpl R, et al. (2002) Endostatin regulates endothelial cell adhesion and cytoskeletal organization. Cancer Res 62: 1944-1947.
-
(2002)
Cancer Res
, vol.62
, pp. 1944-1947
-
-
Dixelius, J.1
Cross, M.2
Matsumoto, T.3
Sasaki, T.4
Timpl, R.5
-
33
-
-
3142736457
-
Endorepellin causes endothelial cell disassembly of actin cytoskeleton and focal adhesions through alpha2beta1 integrin
-
Bix G, Fu J, Gonzalez EM, Macro L, Barker A, et al. (2004) Endorepellin causes endothelial cell disassembly of actin cytoskeleton and focal adhesions through alpha2beta1 integrin. J Cell Biol 166: 97-109.
-
(2004)
J Cell Biol
, vol.166
, pp. 97-109
-
-
Bix, G.1
Fu, J.2
Gonzalez, E.M.3
Macro, L.4
Barker, A.5
-
34
-
-
0033840533
-
Contortrostatin, a snake venom disintegrin, induces alphavbeta3- mediated tyrosine phosphorylation of CAS and FAK in tumor cells
-
Ritter MR, Zhou Q, Markland FS, Jr. (2000) Contortrostatin, a snake venom disintegrin, induces alphavbeta3- mediated tyrosine phosphorylation of CAS and FAK in tumor cells. J Cell Biochem 79: 28-37.
-
(2000)
J Cell Biochem
, vol.79
, pp. 28-37
-
-
Ritter, M.R.1
Zhou, Q.2
Markland Jr., F.S.3
-
35
-
-
21744456192
-
Potent mimicry of fibronectin-induced intracellular signaling in glioma cells by the homodimeric snake venom disintegrin contortrostatin
-
discussion 141-153
-
Schmitmeier S, Markland FS, Schonthal AH, Chen TC (2005) Potent mimicry of fibronectin-induced intracellular signaling in glioma cells by the homodimeric snake venom disintegrin contortrostatin. Neurosurgery 57: 141-153; discussion 141-153.
-
(2005)
Neurosurgery
, vol.57
, pp. 141-153
-
-
Schmitmeier, S.1
Markland, F.S.2
Schonthal, A.H.3
Chen, T.C.4
-
36
-
-
3242681839
-
Fluorescence polarization assay to quantify proteinprotein interactions
-
Park SH, Raines RT (2004) Fluorescence polarization assay to quantify proteinprotein interactions. Methods Mol Biol 261: 161-166.
-
(2004)
Methods Mol Biol
, vol.261
, pp. 161-166
-
-
Park, S.H.1
Raines, R.T.2
-
37
-
-
0021958425
-
Effect of Estrogens and Antiestrogens on Growth of Human Breast Cancer Cells in Athymic Nude Mice
-
Osborne CK, Hobbs K, Clark GM (1985) Effect of Estrogens and Antiestrogens on Growth of Human Breast Cancer Cells in Athymic Nude Mice. Cancer Res 45: 584-590.
-
(1985)
Cancer Res
, vol.45
, pp. 584-590
-
-
Osborne, C.K.1
Hobbs, K.2
Clark, G.M.3
-
38
-
-
0027221927
-
Vascular density and the response of breast carcinomas to mastectomy and adjuvant chemotherapy
-
Protopapa E, Delides GS, Revesz L (1993) Vascular density and the response of breast carcinomas to mastectomy and adjuvant chemotherapy. Eur J Cancer 29A: 1391-1393.
-
(1993)
Eur J Cancer
, vol.29 A
, pp. 1391-1393
-
-
Protopapa, E.1
Delides, G.S.2
Revesz, L.3
-
39
-
-
10344234223
-
Histological quantitation of tumour angiogenesis
-
Fox SB, Harris AL (2004) Histological quantitation of tumour angiogenesis. Apmis 112: 413-430.
-
(2004)
Apmis
, vol.112
, pp. 413-430
-
-
Fox, S.B.1
Harris, A.L.2
-
40
-
-
14744292185
-
A thioredoxin gene fusion expression system that circumvents inclusion body formation in the
-
LaVallie ER, DiBlasio EA, Kovacic S, Grant KL, Schendel PF, et al. (1993) A thioredoxin gene fusion expression system that circumvents inclusion body formation in the E. coli cytoplasm. Biotechnology (N Y) 11: 187-193.
-
(1993)
E. Coli Cytoplasm. Biotechnology (N Y)
, vol.11
, pp. 187-193
-
-
Lavallie, E.R.1
Diblasio, E.A.2
Kovacic, S.3
Grant, K.L.4
Schendel, P.F.5
-
41
-
-
0042887427
-
Crystal structure of trimestatin, a disintegrin containing a cell adhesion recognition motif RGD
-
Fujii Y, Okuda D, Fujimoto Z, Horii K, Morita T, et al. (2003) Crystal structure of trimestatin, a disintegrin containing a cell adhesion recognition motif RGD. J Mol Biol 332: 1115-1122.
-
(2003)
J Mol Biol
, vol.332
, pp. 1115-1122
-
-
Fujii, Y.1
Okuda, D.2
Fujimoto, Z.3
Horii, K.4
Morita, T.5
-
42
-
-
0033621329
-
Structural requirements of echistatin for the recognition of alpha(v)beta(3) and alpha(5)beta(1) integrins
-
Wierzbicka-Patynowski I, Niewiarowski S, Marcinkiewicz C, Calvete JJ, Marcinkiewicz MM, et al. (1999) Structural requirements of echistatin for the recognition of alpha(v)beta(3) and alpha(5)beta(1) integrins. J Biol Chem 274: 37809-37814.
-
(1999)
J Biol Chem
, vol.274
, pp. 37809-37814
-
-
Wierzbicka-Patynowski, I.1
Niewiarowski, S.2
Marcinkiewicz, C.3
Calvete, J.J.4
Marcinkiewicz, M.M.5
-
43
-
-
0000167256
-
A viral cleavage site cassette: Identification of amino acid sequences required for tobacco etch virus polyprotein processing
-
Carrington JC, Dougherty WG (1988) A viral cleavage site cassette: identification of amino acid sequences required for tobacco etch virus polyprotein processing. Proc Natl Acad SciUSA 85: 3391-3395.
-
(1988)
Proc Natl Acad SciUSA
, vol.85
, pp. 3391-3395
-
-
Carrington, J.C.1
Dougherty, W.G.2
-
44
-
-
0034598655
-
Differential regulation of tyrosine phosphorylation in tumor cells by contortrostatin, a homodimeric disintegrin, and monomeric disintegrins echistatin and flavoridin
-
Ritter MR, Markland FS, Jr. (2001) Differential regulation of tyrosine phosphorylation in tumor cells by contortrostatin, a homodimeric disintegrin, and monomeric disintegrins echistatin and flavoridin. Toxicon 39: 283-289.
-
(2001)
Toxicon
, vol.39
, pp. 283-289
-
-
Ritter, M.R.1
Markland Jr., F.S.2
-
45
-
-
4444324533
-
Integrin beta3 regions controlling binding of murine mAb 7E3: Implications for the mechanism of integrin alphaIIbbeta3 activation
-
Artoni A, Li J, Mitchell B, Ruan J, Takagi J, et al. (2004) Integrin beta3 regions controlling binding of murine mAb 7E3: implications for the mechanism of integrin alphaIIbbeta3 activation. Proc Natl Acad SciUSA 101: 13114-13120.
-
(2004)
Proc Natl Acad SciUSA
, vol.101
, pp. 13114-13120
-
-
Artoni, A.1
Li, J.2
Mitchell, B.3
Ruan, J.4
Takagi, J.5
-
46
-
-
0028972105
-
Antiintegrin alphavbeta3 blocks human breast cancer growth and angiogenesis in human skin
-
Brooks PC, Stromblad S, Klemke R, Visscher D, Sarkar FH, et al. (1995) Antiintegrin alphavbeta3 blocks human breast cancer growth and angiogenesis in human skin. Journal of Clinical Investigation 96: 1815-1822.
-
(1995)
Journal of Clinical Investigation
, vol.96
, pp. 1815-1822
-
-
Brooks, P.C.1
Stromblad, S.2
Klemke, R.3
Visscher, D.4
Sarkar, F.H.5
-
47
-
-
1942535898
-
Anti-angiogenic activity of contortrostatin, a disintegrin from Agkistrodon contortrix contortrix snake venom
-
Golubkov V, Hawes D, Markland FS (2003) Anti-angiogenic activity of contortrostatin, a disintegrin from Agkistrodon contortrix contortrix snake venom. Angiogenesis 6: 213-224.
-
(2003)
Angiogenesis
, vol.6
, pp. 213-224
-
-
Golubkov, V.1
Hawes, D.2
Markland, F.S.3
-
48
-
-
0025192243
-
Tumorigenicity and Metastasis of Human Breast Carcinoma Cell Lines in Nude Mice
-
Price JE, Polyzos A, Zhang RD, Daniels LM (1990) Tumorigenicity and Metastasis of Human Breast Carcinoma Cell Lines in Nude Mice. Cancer Res 50: 717-721.
-
(1990)
Cancer Res
, vol.50
, pp. 717-721
-
-
Price, J.E.1
Polyzos, A.2
Zhang, R.D.3
Daniels, L.M.4
-
49
-
-
67650456890
-
MDA-MB-435 and M14 cell lines: Identical but not M14 melanoma?
-
Chambers AF (2009) MDA-MB-435 and M14 cell lines: identical but not M14 melanoma? Cancer Res 69: 5292-5293.
-
(2009)
Cancer Res
, vol.69
, pp. 5292-5293
-
-
Chambers, A.F.1
-
50
-
-
34250869019
-
MDA-MB- 435 cells are derived from M14 melanoma cells-a loss for breast cancer, but a boon for melanoma research
-
Rae JM, Creighton CJ, Meck JM, Haddad BR, Johnson MD (2007) MDA-MB- 435 cells are derived from M14 melanoma cells-a loss for breast cancer, but a boon for melanoma research. Breast Cancer Res Treat 104: 13-19.
-
(2007)
Breast Cancer Res Treat
, vol.104
, pp. 13-19
-
-
Rae, J.M.1
Creighton, C.J.2
Meck, J.M.3
Haddad, B.R.4
Johnson, M.D.5
-
51
-
-
33845961014
-
Bevacizumab: An angiogenesis inhibitor for the treatment of solid malignancies
-
Shih T, Lindley C (2006) Bevacizumab: an angiogenesis inhibitor for the treatment of solid malignancies. Clin Ther 28: 1779-1802.
-
(2006)
Clin Ther
, vol.28
, pp. 1779-1802
-
-
Shih, T.1
Lindley, C.2
-
52
-
-
0036153461
-
Ki67 protein: The immaculate deception?
-
Brown DC, Gatter KC (2002) Ki67 protein: the immaculate deception? Histopathology 40: 2-11.
-
(2002)
Histopathology
, vol.40
, pp. 2-11
-
-
Brown, D.C.1
Gatter, K.C.2
-
53
-
-
64649087149
-
Ki-67 as a prognostic molecular marker in routine clinical use in breast cancer patients
-
Wiesner FG, Magener A, Fasching PA, Wesse J, Bani MR, et al. (2009) Ki-67 as a prognostic molecular marker in routine clinical use in breast cancer patients. Breast 18: 135-141.
-
(2009)
Breast
, vol.18
, pp. 135-141
-
-
Wiesner, F.G.1
Magener, A.2
Fasching, P.A.3
Wesse, J.4
Bani, M.R.5
-
55
-
-
70549105123
-
Integrins as ''functional hubs'' in the regulation of pathological angiogenesis
-
Contois L, Akalu A, Brooks PC (2009) Integrins as ''functional hubs'' in the regulation of pathological angiogenesis. Semin Cancer Biol 19: 318-328.
-
(2009)
Semin Cancer Biol
, vol.19
, pp. 318-328
-
-
Contois, L.1
Akalu, A.2
Brooks, P.C.3
-
56
-
-
72449124139
-
Interplay between cell adhesion and growth factor receptors: From the plasma membrane to the endosomes
-
Ivaska J, Heino J (2009) Interplay between cell adhesion and growth factor receptors: from the plasma membrane to the endosomes. Cell Tissue Res 339: 111-120.
-
(2009)
Cell Tissue Res
, vol.339
, pp. 111-120
-
-
Ivaska, J.1
Heino, J.2
-
57
-
-
41949130937
-
Integrins team up with tyrosine kinase receptors and plexins to control angiogenesis
-
Serini G, Napione L, Bussolino F (2008) Integrins team up with tyrosine kinase receptors and plexins to control angiogenesis. Curr Opin Hematol 15: 235-242.
-
(2008)
Curr Opin Hematol
, vol.15
, pp. 235-242
-
-
Serini, G.1
Napione, L.2
Bussolino, F.3
-
58
-
-
35448983953
-
Integrins: A flexible platform for endothelial vascular tyrosine kinase receptors
-
Napione L, Cascone I, Mitola S, Serini G, Bussolino F (2007) Integrins: a flexible platform for endothelial vascular tyrosine kinase receptors. Autoimmun Rev 7: 18-22.
-
(2007)
Autoimmun Rev
, vol.7
, pp. 18-22
-
-
Napione, L.1
Cascone, I.2
Mitola, S.3
Serini, G.4
Bussolino, F.5
-
60
-
-
12344312042
-
Cellular abnormalities of blood vessels as targets in cancer
-
Baluk P, Hashizume H, McDonald DM (2005) Cellular abnormalities of blood vessels as targets in cancer. Curr Opin Genet Dev 15: 102-111.
-
(2005)
Curr Opin Genet Dev
, vol.15
, pp. 102-111
-
-
Baluk, P.1
Hashizume, H.2
McDonald, D.M.3
-
62
-
-
33645551144
-
Integrins: Molecular targets in cancer therapy
-
Tucker GC (2006) Integrins: molecular targets in cancer therapy. Curr Oncol Rep 8: 96-103.
-
(2006)
Curr Oncol Rep
, vol.8
, pp. 96-103
-
-
Tucker, G.C.1
-
63
-
-
0036734093
-
A reevaluation of integrins as regulators of angiogenesis
-
Hynes RO (2002) A reevaluation of integrins as regulators of angiogenesis. Nature Medicine 8: 918-921.
-
(2002)
Nature Medicine
, vol.8
, pp. 918-921
-
-
Hynes, R.O.1
-
64
-
-
44849100858
-
Genetic ablation of alphav integrins in epithelial cells of the eyelid skin and conjunctiva leads to squamous cell carcinoma
-
McCarty JH, Barry M, Crowley D, Bronson RT, Lacy-Hulbert A, et al. (2008) Genetic ablation of alphav integrins in epithelial cells of the eyelid skin and conjunctiva leads to squamous cell carcinoma. Am J Pathol 172: 1740-1747.
-
(2008)
Am J Pathol
, vol.172
, pp. 1740-1747
-
-
McCarty, J.H.1
Barry, M.2
Crowley, D.3
Bronson, R.T.4
Lacy-Hulbert, A.5
-
65
-
-
20044386305
-
Function of endogenous inhibitors of angiogenesis as endothelium-specific tumor suppressors
-
Sund M, Hamano Y, Sugimoto H, Sudhakar A, Soubasakos M, et al. (2005) Function of endogenous inhibitors of angiogenesis as endothelium-specific tumor suppressors. Proc Natl Acad SciUSA 102: 2934-2939.
-
(2005)
Proc Natl Acad SciUSA
, vol.102
, pp. 2934-2939
-
-
Sund, M.1
Hamano, Y.2
Sugimoto, H.3
Sudhakar, A.4
Soubasakos, M.5
-
66
-
-
27644520996
-
The clinical potential of antiangiogenic fragments of extracellular matrix proteins
-
Clamp AR, Jayson GC (2005) The clinical potential of antiangiogenic fragments of extracellular matrix proteins. Br J Cancer 93: 967-972.
-
(2005)
Br J Cancer
, vol.93
, pp. 967-972
-
-
Clamp, A.R.1
Jayson, G.C.2
-
67
-
-
52049103578
-
Semaphorin-3B is an angiogenesis inhibitor that is inactivated by furin-like proprotein convertases
-
Varshavsky A, Kessler O, Abramovitch S, Kigel B, Zaffryar S, et al. (2008) Semaphorin-3B is an angiogenesis inhibitor that is inactivated by furin-like proprotein convertases. Cancer Res 68: 6922-6931.
-
(2008)
Cancer Res
, vol.68
, pp. 6922-6931
-
-
Varshavsky, A.1
Kessler, O.2
Abramovitch, S.3
Kigel, B.4
Zaffryar, S.5
-
69
-
-
77952549971
-
Matrix biology meets toxinology
-
Eble JA (2010) Matrix biology meets toxinology. Matrix Biol 29: 239-247.
-
(2010)
Matrix Biol
, vol.29
, pp. 239-247
-
-
Eble, J.A.1
-
71
-
-
24944547482
-
Tensional homeostasis and the malignant phenotype
-
Paszek MJ, Zahir N, Johnson KR, Lakins JN, Rozenberg GI, et al. (2005) Tensional homeostasis and the malignant phenotype. Cancer Cell 8: 241-254.
-
(2005)
Cancer Cell
, vol.8
, pp. 241-254
-
-
Paszek, M.J.1
Zahir, N.2
Johnson, K.R.3
Lakins, J.N.4
Rozenberg, G.I.5
-
72
-
-
77950594400
-
Extracellular matrix: A gatekeeper in the transition from dormancy to metastatic growth
-
Barkan D, Green JE, Chambers AF (2010) Extracellular matrix: A gatekeeper in the transition from dormancy to metastatic growth. Eur J Cancer 46: 1181-1188.
-
(2010)
Eur J Cancer
, vol.46
, pp. 1181-1188
-
-
Barkan, D.1
Green, J.E.2
Chambers, A.F.3
-
73
-
-
51049119424
-
Inhibition of metastatic outgrowth from single dormant tumor cells by targeting the cytoskeleton
-
Barkan D, Kleinman H, Simmons JL, Asmussen H, Kamaraju AK, et al. (2008) Inhibition of metastatic outgrowth from single dormant tumor cells by targeting the cytoskeleton. Cancer Res 68: 6241-6250.
-
(2008)
Cancer Res
, vol.68
, pp. 6241-6250
-
-
Barkan, D.1
Kleinman, H.2
Simmons, J.L.3
Asmussen, H.4
Kamaraju, A.K.5
-
74
-
-
0033549864
-
N-Methylated cyclic RGD peptides as highly active and selective alpha(v)beta(3) integrin antagonists
-
Dechantsreiter MA, Planker E, Matha B, Lohof E, Holzemann G, et al. (1999) N-Methylated cyclic RGD peptides as highly active and selective alpha(v)beta(3) integrin antagonists. J Med Chem 42: 3033-3040.
-
(1999)
J Med Chem
, vol.42
, pp. 3033-3040
-
-
Dechantsreiter, M.A.1
Planker, E.2
Matha, B.3
Lohof, E.4
Holzemann, G.5
-
75
-
-
0037186502
-
Nanomolar small molecule inhibitors for alphavbeta6, alphavbeta5, and alphavbeta3 integrins
-
Goodman SL, Holzemann G, Sulyok GA, Kessler H (2002) Nanomolar small molecule inhibitors for alphavbeta6, alphavbeta5, and alphavbeta3 integrins. J Med Chem 45: 1045-1051.
-
(2002)
J Med Chem
, vol.45
, pp. 1045-1051
-
-
Goodman, S.L.1
Holzemann, G.2
Sulyok, G.A.3
Kessler, H.4
-
76
-
-
34548175694
-
Assessment of the biological and pharmacological effects of the alphavbeta3 and alphavbeta5 integrin receptor antagonist, cilengitide (EMD 121974), in patients with advanced solid tumors
-
Hariharan S, Gustafson D, Holden S, McConkey D, Davis D, et al. (2007) Assessment of the biological and pharmacological effects of the alphavbeta3 and alphavbeta5 integrin receptor antagonist, cilengitide (EMD 121974), in patients with advanced solid tumors. Ann Oncol 18: 1400-1407.
-
(2007)
Ann Oncol
, vol.18
, pp. 1400-1407
-
-
Hariharan, S.1
Gustafson, D.2
Holden, S.3
McConkey, D.4
Davis, D.5
-
77
-
-
51449124031
-
Cilengitide: An integrintargeting arginine-glycine-aspartic acid peptide with promising activity for glioblastoma multiforme
-
Reardon DA, Nabors LB, Stupp R, Mikkelsen T (2008) Cilengitide: an integrintargeting arginine-glycine-aspartic acid peptide with promising activity for glioblastoma multiforme. Expert Opin Investig Drugs 17: 1225-1235.
-
(2008)
Expert Opin Investig Drugs
, vol.17
, pp. 1225-1235
-
-
Reardon, D.A.1
Nabors, L.B.2
Stupp, R.3
Mikkelsen, T.4
-
78
-
-
0002588527
-
Inhibition of angiogenesis and tumor growth by murine 7E3, the parent antibody of c7E3 Fab (abciximab; ReoPro)
-
Varner JA, Nakada MT, Jordan RE, Coller BS (1999) Inhibition of angiogenesis and tumor growth by murine 7E3, the parent antibody of c7E3 Fab (abciximab; ReoPro). Angiogenesis 3: 53-60.
-
(1999)
Angiogenesis
, vol.3
, pp. 53-60
-
-
Varner, J.A.1
Nakada, M.T.2
Jordan, R.E.3
Coller, B.S.4
-
80
-
-
10844222440
-
Platelet-cancer interactions: Mechanisms and pharmacology of tumour cell-induced platelet aggregation
-
Jurasz P, Alonso-Escolano D, Radomski MW (2004) Platelet-cancer interactions: mechanisms and pharmacology of tumour cell-induced platelet aggregation. Br J Pharmacol 143: 819-826.
-
(2004)
Br J Pharmacol
, vol.143
, pp. 819-826
-
-
Jurasz, P.1
Alonso-Escolano, D.2
Radomski, M.W.3
-
81
-
-
0034721888
-
Regulation of integrin alphavbeta3- mediated endothelial cell migration and angiogenesis by integrin alpha5beta1 and protein kinase A
-
Kim S, Harris M, Varner JA (2000) Regulation of integrin alphavbeta3- mediated endothelial cell migration and angiogenesis by integrin alpha5beta1 and protein kinase A. J Biol Chem 275: 33920-33928.
-
(2000)
J Biol Chem
, vol.275
, pp. 33920-33928
-
-
Kim, S.1
Harris, M.2
Varner, J.A.3
-
82
-
-
0033843942
-
Regulation of angiogenesis in vivo by ligation of integrin alpha5beta1 with the central cell-binding domain of fibronectin
-
Kim S, Bell K, Mousa SA, Varner JA (2000) Regulation of angiogenesis in vivo by ligation of integrin alpha5beta1 with the central cell-binding domain of fibronectin. Am J Pathol 156: 1345-1362.
-
(2000)
Am J Pathol
, vol.156
, pp. 1345-1362
-
-
Kim, S.1
Bell, K.2
Mousa, S.A.3
Varner, J.A.4
-
84
-
-
60649087564
-
Accelerated metastasis after short-term treatment with a potent inhibitor of tumor angiogenesis
-
Ebos JM, Lee CR, Cruz-Munoz W, Bjarnason GA, Christensen JG, et al. (2009) Accelerated metastasis after short-term treatment with a potent inhibitor of tumor angiogenesis. Cancer Cell 15: 232-239.
-
(2009)
Cancer Cell
, vol.15
, pp. 232-239
-
-
Ebos, J.M.1
Lee, C.R.2
Cruz-Munoz, W.3
Bjarnason, G.A.4
Christensen, J.G.5
-
85
-
-
60649106195
-
Antiangiogenic therapy elicits malignant progression of tumors to increased local invasion and distant metastasis
-
Paez-Ribes M, Allen E, Hudock J, Takeda T, Okuyama H, et al. (2009) Antiangiogenic therapy elicits malignant progression of tumors to increased local invasion and distant metastasis. Cancer Cell 15: 220-231.
-
(2009)
Cancer Cell
, vol.15
, pp. 220-231
-
-
Paez-Ribes, M.1
Allen, E.2
Hudock, J.3
Takeda, T.4
Okuyama, H.5
-
86
-
-
62649101158
-
Cancer: The nuances of therapy
-
Ellis LM, Reardon DA (2009) Cancer: The nuances of therapy. Nature 458: 290-292.
-
(2009)
Nature
, vol.458
, pp. 290-292
-
-
Ellis, L.M.1
Reardon, D.A.2
-
87
-
-
0033860870
-
Contortrostatin, a dimeric disintegrin from Agkistrodon contortrix contortrix, inhibits breast cancer progression
-
Zhou Q, Sherwin RP, Parrish C, Richters V, Groshen SG, et al. (2000) Contortrostatin, a dimeric disintegrin from Agkistrodon contortrix contortrix, inhibits breast cancer progression. Breast Cancer Res Treat 61: 249-260.
-
(2000)
Breast Cancer Res Treat
, vol.61
, pp. 249-260
-
-
Zhou, Q.1
Sherwin, R.P.2
Parrish, C.3
Richters, V.4
Groshen, S.G.5
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