Important role of integrins in the cancer biology

Cancer and Metastasis Reviews

Volumn 29, Issue 1, 2010, Pages 223-237

  Rathinam, R ^a   Alahari, Suresh K ^a  

^a LOUISIANA STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Actin cytoskeleton; Breast cancer; Cancer; Integrin

Indexed keywords

ALPHA6BETA4 INTEGRIN; ALPHA7 INTEGRIN; ALPHAVBETA5 INTEGRIN; ALPHAVBETA6 INTEGRIN; ANGIOGENESIS INHIBITOR; ANTINEOPLASTIC AGENT; CALCIUM BINDING PROTEIN; COLLAGEN RECEPTOR; CYTOHESIN 1; ENDONEXIN; FIBRONECTIN RECEPTOR; INSULIN RECEPTOR SUBSTRATE 1; INTEGRIN; INTEGRIN ALPHA5BETA3 INHIBITOR; INTEGRIN ALPHA5BETA5 INHIBITOR; INTEGRIN BETA1 INHIBITOR; INTEGRIN LINKED KINASE; LAMININ RECEPTOR; MATRIX METALLOPROTEINASE; OSTEOPONTIN; PROTEIN INHIBITOR; SYNDECAN 1; THROMBOSPONDIN 1; TISSUE INHIBITOR OF METALLOPROTEINASE 2; UNCLASSIFIED DRUG; VERY LATE ACTIVATION ANTIGEN 1; VERY LATE ACTIVATION ANTIGEN 2; VERY LATE ACTIVATION ANTIGEN 3; VERY LATE ACTIVATION ANTIGEN 6; VITRONECTIN RECEPTOR; VON WILLEBRAND FACTOR;

ANTINEOPLASTIC ACTIVITY; BREAST ADENOCARCINOMA; BREAST CANCER; BREAST CARCINOGENESIS; CANCER CELL; CANCER CHEMOTHERAPY; CELL ADHESION; CELL MIGRATION; CELL PROLIFERATION; CLINICAL TRIAL; CYTOSKELETON; ENZYME REGULATION; GROWTH REGULATION; HUMAN; NEOPLASM; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; REVIEW; TUMOR GROWTH; TUMOR PROMOTION;

ANIMALS; BIOLOGY; CELL TRANSFORMATION, NEOPLASTIC; DISEASE PROGRESSION; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; INTEGRINS; MICROFILAMENTS; MODELS, BIOLOGICAL; NEOPLASMS;

EID: 77349113764     PISSN: 01677659     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10555-010-9211-x     Document Type: Review

References (115)

1. A van der Flier A Sonnenberg 2001 Function and interactions of integrins Cell and Tissue Research 305 285 298 11572082
2. A Colombatti P Bonaldo R Doliana 1993 Type A modules: Interacting domains found in several non-fibrillar collagens and in other extracellular matrix proteins Matrix 13 297 306 8412987
3. PP Rosen S Groshen PE Saigo DW Kinne S Hellman 1989 Pathological prognostic factors in stage I (T1N0M0) and stage II (T1N1M0) breast carcinoma: a study of 644 patients with median follow-up of 18 years Journal of Clinical Oncology 7 1239 1251 2549203
4. AE Aplin AK Howe RL Juliano 1999 Cell adhesion molecules, signal transduction and cell growth Current Opinion in Cell Biology 11 737 744 10600702
5. SK Sastry K Burridge 2000 Focal adhesions: a nexus for intracellular signaling and cytoskeletal dynamics Experimental Cell Research 261 25 36 11082272
6. VM Weaver AH Fischer OW Peterson MJ Bissell 1996 The importance of the microenvironment in breast cancer progression: Recapitulation of mammary tumorigenesis using a unique human mammary epithelial cell model and a three-dimensional culture assay Biochemistry and Cell Biology 74 833 851 9164652
7. H Liapis A Flath S Kitazawa 1996 Integrin alpha V beta 3 expression by bone-residing breast cancer metastases Diagnostic Molecular Pathology 5 127 135 8727100
8. JM Pawelek AK Chakraborty 2008 The cancer cell-leukocyte fusion theory of metastasis Advances in Cancer Research 101 397 444 19055949
9. M Aumailley M Pesch L Tunggal F Gaill R Fassler 2000 Altered synthesis of laminin 1 and absence of basement membrane component deposition in (beta)1 integrin-deficient embryoid bodies Journal of Cell Science 113 Pt 2 259 268 10633077
10. V Folgiero RE Bachelder G Bon A Sacchi R Falcioni AM Mercurio 2007 The alpha6beta4 integrin can regulate ErbB-3 expression: implications for alpha6beta4 signaling and function Cancer Research 67 1645 1652 17308105
11. TH Kim HI Kim YH Soung LA Shaw J Chung 2009 Integrin (alpha6beta4) signals through Src to increase expression of S100A4, a metastasis-promoting factor: implications for cancer cell invasion Molecular Cancer Res 7 1605 1612
12. PC Brooks S Stromblad LC Sers TL von Schalscha RT Aimes WG Stetler-Stevenson, et al. 1996 Localization of matrix metalloproteinase MMP-2 to the surface of invasive cells by interaction with integrin alpha v beta 3 Cell 85 683 693 8646777 (Pubitemid 26181048)
13. EI Deryugina MA Bourdon GX Luo RA Reisfeld A Strongin 1997 Matrix metalloproteinase-2 activation modulates glioma cell migration Journal of Cell Science 110 Pt 19 2473 2482 9410885
14. AB Glinskii GV Glinsky HY Lin HY Tang M Sun FB Davis, et al. 2009 Modification of survival pathway gene expression in human breast cancer cells by tetraiodothyroacetic acid (tetrac) Cell Cycle 8 3554 3562 19838061
15. J Tang YM Wu P Zhao JL Jiang ZN Chen 2009 Betaig-h3 interacts with alpha3beta1 integrin to promote adhesion and migration of human hepatoma cells Experimental Biology and Medicine (Maywood) 234 35 39
16. MK Wendt WP Schiemann 2009 Therapeutic targeting of the focal adhesion complex prevents oncogenic TGF-beta signaling and metastasis Breast Cancer Research 11 R68 19740433
17. N Gomes J Vassy C Lebos B Arbeille C Legrand F Fauvel-Lafeve 2004 Breast adenocarcinoma cell adhesion to the vascular subendothelium in whole blood and under flow conditions: effects of alphavbeta3 and alphaIIbbeta3 antagonists Clinical & Experimental Metastasis 21 553 561
18. P Rousselle M Aumailley 1994 Kalinin is more efficient than laminin in promoting adhesion of primary keratinocytes and some other epithelial cells and has a different requirement for integrin receptors Journal of Cell Biology 125 205 214 8138572
19. M Kielosto P Nummela K Jarvinen M Yin E Holtta 2009 Identification of integrins alpha6 and beta7 as c-Jun- and transformation-relevant genes in highly invasive fibrosarcoma cells International Journal of Cancer 125 1065 1073
20. Y He XD Liu ZY Chen J Zhu Y Xiong K Li, et al. 2007 Interaction between cancer cells and stromal fibroblasts is required for activation of the uPAR-uPA-MMP-2 cascade in pancreatic cancer metastasis Clinical Cancer Research 13 3115 3124 17545513
21. JS Desgrosellier LA Barnes DJ Shields M Huang SK Lau N Prevost, et al. 2009 An integrin alpha(v)beta(3)-c-Src oncogenic unit promotes anchorage-independence and tumor progression Nature Medicine 15 1163 1169 19734908
22. M Chen M Sinha BA Luxon AR Bresnick KL O'Connor 2009 Integrin alpha6beta4 controls the expression of genes associated with cell motility, invasion, and metastasis, including S100A4/metastasin Journal of Biological Chemistry 284 1484 1494 19011242
23. KL O'Connor LM Shaw AM Mercurio 1998 Release of cAMP gating by the alpha6beta4 integrin stimulates lamellae formation and the chemotactic migration of invasive carcinoma cells Journal of Cell Biology 143 1749 1760 9852165
24. EA Lipscomb AS Dugan I Rabinovitz AM Mercurio 2003 Use of RNA interference to inhibit integrin (alpha6beta4)-mediated invasion and migration of breast carcinoma cells Clinical & Experimental Metastasis 20 569 576
25. SO Yoon S Shin AM Mercurio 2006 Ras stimulation of E2F activity and a consequent E2F regulation of integrin alpha6beta4 promote the invasion of breast carcinoma cells Cancer Research 66 6288 6295 16778205
26. W Guo Y Pylayeva A Pepe T Yoshioka WJ Muller G Inghirami, et al. 2006 Beta 4 integrin amplifies ErbB2 signaling to promote mammary tumorigenesis Cell 126 489 502 16901783
27. MZ Gilcrease X Zhou X Lu WA Woodward BE Hall PJ Morrissey 2009 Alpha6beta4 integrin crosslinking induces EGFR clustering and promotes EGF-mediated Rho activation in breast cancer Journal of Experimental & Clinical Cancer Research 28 67
28. IS Vizirianakis CC Yao Y Chen BL Ziober AS Tsiftsoglou RH Kramer 2001 Transfection of MCF-7 carcinoma cells with human integrin alpha7 cDNA promotes adhesion to laminin Archives of Biochemistry and Biophysics 385 108 116 11361006
29. I Staniszewska EM Walsh VL Rothman A Gaathon GP Tuszynski JJ Calvete, et al. 2009 Effect of VP12 and viperistatin on inhibition of collagen receptors-dependent melanoma metastasis Cancer Biology & Therapy 8 1507 1516
30. N Garamszegi SP Garamszegi LA Shehadeh SP Scully 2009 Extracellular matrix-induced gene expression in human breast cancer cells Molecular Cancer Res 7 319 329
31. S Van Slambrouck C Grijelmo O De Wever E Bruyneel S Emami C Gespach, et al. 2007 Activation of the FAK-src molecular scaffolds and p130Cas-JNK signaling cascades by alpha1-integrins during colon cancer cell invasion International Journal of Oncology 31 1501 1508 17982677
32. Y Wang X Wang Y Zhang S Yang J Wang X Zhang, et al. 2009 RGD-modified polymeric micelles as potential carriers for targeted delivery to integrin-overexpressing tumor vasculature and tumor cells Journal of Drug Targeting 17 459 467 19527117
33. T Meyer JF Marshall IR Hart 1998 Expression of alphav integrins and vitronectin receptor identity in breast cancer cells British Journal of Cancer 77 530 536 9484807
34. M Rolli E Fransvea J Pilch A Saven B Felding-Habermann 2003 Activated integrin alphavbeta3 cooperates with metalloproteinase MMP-9 in regulating migration of metastatic breast cancer cells Proceedings of the National Academy of Sciences of the United States of America 100 9482 9487 12874388
35. B Nieswandt M Hafner B Echtenacher DN Mannel 1999 Lysis of tumor cells by natural killer cells in mice is impeded by platelets Cancer Research 59 1295 1300 10096562
36. J Huang R Roth JE Heuser JE Sadler 2009 Integrin alpha(v)beta(3) on human endothelial cells binds von Willebrand factor strings under fluid shear stress Blood 113 1589 1597 18927433
37. AJ Putnam VV Schulz EM Freiter HM Bill CK Miranti 2009 Src, PKCalpha, and PKCdelta are required for alphavbeta3 integrin-mediated metastatic melanoma invasion Cell Commun Signal 7 10 19400942
38. Y Jia ZZ Zeng SM Markwart KF Rockwood KM Ignatoski SP Ethier, et al. 2004 Integrin fibronectin receptors in matrix metalloproteinase-1-dependent invasion by breast cancer and mammary epithelial cells Cancer Research 64 8674 8681 15574776
39. Y Liu R Pixley M Fusaro G Godoy E Kim ME Bromberg, et al. 2009 Cleaved high-molecular-weight kininogen and its domain 5 inhibit migration and invasion of human prostate cancer cells through the epidermal growth factor receptor pathway Oncogene 28 2756 2765 19483730
40. EH Hall AE Daugherty CK Choi AF Horwitz DL Brautigan 2009 Tensin1 requires protein phosphatase-1alpha in addition to RhoGAP DLC-1 to control cell polarization, migration, and invasion Journal of Biological Chemistry 284 34713 34722 19826001
41. F Stanchi C Grashoff CF Nguemeni Yonga D Grall R Fassler E Van Obberghen-Schilling 2009 Molecular dissection of the ILK-PINCH-parvin triad reveals a fundamental role for the ILK kinase domain in the late stages of focal-adhesion maturation Journal of Cell Science 122 1800 1811 19435803
42. BL Tang EL Ng 2009 Rabs and cancer cell motility Cell Motility and the Cytoskeleton 66 365 370 19418559
43. FG Giancotti E Ruoslahti 1990 Elevated levels of the alpha 5 beta 1 fibronectin receptor suppress the transformed phenotype of Chinese hamster ovary cells Cell 60 849 859 2155708
44. JA Varner DA Emerson RL Juliano 1995 Integrin alpha 5 beta 1 expression negatively regulates cell growth: reversal by attachment to fibronectin Molecular Biology of the Cell 6 725 740 7579691
45. Y Imanishi B Hu MJ Jarzynka P Guo E Elishaev I Bar-Joseph, et al. 2007 Angiopoietin-2 stimulates breast cancer metastasis through the alpha(5)beta(1) integrin-mediated pathway Cancer Research 67 4254 4263 17483337
46. GE Morozevich NI Kozlova IB Cheglakov NA Ushakova ME Preobrazhenskaya AE Berman 2008 Implication of alpha5beta1 integrin in invasion of drug-resistant MCF-7/ADR breast carcinoma cells: a role for MMP-2 collagenase Biochemistry (Moscow) 73 791 796
47. Zhao, R., Liu, X. Q., Wu, X. P., Liu, Y. F., Zhang, Z. Y., Yang, G. Y., et al. (2009). Vascular endothelial growth factor (VEGF) enhances gastric carcinoma invasiveness via integrin alpha(v)beta6. Cancer Letters, 287(2), 150-156.
48. Shen, S., Fan, J., Cai, B., Lv, Y., Zeng, M., Hao, Y., et al. (2009). Vascular endothelial growth factor enhances cancer cell adhesion to microvascular endothelium in vivo. Experimental Physiology. doi: 10.1113/expphysiol.2009.050260.
49. SH Hausner CK Abbey RJ Bold MK Gagnon J Marik JF Marshall, et al. 2009 Targeted in vivo imaging of integrin alphavbeta6 with an improved radiotracer and its relevance in a pancreatic tumor model Cancer Research 69 5843 5850 19549907
50. C Defilles JC Lissitzky MP Montero F Andre C Prevot E Delamarre, et al. 2009 Alphavbeta5/beta6 integrin suppression leads to a stimulation of alpha2beta1 dependent cell migration resistant to PI3K/Akt inhibition Experimental Cell Research 315 1840 1849 19328197
51. RS Sawhney W Liu MG Brattain 2009 A novel role of ERK5 in integrin-mediated cell adhesion and motility in cancer cells via Fak signaling Journal of Cellular Physiology 219 152 161 19089993
52. Z Zhao-Yang X Ke-Sen H Qing-Si N Wei-Bo W Jia-Yong M Yue-Tang, et al. 2008 Signaling and regulatory mechanisms of integrin alphavbeta6 on the apoptosis of colon cancer cells Cancer Letters 266 209 215 18381232
53. GY Yang KS Xu ZQ Pan ZY Zhang YT Mi JS Wang, et al. 2008 Integrin alpha v beta 6 mediates the potential for colon cancer cells to colonize in and metastasize to the liver Cancer Sci 99 879 887 18294287
54. SK Gupta NE Vlahakis 2009 Integrin alpha9beta1 mediates enhanced cell migration through nitric oxide synthase activity regulated by Src tyrosine kinase Journal of Cell Science 122 2043 2054 19470583
55. Jakubowska, A., Rozkrut, D., Antoniou, A., Hamann, U., & Lubinski, J. (2009). The Leu33Pro polymorphism in the ITGB3 gene does not modify BRCA1/2-associated breast or ovarian cancer risks: results from a multicenter study among 15,542 BRCA1 and BRCA2 mutation carriers. Breast Cancer Research and Treatment. doi: 10.1007/s10549-009-0595-7.
56. IE Collier SM Wilhelm AZ Eisen BL Marmer GA Grant JL Seltzer, et al. 1988 H-ras oncogene-transformed human bronchial epithelial cells (TBE-1) secrete a single metalloprotease capable of degrading basement membrane collagen Journal of Biological Chemistry 263 6579 6587 2834383
57. C Monteagudo MJ Merino J San-Juan LA Liotta WG Stetler-Stevenson 1990 Immunohistochemical distribution of type IV collagenase in normal, benign, and malignant breast tissue American Journal of Pathology 136 585 592 2156430
58. AJ Liu YX Hu CJ Liu XL Yao GR Zhang 2009 The mechanism of inhibition of metastasis by cartilage polysaccharide in breast-cancer cells Biotechnology and Applied Biochemistry 53 253 263 19055483
59. J Grassinger DN Haylock MJ Storan GO Haines B Williams GA Whitty, et al. 2009 Thrombin-cleaved osteopontin regulates hemopoietic stem and progenitor cell functions through interactions with alpha9beta1 and alpha4beta1 integrins Blood 114 49 59 19417209
60. Z Mi H Guo MB Russell Y Liu BA Sullenger PC Kuo 2009 RNA aptamer blockade of osteopontin inhibits growth and metastasis of MDA-MB231 breast cancer cells Molecular Ther 17 153 161
61. Behera, R., Kumar, V., Lohite, K., Karnik, S., & Kundu, G. C. (2009). Activation of JAK2/STAT3 signaling by osteopontin promotes tumor growth in human breast cancer cells. Carcinogenesis (in press).
62. El-Tanani, M. K., Jin, D., Campbell, F. C., & Johnston, P. G. (2009). Interferon-induced transmembrane 3 binds osteopontin in vitro: expressed in vivo IFITM3 reduced OPN expression. Oncogene. doi: 10.1038/onc.2009.379.
63. C Conway A Mitra R Jewell J Randerson-Moor S Lobo J Nsengimana, et al. 2009 Gene expression profiling of paraffin-embedded primary melanoma using the DASL assay identifies increased osteopontin expression as predictive of reduced relapse-free survival Clinical Cancer Research 15 6939 6946 19887478
64. BW Robertson MA Chellaiah 2010 Osteopontin induces beta-catenin signaling through activation of Akt in prostate cancer cells Experimental Cell Research 316 1 11 19850036
65. DM Beauvais BJ Ell AR McWhorter AC Rapraeger 2009 Syndecan-1 regulates alphavbeta3 and alphavbeta5 integrin activation during angiogenesis and is blocked by synstatin, a novel peptide inhibitor Journal of Experimental Medicine 206 691 705 19255147
66. Shao, R., Hamel, K., Petersen, L., Cao, Q. J., Arenas, R. B., Bigelow, C., et al. (2009). YKL-40, a secreted glycoprotein, promotes tumor angiogenesis. Oncogene (in press).
67. B Dome E Raso J Dobos L Meszaros N Varga LG Puskas, et al. 2005 Parallel expression of alphaIIbbeta3 and alphavbeta3 integrins in human melanoma cells upregulates bFGF expression and promotes their angiogenic phenotype International Journal of Cancer 116 27 35
68. A Ohtoshi T Maeda H Higashi S Ashizawa M Yamada M Hatakeyama 2000 Beta3-endonexin as a novel inhibitor of cyclin A-associated kinase Biochemical and Biophysical Research Communications 267 947 952 10673397
69. MY Wang PS Chen E Prakash HC Hsu HY Huang MT Lin, et al. 2009 Connective tissue growth factor confers drug resistance in breast cancer through concomitant up-regulation of Bcl-xL and cIAP1 Cancer Research 69 3482 3491 19351859
70. L Hui C Ji B Hui T Lv X Ha J Yang, et al. 2009 The oncoprotein LMO3 interacts with calcium- and integrin-binding protein CIB Brain Research 1265 24 29 19236851
71. JC Denofrio W Yuan BR Temple HR Gentry LV Parise 2008 Characterization of calcium- and integrin-binding protein 1 (CIB1) knockout platelets: potential compensation by CIB family members Thrombosis and Haemostasis 100 847 856 18989529
72. MU Naik UP Naik 2003 Calcium-and integrin-binding protein regulates focal adhesion kinase activity during platelet spreading on immobilized fibrinogen Blood 102 3629 3636 12881299
73. L Haataja V Kaartinen J Groffen N Heisterkamp 2002 The small GTPase Rac3 interacts with the integrin-binding protein CIB and promotes integrin alpha(IIb)beta(3)-mediated adhesion and spreading Journal of Biological Chemistry 277 8321 8328 11756406
74. K Mardilovich LM Shaw 2009 Hypoxia regulates insulin receptor substrate-2 expression to promote breast carcinoma cell survival and invasion Cancer Research 69 8894 8901 19920186
75. SN Yang HT Chen HK Tsou CY Huang WH Yang CM Su, et al. 2009 Leptin enhances cell migration in human chondrosarcoma cells through OBRl leptin receptor Carcinogenesis 30 566 574 19168585
76. C Geiger W Nagel T Boehm Y van Kooyk CG Figdor E Kremmer, et al. 2000 Cytohesin-1 regulates beta-2 integrin-mediated adhesion through both ARF-GEF function and interaction with LFA-1 EMBO Journal 19 2525 2536 10835351
77. S D'Alessio F Blasi 2009 The urokinase receptor as an entertainer of signal transduction Frontiers in Bioscience 14 4575 4587 19273372
78. H Sawai Y Okada H Funahashi Y Matsuo H Takahashi H Takeyama, et al. 2006 Interleukin-1alpha enhances the aggressive behavior of pancreatic cancer cells by regulating the alpha6beta1-integrin and urokinase plasminogen activator receptor expression BMC Cell Biol 7 8 16504015
79. JA Aguirre Ghiso K Kovalski L Ossowski 1999 Tumor dormancy induced by downregulation of urokinase receptor in human carcinoma involves integrin and MAPK signaling Journal of Cell Biology 147 89 104 10508858
80. S Degani F Balzac M Brancaccio S Guazzone SF Retta L Silengo, et al. 2002 The integrin cytoplasmic domain-associated protein ICAP-1 binds and regulates Rho family GTPases during cell spreading Journal of Cell Biology 156 377 387 11807099
81. PJ Stroeken B Alvarez J Van Rheenen YM Wijnands D Geerts K Jalink, et al. 2006 Integrin cytoplasmic domain-associated protein-1 (ICAP-1) interacts with the ROCK-I kinase at the plasma membrane Journal of Cellular Physiology 208 620 628 16741948
82. HN Fournier S Dupe-Manet D Bouvard F Luton S Degani MR Block, et al. 2005 Nuclear translocation of integrin cytoplasmic domain-associated protein 1 stimulates cellular proliferation Molecular Biology of the Cell 16 1859 1871 15703214
83. A Millon-Fremillon D Bouvard A Grichine S Manet-Dupe MR Block C Albiges-Rizo 2008 Cell adaptive response to extracellular matrix density is controlled by ICAP-1-dependent beta1-integrin affinity Journal of Cell Biology 180 427 441 18227284
84. D Bouvard A Aszodi G Kostka MR Block C Albiges-Rizo R Fassler 2007 Defective osteoblast function in ICAP-1-deficient mice Development 134 2615 2625 17567669
85. M D'Amico J Hulit DF Amanatullah BT Zafonte C Albanese B Bouzahzah, et al. 2000 The integrin-linked kinase regulates the cyclin D1 gene through glycogen synthase kinase 3beta and cAMP-responsive element-binding protein-dependent pathways Journal of Biological Chemistry 275 32649 32657 10915780
86. K Vasala P Kuvaja T Turpeenniemi-Hujanen 2008 Low circulating levels of ProMMP-2 are associated with adverse prognosis in bladder cancer Tumour Biology 29 279 286 18802398
87. A Staack S Badendieck D Schnorr SA Loening K Jung 2006 Combined determination of plasma MMP2, MMP9, and TIMP1 improves the non-invasive detection of transitional cell carcinoma of the bladder BMC Urol 6 19 16901349
88. YZ Fan ZM Zhao JY Fu CQ Chen 2006 Anti-tumor mechanism of norcantharidin for the implanted tumors of human gallbladder carcinoma in nude mice in vivo Zhonghua WaiKe ZaZhi 44 618 622 16784656
89. SM Hyder Y Liang J Wu 2009 Estrogen regulation of thrombospondin-1 in human breast cancer cells International Journal of Cancer 125 1045 1053
90. K Lindberg A Strom JG Lock JA Gustafsson LA Haldosen LA Helguero 2010 Expression of estrogen receptor beta increases integrin alpha1 and integrin beta1 levels and enhances adhesion of breast cancer cells Journal of Cellular Physiology 222 156 167 19780039
91. V Terraube I Marx CV Denis 2007 Role of von Willebrand factor in tumor metastasis Thrombosis Research 120 Suppl 2 S64 S70 18023715
92. V Terraube R Pendu D Baruch MF Gebbink D Meyer PJ Lenting, et al. 2006 Increased metastatic potential of tumor cells in von Willebrand factor-deficient mice Journal of Thrombosis Haemost 4 519 526
93. N Gomes C Legrand F Fauvel-Lafeve 2005 Shear stress induced release of von Willebrand factor and thrombospondin-1 in HUVEC extracellular matrix enhances breast tumour cell adhesion Clinical & Experimental Metastasis 22 215 223
94. I Gil-Bazo V Catalan J Paramo C Quero S Escriva de Romani A Perez-Ochoa, et al. 2003 Von Willebrand factor as an intermediate between hemostasis and angiogenesis of tumor origin Revista de Medicina de la Universidad de Navarra 47 22 28 14727571
95. BM Jockusch P Bubeck K Giehl M Kroemker J Moschner M Rothkegel, et al. 1995 The molecular architecture of focal adhesions Annual Review of Cell and Developmental Biology 11 379 416 8689563
96. K Burridge M Chrzanowska-Wodnicka 1996 Focal adhesions, contractility, and signaling Annual Review of Cell and Developmental Biology 12 463 518 8970735
97. SH Lo E Weisberg LB Chen 1994 Tensin: a potential link between the cytoskeleton and signal transduction Bioessays 16 817 823 7840759
98. SK Alahari JW Lee RL Juliano 2000 Nischarin, a novel protein that interacts with the integrin alpha5 subunit and inhibits cell migration Journal of Cell Biology 151 1141 1154 11121431
99. Y Ding T Milosavljevic SK Alahari 2008 Nischarin inhibits LIM kinase to regulate cofilin phosphorylation and cell invasion Molecular and Cellular Biology 28 3742 3756 18332102
100. RL Juliano P Reddig S Alahari M Edin A Howe A Aplin 2004 Integrin regulation of cell signalling and motility Biochemical Society Transactions 32 443 446 15157156
101. WJ Chia BL Tang 2009 Emerging roles for Rab family GTPases in human cancer Biochimica et Biophysica Acta 1795 110 116 19425190
102. PS Bridger S Haupt R Leiser GA Johnson RC Burghardt HR Tinneberg, et al. 2008 Integrin activation in bovine placentomes and in caruncular epithelial cells isolated from pregnant cows Biology of Reproduction 79 274 282 18417711
103. DR Critchley 2009 Biochemical and structural properties of the integrin-associated cytoskeletal protein talin Annual Review of Biophysics 38 235 254 19416068
104. J Wang W Wan R Sun Y Liu X Sun D Ma, et al. 2008 Reduction of Akt2 expression inhibits chemotaxis signal transduction in human breast cancer cells Cellular Signalling 20 1025 1034 18353613
105. J van Rheenen X Song W van Roosmalen M Cammer X Chen V Desmarais, et al. 2007 EGF-induced PIP2 hydrolysis releases and activates cofilin locally in carcinoma cells Journal of Cell Biology 179 1247 1259 18086920
106. SL Payne MJ Hendrix DA Kirschmann 2006 Lysyl oxidase regulates actin filament formation through the p130(Cas)/Crk/DOCK180 signaling complex Journal of Cellular Biochemistry 98 827 837 16440329
107. H Yamaguchi M Lorenz S Kempiak C Sarmiento S Coniglio M Symons, et al. 2005 Molecular mechanisms of invadopodium formation: the role of the N-WASP-Arp2/3 complex pathway and cofilin Journal of Cell Biology 168 441 452 15684033
108. T Uruno J Liu P Zhang Y Fan C Egile R Li, et al. 2001 Activation of Arp2/3 complex-mediated actin polymerization by cortactin Nature Cell Biology 3 259 266 11231575
109. M Lorenz H Yamaguchi Y Wang RH Singer J Condeelis 2004 Imaging sites of N-wasp activity in lamellipodia and invadopodia of carcinoma cells Current Biology 14 697 703 15084285
110. M Katz I Amit A Citri T Shay S Carvalho S Lavi, et al. 2007 A reciprocal tensin-3-cten switch mediates EGF-driven mammary cell migration Nature Cell Biology 9 961 969 17643115
111. JC Friedland MH Lee D Boettiger 2009 Mechanically activated integrin switch controls alpha5beta1 function Science 323 642 644 19179533
112. JH Lee ES Rangarajan SD Yogesha T Izard 2009 Raver1 interactions with vinculin and RNA suggest a feed-forward pathway in directing mRNA to focal adhesions Structure 17 833 842 19523901
113. B Zhang F Gu C She H Guo W Li R Niu, et al. 2009 Reduction of Akt2 inhibits migration and invasion of glioma cells International Journal of Cancer 125 585 595
114. AR Reynolds IR Hart AR Watson JC Welti RG Silva SD Robinson, et al. 2009 Stimulation of tumor growth and angiogenesis by low concentrations of RGD-mimetic integrin inhibitors Nature Medicine 15 392 400 19305413
115. D Barkan H Kleinman JL Simmons H Asmussen AK Kamaraju MJ Hoenorhoff, et al. 2008 Inhibition of metastatic outgrowth from single dormant tumor cells by targeting the cytoskeleton Cancer Research 68 6241 6250 18676848