Rhodostomin, a snake venom disintegrin, inhibits angiogenesis elicited by basic fibroblast growth factor and suppresses tumor growth by a selective αv/β3 blockade of endothelial cells

Molecular Pharmacology

Volumn 59, Issue 5, 2001, Pages 1333-1342

  Yeh, Chia Hsin ^a   Peng, Hui Chin ^a   Yang, Rong Seng ^a   Huang, Tur Fu ^a  

^a NATIONAL TAIWAN UNIVERSITY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

BASIC FIBROBLAST GROWTH FACTOR; DISINTEGRIN; EPTIFIBATIDE; FLUORESCEIN ISOTHIOCYANATE; MONOCLONAL ANTIBODY; RHODOSTOMIN; SNAKE VENOM; UNCLASSIFIED DRUG;

ANGIOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER INHIBITION; CELL COUNT; CELL INVASION; CELL METABOLISM; CELL MIGRATION; CELL PROLIFERATION; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG INHIBITION; DRUG MECHANISM; ENDOTHELIUM CELL; HUMAN; HUMAN CELL; IC 50; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; TUMOR VASCULARIZATION;

EID: 0035028334     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.59.5.1333     Document Type: Article

References (41)

1. 3 integrin in human melanoma cells
2. 3-mediated activation of apoptosis
3. 3 for angiogenesis
4. 3 antagonists promote tumor regression by inducing apoptosis of angiogenic blood vessels
5. 3 on vascular cells controls recognition of prothrombin
6. 3 in vascular biology
7. A new murine monoclonal antibody reports on activation-dependent change in the conformation and/or microenvironment of the platelet glycoprotein IIb/IIIa complex
8. Endothelial cell apoptosis in angiogenesis and vessel regression
9. v integrins during angiogenesis: Insights into potential mechanisms of action and clinical development
10. Basic FGF and TGF-β differentially modulate integrin expression of human microvascular endothelial cells
11. Angiogenesis
12. Clinical applications of research on angiogenesis
13. Selective inhibition of integrin function by antibodies specific to ligand-occupied receptor conformers
14. v integrins
15. Disintegrins: A family of integrin inhibitory proteins from viper venoms
16. Two different laminin domains mediate the differentiation of human endothelial cells into capillary-like structures in vitro
17. Angiogenesis potentials for pharmacological intervention in the treatment of cancer, cardiovascular diseases, and chronic inflammation
18. Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis
19. Rhodostomin, a snake venom peptide and its fragment inhibit platelet aggregation by acting as fibrinogen receptor antagonist
20. What have snakes taught us about integrins?
21. Integrins: Versatility, modulation, and signaling in cell adhesion
22. Culture of human endothelial cells derived from umbilical veins
23. A novel disintegrin salmosin inhibits tumor angiogenesis
24. Suppressive mechanism of salmosin, a novel disintegrin in B16 melanoma cell metastasis
25. Basic fibroblast growth factor modulates integrin expression in microvascular endothelial cells
26. Antiangiogenic agents
27. 3-mediated endothelial cell migration is triggered through distinct signaling mechanisms
28. Antineoplastic urinary protein inhibits Kaposi's sarcoma and angiogenesis in vitro and in vivo
29. v integrins
30. Endostatin: An endogenous inhibitor of angiogenesis and tumor growth
31. A simple, quantitative method for assessing angiogenesis and anti-angiogenic agents using reconstituted basement membrane, heparin and fibroblast growth factor
32. Convergence of integrin and growth factor receptor signaling pathways within the focal adhesion complex
33. Antivascular endothelial growth factor receptor (fetal liver kinase I) monoclonal antibody inhibits angiogenesis and growth of several mouse and human tumor
34. Adhesion-growth factor interactions during differentiation: An integrated biological response
35. Design of potent and specific integrin antagonists. Peptide antagonists with high specificity for glycoprotein IIb-IIIa
36. Triflavin, an Arg-Gly-Asp-containing antiplatelet peptide inhibits cell-substratum adhesion and melanoma cell-induced lung colonization
37. Cell adhesion and angiogenesis
38. 3 antagonist and inducing apoptosis
39. 3-mediated human endothelial cell adhesion and calcium signaling
40. Contortrostatin, a dimeric disintegrin from Agkstrodon contortrix contortrix, inhibits angiogenesis
41. Contortrostatin, a dimeric disintegrin from Agkistrodon contortrix contortrix, inhibits breast cancer progression