Peroxisome deficiency-induced ER stress and SREBP-2 pathway activation in the liver of newborn PEX2 knock-out mice

Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids

Volumn 1821, Issue 6, 2012, Pages 895-907

  Kovacs, Werner J ^a,b   Charles, Khanichi N ^b,e   Walter, Katharina M ^a   Shackelford, Janis E ^b   Wikander, Thomas M ^c   Richards, Michael J ^d   Fliesler, Steven J ^d,f   Krisans, Skaidrite K ^b   Faust, Phyllis L ^c  

^a ETH ZURICH   (Switzerland)

^b SAN DIEGO STATE UNIVERSITY   (United States)

^c NewYork Presbyterian Hospital   (United States)

^d SAINT LOUIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^f UNIVERSITY AT BUFFALO   (United States)

Author keywords

Cholesterol homeostasis; ER stress; Peroxisome; Pex2; PPAR ; SREBP 2

Indexed keywords

CHOLESTEROL; LIVER ENZYME; PEROXIN; PEROXISOME PROLIFERATOR; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PROTEIN; STEROL REGULATORY ELEMENT BINDING PROTEIN 2;

ANIMAL EXPERIMENT; ARTICLE; CHOLESTEROL HOMEOSTASIS; CONGENIC STRAIN; CONTROLLED STUDY; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVATION; GENE; GENE ACTIVATION; GENE EXPRESSION; GENETIC REGULATION; HOMEOSTASIS; MOUSE; NEWBORN; NONHUMAN; PEROXISOME; PEX2 GENE; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; WILD TYPE;

ANIMALS; ANIMALS, NEWBORN; BLOTTING, WESTERN; CHOLESTEROL; ENDOPLASMIC RETICULUM STRESS; FEMALE; GENE EXPRESSION; HYDROXYMETHYLGLUTARYL COA REDUCTASES; HYDROXYMETHYLGLUTARYL-COA SYNTHASE; IMMUNOHISTOCHEMISTRY; LIPIDS; LIVER; MALE; MEMBRANE PROTEINS; MICE; MICE, 129 STRAIN; MICE, INBRED C57BL; MICE, KNOCKOUT; PEROXISOMES; PPAR ALPHA; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; STEROL REGULATORY ELEMENT BINDING PROTEIN 2;

MUS;

EID: 84859299139     PISSN: 13881981     EISSN: 18792618     Source Type: Journal    
DOI: 10.1016/j.bbalip.2012.02.011     Document Type: Article

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