메뉴 건너뛰기




Volumn 36, Issue 4, 2012, Pages 357-365

Inhibition of protein kinase B activity induces cell cycle arrest and apoptosis during early G 1 phase in CHO cells

Author keywords

Apoptosis; Cell cycle; Chinese hamster ovary (CHO) cells; G 1 phase; Protein kinase B; Restriction point

Indexed keywords

CASPASE 3; CYCLIN A; CYCLIN D; PROTEIN KINASE B; THYMIDINE;

EID: 84859240537     PISSN: 10656995     EISSN: 10958355     Source Type: Journal    
DOI: 10.1042/CBI20110092     Document Type: Article
Times cited : (2)

References (50)
  • 2
    • 0031127305 scopus 로고    scopus 로고
    • Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Bα
    • Alessi DR, James SR, Downes CP, Holmes AB, Gaffney PR, Reese CB et al. Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Bα. Curr Biol 1997;7:261-9.
    • (1997) Curr Biol , vol.7 , pp. 261-269
    • Alessi, D.R.1    James, S.R.2    Downes, C.P.3    Holmes, A.B.4    Gaffney, P.R.5    Reese, C.B.6
  • 3
    • 1542781732 scopus 로고    scopus 로고
    • Isoform-specific regulation of insulin-dependent glucose uptake by Akt/protein kinase B
    • Bae SS, Cho H, Mu J, Birnbaum MJ. Isoform-specific regulation of insulin-dependent glucose uptake by Akt/protein kinase B. J Biol Chem 2003;278:49530-6.
    • (2003) J Biol Chem , vol.278 , pp. 49530-49536
    • Bae, S.S.1    Cho, H.2    Mu, J.3    Birnbaum, M.J.4
  • 4
    • 0344035314 scopus 로고    scopus 로고
    • PKB/Akt phosphorylates the CDC25B phosphatase and regulates its intracellular localisation
    • Baldin V, Theis-Febvre N, Benne C, Froment C, Cazales M, Burlet-Schiltz O et al. PKB/Akt phosphorylates the CDC25B phosphatase and regulates its intracellular localisation. Biol Cell 2003;95:547-54.
    • (2003) Biol Cell , vol.95 , pp. 547-554
    • Baldin, V.1    Theis-Febvre, N.2    Benne, C.3    Froment, C.4    Cazales, M.5    Burlet-Schiltz, O.6
  • 7
    • 0034647674 scopus 로고    scopus 로고
    • Translocation of Akt/PKB to the nucleus of osteoblast-like MC3T3-E1 cells exposed to proliferative growth factors
    • Borgatti P, Martelli AM, Bellacosa A, Casto R, Massari L, Capitani S et al. Translocation of Akt/PKB to the nucleus of osteoblast-like MC3T3-E1 cells exposed to proliferative growth factors. FEBS Lett 2000;477:27-32.
    • (2000) FEBS Lett , vol.477 , pp. 27-32
    • Borgatti, P.1    Martelli, A.M.2    Bellacosa, A.3    Casto, R.4    Massari, L.5    Capitani, S.6
  • 8
    • 0033582929 scopus 로고    scopus 로고
    • Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor
    • Brunet A, Bonni A, Zigmond MJ, Lin MZ, Juo P, Hu LS et al. Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor. Cell 1999;96:857-68.
    • (1999) Cell , vol.96 , pp. 857-868
    • Brunet, A.1    Bonni, A.2    Zigmond, M.J.3    Lin, M.Z.4    Juo, P.5    Hu, L.S.6
  • 10
    • 0035914388 scopus 로고    scopus 로고
    • Akt1/PKBa is required for normal growth but dispensable for maintenance of glucose homeostasis in mice
    • Cho H, Thorvaldsen JL, Chu Q, Feng F, Birnbaum MJ. Akt1/PKBa is required for normal growth but dispensable for maintenance of glucose homeostasis in mice. J Biol Chem 2001;276:38349-52.
    • (2001) J Biol Chem , vol.276 , pp. 38349-38352
    • Cho, H.1    Thorvaldsen, J.L.2    Chu, Q.3    Feng, F.4    Birnbaum, M.J.5
  • 11
    • 0035368548 scopus 로고    scopus 로고
    • Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKBβ)
    • Cho H, Mu J, Kim JK, Thorvaldsen JL, Chu Q, Crenshaw III, EB et al. Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKBβ). Science 2001;292:1728-31.
    • (2001) Science , vol.292 , pp. 1728-1731
    • Cho, H.1    Mu, J.2    Kim, J.K.3    Thorvaldsen, J.L.4    Chu, Q.5    Crenshaw III, E.B.6
  • 13
    • 0032189381 scopus 로고    scopus 로고
    • Protein kinase B (c-Akt): a multifunctional mediator of phosphatidylinositol 3-kinase activation
    • Coffer PJ, Jin J, Woodgett JR. Protein kinase B (c-Akt): a multifunctional mediator of phosphatidylinositol 3-kinase activation. Biochem J 1998;335:1-13.
    • (1998) Biochem J , vol.335 , pp. 1-13
    • Coffer, P.J.1    Jin, J.2    Woodgett, J.R.3
  • 14
    • 0032752063 scopus 로고    scopus 로고
    • Cellular survival: a play in three Akts
    • Datta SR, Brunet A, Greenberg ME. Cellular survival: a play in three Akts. Genes Dev 1999;13:2905-27.
    • (1999) Genes Dev , vol.13 , pp. 2905-2927
    • Datta, S.R.1    Brunet, A.2    Greenberg, M.E.3
  • 15
    • 58149175555 scopus 로고    scopus 로고
    • The life of a cell: apoptosis regulation by the PI3K/PKB pathway
    • Duronio V. The life of a cell: apoptosis regulation by the PI3K/PKB pathway. Biochem J 2008;414:333-44.
    • (2008) Biochem J , vol.414 , pp. 333-344
    • Duronio, V.1
  • 18
    • 0030907987 scopus 로고    scopus 로고
    • PI3K: downstream AKTion blocks apoptosis
    • Franke TF, Kaplan DR, Cantley LC. PI3K: downstream AKTion blocks apoptosis. Cell 1997;88:435-7.
    • (1997) Cell , vol.88 , pp. 435-437
    • Franke, T.F.1    Kaplan, D.R.2    Cantley, L.C.3
  • 20
    • 0032806092 scopus 로고    scopus 로고
    • Roles of cyclin D1 and related genes in growth inhibition, senescence and apoptosis
    • Han EK, Ng SC, Arber N, Begemann M, Weinstein IB. Roles of cyclin D1 and related genes in growth inhibition, senescence and apoptosis. Apoptosis 1999;4:213-9.
    • (1999) Apoptosis , vol.4 , pp. 213-219
    • Han, E.K.1    Ng, S.C.2    Arber, N.3    Begemann, M.4    Weinstein, I.B.5
  • 21
    • 0842334471 scopus 로고    scopus 로고
    • Cell cycle progression and activation of Akt kinase are required for insulin-like growth factor Imediated suppression of apoptosis in granulosa cells
    • Hu CL, Cowan RG, Harman RM, Quirk SM. Cell cycle progression and activation of Akt kinase are required for insulin-like growth factor Imediated suppression of apoptosis in granulosa cells. Mol Endocrinol 2004;18:326-38.
    • (2004) Mol Endocrinol , vol.18 , pp. 326-338
    • Hu, C.L.1    Cowan, R.G.2    Harman, R.M.3    Quirk, S.M.4
  • 22
    • 0035128901 scopus 로고    scopus 로고
    • 1 phase progression by growth factors and the extracellular matrix
    • 1 phase progression by growth factors and the extracellular matrix. Cell Mol Life Sci 2001;58:80-93.
    • (2001) Cell Mol Life Sci , vol.58 , pp. 80-93
    • Hulleman, E.1    Boonstra, J.2
  • 23
    • 0032805496 scopus 로고    scopus 로고
    • Nuclear translocation of mitogen-activated protein kinase p42MAPK during the ongoing cell cycle
    • Hulleman E, Bijvelt JJ, Verkleij AJ, Verrips CT, Boonstra J. Nuclear translocation of mitogen-activated protein kinase p42MAPK during the ongoing cell cycle. J Cell Physiol 1999a;180:325-33.
    • (1999) J Cell Physiol , vol.180 , pp. 325-333
    • Hulleman, E.1    Bijvelt, J.J.2    Verkleij, A.J.3    Verrips, C.T.4    Boonstra, J.5
  • 27
    • 0036120725 scopus 로고    scopus 로고
    • Control of cell cycle exit and entry by protein kinase Bregulated forkhead transcription factors
    • Kops GJ, Medema RH, Glassford J, Essers MA, Dijkers PF, Coffer PJ et al. Control of cell cycle exit and entry by protein kinase Bregulated forkhead transcription factors. Mol Cell Biol 2002;22:2025-36.
    • (2002) Mol Cell Biol , vol.22 , pp. 2025-2036
    • Kops, G.J.1    Medema, R.H.2    Glassford, J.3    Essers, M.A.4    Dijkers, P.F.5    Coffer, P.J.6
  • 28
    • 14044266297 scopus 로고    scopus 로고
    • Spatio-temporal dynamics of protein kinase B/Akt signaling revealed by a genetically encoded fluorescent reporter
    • Kunkel MT, Tsien RY, Zhang J, Newton AC. Spatio-temporal dynamics of protein kinase B/Akt signaling revealed by a genetically encoded fluorescent reporter. J Biol Chem 2005;280:5581-7.
    • (2005) J Biol Chem , vol.280 , pp. 5581-5587
    • Kunkel, M.T.1    Tsien, R.Y.2    Zhang, J.3    Newton, A.C.4
  • 29
    • 0021893250 scopus 로고
    • Cell-cycle-specific induction of quiescence achieved by limited inhibition of protein synthesis, counteractive effect of addition of purified growth factors
    • Larsson O, Zetterberg A, Engstróm W. Cell-cycle-specific induction of quiescence achieved by limited inhibition of protein synthesis, counteractive effect of addition of purified growth factors. J Cell Sci 1985;73:375-87.
    • (1985) J Cell Sci , vol.73 , pp. 375-387
    • Larsson, O.1    Zetterberg, A.2    Engstróm, W.3
  • 30
    • 0034845958 scopus 로고    scopus 로고
    • PKB/Akt: a key mediator of cell proliferation, survival and insulin responses?
    • Lawlor MA, Alessi DR. PKB/Akt: a key mediator of cell proliferation, survival and insulin responses? J Cell Sci 2001;114:2903-10.
    • (2001) J Cell Sci , vol.114 , pp. 2903-2910
    • Lawlor, M.A.1    Alessi, D.R.2
  • 31
    • 26444484932 scopus 로고    scopus 로고
    • Akt-induced promotion of cell-cycle progression at G(2)/M phase involves upregulation of NF-Y binding activity in PC12 cells
    • Lee SR, Park JH, Park EK, Chung CH, Kang SS, Bang OS. Akt-induced promotion of cell-cycle progression at G(2)/M phase involves upregulation of NF-Y binding activity in PC12 cells. J Cell Physiol 2005;205:270-7.
    • (2005) J Cell Physiol , vol.205 , pp. 270-277
    • Lee, S.R.1    Park, J.H.2    Park, E.K.3    Chung, C.H.4    Kang, S.S.5    Bang, O.S.6
  • 32
    • 0037192852 scopus 로고    scopus 로고
    • AKT/PKB phosphorylation of p21Cip/WAF1 enhances protein stability of p21Cip/WAF1 and promotes cell survival
    • Li Y, Dowbenko D, Lasky LA. AKT/PKB phosphorylation of p21Cip/WAF1 enhances protein stability of p21Cip/WAF1 and promotes cell survival. J Biol Chem 2001;277:11352-61.
    • (2001) J Biol Chem , vol.277 , pp. 11352-11361
    • Li, Y.1    Dowbenko, D.2    Lasky, L.A.3
  • 33
    • 0030727172 scopus 로고    scopus 로고
    • Mitogenic activation, phosphorylation, and nuclear translocation of protein kinase Bβ
    • Meier R, Alessi DR, Cron P, Andjelkovic M, Hemmings BA. Mitogenic activation, phosphorylation, and nuclear translocation of protein kinase Bβ. J Biol Chem 1997;272:30491-7.
    • (1997) J Biol Chem , vol.272 , pp. 30491-30497
    • Meier, R.1    Alessi, D.R.2    Cron, P.3    Andjelkovic, M.4    Hemmings, B.A.5
  • 34
    • 0032491579 scopus 로고    scopus 로고
    • Cyclin D expression is controlled posttranscriptionally via a phosphatidylinositol 3-kinase/Akt-dependent pathway
    • Muise-Helmericks RC, Grimes HL, Bellacosa A, Malstrom SE, Tsichlis PN, Rosen N. Cyclin D expression is controlled posttranscriptionally via a phosphatidylinositol 3-kinase/Akt-dependent pathway. J Biol Chem 1998;273:29864-72.
    • (1998) J Biol Chem , vol.273 , pp. 29864-29872
    • Muise-Helmericks, R.C.1    Grimes, H.L.2    Bellacosa, A.3    Malstrom, S.E.4    Tsichlis, P.N.5    Rosen, N.6
  • 35
    • 0037057801 scopus 로고    scopus 로고
    • The nuclear phosphoinositide 3-kinase/Akt pathway: a new second messenger system
    • Neri LM, Borgatti P, Capitani S, Martelli AM. The nuclear phosphoinositide 3-kinase/Akt pathway: a new second messenger system. Biochim Biophys Acta 2002;1584:73-80.
    • (2002) Biochim Biophys Acta , vol.1584 , pp. 73-80
    • Neri, L.M.1    Borgatti, P.2    Capitani, S.3    Martelli, A.M.4
  • 36
    • 13844312400 scopus 로고    scopus 로고
    • Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
    • Sarbassov DD, Guertin DA, Siraj MA, Sabatini DM. Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. Science 2005;307:1098-101.
    • (2005) Science , vol.307 , pp. 1098-1101
    • Sarbassov, D.D.1    Guertin, D.A.2    Siraj, M.A.3    Sabatini, D.M.4
  • 37
    • 0036333737 scopus 로고    scopus 로고
    • Multiple phosphoinositide 3-kinase-dependent steps in activation of protein kinase B
    • Scheid MP, Marignani PA, Woodgett JR. Multiple phosphoinositide 3-kinase-dependent steps in activation of protein kinase B. Mol Cell Biol 2002;22:6247-60.
    • (2002) Mol Cell Biol , vol.22 , pp. 6247-6260
    • Scheid, M.P.1    Marignani, P.A.2    Woodgett, J.R.3
  • 40
    • 17144395975 scopus 로고    scopus 로고
    • The activation of Akt/PKB signaling pathway and cell survival
    • Song G, Ouyang G, Bao S. The activation of Akt/PKB signaling pathway and cell survival. J Cell Mol Med 2005;9:59-71.
    • (2005) J Cell Mol Med , vol.9 , pp. 59-71
    • Song, G.1    Ouyang, G.2    Bao, S.3
  • 41
    • 0032578999 scopus 로고    scopus 로고
    • Protein kinase B kinases that mediate phosphatidylinositol 3,4 5-trisphosphate-dependent activation of protein kinase B
    • Stephens L, Anderson K, Stokoe D, Erdjument-Bromage H, Painter GF, Holmes AB et al. Protein kinase B kinases that mediate phosphatidylinositol 3,4,5-trisphosphate-dependent activation of protein kinase B. Science 1998;279:710-4.
    • (1998) Science , vol.279 , pp. 710-714
    • Stephens, L.1    Anderson, K.2    Stokoe, D.3    Erdjument-Bromage, H.4    Painter, G.F.5    Holmes, A.B.6
  • 42
    • 0034708482 scopus 로고    scopus 로고
    • Akt/protein kinase B is regulated by autophosphorylation at the hypothetical PDK-2 site
    • Toker A, Newton AC. Akt/protein kinase B is regulated by autophosphorylation at the hypothetical PDK-2 site. J Biol Chem 2000;275:8271-4.
    • (2000) J Biol Chem , vol.275 , pp. 8271-8274
    • Toker, A.1    Newton, A.C.2
  • 43
    • 0015620349 scopus 로고
    • A technique for ultracryotomy of cell suspensions and tissues
    • Tokuyasu KT. A technique for ultracryotomy of cell suspensions and tissues. J Cell Biol 1973;57:551-65.
    • (1973) J Cell Biol , vol.57 , pp. 551-565
    • Tokuyasu, K.T.1
  • 44
    • 30744457560 scopus 로고    scopus 로고
    • Inhibitors of phosphatidylinositol-3-kinase activity prevent cell cycle progression and induce apoptosis at the M/G1 transition in CHO cells
    • van Opstal AJM, Boonstra J. Inhibitors of phosphatidylinositol-3-kinase activity prevent cell cycle progression and induce apoptosis at the M/G1 transition in CHO cells. Cell Mol Life Sci 2006;63:220-8.
    • (2006) Cell Mol Life Sci , vol.63 , pp. 220-228
    • van Opstal, A.J.M.1    Boonstra, J.2
  • 46
    • 3042743988 scopus 로고    scopus 로고
    • Akt/protein kinase B signaling inhibitor-2, a selective small molecule inhibitor of Akt signaling with antitumor activity in cancer cells overexpressing Akt
    • Yang L, Dan HC, Sun M, Liu Q, Sun XM, Feldman RI et al. Akt/protein kinase B signaling inhibitor-2, a selective small molecule inhibitor of Akt signaling with antitumor activity in cancer cells overexpressing Akt. Cancer Res 2004;64:4394-9.
    • (2004) Cancer Res , vol.64 , pp. 4394-4399
    • Yang, L.1    Dan, H.C.2    Sun, M.3    Liu, Q.4    Sun, X.M.5    Feldman, R.I.6
  • 47
    • 59849097995 scopus 로고    scopus 로고
    • Differential regulation of Akt/protein kinase B isoforms during cell cycle progression
    • Yun SJ, Tucker DF, Kim EK, Kim MS, Do KH, Ha JM et al. Differential regulation of Akt/protein kinase B isoforms during cell cycle progression. FEBS Lett 2009;583:685-90.
    • (2009) FEBS Lett , vol.583 , pp. 685-690
    • Yun, S.J.1    Tucker, D.F.2    Kim, E.K.3    Kim, M.S.4    Do, K.H.5    Ha, J.M.6
  • 48
    • 0021855166 scopus 로고
    • Kinetic analysis of regulatory events in G1 leading to proliferation or quiescence of Swiss 3T3 cells
    • Zetterberg A, Larsson O. Kinetic analysis of regulatory events in G1 leading to proliferation or quiescence of Swiss 3T3 cells. Proc Natl Acad Sci USA 1985;82:5365-9.
    • (1985) Proc Natl Acad Sci USA , vol.82 , pp. 5365-5369
    • Zetterberg, A.1    Larsson, O.2
  • 50
    • 34047138426 scopus 로고    scopus 로고
    • Real-time imaging nuclear translocation of Akt1 in HCC cells
    • Zhu L, Hu C, Li J, Xue P, He X, Ge C et al. Real-time imaging nuclear translocation of Akt1 in HCC cells. Biochem Biophys Res Commun 2007;356:1038-43.
    • (2007) Biochem Biophys Res Commun , vol.356 , pp. 1038-1043
    • Zhu, L.1    Hu, C.2    Li, J.3    Xue, P.4    He, X.5    Ge, C.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.