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Volumn 30, Issue 6, 2009, Pages 621-633

Influence of standard treatment on ileal and colonic antimicrobial defensin expression in active Crohn's disease

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA DEFENSIN; ANTIBIOTIC AGENT; AZATHIOPRINE; BETA DEFENSIN; BETA DEFENSIN 1; BETA DEFENSIN 2; CATHELICIDIN ANTIMICROBIAL PEPTIDE LL 37; CORTICOSTEROID; CYTOKINE; DEFENSIN; MESALAZINE; TUMOR NECROSIS FACTOR ANTIBODY; ZINC;

EID: 68949210469     PISSN: 02692813     EISSN: 13652036     Source Type: Journal    
DOI: 10.1111/j.1365-2036.2009.04070.x     Document Type: Article
Times cited : (19)

References (66)
  • 1
    • 0037043658 scopus 로고    scopus 로고
    • Inflammatory bowel disease
    • Podolsky DK. Inflammatory bowel disease. N Engl J Med 2002 347 : 417 29.
    • (2002) N Engl J Med , vol.347 , pp. 417-429
    • Podolsky, D.K.1
  • 2
    • 33749341758 scopus 로고    scopus 로고
    • Environmental factors in inflammatory bowel disease: A co-twin control study of a Swedish-Danish twin population
    • Halfvarson J, Jess T, Magnuson A, et al. Environmental factors in inflammatory bowel disease: a co-twin control study of a Swedish-Danish twin population. Inflamm Bowel Dis 2006 12 : 925 33.
    • (2006) Inflamm Bowel Dis , vol.12 , pp. 925-933
    • Halfvarson, J.1    Jess, T.2    Magnuson, A.3
  • 3
    • 33748059226 scopus 로고    scopus 로고
    • Immunology. Unraveling gut inflammation
    • Strober W. Immunology. Unraveling gut inflammation. Science 2006 313 : 1052 4.
    • (2006) Science , vol.313 , pp. 1052-1054
    • Strober, W.1
  • 4
    • 0034463992 scopus 로고    scopus 로고
    • Immunology of inflammatory bowel disease
    • Levine AD, Fiocchi C. Immunology of inflammatory bowel disease. Curr Opin Gastroenterol 2000 16 : 306 9.
    • (2000) Curr Opin Gastroenterol , vol.16 , pp. 306-309
    • Levine, A.D.1    Fiocchi, C.2
  • 5
    • 33144459948 scopus 로고    scopus 로고
    • European evidence based consensus on the diagnosis and management of Crohn's disease: Current management
    • Travis SP, Stange EF, Lemann M, et al. European evidence based consensus on the diagnosis and management of Crohn's disease: current management. Gut 2006 55 (Suppl 1) i16 35.
    • (2006) Gut , vol.55 , Issue.SUPPL. 1
    • Travis, S.P.1    Stange, E.F.2    Lemann, M.3
  • 6
    • 33645958908 scopus 로고    scopus 로고
    • Infliximab plus azathioprine for steroid-dependent Crohn's disease patients: A randomized placebo-controlled trial
    • Lemann M, Mary JY, Duclos B, et al. Infliximab plus azathioprine for steroid-dependent Crohn's disease patients: a randomized placebo-controlled trial. Gastroenterology 2006 130 : 1054 61.
    • (2006) Gastroenterology , vol.130 , pp. 1054-1061
    • Lemann, M.1    Mary, J.Y.2    Duclos, B.3
  • 7
    • 0032982463 scopus 로고    scopus 로고
    • T cell specifity and cross reactivity towards enterobacteria, Bacteroides, Bifidobacterium, and antigens from resident intestinal flora in humans
    • Duchmann R, May E, Heike M, Knolle P, Neurath M, Meyer zum Büschenfelde K-H. T cell specifity and cross reactivity towards enterobacteria, Bacteroides, Bifidobacterium, and antigens from resident intestinal flora in humans. Gut 1999 44 : 812 8.
    • (1999) Gut , vol.44 , pp. 812-818
    • Duchmann, R.1    May, E.2    Heike, M.3    Knolle, P.4    Neurath, M.5    Meyer Zum Büschenfelde, K.-H.6
  • 8
    • 0034938204 scopus 로고    scopus 로고
    • Intestinal microflora in human and experimental inflammatory bowel disease
    • Sartor RB. Intestinal microflora in human and experimental inflammatory bowel disease. Curr Opin Gastroenterol 2001 17 : 324 30.
    • (2001) Curr Opin Gastroenterol , vol.17 , pp. 324-330
    • Sartor, R.B.1
  • 9
    • 0029866466 scopus 로고    scopus 로고
    • Mucosal antibodies in inflammatory bowel disease are directed against intestinal bacteria
    • MacPherson A, Khoo UY, Forgacs I, Philpott-Howard J, Bjarnason I. Mucosal antibodies in inflammatory bowel disease are directed against intestinal bacteria. Gut 1996 38 : 365 75.
    • (1996) Gut , vol.38 , pp. 365-375
    • MacPherson, A.1    Khoo, U.Y.2    Forgacs, I.3    Philpott-Howard, J.4    Bjarnason, I.5
  • 11
    • 44149126798 scopus 로고    scopus 로고
    • Secreted enteric antimicrobial activity localises to the mucus surface layer
    • Meyer-Hoffert U, Hornef MW, Henriques-Normark B, et al. Secreted enteric antimicrobial activity localises to the mucus surface layer. Gut 2008 57 : 764 71.
    • (2008) Gut , vol.57 , pp. 764-771
    • Meyer-Hoffert, U.1    Hornef, M.W.2    Henriques-Normark, B.3
  • 12
    • 4244008275 scopus 로고    scopus 로고
    • Human defensin-5 (HD-5) transgenic mice:paneth cell expression and protection from lethal salmonella typhimurium infection
    • 2 A.D.
    • Bevins CL, Nita H, Salzman NH, Ghosh D, Huttner KM. Human defensin-5 (HD-5) transgenic mice:paneth cell expression and protection from lethal salmonella typhimurium infection. Gastroenterology 122 (Suppl. 1) 2 A.D.
    • Gastroenterology , vol.122 , Issue.SUPPL. 1
    • Bevins, C.L.1    Nita, H.2    Salzman, N.H.3    Ghosh, D.4    Huttner, K.M.5
  • 14
    • 34247526816 scopus 로고    scopus 로고
    • The role of Escherichia coli in inflammatory bowel disease
    • Rhodes JM. The role of Escherichia coli in inflammatory bowel disease. Gut 2007 56 : 610 2.
    • (2007) Gut , vol.56 , pp. 610-612
    • Rhodes, J.M.1
  • 15
    • 4143069158 scopus 로고    scopus 로고
    • High prevalence of adherent-invasive Escherichia coli associated with ileal mucosa in Crohn's disease
    • Darfeuille-Michaud A, Boudeau J, Bulois P, et al. High prevalence of adherent-invasive Escherichia coli associated with ileal mucosa in Crohn's disease. Gastroenterology 2004 127 : 412 21.
    • (2004) Gastroenterology , vol.127 , pp. 412-421
    • Darfeuille-Michaud, A.1    Boudeau, J.2    Bulois, P.3
  • 16
    • 54349102824 scopus 로고    scopus 로고
    • Barrier dysfunction due to distinct defensin deficiencies in small intestinal and colonic Crohn's disease
    • Wehkamp J, Koslowski M, Wang G, Stange EF. Barrier dysfunction due to distinct defensin deficiencies in small intestinal and colonic Crohn's disease. Mucosal Immunol 2008 1 (Suppl. 1) S67 74.
    • (2008) Mucosal Immunol , vol.1 , Issue.SUPPL. 1
    • Wehkamp, J.1    Koslowski, M.2    Wang, G.3    Stange, E.F.4
  • 17
    • 29144483937 scopus 로고    scopus 로고
    • Reduced Paneth cell alpha-defensins in ileal Crohn's disease
    • Wehkamp J, Salzman NH, Porter E, et al. Reduced Paneth cell alpha-defensins in ileal Crohn's disease. Proc Natl Acad Sci U S A 2005 102 : 18129 34.
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 18129-18134
    • Wehkamp, J.1    Salzman, N.H.2    Porter, E.3
  • 18
    • 33748861096 scopus 로고    scopus 로고
    • Paneth cell antimicrobial peptides: Topographical distribution and quantification in human gastrointestinal tissues
    • Wehkamp J, Chu H, Shen B, et al. Paneth cell antimicrobial peptides: topographical distribution and quantification in human gastrointestinal tissues. FEBS Lett 2006 580 : 5344 50.
    • (2006) FEBS Lett , vol.580 , pp. 5344-5350
    • Wehkamp, J.1    Chu, H.2    Shen, B.3
  • 19
    • 44349083637 scopus 로고    scopus 로고
    • In vivo gene expression profiling of human intestinal epithelial cells: Analysis by laser microdissection of formalin fixed tissues
    • 209.
    • George MD, Wehkamp J, Kays RJ, et al. In vivo gene expression profiling of human intestinal epithelial cells: analysis by laser microdissection of formalin fixed tissues. BMC Genomics 2008 9 : 209. 209.
    • (2008) BMC Genomics , vol.9 , pp. 209
    • George, M.D.1    Wehkamp, J.2    Kays, R.J.3
  • 20
    • 0035978533 scopus 로고    scopus 로고
    • A frameshift mutation in NOD2 associated with susceptibility to Crohn's diease
    • Ogura Y, Bonen DK, Inohara N, et al. A frameshift mutation in NOD2 associated with susceptibility to Crohn's diease. Nature 2001 411 : 603 6.
    • (2001) Nature , vol.411 , pp. 603-606
    • Ogura, Y.1    Bonen, D.K.2    Inohara, N.3
  • 21
    • 7244257312 scopus 로고    scopus 로고
    • NOD2 (CARD15) mutations in Crohn's disease are associated with diminished mucosal alpha-defensin expression
    • Wehkamp J, Harder J, Weichenthal M, et al. NOD2 (CARD15) mutations in Crohn's disease are associated with diminished mucosal alpha-defensin expression. Gut 2004 53 : 1658 64.
    • (2004) Gut , vol.53 , pp. 1658-1664
    • Wehkamp, J.1    Harder, J.2    Weichenthal, M.3
  • 22
    • 56249135538 scopus 로고    scopus 로고
    • A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells
    • Cadwell K, Liu JY, Brown SL, et al. A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells. Nature 2008 456 : 259 63.
    • (2008) Nature , vol.456 , pp. 259-263
    • Cadwell, K.1    Liu, J.Y.2    Brown, S.L.3
  • 23
    • 84887212530 scopus 로고    scopus 로고
    • Genetic variants of Wnt transcription factor TCF-4 (TCF7L2) putative promoter region are associated with small intestinal Crohn's disease
    • Koslowski MJ, Kubler I, Chamaillard M, et al. Genetic variants of Wnt transcription factor TCF-4 (TCF7L2) putative promoter region are associated with small intestinal Crohn's disease. PLoS ONE 2009 4 : e4496.
    • (2009) PLoS ONE , vol.4
    • Koslowski, M.J.1    Kubler, I.2    Chamaillard, M.3
  • 24
    • 63649083218 scopus 로고    scopus 로고
    • Fecal beta-defensin-2 in children with inflammatory bowel diseases
    • Kapel N, Benahmed N, Morali A, et al. Fecal beta-defensin-2 in children with inflammatory bowel diseases. J Pediatr Gastroenterol Nutr 2009 48 : 117 20.
    • (2009) J Pediatr Gastroenterol Nutr , vol.48 , pp. 117-120
    • Kapel, N.1    Benahmed, N.2    Morali, A.3
  • 25
    • 0142026070 scopus 로고    scopus 로고
    • Inducible and constitutive beta-defensins are differentially expressed in Crohn's disease and ulcerative colitis
    • Wehkamp J, Harder J, Weichenthal M, et al. Inducible and constitutive beta-defensins are differentially expressed in Crohn's disease and ulcerative colitis. Inflamm Bowel Dis 2003 9 : 215 23.
    • (2003) Inflamm Bowel Dis , vol.9 , pp. 215-223
    • Wehkamp, J.1    Harder, J.2    Weichenthal, M.3
  • 26
    • 34548130847 scopus 로고    scopus 로고
    • Reduced mucosal antimicrobial activity in Crohn's disease of the colon
    • Nuding S, Fellermann K, Wehkamp J, Stange EF. Reduced mucosal antimicrobial activity in Crohn's disease of the colon. Gut 2007 56 : 1240 7.
    • (2007) Gut , vol.56 , pp. 1240-1247
    • Nuding, S.1    Fellermann, K.2    Wehkamp, J.3    Stange, E.F.4
  • 27
    • 33748558056 scopus 로고    scopus 로고
    • A chromosome 8 gene-cluster polymorphism with low human beta-defensin 2 gene copy number predisposes to Crohn disease of the colon
    • Fellermann K, Stange DE, Schaeffeler E, et al. A chromosome 8 gene-cluster polymorphism with low human beta-defensin 2 gene copy number predisposes to Crohn disease of the colon. Am J Hum Genet 2006 79 : 439 48.
    • (2006) Am J Hum Genet , vol.79 , pp. 439-448
    • Fellermann, K.1    Stange, D.E.2    Schaeffeler, E.3
  • 28
    • 0035839525 scopus 로고    scopus 로고
    • Salmonella enteritidis FliC (flagella filament protein) induces hu beta-defensin-2 mRNA production by Caco-2 cells
    • Ogushi KF, Wada AF, Niidome TF, et al. Salmonella enteritidis FliC (flagella filament protein) induces hu beta-defensin-2 mRNA production by Caco-2 cells. J Biol Chem 2001 276 : 30521 6.
    • (2001) J Biol Chem , vol.276 , pp. 30521-30526
    • Ogushi, K.F.1    Wada, A.F.2    Niidome, T.F.3
  • 29
    • 0038752628 scopus 로고    scopus 로고
    • Defensin pattern in chronic gastritis: HBD-2 is differentially expressed with respect to Helicobacter pylori status
    • Wehkamp J, Schmidt K, Herrlinger KR, et al. Defensin pattern in chronic gastritis: HBD-2 is differentially expressed with respect to Helicobacter pylori status. J Clin Pathol 2003 56 : 352 7.
    • (2003) J Clin Pathol , vol.56 , pp. 352-357
    • Wehkamp, J.1    Schmidt, K.2    Herrlinger, K.R.3
  • 30
    • 60549106052 scopus 로고    scopus 로고
    • Probiotic E. coli treatment mediates antimicrobial human beta-defensin synthesis and fecal excretion in humans
    • Mondel M, Schroeder BO, Zimmermann K, et al. Probiotic E. coli treatment mediates antimicrobial human beta-defensin synthesis and fecal excretion in humans. Mucosal Immunol 2008 2 : 166 72.
    • (2008) Mucosal Immunol , vol.2 , pp. 166-172
    • Mondel, M.1    Schroeder, B.O.2    Zimmermann, K.3
  • 31
    • 34248399194 scopus 로고    scopus 로고
    • The induction of human beta-defensin-2 by the probiotic Escherichia coli Nissle 1917 is mediated through flagellin
    • Schlee M, Wehkamp J, Altenhoefer A, Oelschlaeger TA, Stange EF, Fellermann K. The induction of human beta-defensin-2 by the probiotic Escherichia coli Nissle 1917 is mediated through flagellin. Infect Immun 2007 75 (5) 2399 407.
    • (2007) Infect Immun , vol.75 , Issue.5 , pp. 2399-2407
    • Schlee, M.1    Wehkamp, J.2    Altenhoefer, A.3    Oelschlaeger, T.A.4    Stange, E.F.5    Fellermann, K.6
  • 33
    • 55349135190 scopus 로고    scopus 로고
    • Rationale for probiotic treatment strategies in inflammatory bowel disease
    • Schultz M, Lindstrom AL. Rationale for probiotic treatment strategies in inflammatory bowel disease. Expert Rev Gastroenterol Hepatol 2008 2 : 337 55.
    • (2008) Expert Rev Gastroenterol Hepatol , vol.2 , pp. 337-355
    • Schultz, M.1    Lindstrom, A.L.2
  • 34
    • 4644249955 scopus 로고    scopus 로고
    • NF-kappaB- and AP-1-mediated induction of human beta defensin-2 in intestinal epithelial cells by Escherichia coli Nissle 1917: A novel effect of a probiotic bacterium
    • Wehkamp J, Harder J, Wehkamp K, et al. NF-kappaB- and AP-1-mediated induction of human beta defensin-2 in intestinal epithelial cells by Escherichia coli Nissle 1917: a novel effect of a probiotic bacterium. Infect Immun 2004 72 : 5750 8.
    • (2004) Infect Immun , vol.72 , pp. 5750-5758
    • Wehkamp, J.1    Harder, J.2    Wehkamp, K.3
  • 35
    • 56749157692 scopus 로고    scopus 로고
    • Antimicrobial host defense in the upper gastrointestinal tract
    • Hosaka Y, Koslowski M, Nuding S, et al. Antimicrobial host defense in the upper gastrointestinal tract. Eur J Gastroenterol Hepatol 2008 20 : 1151 8.
    • (2008) Eur J Gastroenterol Hepatol , vol.20 , pp. 1151-1158
    • Hosaka, Y.1    Koslowski, M.2    Nuding, S.3
  • 36
    • 52849088394 scopus 로고    scopus 로고
    • Diminished expression of apical sodium-dependent bile acid transporter in gallstone disease is independent of ileal inflammation
    • Holzer A, Harsch S, Renner O, et al. Diminished expression of apical sodium-dependent bile acid transporter in gallstone disease is independent of ileal inflammation. Digestion 2008 78 : 52 9.
    • (2008) Digestion , vol.78 , pp. 52-59
    • Holzer, A.1    Harsch, S.2    Renner, O.3
  • 37
    • 10844229057 scopus 로고    scopus 로고
    • Genotypes and phenotypes in Crohn's disease: Do they help in clinical management?
    • Gasche C, Grundtner P. Genotypes and phenotypes in Crohn's disease: do they help in clinical management? Gut 2005 54 : 162 7.
    • (2005) Gut , vol.54 , pp. 162-167
    • Gasche, C.1    Grundtner, P.2
  • 38
    • 29144483937 scopus 로고    scopus 로고
    • Reduced Paneth cell {alpha}-defensins in ileal Crohn's disease
    • Wehkamp J, Salzman NH, Porter E, et al. Reduced Paneth cell {alpha}-defensins in ileal Crohn's disease. Proc Natl Acad Sci U S A 2005 102 : 18129 34.
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 18129-18134
    • Wehkamp, J.1    Salzman, N.H.2    Porter, E.3
  • 39
    • 13244292161 scopus 로고    scopus 로고
    • Nod2-dependent regulation of innate and adaptive immunity in the intestinal tract
    • Kobayashi KS, Chamaillard M, Ogura Y, et al. Nod2-dependent regulation of innate and adaptive immunity in the intestinal tract. Science 2005 307 : 731 4.
    • (2005) Science , vol.307 , pp. 731-734
    • Kobayashi, K.S.1    Chamaillard, M.2    Ogura, Y.3
  • 40
    • 40449103288 scopus 로고    scopus 로고
    • Impaired luminal processing of human defensin-5 in crohn's disease: Persistence in a complex with chymotrypsinogen and trypsin
    • Elphick D, Liddell S, Mahida YR. Impaired luminal processing of human defensin-5 in crohn's disease: persistence in a complex with chymotrypsinogen and trypsin. Am J Pathol 2008 172 : 702 13.
    • (2008) Am J Pathol , vol.172 , pp. 702-713
    • Elphick, D.1    Liddell, S.2    Mahida, Y.R.3
  • 42
    • 39649107153 scopus 로고    scopus 로고
    • NOD2-expressing bone marrow-derived cells appear to regulate epithelial innate immunity of the transplanted human small intestine
    • Fishbein T, Novitskiy G, Mishra L, et al. NOD2-expressing bone marrow-derived cells appear to regulate epithelial innate immunity of the transplanted human small intestine. Gut 2008 57 : 323 30.
    • (2008) Gut , vol.57 , pp. 323-330
    • Fishbein, T.1    Novitskiy, G.2    Mishra, L.3
  • 43
    • 37349070287 scopus 로고    scopus 로고
    • The Paneth cell alpha-defensin deficiency of ileal Crohn's disease is linked to Wnt/Tcf-4
    • Wehkamp J, Wang G, Kubler I, et al. The Paneth cell alpha-defensin deficiency of ileal Crohn's disease is linked to Wnt/Tcf-4. J Immunol 2007 179 : 3109 18.
    • (2007) J Immunol , vol.179 , pp. 3109-3118
    • Wehkamp, J.1    Wang, G.2    Kubler, I.3
  • 44
    • 20244364236 scopus 로고    scopus 로고
    • Wnt signalling induces maturation of Paneth cells in intestinal crypts
    • van Es JH, Jay P, Gregorieff A, et al. Wnt signalling induces maturation of Paneth cells in intestinal crypts. Nat Cell Biol 2005 7 : 381 6.
    • (2005) Nat Cell Biol , vol.7 , pp. 381-386
    • Van Es, J.H.1    Jay, P.2    Gregorieff, A.3
  • 45
    • 46349102893 scopus 로고    scopus 로고
    • Reduced alpha-defensin expression is associated with inflammation and not NOD2 mutation status in ileal Crohn's disease
    • Simms LA, Doecke JD, Walsh MD, Huang N, Fowler EV, Radford-Smith GL. Reduced alpha-defensin expression is associated with inflammation and not NOD2 mutation status in ileal Crohn's disease. Gut 2008 57 : 903 10.
    • (2008) Gut , vol.57 , pp. 903-910
    • Simms, L.A.1    Doecke, J.D.2    Walsh, M.D.3    Huang, N.4    Fowler, E.V.5    Radford-Smith, G.L.6
  • 46
    • 66649111859 scopus 로고    scopus 로고
    • Decreased Paneth cell defensin expression in ileal Crohn's disease is independent of inflammation, but linked to the NOD2 1007fs genotype
    • Bevins CL, Stange EF, Wehkamp J. Decreased Paneth cell defensin expression in ileal Crohn's disease is independent of inflammation, but linked to the NOD2 1007fs genotype. Gut 2009 58 : 882 3.
    • (2009) Gut , vol.58 , pp. 882-883
    • Bevins, C.L.1    Stange, E.F.2    Wehkamp, J.3
  • 47
    • 0032734313 scopus 로고    scopus 로고
    • Expression and regulation of the human β-defensins hBD-1 and hBD-2 in intestinal epithelium
    • O'Neil DA, Porter EM, Elewaut D, et al. Expression and regulation of the human β-defensins hBD-1 and hBD-2 in intestinal epithelium. J Immunol 1999 163 : 6718 24.
    • (1999) J Immunol , vol.163 , pp. 6718-6724
    • O'Neil, D.A.1    Porter, E.M.2    Elewaut, D.3
  • 48
    • 34548133583 scopus 로고    scopus 로고
    • Development, cytokine profile and function of human interleukin 17-producing helper T cells
    • Wilson NJ, Boniface K, Chan JR, et al. Development, cytokine profile and function of human interleukin 17-producing helper T cells. Nat Immunol 2007 8 : 950 7.
    • (2007) Nat Immunol , vol.8 , pp. 950-957
    • Wilson, N.J.1    Boniface, K.2    Chan, J.R.3
  • 49
    • 0034284355 scopus 로고    scopus 로고
    • Molecular mechanisms and Th1/Th2 pathways in corticosteroid regulation of cytokine production
    • Kovalovsky D, Refojo D, Holsboer F, Arzt E. Molecular mechanisms and Th1/Th2 pathways in corticosteroid regulation of cytokine production. J Neuroimmunol 2000 109 : 23 9.
    • (2000) J Neuroimmunol , vol.109 , pp. 23-29
    • Kovalovsky, D.1    Refojo, D.2    Holsboer, F.3    Arzt, E.4
  • 50
    • 23044478089 scopus 로고    scopus 로고
    • Enhanced human beta-defensin-2 (hBD-2) expression by corticosteroids is independent of NF-kappaB in colonic epithelial cells (CaCo2)
    • Witthoft T, Pilz CS, Fellermann K, Nitschke M, Stange EF, Ludwig D. Enhanced human beta-defensin-2 (hBD-2) expression by corticosteroids is independent of NF-kappaB in colonic epithelial cells (CaCo2). Dig Dis Sci 2005 50 : 1252 9.
    • (2005) Dig Dis Sci , vol.50 , pp. 1252-1259
    • Witthoft, T.1    Pilz, C.S.2    Fellermann, K.3    Nitschke, M.4    Stange, E.F.5    Ludwig, D.6
  • 51
    • 4944240246 scopus 로고    scopus 로고
    • Corticosteroid and cytokines synergistically enhance toll-like receptor 2 expression in respiratory epithelial cells
    • Homma T, Kato A, Hashimoto N, et al. Corticosteroid and cytokines synergistically enhance toll-like receptor 2 expression in respiratory epithelial cells. Am J Respir Cell Mol Biol 2004 31 : 463 9.
    • (2004) Am J Respir Cell Mol Biol , vol.31 , pp. 463-469
    • Homma, T.1    Kato, A.2    Hashimoto, N.3
  • 52
    • 33947287144 scopus 로고    scopus 로고
    • Thiopurine treatment in inflammatory bowel disease: Clinical pharmacology and implication of pharmacogenetically guided dosing
    • Teml A, Schaeffeler E, Herrlinger KR, Klotz U, Schwab M. Thiopurine treatment in inflammatory bowel disease: clinical pharmacology and implication of pharmacogenetically guided dosing. Clin Pharmacokinet 2007 46 : 187 208.
    • (2007) Clin Pharmacokinet , vol.46 , pp. 187-208
    • Teml, A.1    Schaeffeler, E.2    Herrlinger, K.R.3    Klotz, U.4    Schwab, M.5
  • 53
    • 49149091001 scopus 로고    scopus 로고
    • Azathioprine in inflammatory bowel disease: Improved molecular insights and resulting clinical implications
    • Atreya I, Neurath MF. Azathioprine in inflammatory bowel disease: improved molecular insights and resulting clinical implications. Expert Rev Gastroenterol Hepatol 2008 2 : 23 34.
    • (2008) Expert Rev Gastroenterol Hepatol , vol.2 , pp. 23-34
    • Atreya, I.1    Neurath, M.F.2
  • 54
    • 33646182727 scopus 로고    scopus 로고
    • Organizing cell renewal in the intestine: Stem cells, signals and combinatorial control
    • Crosnier C, Stamataki D, Lewis J. Organizing cell renewal in the intestine: stem cells, signals and combinatorial control. Nat Rev Genet 2006 7 : 349 59.
    • (2006) Nat Rev Genet , vol.7 , pp. 349-359
    • Crosnier, C.1    Stamataki, D.2    Lewis, J.3
  • 55
    • 17444423289 scopus 로고    scopus 로고
    • Wnt signaling in the intestinal epithelium: From endoderm to cancer
    • Gregorieff A, Clevers H. Wnt signaling in the intestinal epithelium: from endoderm to cancer. Genes Dev 2005 19 : 877 90.
    • (2005) Genes Dev , vol.19 , pp. 877-890
    • Gregorieff, A.1    Clevers, H.2
  • 56
    • 0033637218 scopus 로고    scopus 로고
    • Mesalazine inhibits activation of transcription factor NF-kappaB in inflamed mucosa of patients with ulcerative colitis
    • Bantel H, Berg C, Vieth M, Stolte M, Kruis W, Schulze-Osthoff K. Mesalazine inhibits activation of transcription factor NF-kappaB in inflamed mucosa of patients with ulcerative colitis. Am J Gastroenterol 2000 95 : 3452 7.
    • (2000) Am J Gastroenterol , vol.95 , pp. 3452-3457
    • Bantel, H.1    Berg, C.2    Vieth, M.3    Stolte, M.4    Kruis, W.5    Schulze-Osthoff, K.6
  • 57
    • 0033047588 scopus 로고    scopus 로고
    • Mesalamine blocks tumor necrosis factor growth inhibition and nuclear factor kappaB activation in mouse colonocytes
    • Kaiser GC, Yan F, Polk DB. Mesalamine blocks tumor necrosis factor growth inhibition and nuclear factor kappaB activation in mouse colonocytes. Gastroenterology 1999 116 : 602 9.
    • (1999) Gastroenterology , vol.116 , pp. 602-609
    • Kaiser, G.C.1    Yan, F.2    Polk, D.B.3
  • 58
    • 0026081338 scopus 로고
    • 5-Aminosalicylic acid is a potent inhibitor of interleukin 1 beta production in organ culture of colonic biopsy specimens from patients with inflammatory bowel disease
    • Mahida YR, Lamming CE, Gallagher A, Hawthorne AB, Hawkey CJ. 5-Aminosalicylic acid is a potent inhibitor of interleukin 1 beta production in organ culture of colonic biopsy specimens from patients with inflammatory bowel disease. Gut 1991 32 : 50 4.
    • (1991) Gut , vol.32 , pp. 50-54
    • Mahida, Y.R.1    Lamming, C.E.2    Gallagher, A.3    Hawthorne, A.B.4    Hawkey, C.J.5
  • 59
    • 0033950737 scopus 로고    scopus 로고
    • Mesalazine changes apoptosis and proliferation in normal mucosa of patients with sporadic polyps of the large bowel
    • Reinacher-Schick A, Seidensticker F, Petrasch S, et al. Mesalazine changes apoptosis and proliferation in normal mucosa of patients with sporadic polyps of the large bowel. Endoscopy 2000 32 : 245 54.
    • (2000) Endoscopy , vol.32 , pp. 245-254
    • Reinacher-Schick, A.1    Seidensticker, F.2    Petrasch, S.3
  • 62
    • 67449116312 scopus 로고    scopus 로고
    • Effects of the cathelicidin LL-37 on intestinal epithelial barrier integrity
    • Otte JM, Zdebik AE, Brand S, et al. Effects of the cathelicidin LL-37 on intestinal epithelial barrier integrity. Regul Pept 2009 156 : 1 3.
    • (2009) Regul Pept , vol.156 , pp. 1-3
    • Otte, J.M.1    Zdebik, A.E.2    Brand, S.3
  • 63
    • 48349087831 scopus 로고    scopus 로고
    • Antimicrobial peptides and the skin immune defense system
    • Schauber J, Gallo RL. Antimicrobial peptides and the skin immune defense system. J Allergy Clin Immunol 2008 122 : 261 6.
    • (2008) J Allergy Clin Immunol , vol.122 , pp. 261-266
    • Schauber, J.1    Gallo, R.L.2
  • 64
    • 0036151109 scopus 로고    scopus 로고
    • Cell differentiation is a key determinant of cathelicidin LL-37/human cationic antimicrobial protein 18 expression by human colon epithelium
    • Hase K, Eckmann L, Leopard JD, Varki N, Kagnoff MF. Cell differentiation is a key determinant of cathelicidin LL-37/human cationic antimicrobial protein 18 expression by human colon epithelium. Infect Immun 2002 70 : 953 63.
    • (2002) Infect Immun , vol.70 , pp. 953-963
    • Hase, K.1    Eckmann, L.2    Leopard, J.D.3    Varki, N.4    Kagnoff, M.F.5
  • 65
    • 58849143880 scopus 로고    scopus 로고
    • IL-17A enhances vitamin D3-induced expression of cathelicidin antimicrobial peptide in human keratinocytes
    • Peric M, Koglin S, Kim SM, et al. IL-17A enhances vitamin D3-induced expression of cathelicidin antimicrobial peptide in human keratinocytes. J Immunol 2008 181 : 8504 12.
    • (2008) J Immunol , vol.181 , pp. 8504-8512
    • Peric, M.1    Koglin, S.2    Kim, S.M.3
  • 66
    • 33744493110 scopus 로고    scopus 로고
    • Heterogeneous expression of human cathelicidin hCAP18/LL-37 in inflammatory bowel diseases
    • Schauber J, Rieger D, Weiler F, et al. Heterogeneous expression of human cathelicidin hCAP18/LL-37 in inflammatory bowel diseases. Eur J Gastroenterol Hepatol 2006 18 : 615 21.
    • (2006) Eur J Gastroenterol Hepatol , vol.18 , pp. 615-621
    • Schauber, J.1    Rieger, D.2    Weiler, F.3


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