-
1
-
-
0037043658
-
Inflammatory bowel disease
-
Podolsky DK. Inflammatory bowel disease. N Engl J Med 2002 347 : 417 29.
-
(2002)
N Engl J Med
, vol.347
, pp. 417-429
-
-
Podolsky, D.K.1
-
2
-
-
33749341758
-
Environmental factors in inflammatory bowel disease: A co-twin control study of a Swedish-Danish twin population
-
Halfvarson J, Jess T, Magnuson A, et al. Environmental factors in inflammatory bowel disease: a co-twin control study of a Swedish-Danish twin population. Inflamm Bowel Dis 2006 12 : 925 33.
-
(2006)
Inflamm Bowel Dis
, vol.12
, pp. 925-933
-
-
Halfvarson, J.1
Jess, T.2
Magnuson, A.3
-
3
-
-
33748059226
-
Immunology. Unraveling gut inflammation
-
Strober W. Immunology. Unraveling gut inflammation. Science 2006 313 : 1052 4.
-
(2006)
Science
, vol.313
, pp. 1052-1054
-
-
Strober, W.1
-
5
-
-
33144459948
-
European evidence based consensus on the diagnosis and management of Crohn's disease: Current management
-
Travis SP, Stange EF, Lemann M, et al. European evidence based consensus on the diagnosis and management of Crohn's disease: current management. Gut 2006 55 (Suppl 1) i16 35.
-
(2006)
Gut
, vol.55
, Issue.SUPPL. 1
-
-
Travis, S.P.1
Stange, E.F.2
Lemann, M.3
-
6
-
-
33645958908
-
Infliximab plus azathioprine for steroid-dependent Crohn's disease patients: A randomized placebo-controlled trial
-
Lemann M, Mary JY, Duclos B, et al. Infliximab plus azathioprine for steroid-dependent Crohn's disease patients: a randomized placebo-controlled trial. Gastroenterology 2006 130 : 1054 61.
-
(2006)
Gastroenterology
, vol.130
, pp. 1054-1061
-
-
Lemann, M.1
Mary, J.Y.2
Duclos, B.3
-
7
-
-
0032982463
-
T cell specifity and cross reactivity towards enterobacteria, Bacteroides, Bifidobacterium, and antigens from resident intestinal flora in humans
-
Duchmann R, May E, Heike M, Knolle P, Neurath M, Meyer zum Büschenfelde K-H. T cell specifity and cross reactivity towards enterobacteria, Bacteroides, Bifidobacterium, and antigens from resident intestinal flora in humans. Gut 1999 44 : 812 8.
-
(1999)
Gut
, vol.44
, pp. 812-818
-
-
Duchmann, R.1
May, E.2
Heike, M.3
Knolle, P.4
Neurath, M.5
Meyer Zum Büschenfelde, K.-H.6
-
8
-
-
0034938204
-
Intestinal microflora in human and experimental inflammatory bowel disease
-
Sartor RB. Intestinal microflora in human and experimental inflammatory bowel disease. Curr Opin Gastroenterol 2001 17 : 324 30.
-
(2001)
Curr Opin Gastroenterol
, vol.17
, pp. 324-330
-
-
Sartor, R.B.1
-
9
-
-
0029866466
-
Mucosal antibodies in inflammatory bowel disease are directed against intestinal bacteria
-
MacPherson A, Khoo UY, Forgacs I, Philpott-Howard J, Bjarnason I. Mucosal antibodies in inflammatory bowel disease are directed against intestinal bacteria. Gut 1996 38 : 365 75.
-
(1996)
Gut
, vol.38
, pp. 365-375
-
-
MacPherson, A.1
Khoo, U.Y.2
Forgacs, I.3
Philpott-Howard, J.4
Bjarnason, I.5
-
10
-
-
0037600703
-
Crohn's disease: A defensin deficiency syndrome?
-
Jun;
-
Fellermann K, Wehkamp J, Herrlinger KR, Stange EF. Crohn's disease: a defensin deficiency syndrome? Eur J Gastroenterol Hepatol 2003 Jun; 15 (6) 627 34.
-
(2003)
Eur J Gastroenterol Hepatol
, vol.15
, Issue.6
, pp. 627-634
-
-
Fellermann, K.1
Wehkamp, J.2
Herrlinger, K.R.3
Stange, E.F.4
-
11
-
-
44149126798
-
Secreted enteric antimicrobial activity localises to the mucus surface layer
-
Meyer-Hoffert U, Hornef MW, Henriques-Normark B, et al. Secreted enteric antimicrobial activity localises to the mucus surface layer. Gut 2008 57 : 764 71.
-
(2008)
Gut
, vol.57
, pp. 764-771
-
-
Meyer-Hoffert, U.1
Hornef, M.W.2
Henriques-Normark, B.3
-
12
-
-
4244008275
-
Human defensin-5 (HD-5) transgenic mice:paneth cell expression and protection from lethal salmonella typhimurium infection
-
2 A.D.
-
Bevins CL, Nita H, Salzman NH, Ghosh D, Huttner KM. Human defensin-5 (HD-5) transgenic mice:paneth cell expression and protection from lethal salmonella typhimurium infection. Gastroenterology 122 (Suppl. 1) 2 A.D.
-
Gastroenterology
, vol.122
, Issue.SUPPL. 1
-
-
Bevins, C.L.1
Nita, H.2
Salzman, N.H.3
Ghosh, D.4
Huttner, K.M.5
-
14
-
-
34247526816
-
The role of Escherichia coli in inflammatory bowel disease
-
Rhodes JM. The role of Escherichia coli in inflammatory bowel disease. Gut 2007 56 : 610 2.
-
(2007)
Gut
, vol.56
, pp. 610-612
-
-
Rhodes, J.M.1
-
15
-
-
4143069158
-
High prevalence of adherent-invasive Escherichia coli associated with ileal mucosa in Crohn's disease
-
Darfeuille-Michaud A, Boudeau J, Bulois P, et al. High prevalence of adherent-invasive Escherichia coli associated with ileal mucosa in Crohn's disease. Gastroenterology 2004 127 : 412 21.
-
(2004)
Gastroenterology
, vol.127
, pp. 412-421
-
-
Darfeuille-Michaud, A.1
Boudeau, J.2
Bulois, P.3
-
16
-
-
54349102824
-
Barrier dysfunction due to distinct defensin deficiencies in small intestinal and colonic Crohn's disease
-
Wehkamp J, Koslowski M, Wang G, Stange EF. Barrier dysfunction due to distinct defensin deficiencies in small intestinal and colonic Crohn's disease. Mucosal Immunol 2008 1 (Suppl. 1) S67 74.
-
(2008)
Mucosal Immunol
, vol.1
, Issue.SUPPL. 1
-
-
Wehkamp, J.1
Koslowski, M.2
Wang, G.3
Stange, E.F.4
-
17
-
-
29144483937
-
Reduced Paneth cell alpha-defensins in ileal Crohn's disease
-
Wehkamp J, Salzman NH, Porter E, et al. Reduced Paneth cell alpha-defensins in ileal Crohn's disease. Proc Natl Acad Sci U S A 2005 102 : 18129 34.
-
(2005)
Proc Natl Acad Sci U S A
, vol.102
, pp. 18129-18134
-
-
Wehkamp, J.1
Salzman, N.H.2
Porter, E.3
-
18
-
-
33748861096
-
Paneth cell antimicrobial peptides: Topographical distribution and quantification in human gastrointestinal tissues
-
Wehkamp J, Chu H, Shen B, et al. Paneth cell antimicrobial peptides: topographical distribution and quantification in human gastrointestinal tissues. FEBS Lett 2006 580 : 5344 50.
-
(2006)
FEBS Lett
, vol.580
, pp. 5344-5350
-
-
Wehkamp, J.1
Chu, H.2
Shen, B.3
-
19
-
-
44349083637
-
In vivo gene expression profiling of human intestinal epithelial cells: Analysis by laser microdissection of formalin fixed tissues
-
209.
-
George MD, Wehkamp J, Kays RJ, et al. In vivo gene expression profiling of human intestinal epithelial cells: analysis by laser microdissection of formalin fixed tissues. BMC Genomics 2008 9 : 209. 209.
-
(2008)
BMC Genomics
, vol.9
, pp. 209
-
-
George, M.D.1
Wehkamp, J.2
Kays, R.J.3
-
20
-
-
0035978533
-
A frameshift mutation in NOD2 associated with susceptibility to Crohn's diease
-
Ogura Y, Bonen DK, Inohara N, et al. A frameshift mutation in NOD2 associated with susceptibility to Crohn's diease. Nature 2001 411 : 603 6.
-
(2001)
Nature
, vol.411
, pp. 603-606
-
-
Ogura, Y.1
Bonen, D.K.2
Inohara, N.3
-
21
-
-
7244257312
-
NOD2 (CARD15) mutations in Crohn's disease are associated with diminished mucosal alpha-defensin expression
-
Wehkamp J, Harder J, Weichenthal M, et al. NOD2 (CARD15) mutations in Crohn's disease are associated with diminished mucosal alpha-defensin expression. Gut 2004 53 : 1658 64.
-
(2004)
Gut
, vol.53
, pp. 1658-1664
-
-
Wehkamp, J.1
Harder, J.2
Weichenthal, M.3
-
22
-
-
56249135538
-
A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells
-
Cadwell K, Liu JY, Brown SL, et al. A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells. Nature 2008 456 : 259 63.
-
(2008)
Nature
, vol.456
, pp. 259-263
-
-
Cadwell, K.1
Liu, J.Y.2
Brown, S.L.3
-
23
-
-
84887212530
-
Genetic variants of Wnt transcription factor TCF-4 (TCF7L2) putative promoter region are associated with small intestinal Crohn's disease
-
Koslowski MJ, Kubler I, Chamaillard M, et al. Genetic variants of Wnt transcription factor TCF-4 (TCF7L2) putative promoter region are associated with small intestinal Crohn's disease. PLoS ONE 2009 4 : e4496.
-
(2009)
PLoS ONE
, vol.4
-
-
Koslowski, M.J.1
Kubler, I.2
Chamaillard, M.3
-
24
-
-
63649083218
-
Fecal beta-defensin-2 in children with inflammatory bowel diseases
-
Kapel N, Benahmed N, Morali A, et al. Fecal beta-defensin-2 in children with inflammatory bowel diseases. J Pediatr Gastroenterol Nutr 2009 48 : 117 20.
-
(2009)
J Pediatr Gastroenterol Nutr
, vol.48
, pp. 117-120
-
-
Kapel, N.1
Benahmed, N.2
Morali, A.3
-
25
-
-
0142026070
-
Inducible and constitutive beta-defensins are differentially expressed in Crohn's disease and ulcerative colitis
-
Wehkamp J, Harder J, Weichenthal M, et al. Inducible and constitutive beta-defensins are differentially expressed in Crohn's disease and ulcerative colitis. Inflamm Bowel Dis 2003 9 : 215 23.
-
(2003)
Inflamm Bowel Dis
, vol.9
, pp. 215-223
-
-
Wehkamp, J.1
Harder, J.2
Weichenthal, M.3
-
26
-
-
34548130847
-
Reduced mucosal antimicrobial activity in Crohn's disease of the colon
-
Nuding S, Fellermann K, Wehkamp J, Stange EF. Reduced mucosal antimicrobial activity in Crohn's disease of the colon. Gut 2007 56 : 1240 7.
-
(2007)
Gut
, vol.56
, pp. 1240-1247
-
-
Nuding, S.1
Fellermann, K.2
Wehkamp, J.3
Stange, E.F.4
-
27
-
-
33748558056
-
A chromosome 8 gene-cluster polymorphism with low human beta-defensin 2 gene copy number predisposes to Crohn disease of the colon
-
Fellermann K, Stange DE, Schaeffeler E, et al. A chromosome 8 gene-cluster polymorphism with low human beta-defensin 2 gene copy number predisposes to Crohn disease of the colon. Am J Hum Genet 2006 79 : 439 48.
-
(2006)
Am J Hum Genet
, vol.79
, pp. 439-448
-
-
Fellermann, K.1
Stange, D.E.2
Schaeffeler, E.3
-
28
-
-
0035839525
-
Salmonella enteritidis FliC (flagella filament protein) induces hu beta-defensin-2 mRNA production by Caco-2 cells
-
Ogushi KF, Wada AF, Niidome TF, et al. Salmonella enteritidis FliC (flagella filament protein) induces hu beta-defensin-2 mRNA production by Caco-2 cells. J Biol Chem 2001 276 : 30521 6.
-
(2001)
J Biol Chem
, vol.276
, pp. 30521-30526
-
-
Ogushi, K.F.1
Wada, A.F.2
Niidome, T.F.3
-
29
-
-
0038752628
-
Defensin pattern in chronic gastritis: HBD-2 is differentially expressed with respect to Helicobacter pylori status
-
Wehkamp J, Schmidt K, Herrlinger KR, et al. Defensin pattern in chronic gastritis: HBD-2 is differentially expressed with respect to Helicobacter pylori status. J Clin Pathol 2003 56 : 352 7.
-
(2003)
J Clin Pathol
, vol.56
, pp. 352-357
-
-
Wehkamp, J.1
Schmidt, K.2
Herrlinger, K.R.3
-
30
-
-
60549106052
-
Probiotic E. coli treatment mediates antimicrobial human beta-defensin synthesis and fecal excretion in humans
-
Mondel M, Schroeder BO, Zimmermann K, et al. Probiotic E. coli treatment mediates antimicrobial human beta-defensin synthesis and fecal excretion in humans. Mucosal Immunol 2008 2 : 166 72.
-
(2008)
Mucosal Immunol
, vol.2
, pp. 166-172
-
-
Mondel, M.1
Schroeder, B.O.2
Zimmermann, K.3
-
31
-
-
34248399194
-
The induction of human beta-defensin-2 by the probiotic Escherichia coli Nissle 1917 is mediated through flagellin
-
Schlee M, Wehkamp J, Altenhoefer A, Oelschlaeger TA, Stange EF, Fellermann K. The induction of human beta-defensin-2 by the probiotic Escherichia coli Nissle 1917 is mediated through flagellin. Infect Immun 2007 75 (5) 2399 407.
-
(2007)
Infect Immun
, vol.75
, Issue.5
, pp. 2399-2407
-
-
Schlee, M.1
Wehkamp, J.2
Altenhoefer, A.3
Oelschlaeger, T.A.4
Stange, E.F.5
Fellermann, K.6
-
32
-
-
38549171792
-
Probiotic lactobacilli and VSL#3 induce enterocyte beta-defensin 2
-
Schlee M, Harder J, Koten B, Stange EF, Wehkamp J, Fellermann K. Probiotic lactobacilli and VSL#3 induce enterocyte beta-defensin 2. Clin Exp Immunol 2008 151 : 528 35.
-
(2008)
Clin Exp Immunol
, vol.151
, pp. 528-535
-
-
Schlee, M.1
Harder, J.2
Koten, B.3
Stange, E.F.4
Wehkamp, J.5
Fellermann, K.6
-
33
-
-
55349135190
-
Rationale for probiotic treatment strategies in inflammatory bowel disease
-
Schultz M, Lindstrom AL. Rationale for probiotic treatment strategies in inflammatory bowel disease. Expert Rev Gastroenterol Hepatol 2008 2 : 337 55.
-
(2008)
Expert Rev Gastroenterol Hepatol
, vol.2
, pp. 337-355
-
-
Schultz, M.1
Lindstrom, A.L.2
-
34
-
-
4644249955
-
NF-kappaB- and AP-1-mediated induction of human beta defensin-2 in intestinal epithelial cells by Escherichia coli Nissle 1917: A novel effect of a probiotic bacterium
-
Wehkamp J, Harder J, Wehkamp K, et al. NF-kappaB- and AP-1-mediated induction of human beta defensin-2 in intestinal epithelial cells by Escherichia coli Nissle 1917: a novel effect of a probiotic bacterium. Infect Immun 2004 72 : 5750 8.
-
(2004)
Infect Immun
, vol.72
, pp. 5750-5758
-
-
Wehkamp, J.1
Harder, J.2
Wehkamp, K.3
-
35
-
-
56749157692
-
Antimicrobial host defense in the upper gastrointestinal tract
-
Hosaka Y, Koslowski M, Nuding S, et al. Antimicrobial host defense in the upper gastrointestinal tract. Eur J Gastroenterol Hepatol 2008 20 : 1151 8.
-
(2008)
Eur J Gastroenterol Hepatol
, vol.20
, pp. 1151-1158
-
-
Hosaka, Y.1
Koslowski, M.2
Nuding, S.3
-
36
-
-
52849088394
-
Diminished expression of apical sodium-dependent bile acid transporter in gallstone disease is independent of ileal inflammation
-
Holzer A, Harsch S, Renner O, et al. Diminished expression of apical sodium-dependent bile acid transporter in gallstone disease is independent of ileal inflammation. Digestion 2008 78 : 52 9.
-
(2008)
Digestion
, vol.78
, pp. 52-59
-
-
Holzer, A.1
Harsch, S.2
Renner, O.3
-
37
-
-
10844229057
-
Genotypes and phenotypes in Crohn's disease: Do they help in clinical management?
-
Gasche C, Grundtner P. Genotypes and phenotypes in Crohn's disease: do they help in clinical management? Gut 2005 54 : 162 7.
-
(2005)
Gut
, vol.54
, pp. 162-167
-
-
Gasche, C.1
Grundtner, P.2
-
38
-
-
29144483937
-
Reduced Paneth cell {alpha}-defensins in ileal Crohn's disease
-
Wehkamp J, Salzman NH, Porter E, et al. Reduced Paneth cell {alpha}-defensins in ileal Crohn's disease. Proc Natl Acad Sci U S A 2005 102 : 18129 34.
-
(2005)
Proc Natl Acad Sci U S A
, vol.102
, pp. 18129-18134
-
-
Wehkamp, J.1
Salzman, N.H.2
Porter, E.3
-
39
-
-
13244292161
-
Nod2-dependent regulation of innate and adaptive immunity in the intestinal tract
-
Kobayashi KS, Chamaillard M, Ogura Y, et al. Nod2-dependent regulation of innate and adaptive immunity in the intestinal tract. Science 2005 307 : 731 4.
-
(2005)
Science
, vol.307
, pp. 731-734
-
-
Kobayashi, K.S.1
Chamaillard, M.2
Ogura, Y.3
-
40
-
-
40449103288
-
Impaired luminal processing of human defensin-5 in crohn's disease: Persistence in a complex with chymotrypsinogen and trypsin
-
Elphick D, Liddell S, Mahida YR. Impaired luminal processing of human defensin-5 in crohn's disease: persistence in a complex with chymotrypsinogen and trypsin. Am J Pathol 2008 172 : 702 13.
-
(2008)
Am J Pathol
, vol.172
, pp. 702-713
-
-
Elphick, D.1
Liddell, S.2
Mahida, Y.R.3
-
41
-
-
27144520307
-
Mechanisms of disease: Defensins in gastrointestinal diseases
-
Wehkamp J, Fellermann K, Herrlinger KR, Bevins CL, Stange EF. Mechanisms of disease: defensins in gastrointestinal diseases. Nat Clin Pract Gastroenterol Hepatol 2005 2 : 406 15.
-
(2005)
Nat Clin Pract Gastroenterol Hepatol
, vol.2
, pp. 406-415
-
-
Wehkamp, J.1
Fellermann, K.2
Herrlinger, K.R.3
Bevins, C.L.4
Stange, E.F.5
-
42
-
-
39649107153
-
NOD2-expressing bone marrow-derived cells appear to regulate epithelial innate immunity of the transplanted human small intestine
-
Fishbein T, Novitskiy G, Mishra L, et al. NOD2-expressing bone marrow-derived cells appear to regulate epithelial innate immunity of the transplanted human small intestine. Gut 2008 57 : 323 30.
-
(2008)
Gut
, vol.57
, pp. 323-330
-
-
Fishbein, T.1
Novitskiy, G.2
Mishra, L.3
-
43
-
-
37349070287
-
The Paneth cell alpha-defensin deficiency of ileal Crohn's disease is linked to Wnt/Tcf-4
-
Wehkamp J, Wang G, Kubler I, et al. The Paneth cell alpha-defensin deficiency of ileal Crohn's disease is linked to Wnt/Tcf-4. J Immunol 2007 179 : 3109 18.
-
(2007)
J Immunol
, vol.179
, pp. 3109-3118
-
-
Wehkamp, J.1
Wang, G.2
Kubler, I.3
-
44
-
-
20244364236
-
Wnt signalling induces maturation of Paneth cells in intestinal crypts
-
van Es JH, Jay P, Gregorieff A, et al. Wnt signalling induces maturation of Paneth cells in intestinal crypts. Nat Cell Biol 2005 7 : 381 6.
-
(2005)
Nat Cell Biol
, vol.7
, pp. 381-386
-
-
Van Es, J.H.1
Jay, P.2
Gregorieff, A.3
-
45
-
-
46349102893
-
Reduced alpha-defensin expression is associated with inflammation and not NOD2 mutation status in ileal Crohn's disease
-
Simms LA, Doecke JD, Walsh MD, Huang N, Fowler EV, Radford-Smith GL. Reduced alpha-defensin expression is associated with inflammation and not NOD2 mutation status in ileal Crohn's disease. Gut 2008 57 : 903 10.
-
(2008)
Gut
, vol.57
, pp. 903-910
-
-
Simms, L.A.1
Doecke, J.D.2
Walsh, M.D.3
Huang, N.4
Fowler, E.V.5
Radford-Smith, G.L.6
-
46
-
-
66649111859
-
Decreased Paneth cell defensin expression in ileal Crohn's disease is independent of inflammation, but linked to the NOD2 1007fs genotype
-
Bevins CL, Stange EF, Wehkamp J. Decreased Paneth cell defensin expression in ileal Crohn's disease is independent of inflammation, but linked to the NOD2 1007fs genotype. Gut 2009 58 : 882 3.
-
(2009)
Gut
, vol.58
, pp. 882-883
-
-
Bevins, C.L.1
Stange, E.F.2
Wehkamp, J.3
-
47
-
-
0032734313
-
Expression and regulation of the human β-defensins hBD-1 and hBD-2 in intestinal epithelium
-
O'Neil DA, Porter EM, Elewaut D, et al. Expression and regulation of the human β-defensins hBD-1 and hBD-2 in intestinal epithelium. J Immunol 1999 163 : 6718 24.
-
(1999)
J Immunol
, vol.163
, pp. 6718-6724
-
-
O'Neil, D.A.1
Porter, E.M.2
Elewaut, D.3
-
48
-
-
34548133583
-
Development, cytokine profile and function of human interleukin 17-producing helper T cells
-
Wilson NJ, Boniface K, Chan JR, et al. Development, cytokine profile and function of human interleukin 17-producing helper T cells. Nat Immunol 2007 8 : 950 7.
-
(2007)
Nat Immunol
, vol.8
, pp. 950-957
-
-
Wilson, N.J.1
Boniface, K.2
Chan, J.R.3
-
49
-
-
0034284355
-
Molecular mechanisms and Th1/Th2 pathways in corticosteroid regulation of cytokine production
-
Kovalovsky D, Refojo D, Holsboer F, Arzt E. Molecular mechanisms and Th1/Th2 pathways in corticosteroid regulation of cytokine production. J Neuroimmunol 2000 109 : 23 9.
-
(2000)
J Neuroimmunol
, vol.109
, pp. 23-29
-
-
Kovalovsky, D.1
Refojo, D.2
Holsboer, F.3
Arzt, E.4
-
50
-
-
23044478089
-
Enhanced human beta-defensin-2 (hBD-2) expression by corticosteroids is independent of NF-kappaB in colonic epithelial cells (CaCo2)
-
Witthoft T, Pilz CS, Fellermann K, Nitschke M, Stange EF, Ludwig D. Enhanced human beta-defensin-2 (hBD-2) expression by corticosteroids is independent of NF-kappaB in colonic epithelial cells (CaCo2). Dig Dis Sci 2005 50 : 1252 9.
-
(2005)
Dig Dis Sci
, vol.50
, pp. 1252-1259
-
-
Witthoft, T.1
Pilz, C.S.2
Fellermann, K.3
Nitschke, M.4
Stange, E.F.5
Ludwig, D.6
-
51
-
-
4944240246
-
Corticosteroid and cytokines synergistically enhance toll-like receptor 2 expression in respiratory epithelial cells
-
Homma T, Kato A, Hashimoto N, et al. Corticosteroid and cytokines synergistically enhance toll-like receptor 2 expression in respiratory epithelial cells. Am J Respir Cell Mol Biol 2004 31 : 463 9.
-
(2004)
Am J Respir Cell Mol Biol
, vol.31
, pp. 463-469
-
-
Homma, T.1
Kato, A.2
Hashimoto, N.3
-
52
-
-
33947287144
-
Thiopurine treatment in inflammatory bowel disease: Clinical pharmacology and implication of pharmacogenetically guided dosing
-
Teml A, Schaeffeler E, Herrlinger KR, Klotz U, Schwab M. Thiopurine treatment in inflammatory bowel disease: clinical pharmacology and implication of pharmacogenetically guided dosing. Clin Pharmacokinet 2007 46 : 187 208.
-
(2007)
Clin Pharmacokinet
, vol.46
, pp. 187-208
-
-
Teml, A.1
Schaeffeler, E.2
Herrlinger, K.R.3
Klotz, U.4
Schwab, M.5
-
53
-
-
49149091001
-
Azathioprine in inflammatory bowel disease: Improved molecular insights and resulting clinical implications
-
Atreya I, Neurath MF. Azathioprine in inflammatory bowel disease: improved molecular insights and resulting clinical implications. Expert Rev Gastroenterol Hepatol 2008 2 : 23 34.
-
(2008)
Expert Rev Gastroenterol Hepatol
, vol.2
, pp. 23-34
-
-
Atreya, I.1
Neurath, M.F.2
-
54
-
-
33646182727
-
Organizing cell renewal in the intestine: Stem cells, signals and combinatorial control
-
Crosnier C, Stamataki D, Lewis J. Organizing cell renewal in the intestine: stem cells, signals and combinatorial control. Nat Rev Genet 2006 7 : 349 59.
-
(2006)
Nat Rev Genet
, vol.7
, pp. 349-359
-
-
Crosnier, C.1
Stamataki, D.2
Lewis, J.3
-
55
-
-
17444423289
-
Wnt signaling in the intestinal epithelium: From endoderm to cancer
-
Gregorieff A, Clevers H. Wnt signaling in the intestinal epithelium: from endoderm to cancer. Genes Dev 2005 19 : 877 90.
-
(2005)
Genes Dev
, vol.19
, pp. 877-890
-
-
Gregorieff, A.1
Clevers, H.2
-
56
-
-
0033637218
-
Mesalazine inhibits activation of transcription factor NF-kappaB in inflamed mucosa of patients with ulcerative colitis
-
Bantel H, Berg C, Vieth M, Stolte M, Kruis W, Schulze-Osthoff K. Mesalazine inhibits activation of transcription factor NF-kappaB in inflamed mucosa of patients with ulcerative colitis. Am J Gastroenterol 2000 95 : 3452 7.
-
(2000)
Am J Gastroenterol
, vol.95
, pp. 3452-3457
-
-
Bantel, H.1
Berg, C.2
Vieth, M.3
Stolte, M.4
Kruis, W.5
Schulze-Osthoff, K.6
-
57
-
-
0033047588
-
Mesalamine blocks tumor necrosis factor growth inhibition and nuclear factor kappaB activation in mouse colonocytes
-
Kaiser GC, Yan F, Polk DB. Mesalamine blocks tumor necrosis factor growth inhibition and nuclear factor kappaB activation in mouse colonocytes. Gastroenterology 1999 116 : 602 9.
-
(1999)
Gastroenterology
, vol.116
, pp. 602-609
-
-
Kaiser, G.C.1
Yan, F.2
Polk, D.B.3
-
58
-
-
0026081338
-
5-Aminosalicylic acid is a potent inhibitor of interleukin 1 beta production in organ culture of colonic biopsy specimens from patients with inflammatory bowel disease
-
Mahida YR, Lamming CE, Gallagher A, Hawthorne AB, Hawkey CJ. 5-Aminosalicylic acid is a potent inhibitor of interleukin 1 beta production in organ culture of colonic biopsy specimens from patients with inflammatory bowel disease. Gut 1991 32 : 50 4.
-
(1991)
Gut
, vol.32
, pp. 50-54
-
-
Mahida, Y.R.1
Lamming, C.E.2
Gallagher, A.3
Hawthorne, A.B.4
Hawkey, C.J.5
-
59
-
-
0033950737
-
Mesalazine changes apoptosis and proliferation in normal mucosa of patients with sporadic polyps of the large bowel
-
Reinacher-Schick A, Seidensticker F, Petrasch S, et al. Mesalazine changes apoptosis and proliferation in normal mucosa of patients with sporadic polyps of the large bowel. Endoscopy 2000 32 : 245 54.
-
(2000)
Endoscopy
, vol.32
, pp. 245-254
-
-
Reinacher-Schick, A.1
Seidensticker, F.2
Petrasch, S.3
-
60
-
-
0037355174
-
Mesalazine causes a mitotic arrest and induces caspase-dependent apoptosis in colon carcinoma cells
-
Reinacher-Schick A, Schoeneck A, Graeven U, Schwarte-Waldhoff I, Schmiegel W. Mesalazine causes a mitotic arrest and induces caspase-dependent apoptosis in colon carcinoma cells. Carcinogenesis 2003 24 : 443 51.
-
(2003)
Carcinogenesis
, vol.24
, pp. 443-451
-
-
Reinacher-Schick, A.1
Schoeneck, A.2
Graeven, U.3
Schwarte-Waldhoff, I.4
Schmiegel, W.5
-
61
-
-
58049107852
-
Molecular basis of the potential of mesalazine to prevent colorectal cancer
-
Stolfi C, Pellegrini R, Franze E, Pallone F, Monteleone G. Molecular basis of the potential of mesalazine to prevent colorectal cancer. World J Gastroenterol 2008 14 : 4434 9.
-
(2008)
World J Gastroenterol
, vol.14
, pp. 4434-4439
-
-
Stolfi, C.1
Pellegrini, R.2
Franze, E.3
Pallone, F.4
Monteleone, G.5
-
62
-
-
67449116312
-
Effects of the cathelicidin LL-37 on intestinal epithelial barrier integrity
-
Otte JM, Zdebik AE, Brand S, et al. Effects of the cathelicidin LL-37 on intestinal epithelial barrier integrity. Regul Pept 2009 156 : 1 3.
-
(2009)
Regul Pept
, vol.156
, pp. 1-3
-
-
Otte, J.M.1
Zdebik, A.E.2
Brand, S.3
-
63
-
-
48349087831
-
Antimicrobial peptides and the skin immune defense system
-
Schauber J, Gallo RL. Antimicrobial peptides and the skin immune defense system. J Allergy Clin Immunol 2008 122 : 261 6.
-
(2008)
J Allergy Clin Immunol
, vol.122
, pp. 261-266
-
-
Schauber, J.1
Gallo, R.L.2
-
64
-
-
0036151109
-
Cell differentiation is a key determinant of cathelicidin LL-37/human cationic antimicrobial protein 18 expression by human colon epithelium
-
Hase K, Eckmann L, Leopard JD, Varki N, Kagnoff MF. Cell differentiation is a key determinant of cathelicidin LL-37/human cationic antimicrobial protein 18 expression by human colon epithelium. Infect Immun 2002 70 : 953 63.
-
(2002)
Infect Immun
, vol.70
, pp. 953-963
-
-
Hase, K.1
Eckmann, L.2
Leopard, J.D.3
Varki, N.4
Kagnoff, M.F.5
-
65
-
-
58849143880
-
IL-17A enhances vitamin D3-induced expression of cathelicidin antimicrobial peptide in human keratinocytes
-
Peric M, Koglin S, Kim SM, et al. IL-17A enhances vitamin D3-induced expression of cathelicidin antimicrobial peptide in human keratinocytes. J Immunol 2008 181 : 8504 12.
-
(2008)
J Immunol
, vol.181
, pp. 8504-8512
-
-
Peric, M.1
Koglin, S.2
Kim, S.M.3
-
66
-
-
33744493110
-
Heterogeneous expression of human cathelicidin hCAP18/LL-37 in inflammatory bowel diseases
-
Schauber J, Rieger D, Weiler F, et al. Heterogeneous expression of human cathelicidin hCAP18/LL-37 in inflammatory bowel diseases. Eur J Gastroenterol Hepatol 2006 18 : 615 21.
-
(2006)
Eur J Gastroenterol Hepatol
, vol.18
, pp. 615-621
-
-
Schauber, J.1
Rieger, D.2
Weiler, F.3
|