Interaction of Tau protein with model lipid membranes induces tau structural compaction and membrane disruption

Biochemistry

Volumn 51, Issue 12, 2012, Pages 2539-2550

  Jones, Emmalee M ^a   Dubey, Manish ^b   Camp, Phillip J ^a   Vernon, Briana C ^a   Biernat, Jacek ^c,d   Mandelkow, Eckhard ^c,d   Majewski, Jaroslaw ^b   Chi, Eva Y ^a  

^a University of New Mexico   (United States)

^b LOS ALAMOS NATIONAL LABORATORY   (United States)

^c CENTER OF ADVANCED EUROPEAN STUDIES AND RESEARCH CAESAR   (Germany)

^d MAX PLANCK INSTITUTE FOR NEUROLOGICAL RESEARCH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ALZHEIMER'S DISEASE; ANIONIC LIPIDS; BI-LAYER; DUAL ROLE; FOLDED PROTEINS; GRAZING INCIDENCE X-RAY DIFFRACTION; HEAD GROUPS; LIPID MEMBRANES; LIPID MONOLAYER; MEMBRANE DISRUPTION; MEMBRANE PERMEABILIZATION; MISFOLDING; MORPHOLOGICAL CHANGES; NEUROFIBRILLARY TANGLES; NEUTRON REFLECTIVITY; NEUTRON SCATTERING TECHNIQUES; PROTEIN AGGREGATES; STRONG INTERACTION; STRUCTURAL COMPACTION; STRUCTURAL DETAILS; STRUCTURAL PERTURBATION; SURFACE ACTIVE; TAU PATHOLOGY; TAU PROTEINS; X RAY REFLECTIVITY;

CELL MEMBRANES; DISEASES; DYES; LIPIDS; MONOLAYERS; PROTEINS; TOXICITY; X RAY DIFFRACTION;

MEMBRANES;

1,2 DIMYRISTOYL 3 TRIMETHYLAMMONIUMPROPANE; 1,2 DIMYRISTOYL SN GLYCERO 3 [PHOSPHO RAC(1 GLYCEROL)]; 1,2 DIMYRISTOYL SN GLYCERO 3 PHOSPHOCHOLINE; DIPALMITOYLPHOSPHATIDYLCHOLINE; LIPID; TAU PROTEIN; UNCLASSIFIED DRUG;

ADSORPTION; ARTICLE; LIPID MONOLAYER; MEMBRANE DAMAGE; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN INTERACTION;

CELL MEMBRANE; HUMANS; LIPID BILAYERS; NEUTRON DIFFRACTION; PROTEIN BINDING; PROTEIN CONFORMATION; SOLUBILITY; TAU PROTEINS; X-RAY DIFFRACTION;

EID: 84859194796     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi201857v     Document Type: Article

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