A crucial role of IL-17 and IFN-γ during acute rejection of peripheral nerve xenotransplantation in mice

PLoS ONE

Volumn 7, Issue 3, 2012, Pages

  Yu, Xin ^a   Jiang, Yanfang ^a   Lu, Lu ^a   Gong, Xu ^a   Sun, Xiguang ^a   Xuan, Zhaopeng ^a   Lu, Laijin ^a  

^a JILIN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; GAMMA INTERFERON ANTIBODY; INTERLEUKIN 17; INTERLEUKIN 17 ANTIBODY; INTERLEUKIN 4;

ACUTE GRAFT REJECTION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CHEMOPROPHYLAXIS; CONTROLLED STUDY; CYTOKINE PRODUCTION; MALE; MONONUCLEAR CELL; MOUSE; NERVE TRANSPLANTATION; NONHUMAN; PROTEIN EXPRESSION; RAT; TH1 CELL; TH17 CELL; XENOTRANSPLANTATION; ANIMAL; BAGG ALBINO MOUSE; GRAFT REJECTION; IMMUNOLOGY; PERIPHERAL NERVE; SPRAGUE DAWLEY RAT; TRANSPLANTATION; XENOGRAFT;

MUS; RATTUS;

ANIMALS; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; GRAFT REJECTION; INTERFERON-GAMMA; INTERLEUKIN-17; MALE; MICE; MICE, INBRED BALB C; PERIPHERAL NERVES; RATS; RATS, SPRAGUE-DAWLEY; TH1 CELLS; TRANSPLANTATION, HETEROLOGOUS;

EID: 84859121180     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0034419     Document Type: Article

References (45)

1. Novak CB, Anastakis DJ, Beaton DE, Katz J, (2009) Patient-Reported Outcome After Peripheral Nerve Injury. Journal of Hand Surgery-American Volume 34: 281-287.
2. Berger A, Hierner R, Rohde U, Shen ZL, (1999) Diagnosis and treatment of peripheral nerve injury. The "integrated therapy" concept. Unfallchirurg 102: 59-68.
3. Sinis N, Haerle M, Becker ST, Schulte-Eversum C, Vonthein R, et al. (2007) Neuroma formation in a rat median nerve model: Influence of distal stump and muscular coating. Plastic and Reconstructive Surgery 119: 960-966.
4. Galeano M, Manasseri B, Risitano G, Geuna S, Di Scipio F, et al. (2009) A Free Vein Graft Cap Influences Neuroma Formation after Nerve Transection. Microsurgery 29: 568-572.
5. Schaller E, Berger A, (1987) Peripheral-Nerve Allograft. Plastic and Reconstructive Surgery 80: 870-871.
6. Lu LJ, Sun JB, Liu ZG, Gong X, Cui JL, et al. (2009) Immune responses following mouse peripheral nerve xenotransplantation in rats. J Biomed Biotechnol DOI:10.1155/2009/412598.
7. Fox IK, Jaramillo A, Hunter DA, Rickman SR, Mohanakumar T, et al. (2005) Prolonged cold-preservation of nerve allografts. Muscle Nerve 31: 59-69.
8. Dorling A, Lombardi G, Binns R, Lechler RI, (1996) Detection of primary direct and indirect human anti-porcine T cell responses using a porcine dendritic cell population. Eur J Immunol 26: 1378-1387.
9. Davila E, Byrne GW, LaBreche PT, McGregor HC, Schwab AK, et al. (2006) T-cell responses during pig-to-primate xenotransplantation. Xenotransplantation 13: 31-40.
10. Liang SC, Tan XY, Luxenberg DP, Karim R, Dunussi-Joannopoulos K, et al. (2006) Interleukin (IL)-22 and IL-17 are coexpressed by Th17 cells and cooperatively enhance expression of antimicrobial peptides. Journal of Experimental Medicine 203: 2271-2279.
11. Mangan PR, Harrington LE, O'Quinn DB, Helms WS, Bullard DC, et al. (2006) Transforming growth factor-beta induces development of the T(H)17 lineage. Nature 441: 231-234.
12. Bettelli E, Carrier Y, Gao W, Korn T, Strom TB, et al. (2006) Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells. Nature 441: 235-238.
13. Park H, Li Z, Yang XO, Chang SH, Nurieva R, et al. (2005) A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17. Nat Immunol 6: 1133-1141.
14. Harrington LE, Hatton RD, Mangan PR, Turner H, Mruphy TL, et al. (2005) Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages. Nat Immunol 6: 1123-1132.
15. Ivano II, McKenzie BS, Zhou L, Tadokoro CE, Lepelley A, et al. (2006) The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells. Cell 126: 1121-1133.
16. Crome SQ, Wang AY, Levings MK, (2010) Translational Mini-Review Series on Th17 Cells: Function and regulation of human T helper 17 cells in health and disease. Clinical and Experimental Immunology 159: 109-119.
17. Faust SM, Lu G, Marini BL, Zou W, Gordon D, et al. (2009) Role of T Cell TGF beta Signaling and IL-17 in Allograft Acceptance and Fibrosis Associated with Chronic Rejection. Journal of Immunology 183: 7297-7306.
18. Szabo SJ, Kim ST, Costa GL, Zhang X, Fathman CG, et al. (2000) A novel transcription factor, T-bet, directs Th1 lineage commitment. Cell 100: 655-669.
19. Yuan XL, Cortez JP, Knosalla IS, D'Addio Francesca, Mfarrej Bechara, et al. (2008) A novel role of CD4 Th17 cells in mediating cardiac allograft rejection and vasculopathy. Journal of Experimental Medicine 205: 3133-3144.
20. Antonysamy MA, Fanslow WC, Fu F, Li W, Qian S, et al. (1999) Evidence for a role of IL-17 in organ allograft rejection: IL-17 promotes the functional differentiation of dendritic cell progenitors. Journal of Immunology 162: 577-584.
21. Kortylewski M, Xin H, Kujawski M, Lee H, Liu Y, et al. (2009) Regulation of the IL-23 and IL-12 balance by Stat3 signaling in the tumor microenvironment. Cancer Cell 15: 114-123.
22. Veldhoen M, Hocking RJ, Flavell RA, Stockinger B, (2006) Signals mediated by transforming growth factor-beta initiate autoimmune encephalomyelitis, but chronic inflammation is needed to sustain disease. Nat Immunol 7: 1151-1156.
23. Luger D, Silver PB, Tang J, Cua D, Chen Z, et al. (2008) Either a Th17 or a Th1 effector response can drive autoimmunity: conditions of disease induction affect dominant effector category. Journal of Experimental Medicine 205: 799-810.
24. Su SB, Grajewski RS, Luger D, Agarwal RK, Silver PB, et al. (2007) Altered chemokine profile associated with exacerbated autoimmune pathology under conditions of genetic interferon-gamma deficiency. Invest Ophthalmol Vis Sci 48: 4616-4625.
25. O'Connor RA, Prendergast CT, Sabatos CA, Lau CW, Leech MD, et al. (2008) Cutting edge: Th1 cells facilitate the entry of Th17 cells to the central nervous system during experimental autoimmune encephalomyelitis. Journal of Immunology 181: 3750-3754.
26. Khader SA, Bell GK, Pearl JE, Fountain JJ, Rangel-Moreno J, et al. (2007) IL-23 and IL-17 in the establishment of protective pulmonary CD4+ T cell responses after vaccination and during Mycobacterium tuberculosis challenge. Nat Immunol 8: 369-377.
27. Bending D, De la Pena H, Veldhoen M, Phillips JM, Uyttenhove C, et al. (2009) Highly purified Th17 cells from BDC2.5NOD mice convert into Th1-like cells in NOD/SCID recipient mice. J Clin Invest 119: 565-572.
28. Lee YK, Turner H, Maynard CL, Oliver JR, Chen D, et al. (2009) Late developmental plasticity in the T helper 17 lineage. Immunity 30: 92-107.
29. Wei G, Wei L, Zhu J, Zang C, Hu-Li J, et al. (2009) Global mapping of H3K4me3 and H3K27me3 reveals specificity and plasticity in lineage fate determination of differentiating CD4+ T cells. Immunity 30: 155-167.
30. Martin-Orozco N, Chung Y, Chang SH, Wang YH, Dong C, (2009) Th17 cells promote pancreatic inflammation but only induce diabetes efficiently in lymphopenic hosts after conversion into Th1 cells. Eur J Immunol 39: 216-224.
31. Trumble TE, Shon FG, (2000) The physiology of nerve transplantation. Hand Clin 16: 105-122.
32. Hebebrand D, Zohman G, Jones NF, (1997) Nerve xenograft transplantation. Immunosuppression with FK-506 and RS-61443. J Hand Surg Br 22: 304-307.
33. Cardona K, Korbutt GS, Milas Z, Lyon J, Cano J, et al. (2006) Long-term survival of neonatal porcine islets in nonhuman primates by targeting costimulation pathways. Nat Med 12: 304-306.
34. Hering BJ, Wijkstrom M, Graham ML, Hardstedt M, Aasheim TC, et al. (2006) Prolonged diabetes reversal after intraportal xenotransplantation of wild-type porcine islets in immunosuppressed nonhuman primates. Nat Med 12: 301-303.
35. Yang YG, Sykes M, (2007) Xenotransplantation: current status and a perspective on the future. Nat Rev Immunol 7: 519-531.
36. Guo Z, Wang J, Meng L, Wu Q, Kim O, et al. (2002) Membrane lymphotoxin regulates CD8(+) T cell-mediated intestinal allograft rejection. Modern Pathology 15: 133a-133a.
37. Trambley J, Bingaman AW, Lin A, Elwood ET, Waitze SY, et al. (1999) Asialo GM1(+) CD8(+) T cells play a critical role in costimulation blockade-resistant allograft rejection. Journal of Clinical Investigation 104: 1715-1722.
38. Jones ND, Carvalho-Gaspar M, Luo S, Brook MD, Martin L, et al. (2006) Effector and memory CD8(+) T cells can be generated in response to alloantigen independently of CD4(+) T cell help. Journal of Immunology 176: 2316-2323.
39. Waldmann H, Honey K, Cobbold SP, (1999) CD40 ligand blockade induces CD4+T cell tolerance and linked suppression. Journal of Immunology 163: 4805-4810.
40. Kreisel D, Krupnick AS, Gelman AE, Engels FH, Popma SH, et al. (2002) Non-hematopoietic allograft cells directly activate CD8(+) T cells and trigger acute rejection: An alternative mechanism of allorecognition. Nature Medicine 8: 233-239.
41. He D, Wu L, Kim HK, Li H, Elmets CA, et al. (2006) CD8+IL-17 producing T cells are important in effector functions for the elicitation of contact hypersensitivity. Journal of Investigative Dermatology 126: 110-110.
42. Chen Y, Chen J, Liu Z, Liang S, Luan X, et al. (2008) Relationship between TH1/TH2 cytokines and immune tolerance in liver transplantation in rats. Transplant Proc 40: 2691-2695.
43. Fabrega E, Lopez-Hoyos M, San Sequndo D, Casafont F, Pons-Romero F, (2009) Changes in the serum levels of interleukin-17/interleukin-23 during acute rejection in liver transplantation. Liver Transpl 15: 629-633.
44. Yuan X, Paez-Cortez J, Schmitt-Knosalla I, D'Addio F, Mfarrej B, et al. (2008) A novel role of CD4 Th17 cells in mediating cardiac allograft rejection and vasculopathy. Journal of Experimental Medicine 205: 3133-3144.
45. Szabo SJ, Kim ST, Costa GL, Zhang X, Fathman CG, et al. (2000) A novel transcription factor, T-bet, directs Th1 lineage commitment. Cell 100: 655-669.