T-cell responses during pig-to-primate xenotransplantation

Xenotransplantation

Volumn 13, Issue 1, 2006, Pages 31-40

  Davila, Eduardo ^a,b   Byrne, Guerard W ^b   LaBreche, Peter T ^b   McGregor, Hugh C J ^b   Schwab, Allison K ^b   Davies, William R ^b,c   Rao, Vinay P ^b   Oi, Keiji ^b,d   Tazelaar, Henry D ^b   Logan, John S ^b   McGregor, Christopher G A ^b  

^a LOUISIANA STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b MAYO CLINIC   (United States)

^c PAPWORTH HOSPITAL   (United Kingdom)

^d TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

Author keywords

Cell activation; Cytotoxicity; T cells; Transplantation

Indexed keywords

ALPHA 1,3 GALACTOSYLTRANSFERASE; ANTIBODY; CD11B ANTIGEN; CD16 ANTIGEN; CD28 ANTIGEN; GAMMA INTERFERON; INTERLEUKIN 2; MACROGOL; MEMBRANE COFACTOR PROTEIN; RITUXIMAB;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN RECOGNITION; ARTICLE; BABOON; CARDIAC GRAFT REJECTION; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL ISOLATION; CELL MEDIATED CYTOTOXICITY; CONTROLLED STUDY; CYTOKINE RELEASE; ECHOCARDIOGRAPHY; ELECTROCARDIOGRAPHY; ENDOTHELIUM CELL; HEART MUSCLE BIOPSY; HEART TRANSPLANTATION; HISTOLOGY; IMMUNOHISTOCHEMISTRY; IMMUNOSUPPRESSIVE TREATMENT; LYMPHOCYTE PROLIFERATION; LYMPHOCYTIC INFILTRATION; NONHUMAN; PRIMATE; PRIORITY JOURNAL; STATISTICAL ANALYSIS; SWINE; T LYMPHOCYTE ACTIVATION; TRANSGENIC ANIMAL; XENOTRANSPLANTATION;

ANIMALS; ANIMALS, GENETICALLY MODIFIED; ANTIBODIES, MONOCLONAL; ANTIGENS; CELLS, CULTURED; ENDOTHELIAL CELLS; GRAFT REJECTION; HEART TRANSPLANTATION; HUMANS; LYMPHOCYTE ACTIVATION; PAPIO; SWINE; T-LYMPHOCYTES; TRANSPLANTATION, HETEROLOGOUS;

EID: 33645963970     PISSN: 0908665X     EISSN: 13993089     Source Type: Journal    
DOI: 10.1111/j.1399-3089.2005.00258.x     Document Type: Article

References (55)

1. Schuurman H-J Cheng J Lam T. Pathology of xenograft rejection a commentary Xenotransplantation 2003 10 293
2. Lin SS Kooyman DL Daniels LJ et al The role of natural anti-Gal-alpha-1-3Gal antibodies in hyperacute rejection of pig-to-baboon cardiac xenotransplants Transplant Immunol 1997 5 212
3. Leventhal JR Dalmasso AP Cromwell JW et al Prolongation of cardiac xenograft survival by depletion of complement Transplantation 1993 55 857
4. Pruitt SK Kirk AD Bollinger RR et al The effects of soluble complement receptor type 1 on hyperacute rejection of porcine xenografts Transplantation 1994 57 363
5. McCurry KR Kooyman DL Alvarado CG et al Human complement regulatory proteins protect swine-to-primate cardiac xenografts from humoral injury Nat Med 1995 1 423
6. Byrne GW McCurry KR Martin MJ et al Transgenic pigs expressing human CD59 and decay-accelerating factor produce an intrinsic barrier to complement-mediated damage Transplantation 1997 63 149
7. Cozzi E Tucker AW Langford GA et al Characterization of pigs transgenic for human decay-accelerating factor Transplantation 1997 64 1383
8. Kuwaki K Tseng YL Dor FJ et al Heart transplantation in baboons using alpha1,3-galactosyltransferase gene-knockout pigs as donors initial experience Nat Med 2005 11 29
9. Bach FH Winkler H Ferran C Hancock WW Robson SC. Delayed xenograft rejection Immunol Today 1996 17 379
10. Platt JL Lin SS McGregor CGA. Acute vascular rejection Xenotransplantation 1998 5 169
11. Buhler LH Cooper DK. How strong is the T cell response in the pig-to-primate model? Xenotransplantation 2005 12 85
12. Dorling A. Are anti-endothelial cell antibodies a pre-requisite for the acute vascular rejection of xenografts? Xenotransplantation 2003 10 16
13. Mazzucato M Demarco L Pradella P Masotti A Pareti FI. Porcine von Willebrand factor binding to human platelet GPIb induces transmembrane calcium influx Thromb Haemost 1996 75 655
14. Kopp CW Siegel JB Hancock WW et al Effect of porcine endothelial tissue factor pathway inhibitor on human coagulation factors Transplantation 1997 63 749
15. Siegel JB Grey ST Lesnikoski BA et al Xenogeneic endothelial cells activate human prothrombin Transplantation 1997 64 888
16. Schirmer JM Fass DN Byrne GW et al Effective antiplatelet therapy does not prolong transgenic pig to baboon cardiac xenograft survival Xenotransplantation 2004 11 436
17. Byrne GW Schirmer JM Fass DN et al Warfarin or low-molecular-weight heparin therapy does not prolong pig-to-primate cardiac xenograft function Am J Transplant 2005 5 1011
18. Meyer C Wolf P Romain N et al Use of von Willebrand diseased kidney as donor in a pig-to-primate model of xenotransplantation Transplantation 1999 67 38
19. Kuwaki K Knosalla C Dor FJMF et al Suppression of natural and elicited antibodies in pig-to-baboon heart transplantation using a human anti-human CD154 mAb-based regimen Am J Transplant 2004 4 363
20. McGregor CGA Teotia SS Byrne GW et al Cardiac xenotransplantation progress toward the clinic Transplantation 2004 78 1569
21. McGregor CGA Davies WR Oi K et al Cardiac xenotransplantation recent preclinical progress with 3-month median survival J Thorac Cardiovasc Surg 2005 130 844
22. Yamada K Sachs DH Dersimonian H. Human anti-porcine xenogeneic T cell response J Immunol 1995 155 5249
23. Bravery CA Batten P Yacoub MH Rose ML. Direct recognition of SLA- and HLA-like class II antigens on porcine endothelium by human T cells results in T cell activation and release of interleukin-2 Transplantation 1995 60 1024
24. + cytolytic T cell clones Transplantation 1997 64 340
25. Murray AG Khodadoust MM Pober JS Bothwell ALM. Porcine aortic endothelial cells activate human T cells direct presentation of MHC antigens and costimulation by ligands for human CD2 and CD28 Immunity 1994 1 57
26. Maher S Karmann K Min W et al Porcine endothelial CD86 is a major costimulator of xenogeneic human T cells J Immunol 1996 157 3838
27. Adaki DK Williams A Lee KP Kirk AD Harlan DM. Porcine CD80 cloning, characterization, and evidence for its role in direct human T-cell activation Xenotransplantation 2003 10 252
28. Lee RS Yamada K Womer KL et al Blockade of CD28-B7, but not CD40-CD154, prevents costimulation of allogeneic porcine and xenogeneic human anti-porcine T cell responses J Immunol 2000 164 3434
29. Sebille F Dorling A Lechler RI. The cellular rejection of xenografts - recent insights Xenotransplantation 2003 10 4
30. Cowan PJ Aminian A Barlow H et al Renal xenografts from triple-transgenic pigs are not hyperacutely rejected but cause coagulopathy in non-immunosuppressed baboons Transplantation 2000 69 2504
31. Ashton-Chess J Roussel JC Manez R et al Cellular participation in delayed xenograft rejection of hCD55 transgenic pig hearts by baboons Xenotransplantation 2003 10 446
32. Kirchhof N Shibata S Wijkstrom M et al Reversal of diabetes in non-immunosuppressed rhesus macaques by intraportal porcine islet xenografts precedes acute cellular rejection Xenotransplantation 2004 11 396
33. + T cells activated through the indirect antigen recognition pathway Xenotransplantation 2002 9 393
34. + T lymphocytes J Immunol 2000 165 1294
35. Diamond LE Quinn CM Martin MJ et al A human CD46 transgenic pig model system for the study of discordant xenotransplantation Transplantation 2001 71 132
36. Adams DH Chen RH Kadner A Naficy S. Technique for heterotopic pig heart xenotransplantation in primates Ann Thorac Surg 1999 68 265
37. Michler RE Mcmanus RP Smith CR Sadeghi AN Rose EA. Technique for primate heterotopic cardiac xenotransplantation J Med Primatol 1985 14 357
38. Groth FDS. The evaluation of limiting dilution assays J Immunol Methods 1982 49 R11
39. Dorling A Lombardi G Binns R Lechler RI. Detection of primary direct and indirect human anti-porcine T cell responses using a porcine dendritic cell population Eur J Immunol 1996 26 1378
40. Hartig CV Haller GW Sachs DH Kuhlenschmidt S Heeger PS. Naturally developing memory T cell xenoreactivity to swine antigens in human peripheral blood lymphocytes J Immunol 2000 164 2790
41. Rollins SA Kennedy SP Chodera AJ et al Evidence that activation of human T cells by porcine endothelium involves direct recognition of porcine SLA and costimulation by porcine ligands for LFA-1 and CD2 Transplantation 1994 57 1709
42. + T-cells in rejection of porcine islet cell xenografts Diabetes 1999 48 2340
43. +, lymphocyte proliferation and resist cell-mediated cytolytic injury in vitro Diabetes 1999 48 1713
44. + T cells mediate rejection of porcine xenografts J Immunol 1999 162 5256
45. + lymphocytes from type 1 diabetic or healthy subjects Diabetologia 1999 42 330
46. Itescu S Kwiatkowski P Artrip JH et al Role of natural killer cells, macrophages, and accessory molecule interactions in the rejection of pig-to-primate xenografts beyond the hyperacute period Hum Immunol 1998 59 275
47. Watier H Guillaumin JM Piller F et al Removal of terminal alpha-galactosyl residues from xenogeneic porcine endothelial cells. Decrease in complement-mediated cytotoxicity but persistence of IgG1-mediated antibody-dependent cell-mediated cytotoxicity Transplantation 1996 62 105
48. Itescu S Kwiatkowski P Wang SF et al Circulating human mononuclear cells exhibit augmented lysis of pig endothelium after activation with interleukin 2 Transplantation 1996 62 1927
49. +CD28null T cells clonally expanded in rheumatoid arthritis J Immunol 2000 165 1138
50. Nakajima T Schulte S Warrington KJ et al T-cell-mediated lysis of endothelial cells in acute coronary syndromes Circulation 2002 105 570
51. - T cells in patients with chronic kidney graft rejection Transpl Proc 2003 35 2902
52. Vallejo AN Weyand CM Goronzy JJ. T-cell senescence a culprit of immune abnormalities in chronic inflammation and persistent infection Trends Mol Med 2004 10 119
53. Goronzy JJ Weyand CM. T-cell regulation in rheumatoid arthritis Curr Opin Rheumatol 2004 16 212
54. Rose ML. Activation of autoimmune B cells and chronic rejection Transplantation 2005 79 S22
55. Lam TT Paniagua R Shivaram G et al Anti-non-Gal porcine endothelial cell antibodies in acute humoral xenograft rejection of hDAF-transgenic porcine hearts in cynomolgus monkeys Xenotransplantation 2004 11 531