CD95 (Fas/APO-1) and p53 signal apoptosis independently in diverse cell types

Cancer Research

Volumn 60, Issue 5, 2000, Pages 1217-1220

  O'Connor, Liam ^b   Harris, Alan W ^b   Strasser, Andreas ^a,b  

^a ROYAL MELBOURNE HOSPITAL   (Australia)

^b Institute of Medical Research   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

FAS ANTIGEN; FAS LIGAND; PROTEIN P53;

ANIMAL CELL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CELL CYCLE; CELL TYPE; CONTROLLED STUDY; LIVER CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; THYMOCYTE; TUMOR SUPPRESSOR GENE;

ANIMALS; ANTIGENS, CD95; APOPTOSIS; GENE EXPRESSION REGULATION; GENES, P53; MICE; MICE, INBRED STRAINS; SIGNAL TRANSDUCTION; SPECIES SPECIFICITY; TUMOR SUPPRESSOR PROTEIN P53;

EID: 0034163385     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (32)

1. Levine, A. J. p53, the cellular gatekeeper for growth and division. Cell, 88: 323-331, 1997.
2. Agarwal, M. L., Taylor, W. R., Chernov, M. V., Chernova, O. B., and Stark, G. R. The p53 network. J. Biol. Chem., 273: 1-4, 1998.
3. Fritsche, M., Haessler, C., and Brandner, G. Induction of nuclear accumulation of the tumor-suppressor protein p53 by DNA-damaging agents. Oncogene, 8: 307-318, 1993.
4. Maltzman, W., and Czyzyk, L. UV irradiation stimulates levels of p53 cellular tumor antigen in nontransformed mouse cells. Mol. Cell. Biol., 4: 1689-1694, 1984.
5. Kuerbitz, S. J., Plunkett, B. S., Walsh, W. V., and Kastan, M. B. Wild-type p53 is a cell cycle checkpoint determinant following irradiation. Proc. Natl. Acad. Sci. USA, 89: 7491-7495, 1992.
6. Kubbutat, M. H. G., Jones, S. N., and Vousden, K. H. Regulation of p53 stability by Mdm2. Nature (Lond.), 387: 299-303, 1997.
7. Sakaguchi, K., Herrera, J. E., Saito, S., Miki, T., Bustin, M., Vassilev, A., Anderson, C. W., and Appella, E. DNA damage activates p53 through a phosphorylation-acetylation cascade. Genes Dev., 12: 2831-2841, 1998.
8. Lowe, S. W., Schmitt, E. M., Smith, S. W., Osborne, B. A., and Jacks, T. p53 is required for radiation-induced apoptosis in mouse thymocytes. Nature (Lond.), 362: 847-849, 1993.
9. Clarke, A. R., Purdie, C. A., Harrison, D. J., Morris, R. G., Bird, C. C., Hooper, M. L., and Wyllie, A. H. Thymocyte apoptosis induced by p53-dependent and independent pathways. Nature (Lond.), 362: 849-852, 1993.
10. Strasser, A., Harris, A. W., Jacks, T., and Cory, S. DNA damage can induce apoptosis in proliferating lymphoid cells via p53-independent mechanisms inhibitable by Bcl-2. Cell. 79: 329-339, 1994.
11. Miyashita, T., and Reed, J. C. Tumor suppressor p53 is a direct transcriptional activator of the human box gene. Cell, 80: 293-299, 1995.
12. Brady, H. J. M., Salomns, G. S., Bobeldijk, R. C., and Berns, A. J. M. T cells from baxa transgenic mice show accelerated apoptosis in response to stimuli but do not show restored DNA damage-induced cell death in the absence of p53. EMBO J., 15: 1221-1230, 1996.
13. Atlardi, L. D., Lowe, S. W., Brugarolas, J., and Jacks, T. Transcriptional activation by p53, but not induction of the p21 gene, is essential for oncogene-mediated apoptosis. EMBO J., 15: 3693-3701, 1996.
14. Ashkenazi, A., and Dixit, V. M. Death receptors: signaling and modulation. Science (Washington DC), 281: 1305-1308, 1998.
15. Bennett, M., MacDonald, K., Chan, S-W., Luzio, J. P., Simari, R., and Weissberg, P. Cell surface trafficking of Fas: a rapid mechanism of p53-mediated apoptosis. Science (Washington DC), 282: 290-293, 1998.
16. Müller, M., Wilder, S., Bannasch, D., Israeli, D., Lehlbach, K., Li-Weber, M., Friedman, S. L., Galle, P. R., Stremmel, W., Oren, M., and Krammer, P. H. p53 activates the CD95 (APO-I/Fas) gene in response to DNA damage by anticancer drugs. J. Exp. Med., 188: 2033-2045, 1998.
17. Unger, C., Buchmann, A., Buenemann, C. L., Kress, S., and Schwarz, M. Wild-type function of the p53 tumor suppressor protein is not required for apoptosis of mouse hepatoma cells. Cell Death Differ., 5: 87-95, 1998.
18. Jacks, T., Remington, L., Williams, B. O., Schmitt, E. M., Halachmi, S., Bronson, R. T., and Weinberg, R. A. Tumor spectrum analysis in p53-mutant mice. Curr. Biol., 4: 1-7, 1994.
19. Cohen, P. L., and Eisenberg, R. A. The lpr and gld genes in systemic autoimmunity: life and death in the Fas lane. Immunol. Today. 13: 427-428, 1993.
20. Strasser, A., Harris, A. W., Huang, D. C. S., Krammer, P. H., and Cory, S. Bcl-2 and Fas/APO-1 regulate distinct pathways to lymphocyte apoptosis. EMBO J., 14: 6136-6147, 1995.
21. Gorczyca, W., Gong, J., and Darzynkiewicz, Z. Detection of DNA strand breaks in individual apoptotic cells by the in situ terminal deoxynucleotidyl transferase and nick translation assays. Cancer Res., 53: 1945-1951, 1993.
22. Ogasawara, J., Watanabe-Fukunaga, R., Adachi, M., Matsuzawa, A., Kasugai, T., Kitamura, Y., Itoh, N., Suda, T., and Nagata, S. Lethal effect of the anti-Fas antibody in mice. Nature (Lond.), 364: 806-809, 1993.
23. Fuchs, E. J., McKenna, K. A., and Bedi, A. p53-dependent DNA damage-induced apoptosis requires Fas/APO-1-independent activation of CPP32β. Cancer Res., 57: 2550-2554, 1997.
24. Newton, K., and Strasser, A. Ionizing radiation and chemotherapeutic drugs induce apoptosis in lymphocytes in the absence of Fas- or FADD/MORT-1-signaling-implications for cancer therapy. J. Exp. Med., 191: 195-200, 2000.
25. Newton, K., Harris, A. W., Bath, M. L., Smith, K. G. C., and Strasser, A. A dominant interfering mutant of FADD/Mort1 enhances deletion of autoreactive thymocytes and inhibits proliferation of mature T lymphocytes. EMBO J., 17: 706-718, 1998.
26. Nagata, S. Apoptosis by death factor. Cell, 88: 355-365, 1997.
27. Soengas, M. S., Alarc≤sn, R. M., Yoshida, H., Giaccia, A. J., Hakem, R., Mak, T. W., and Lowe, S. W. Apaf-1 and caspase-9 in p53-dependent apoptosis and tumor inhibition. Science (Washington DC), 284: 156-159, 1999.
28. Yoshida, H., Kong, Y-Y., Yoshida, R., Elia, A. J., Hakem, A., Hakem, R., Penninger, J. M., and Mak, T. W. Apaf1 is required for milochondrial pathways of apoptosis and brain development. Cell, 94: 739-750, 1998.
29. Cecconi, F., Alvarez-Bolado, G., Meyer, B. I., Roth, K. A., and Gruss, P. Apaf-1 (CED-4 homologue) regulates programmed cell death in mammalian development. Cell, 94: 727-737, 1998.
30. Kuida, K., Haydar. T. F., Kuan, C-Y., Gu. Y.,Taya, C., Karasuyama, H., Su, M. S-S., Rakic, P., and Flavell, R. A. Reduced apoptosis and cytochrome c-mediated caspase activation in mice lacking caspase 9. Cell, 94: 325-337, 1998.
31. Hakem, R., Hakem, A., Duncan, G. S., Henderson, J. T., Woo, M., Soengas, M. S., Elia, A., de la Pompa, J. L., Kagi, D., Khoo, W., Potter, J., Yoshida, R., Kaufman, S. A., and Lowe, S. W. Differential requirement for caspase 9 in apoptotic pathways in vivo. Cell, 94: 339-352, 1998.
32. Seino, K-I., Kayagaki, N., Okumura, K., and Yagita, H. Antitumor effect of locally produced CD95 ligand. Nat. Med., 3: 165-170, 1997.