Proanthocyanidin from grape seeds inactivates the PI3-kinase/PKB pathway and induces apoptosis in a colon cancer cell line

Cancer Letters

Volumn 258, Issue 1, 2007, Pages 144-153

  Engelbrecht, A M ^a   Mattheyse, M ^a   Ellis, B ^a   Loos, B ^a   Thomas, M ^a   Smith, R ^a   Peters, S ^a   Smith, C ^a   Myburgh, K ^a  

^a STELLENBOSCH UNIVERSITY   (South Africa)

Author keywords

Apoptosis; Colon cancer; PI3 K; PKB Akt

Indexed keywords

PHOSPHATIDYLINOSITOL 3 KINASE; PROANTHOCYANIDIN; PROTEIN KINASE B; PROTEIN P110; PROTEIN P85; SERINE;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CELL SURVIVAL; CELL VIABILITY; CHEMOPROPHYLAXIS; COLON CANCER; CONCENTRATION RESPONSE; CONTROLLED STUDY; CORRELATION ANALYSIS; DRUG EFFECT; DRUG MECHANISM; ENZYME INACTIVATION; ENZYME PHOSPHORYLATION; ENZYME SUBUNIT; GRAPE; HUMAN; HUMAN CELL; PLANT SEED; PRIORITY JOURNAL;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANTIOXIDANTS; APOPTOSIS; CACO-2 CELLS; CELL SURVIVAL; HUMANS; PROANTHOCYANIDINS; PROTEIN-SERINE-THREONINE KINASES; SEEDS; VITIS;

VITACEAE;

EID: 35348992576     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.canlet.2007.08.020     Document Type: Article

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