메뉴 건너뛰기




Volumn 18, Issue 7, 1998, Pages 3692-3698

Characterization of structural p53 mutants which show selective defects in apoptosis but not cell cycle arrest

Author keywords

[No Author keywords available]

Indexed keywords

MUTANT PROTEIN; PROTEIN P53;

EID: 0031806708     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.18.7.3692     Document Type: Article
Times cited : (169)

References (43)
  • 2
    • 0029670589 scopus 로고    scopus 로고
    • p53 in signalling checkpoint arrest or apoptosis
    • Bates, S., and K. H. Vousden. 1996. p53 in signalling checkpoint arrest or apoptosis. Curr. Opin. Genet. Dev. 6:1-7.
    • (1996) Curr. Opin. Genet. Dev. , vol.6 , pp. 1-7
    • Bates, S.1    Vousden, K.H.2
  • 5
    • 0028070989 scopus 로고
    • p53-dependent apoptosis in the absence of transcriptional activation of p53-target genes
    • Caelles, C., A. Helmberg, and M. Karin. 1994. p53-dependent apoptosis in the absence of transcriptional activation of p53-target genes. Nature 370: 220-223.
    • (1994) Nature , vol.370 , pp. 220-223
    • Caelles, C.1    Helmberg, A.2    Karin, M.3
  • 6
    • 0029802591 scopus 로고    scopus 로고
    • p53 levels, functional domains, and DNA damage determine the extent of the apoptotic response of tumor cells
    • Chen, X., L. J. Ko, L. Jayaraman, and C. Prives. 1996. p53 levels, functional domains, and DNA damage determine the extent of the apoptotic response of tumor cells. Genes Dev. 10:2438-2451.
    • (1996) Genes Dev. , vol.10 , pp. 2438-2451
    • Chen, X.1    Ko, L.J.2    Jayaraman, L.3    Prives, C.4
  • 7
    • 0027983669 scopus 로고
    • Crystal structure of a p53 tumor suppressor-DNA complex: Understanding tumorigenic mutations
    • Cho, Y., S. Gorina, P. D. Jeffery, and N. P. Pavletich. 1994. Crystal structure of a p53 tumor suppressor-DNA complex: understanding tumorigenic mutations. Sciences 265:346-355.
    • (1994) Sciences , vol.265 , pp. 346-355
    • Cho, Y.1    Gorina, S.2    Jeffery, P.D.3    Pavletich, N.P.4
  • 8
    • 0028347587 scopus 로고
    • Modulation of transcriptional regulatory properties of p53 by HPV E6
    • Crook, T., C. Fisher, P. J. Masterson, and K. H. Vousden. 1994. Modulation of transcriptional regulatory properties of p53 by HPV E6. Oncogene 9:1225-1230.
    • (1994) Oncogene , vol.9 , pp. 1225-1230
    • Crook, T.1    Fisher, C.2    Masterson, P.J.3    Vousden, K.H.4
  • 9
    • 0028131554 scopus 로고
    • Transcriptional activation by p53 correlates with suppression of growth but not transformation
    • Crook, T., N. J. Marston, E. A. Sara, and K. H. Vousden. 1994. Transcriptional activation by p53 correlates with suppression of growth but not transformation. Cell 79:817-827.
    • (1994) Cell , vol.79 , pp. 817-827
    • Crook, T.1    Marston, N.J.2    Sara, E.A.3    Vousden, K.H.4
  • 11
    • 0028978183 scopus 로고
    • CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control
    • CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control. Cell 82:657-684.
    • (1995) Cell , vol.82 , pp. 657-684
    • Deng, C.1    Zang, P.2    Harper, J.W.3    Elledge, S.J.4    Leder, P.5
  • 12
    • 0027970713 scopus 로고
    • DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts
    • Di Leonardo, A., S. P. Linke, K. Clarkin, and G. M. Wahl. 1994. DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts. Genes Dev. 8:2540-2551.
    • (1994) Genes Dev. , vol.8 , pp. 2540-2551
    • Di Leonardo, A.1    Linke, S.P.2    Clarkin, K.3    Wahl, G.M.4
  • 13
    • 0029783722 scopus 로고    scopus 로고
    • A mutant p53 that discriminates between p53-responsive genes cannot induce apoptosis
    • Friedlander, P., Y. Haupt, C. Prives, and M. Oren. 1996. A mutant p53 that discriminates between p53-responsive genes cannot induce apoptosis. Mol. Cell. Biol. 16:4961-4971.
    • (1996) Mol. Cell. Biol. , vol.16 , pp. 4961-4971
    • Friedlander, P.1    Haupt, Y.2    Prives, C.3    Oren, M.4
  • 14
    • 0025887476 scopus 로고
    • Wild type p53 can down-modulate the activity of various promoters
    • Ginsberg, D., F. Mechta, M. Yaniv, and M. Oren. 1991. Wild type p53 can down-modulate the activity of various promoters. Proc. Natl. Acad. Sci. USA 88:9979-9983.
    • (1991) Proc. Natl. Acad. Sci. USA , vol.88 , pp. 9979-9983
    • Ginsberg, D.1    Mechta, F.2    Yaniv, M.3    Oren, M.4
  • 15
    • 0030905284 scopus 로고    scopus 로고
    • Mdm2 promotes the rapid degradation of p53
    • Haupt, Y., R. Maya, A. Kazaz, and M. Oren. 1997. Mdm2 promotes the rapid degradation of p53. Nature 387:296-299.
    • (1997) Nature , vol.387 , pp. 296-299
    • Haupt, Y.1    Maya, R.2    Kazaz, A.3    Oren, M.4
  • 16
    • 0029092356 scopus 로고
    • Induction of apoptosis in HeLa cells by trans-activation deficient p53
    • Haupt, Y., S. Rowan, E. Shaulian, K. H. Vousden, and M. Oren. 1995. Induction of apoptosis in HeLa cells by trans-activation deficient p53. Genes Dev. 9:2170-2183.
    • (1995) Genes Dev. , vol.9 , pp. 2170-2183
    • Haupt, Y.1    Rowan, S.2    Shaulian, E.3    Vousden, K.H.4    Oren, M.5
  • 18
    • 0030768181 scopus 로고    scopus 로고
    • DNA-conformation is an important determinant of sequence-specific DNA binding by tumor suppressor p53
    • Kim, E., N. Albrechtsen, and W. Deppert. 1997. DNA-conformation is an important determinant of sequence-specific DNA binding by tumor suppressor p53. Oncogene 15:857-869.
    • (1997) Oncogene , vol.15 , pp. 857-869
    • Kim, E.1    Albrechtsen, N.2    Deppert, W.3
  • 20
    • 0029972806 scopus 로고    scopus 로고
    • p53: Puzzle and paradigm
    • Ko, L. J., and C. Prives. 1996. p53: puzzle and paradigm. Genes Dev. 10:1054-1072.
    • (1996) Genes Dev. , vol.10 , pp. 1054-1072
    • Ko, L.J.1    Prives, C.2
  • 21
    • 0030965946 scopus 로고    scopus 로고
    • Regulation of p53 stability by Mdm2
    • Kubbutat, M. H. G., S. N. Jones, and K. H. Vousden. 1997. Regulation of p53 stability by Mdm2. Nature 387:299-303.
    • (1997) Nature , vol.387 , pp. 299-303
    • Kubbutat, M.H.G.1    Jones, S.N.2    Vousden, K.H.3
  • 22
    • 0027316813 scopus 로고
    • An E2F-binding site mediates cell-cycle regulation repression of mouse B-myb transcription
    • Lam, E. W. F., and R. J. Waston. 1993. An E2F-binding site mediates cell-cycle regulation repression of mouse B-myb transcription. EMBO J. 12:2705-2713.
    • (1993) EMBO J. , vol.12 , pp. 2705-2713
    • Lam, E.W.F.1    Waston, R.J.2
  • 23
    • 0027109075 scopus 로고
    • p53, guardian of the genome
    • Lane, D. P. 1992. p53, guardian of the genome. Nature 358:15-16.
    • (1992) Nature , vol.358 , pp. 15-16
    • Lane, D.P.1
  • 24
    • 0030941458 scopus 로고    scopus 로고
    • p53, the cellular gatekeeper for growth and division
    • Levine, A. J. 1997. p53, the cellular gatekeeper for growth and division. Cell 88:323-331.
    • (1997) Cell , vol.88 , pp. 323-331
    • Levine, A.J.1
  • 25
    • 0027451668 scopus 로고
    • p53-dependent apoptosis modulates the cytotoxicity of anticancer agents
    • Lowe, S. W., H. E. Ruley, T. Jacks, and D. E. Housman. 1993. p53-dependent apoptosis modulates the cytotoxicity of anticancer agents. Cell 74:957-967.
    • (1993) Cell , vol.74 , pp. 957-967
    • Lowe, S.W.1    Ruley, H.E.2    Jacks, T.3    Housman, D.E.4
  • 26
    • 0029742781 scopus 로고    scopus 로고
    • Differential transcriptional activation of target celluar promotes by p 63 mutants with impaired apoptotic function
    • Ludwig, R. L., S. Bates, and K. H. Vousden. 1996. Differential transcriptional activation of target celluar promotes by p 63 mutants with impaired apoptotic function. Mol. Cell. Biol. 16:4952-4960.
    • (1996) Mol. Cell. Biol. , vol.16 , pp. 4952-4960
    • Ludwig, R.L.1    Bates, S.2    Vousden, K.H.3
  • 27
    • 0027318117 scopus 로고
    • Specific repression of TATA-mediated but not initiator-mediated transcription by wild-type p53
    • Mack, D. H., J. Vartikar, J. M. Pipas, and L. A. Laimins. 1993. Specific repression of TATA-mediated but not initiator-mediated transcription by wild-type p53. Nature 363:281-283.
    • (1993) Nature , vol.363 , pp. 281-283
    • Mack, D.H.1    Vartikar, J.2    Pipas, J.M.3    Laimins, L.A.4
  • 28
    • 0030938089 scopus 로고    scopus 로고
    • Bax-deficiency promotes drug resistance and oncogenic transformation by attenuating p53-dependent apoptosis
    • McCurrach, M. E., T. M. F. Connor, M. C. Knudson, S. J. Korsmeyer, and S. W. Lowe. 1997. bax-deficiency promotes drug resistance and oncogenic transformation by attenuating p53-dependent apoptosis. Proc. Natl. Acad. Sci. USA 94:2345-2349.
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 2345-2349
    • McCurrach, M.E.1    Connor, T.M.F.2    Knudson, M.C.3    Korsmeyer, S.J.4    Lowe, S.W.5
  • 29
    • 0028883179 scopus 로고
    • Tumor suppressor p53 is a direct transcriptional activator of the human bax gene
    • Miyashita, T., and J. C. Reed. 1995. Tumor suppressor p53 is a direct transcriptional activator of the human bax gene. Cell 80:293-299.
    • (1995) Cell , vol.80 , pp. 293-299
    • Miyashita, T.1    Reed, J.C.2
  • 30
    • 0026649648 scopus 로고
    • The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation
    • Momand, J., G. P. Zambetti, D. L. George, and A. J. Levine. 1992. The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation. Cell 69:1237-1245.
    • (1992) Cell , vol.69 , pp. 1237-1245
    • Momand, J.1    Zambetti, G.P.2    George, D.L.3    Levine, A.J.4
  • 31
    • 0029803281 scopus 로고    scopus 로고
    • Wild-type p53 negatively regulates the expression of a microtubule-associated protein
    • Murphy, M., A. Hinman, and A. J. Levine. 1996. Wild-type p53 negatively regulates the expression of a microtubule-associated protein. Genes Dev. 10:2971-2980.
    • (1996) Genes Dev. , vol.10 , pp. 2971-2980
    • Murphy, M.1    Hinman, A.2    Levine, A.J.3
  • 32
    • 0027994037 scopus 로고
    • Analysis of the most representative tumuor-derived p53 mutants reveals that changes in protein conformation are not correlated with loss of transactivation or inhibition of cell proliferation
    • Ory, K., Y. Legros, C. Auguin, and T. Soussi. 1994. Analysis of the most representative tumuor-derived p53 mutants reveals that changes in protein conformation are not correlated with loss of transactivation or inhibition of cell proliferation. EMBO J. 13:3496-3504.
    • (1994) EMBO J. , vol.13 , pp. 3496-3504
    • Ory, K.1    Legros, Y.2    Auguin, C.3    Soussi, T.4
  • 34
    • 0029811984 scopus 로고    scopus 로고
    • Genetic determinants of p53-induced apoptosis and growth arrest
    • Polyak, K., T. Waldman, T.-C., He, K. W. Kinzler, and B. Vogelstein. 1996. Genetic determinants of p53-induced apoptosis and growth arrest. Genes Dev. 10:1945-1952.
    • (1996) Genes Dev. , vol.10 , pp. 1945-1952
    • Polyak, K.1    Waldman, T.2    He, T.-C.3    Kinzler, K.W.4    Vogelstein, B.5
  • 35
    • 0030021748 scopus 로고    scopus 로고
    • Specific loss of apoptotic but not cell cycle arrest function in a human tumour derived p53 mutant
    • Rowan, S., R. L. Ludwig, Y. Haupt, S. Bates, X. Lu, M. Oren, and K. H. Vousden. 1996. Specific loss of apoptotic but not cell cycle arrest function in a human tumour derived p53 mutant. EMBO J. 15:827-838.
    • (1996) EMBO J. , vol.15 , pp. 827-838
    • Rowan, S.1    Ludwig, R.L.2    Haupt, Y.3    Bates, S.4    Lu, X.5    Oren, M.6    Vousden, K.H.7
  • 36
    • 0028847563 scopus 로고
    • Modulation of p53-mediated transcriptional repression and apoptosis by the adenovirus E1B 19K protein
    • Sabbatini, P., S.-K. Chiou, L. Rao, and E. White. 1995. Modulation of p53-mediated transcriptional repression and apoptosis by the adenovirus E1B 19K protein. Mol. Cell. Biol. 15:1060-1070.
    • (1995) Mol. Cell. Biol. , vol.15 , pp. 1060-1070
    • Sabbatini, P.1    Chiou, S.-K.2    Rao, L.3    White, E.4
  • 37
    • 0028575705 scopus 로고
    • Relief of p53-mediated transcriptional repression by the adenovirus E1B 19-kDa protein or the cellular bcl-2 protein
    • Shen, Y. Q., and T. Shenk. 1994. Relief of p53-mediated transcriptional repression by the adenovirus E1B 19-kDa protein or the cellular bcl-2 protein. Proc. Natl. Acad. Sci. USA 91:8940-8944.
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 8940-8944
    • Shen, Y.Q.1    Shenk, T.2
  • 38
    • 0026642078 scopus 로고
    • Inhibition of viral and cellular promoters by human wild-type p53
    • Subler, M. A., D. W. Martin, and S. Deb. 1992. Inhibition of viral and cellular promoters by human wild-type p53. J. Virol. 66:4757-4762.
    • (1992) J. Virol. , vol.66 , pp. 4757-4762
    • Subler, M.A.1    Martin, D.W.2    Deb, S.3
  • 40
    • 0022486539 scopus 로고
    • Identification of a protein-binding site that mediates transcriptional response of the c-fos gene to serum factors
    • Treisman, R. 1986. Identification of a protein-binding site that mediates transcriptional response of the c-fos gene to serum factors. Cell 46:567-574.
    • (1986) Cell , vol.46 , pp. 567-574
    • Treisman, R.1
  • 42
    • 0028849274 scopus 로고
    • p21 is necessary for the p53-mediated G1 arrest in human cancer cells
    • Waldman, T., K. W. Kinzler, and B. Vogelstein. 1995. p21 is necessary for the p53-mediated G1 arrest in human cancer cells. Cancer Res. 55:5187-5190.
    • (1995) Cancer Res. , vol.55 , pp. 5187-5190
    • Waldman, T.1    Kinzler, K.W.2    Vogelstein, B.3
  • 43
    • 0031038137 scopus 로고    scopus 로고
    • Bax suppresses tumorigenesis and stimulates apoptosis in vivo
    • Yin, C., C. M. Knudson, S. J. Korsmeyer, and T. Van Dyke. 1997. Bax suppresses tumorigenesis and stimulates apoptosis in vivo. Nature 385:637-640.
    • (1997) Nature , vol.385 , pp. 637-640
    • Yin, C.1    Knudson, C.M.2    Korsmeyer, S.J.3    Van Dyke, T.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.