On the reaction mechanism of tirapazamine reduction chemistry: Unimolecular N-OH homolysis, stepwise dehydration, or triazene ring-opening

Chemical Research in Toxicology

Volumn 25, Issue 3, 2012, Pages 634-645

  Yin, Jian ^a   Glaser, Rainer ^a   Gates, Kent S ^a,b  

^a UNIVERSITY OF MISSOURI   (United States)

^b University of Missouri   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANION; HYDROXYL GROUP; PHENYL GROUP; RADICAL; TIRAPAZAMINE; TRIAZENE DERIVATIVE; WATER;

ARTICLE; CHEMICAL BOND; DEHYDRATION; DENSITY FUNCTIONAL THEORY; ELECTRON; HYPOXIA; PROTON TRANSPORT; REACTION ANALYSIS; REDUCTION; REDUCTION KINETICS; RING OPENING;

ANTINEOPLASTIC AGENTS; DESICCATION; HYDROXYL RADICAL; NITROGEN; OXIDATION-REDUCTION; SPIN TRAPPING; TRIAZINES;

EID: 84858640779     PISSN: 0893228X     EISSN: 15205010     Source Type: Journal    
DOI: 10.1021/tx200546u     Document Type: Article

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