메뉴 건너뛰기




Volumn 73, Issue 11, 2007, Pages 1727-1737

Modulation of GSH levels in ABCC1 expressing tumor cells triggers apoptosis through oxidative stress

Author keywords

Apigenin; ATP binding cassette; Glutathione; l Buthionine (S,R) sulfoximine; Multidrug resistance; Reactive oxygen species

Indexed keywords

ABC TRANSPORTER A1; APIGENIN; BUTHIONINE SULFOXIMINE; GLUTATHIONE; VERAPAMIL;

EID: 34247149458     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2007.02.005     Document Type: Article
Times cited : (69)

References (51)
  • 1
    • 14644444547 scopus 로고    scopus 로고
    • ABC transporters in the balance: is there a role in multidrug resistance?
    • Polgar O., and Bates S.E. ABC transporters in the balance: is there a role in multidrug resistance?. Biochem Soc Trans 33 (2005) 241-245
    • (2005) Biochem Soc Trans , vol.33 , pp. 241-245
    • Polgar, O.1    Bates, S.E.2
  • 2
    • 0141888537 scopus 로고    scopus 로고
    • The role of ABC transporters in clinical practice
    • Leonard G.D., Fojo T., and Bates S.E. The role of ABC transporters in clinical practice. Oncologist 8 (2003) 411-424
    • (2003) Oncologist , vol.8 , pp. 411-424
    • Leonard, G.D.1    Fojo, T.2    Bates, S.E.3
  • 3
    • 0024996306 scopus 로고
    • Non-P-glycoprotein mediated mechanism for multidrug resistance precedes P-glycoprotein expression during in vitro selection for doxorubicin resistance in a human lung cancer cell line
    • Baas F., Jongsma A.P., Broxterman H.J., Arceci R.J., Housman D., Scheffer G.L., et al. Non-P-glycoprotein mediated mechanism for multidrug resistance precedes P-glycoprotein expression during in vitro selection for doxorubicin resistance in a human lung cancer cell line. Cancer Res 50 (1990) 5392-5398
    • (1990) Cancer Res , vol.50 , pp. 5392-5398
    • Baas, F.1    Jongsma, A.P.2    Broxterman, H.J.3    Arceci, R.J.4    Housman, D.5    Scheffer, G.L.6
  • 4
    • 0023278796 scopus 로고
    • Multidrug resistance in a human small cell lung cancer cell line selected in adriamycin
    • Mirski S.E., Gerlach J.H., and Cole S.P. Multidrug resistance in a human small cell lung cancer cell line selected in adriamycin. Cancer Res 47 (1987) 2594-2598
    • (1987) Cancer Res , vol.47 , pp. 2594-2598
    • Mirski, S.E.1    Gerlach, J.H.2    Cole, S.P.3
  • 5
    • 0023278073 scopus 로고
    • Adriamycin resistance in HL60 cells in the absence of detectable P-glycoprotein
    • McGrath T., and Center M.S. Adriamycin resistance in HL60 cells in the absence of detectable P-glycoprotein. Biochem Biophys Res Commun 145 (1987) 1171-1176
    • (1987) Biochem Biophys Res Commun , vol.145 , pp. 1171-1176
    • McGrath, T.1    Center, M.S.2
  • 6
    • 0027095653 scopus 로고
    • Overexpression of a transporter gene in a multidrug-resistant human lung cancer cell line
    • Cole S.P., Bhardwaj G., Gerlach J.H., Mackie J.E., Grant C.E., Almquist K.C., et al. Overexpression of a transporter gene in a multidrug-resistant human lung cancer cell line. Science 258 (1992) 1650-1654
    • (1992) Science , vol.258 , pp. 1650-1654
    • Cole, S.P.1    Bhardwaj, G.2    Gerlach, J.H.3    Mackie, J.E.4    Grant, C.E.5    Almquist, K.C.6
  • 8
    • 0032562616 scopus 로고    scopus 로고
    • Multidrug resistance protein. Identification of regions required for active transport of leukotriene C4
    • Gao M., Yamazaki M., Loe D.W., Westlake C.J., Grant C.E., Cole S.P., et al. Multidrug resistance protein. Identification of regions required for active transport of leukotriene C4. J Biol Chem 273 (1998) 10733-10740
    • (1998) J Biol Chem , vol.273 , pp. 10733-10740
    • Gao, M.1    Yamazaki, M.2    Loe, D.W.3    Westlake, C.J.4    Grant, C.E.5    Cole, S.P.6
  • 9
    • 0027960078 scopus 로고
    • Pharmacological characterization of multidrug resistant MRP-transfected human tumor cells
    • Cole S.P., Sparks K.E., Fraser K., Loe D.W., Grant C.E., Wilson G.M., et al. Pharmacological characterization of multidrug resistant MRP-transfected human tumor cells. Cancer Res 54 (1994) 5902-5910
    • (1994) Cancer Res , vol.54 , pp. 5902-5910
    • Cole, S.P.1    Sparks, K.E.2    Fraser, K.3    Loe, D.W.4    Grant, C.E.5    Wilson, G.M.6
  • 11
    • 0027984511 scopus 로고
    • The MRP gene encodes an ATP-dependent export pump for leukotriene C4 and structurally related conjugates
    • Leier I., Jedlitschky G., Buchholz U., Cole S.P., Deeley R.G., and Keppler D. The MRP gene encodes an ATP-dependent export pump for leukotriene C4 and structurally related conjugates. J Biol Chem 269 (1994) 27807-27810
    • (1994) J Biol Chem , vol.269 , pp. 27807-27810
    • Leier, I.1    Jedlitschky, G.2    Buchholz, U.3    Cole, S.P.4    Deeley, R.G.5    Keppler, D.6
  • 12
    • 0028578004 scopus 로고
    • Overexpression of the gene encoding the multidrug resistance-associated protein results in increased ATP-dependent glutathione S-conjugate transport
    • Muller M., Meijer C., Zaman G.J., Borst P., Scheper R.J., Mulder N.H., et al. Overexpression of the gene encoding the multidrug resistance-associated protein results in increased ATP-dependent glutathione S-conjugate transport. Proc Natl Acad Sci USA 91 (1994) 13033-13037
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 13033-13037
    • Muller, M.1    Meijer, C.2    Zaman, G.J.3    Borst, P.4    Scheper, R.J.5    Mulder, N.H.6
  • 13
    • 0029995238 scopus 로고    scopus 로고
    • Basolateral localization and export activity of the human multidrug resistance-associated protein in polarized pig kidney cells
    • Evers R., Zaman G.J., van Deemter L., Jansen H., Calafat J., Oomen L.C., et al. Basolateral localization and export activity of the human multidrug resistance-associated protein in polarized pig kidney cells. J Clin Invest 97 (1996) 1211-1218
    • (1996) J Clin Invest , vol.97 , pp. 1211-1218
    • Evers, R.1    Zaman, G.J.2    van Deemter, L.3    Jansen, H.4    Calafat, J.5    Oomen, L.C.6
  • 14
    • 0029918142 scopus 로고    scopus 로고
    • ATP-dependent 17 beta-estradiol 17-(beta-d-glucuronide) transport by multidrug resistance protein (MRP). Inhibition by cholestatic steroids
    • Loe D.W., Almquist K.C., Cole S.P., and Deeley R.G. ATP-dependent 17 beta-estradiol 17-(beta-d-glucuronide) transport by multidrug resistance protein (MRP). Inhibition by cholestatic steroids. J Biol Chem 271 (1996) 9683-9689
    • (1996) J Biol Chem , vol.271 , pp. 9683-9689
    • Loe, D.W.1    Almquist, K.C.2    Cole, S.P.3    Deeley, R.G.4
  • 15
    • 0025099593 scopus 로고
    • Alterations in glutathione and glutathione-related enzymes in a multidrug-resistant small cell lung cancer cell line
    • Cole S.P., Downes H.F., Mirski S.E., and Clements D.J. Alterations in glutathione and glutathione-related enzymes in a multidrug-resistant small cell lung cancer cell line. Mol Pharmacol 37 (1990) 192-197
    • (1990) Mol Pharmacol , vol.37 , pp. 192-197
    • Cole, S.P.1    Downes, H.F.2    Mirski, S.E.3    Clements, D.J.4
  • 16
    • 0029095763 scopus 로고
    • Role of glutathione in the export of compounds from cells by the multidrug-resistance-associated protein
    • Zaman G.J., Lankelma J., van Tellingen O., Beijnen J., Dekker H., Paulusma C., et al. Role of glutathione in the export of compounds from cells by the multidrug-resistance-associated protein. Proc Natl Acad Sci USA 92 (1995) 7690-7694
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 7690-7694
    • Zaman, G.J.1    Lankelma, J.2    van Tellingen, O.3    Beijnen, J.4    Dekker, H.5    Paulusma, C.6
  • 17
    • 0033104810 scopus 로고    scopus 로고
    • Canalicular multispecific organic anion transporter/multidrug resistance protein 2 mediates low-affinity transport of reduced glutathione
    • Paulusma C.C., van Geer M.A., Evers R., Heijn M., Ottenhoff R., Borst P., et al. Canalicular multispecific organic anion transporter/multidrug resistance protein 2 mediates low-affinity transport of reduced glutathione. Biochem J 338 Pt. 2 (1999) 393-401
    • (1999) Biochem J , vol.338 , Issue.PART 2 , pp. 393-401
    • Paulusma, C.C.1    van Geer, M.A.2    Evers, R.3    Heijn, M.4    Ottenhoff, R.5    Borst, P.6
  • 18
    • 0030678131 scopus 로고    scopus 로고
    • Evidence that the multidrug resistance protein (MRP) functions as a co-transporter of glutathione and natural product toxins
    • Rappa G., Lorico A., Flavell R.A., and Sartorelli A.C. Evidence that the multidrug resistance protein (MRP) functions as a co-transporter of glutathione and natural product toxins. Cancer Res 57 (1997) 5232-5237
    • (1997) Cancer Res , vol.57 , pp. 5232-5237
    • Rappa, G.1    Lorico, A.2    Flavell, R.A.3    Sartorelli, A.C.4
  • 19
    • 0035369997 scopus 로고    scopus 로고
    • Kinetics of glutathione and daunorubicin efflux from multidrug resistance protein overexpressing small-cell lung cancer cells
    • Salerno M., and Garnier-Suillerot A. Kinetics of glutathione and daunorubicin efflux from multidrug resistance protein overexpressing small-cell lung cancer cells. Eur J Pharmacol 421 (2001) 1-9
    • (2001) Eur J Pharmacol , vol.421 , pp. 1-9
    • Salerno, M.1    Garnier-Suillerot, A.2
  • 20
    • 17444419342 scopus 로고    scopus 로고
    • Molecular mechanisms of reduced glutathione transport: role of the MRP/CFTR/ABCC and OATP/SLC21A families of membrane proteins
    • Ballatori N., Hammond C.L., Cunningham J.B., Krance S.M., and Marchan R. Molecular mechanisms of reduced glutathione transport: role of the MRP/CFTR/ABCC and OATP/SLC21A families of membrane proteins. Toxicol Appl Pharmacol 204 (2005) 238-255
    • (2005) Toxicol Appl Pharmacol , vol.204 , pp. 238-255
    • Ballatori, N.1    Hammond, C.L.2    Cunningham, J.B.3    Krance, S.M.4    Marchan, R.5
  • 21
    • 0020444895 scopus 로고
    • Mechanism of action, metabolism, and toxicity of buthionine sulfoximine and its higher homologs, potent inhibitors of glutathione synthesis
    • Griffith O.W. Mechanism of action, metabolism, and toxicity of buthionine sulfoximine and its higher homologs, potent inhibitors of glutathione synthesis. J Biol Chem 257 (1982) 13704-13712
    • (1982) J Biol Chem , vol.257 , pp. 13704-13712
    • Griffith, O.W.1
  • 22
    • 0013016426 scopus 로고    scopus 로고
    • Bioflavonoid stimulation of glutathione transport by the 190-kDa multidrug resistance protein 1 (MRP1)
    • Leslie E.M., Deeley R.G., and Cole S.P. Bioflavonoid stimulation of glutathione transport by the 190-kDa multidrug resistance protein 1 (MRP1). Drug Metab Dispos 31 (2003) 11-15
    • (2003) Drug Metab Dispos , vol.31 , pp. 11-15
    • Leslie, E.M.1    Deeley, R.G.2    Cole, S.P.3
  • 23
    • 0035882764 scopus 로고    scopus 로고
    • Verapamil-stimulated glutathione transport by the multidrug resistance-associated protein (MRP1) in leukaemia cells
    • Cullen K.V., Davey R.A., and Davey M.W. Verapamil-stimulated glutathione transport by the multidrug resistance-associated protein (MRP1) in leukaemia cells. Biochem Pharmacol 62 (2001) 417-424
    • (2001) Biochem Pharmacol , vol.62 , pp. 417-424
    • Cullen, K.V.1    Davey, R.A.2    Davey, M.W.3
  • 25
    • 0026387907 scopus 로고
    • Glutathione metabolism and its role in hepatotoxicity
    • DeLeve L.D., and Kaplowitz N. Glutathione metabolism and its role in hepatotoxicity. Pharmacol Ther 52 (1991) 287-305
    • (1991) Pharmacol Ther , vol.52 , pp. 287-305
    • DeLeve, L.D.1    Kaplowitz, N.2
  • 26
    • 0033953170 scopus 로고    scopus 로고
    • GSH extrusion and the mitochondrial pathway of apoptotic signalling
    • Coppola S., and Ghibelli L. GSH extrusion and the mitochondrial pathway of apoptotic signalling. Biochem Soc Trans 28 (2000) 56-61
    • (2000) Biochem Soc Trans , vol.28 , pp. 56-61
    • Coppola, S.1    Ghibelli, L.2
  • 27
    • 0345583662 scopus 로고    scopus 로고
    • Overproduction of Cu/Zn-superoxide dismutase or Bcl-2 prevents the brain mitochondrial respiratory dysfunction induced by glutathione depletion
    • Merad-Saidoune M., Boitier E., Nicole A., Marsac C., Martinou J.C., Sola B., et al. Overproduction of Cu/Zn-superoxide dismutase or Bcl-2 prevents the brain mitochondrial respiratory dysfunction induced by glutathione depletion. Exp Neurol 158 (1999) 428-436
    • (1999) Exp Neurol , vol.158 , pp. 428-436
    • Merad-Saidoune, M.1    Boitier, E.2    Nicole, A.3    Marsac, C.4    Martinou, J.C.5    Sola, B.6
  • 28
    • 0023176822 scopus 로고
    • Chemical modification of charged amino acid moieties alters the electrophoretic mobilities of neurofilament subunits on SDS/polyacrylamide gels
    • Georges E., and Mushynski W.E. Chemical modification of charged amino acid moieties alters the electrophoretic mobilities of neurofilament subunits on SDS/polyacrylamide gels. Eur J Biochem 165 (1987) 281-287
    • (1987) Eur J Biochem , vol.165 , pp. 281-287
    • Georges, E.1    Mushynski, W.E.2
  • 29
    • 0018902461 scopus 로고
    • Use of glutaraldehyde as a coupling agent for proteins and peptides
    • Reichlin M. Use of glutaraldehyde as a coupling agent for proteins and peptides. Meth Enzymol 70 (1980) 159-165
    • (1980) Meth Enzymol , vol.70 , pp. 159-165
    • Reichlin, M.1
  • 30
    • 0014949207 scopus 로고
    • Cleavage of structural proteins during the assembly of the head of bacteriophage T4
    • Laemmli U.K. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227 (1970) 680-685
    • (1970) Nature , vol.227 , pp. 680-685
    • Laemmli, U.K.1
  • 31
    • 0009482260 scopus 로고
    • Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications
    • Towbin H., Staehelin T., and Gordon J. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. Proc Natl Acad Sci USA 76 (1979) 4350-4354
    • (1979) Proc Natl Acad Sci USA , vol.76 , pp. 4350-4354
    • Towbin, H.1    Staehelin, T.2    Gordon, J.3
  • 32
    • 0021061819 scopus 로고
    • Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays
    • Mosmann T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Meth 65 (1983) 55-63
    • (1983) J Immunol Meth , vol.65 , pp. 55-63
    • Mosmann, T.1
  • 34
    • 0037465764 scopus 로고    scopus 로고
    • Binding of a photoaffinity analogue of glutathione to MRP1 (ABCC1) within two cytoplasmic regions (L0 and L1) as well as transmembrane domains 10-11 and 16-17
    • Karwatsky J., Daoud R., Cai J., Gros P., and Georges E. Binding of a photoaffinity analogue of glutathione to MRP1 (ABCC1) within two cytoplasmic regions (L0 and L1) as well as transmembrane domains 10-11 and 16-17. Biochemistry 42 (2003) 3286-3294
    • (2003) Biochemistry , vol.42 , pp. 3286-3294
    • Karwatsky, J.1    Daoud, R.2    Cai, J.3    Gros, P.4    Georges, E.5
  • 35
    • 0028284288 scopus 로고
    • Characterization of rhodamine 123 binding to P-glycoprotein in human multidrug-resistant cells
    • Nare B., Prichard R.K., and Georges E. Characterization of rhodamine 123 binding to P-glycoprotein in human multidrug-resistant cells. Mol Pharmacol 45 (1994) 1145-1152
    • (1994) Mol Pharmacol , vol.45 , pp. 1145-1152
    • Nare, B.1    Prichard, R.K.2    Georges, E.3
  • 36
    • 0025940471 scopus 로고
    • Modulation of ATP and drug binding by monoclonal antibodies against P-glycoprotein
    • Georges E., Zhang J.T., and Ling V. Modulation of ATP and drug binding by monoclonal antibodies against P-glycoprotein. J Cell Physiol 148 (1991) 479-484
    • (1991) J Cell Physiol , vol.148 , pp. 479-484
    • Georges, E.1    Zhang, J.T.2    Ling, V.3
  • 37
    • 0015236352 scopus 로고
    • Electrophoretic analysis of the major polypeptides of the human erythrocyte membrane
    • Fairbanks G., Steck T.L., and Wallach D.F. Electrophoretic analysis of the major polypeptides of the human erythrocyte membrane. Biochemistry 10 (1971) 2606-2617
    • (1971) Biochemistry , vol.10 , pp. 2606-2617
    • Fairbanks, G.1    Steck, T.L.2    Wallach, D.F.3
  • 38
    • 0034806474 scopus 로고    scopus 로고
    • Identification of DNA-protein interactions in the 5′ flanking and 5′ untranslated regions of the human multidrug resistance protein (MRP1) gene: evaluation of a putative antioxidant response element/AP-1 binding site
    • Kurz E.U., Cole S.P., and Deeley R.G. Identification of DNA-protein interactions in the 5′ flanking and 5′ untranslated regions of the human multidrug resistance protein (MRP1) gene: evaluation of a putative antioxidant response element/AP-1 binding site. Biochem Biophys Res Commun 285 (2001) 981-990
    • (2001) Biochem Biophys Res Commun , vol.285 , pp. 981-990
    • Kurz, E.U.1    Cole, S.P.2    Deeley, R.G.3
  • 40
    • 17444419341 scopus 로고    scopus 로고
    • Role of glutathione transport processes in kidney function
    • Lash L.H. Role of glutathione transport processes in kidney function. Toxicol Appl Pharmacol 204 (2005) 329-342
    • (2005) Toxicol Appl Pharmacol , vol.204 , pp. 329-342
    • Lash, L.H.1
  • 41
    • 0034012019 scopus 로고    scopus 로고
    • Verapamil stimulates glutathione transport by the 190-kDa multidrug resistance protein 1 (MRP1)
    • Loe D.W., Deeley R.G., and Cole S.P. Verapamil stimulates glutathione transport by the 190-kDa multidrug resistance protein 1 (MRP1). J Pharmacol Exp Ther 293 (2000) 530-538
    • (2000) J Pharmacol Exp Ther , vol.293 , pp. 530-538
    • Loe, D.W.1    Deeley, R.G.2    Cole, S.P.3
  • 42
    • 0035033774 scopus 로고    scopus 로고
    • Modulation of multidrug resistance protein 1 (MRP1/ABCC1) transport and atpase activities by interaction with dietary flavonoids
    • Leslie E.M., Mao Q., Oleschuk C.J., Deeley R.G., and Cole S.P. Modulation of multidrug resistance protein 1 (MRP1/ABCC1) transport and atpase activities by interaction with dietary flavonoids. Mol Pharmacol 59 (2001) 1171-1180
    • (2001) Mol Pharmacol , vol.59 , pp. 1171-1180
    • Leslie, E.M.1    Mao, Q.2    Oleschuk, C.J.3    Deeley, R.G.4    Cole, S.P.5
  • 43
    • 31844455959 scopus 로고    scopus 로고
    • Substrate recognition and transport by multidrug resistance protein 1 (ABCC1)
    • Deeley R.G., and Cole S.P. Substrate recognition and transport by multidrug resistance protein 1 (ABCC1). FEBS Lett 580 (2006) 1103-1111
    • (2006) FEBS Lett , vol.580 , pp. 1103-1111
    • Deeley, R.G.1    Cole, S.P.2
  • 44
    • 0021228410 scopus 로고
    • New developments in glutathione metabolism and their potential application in therapy
    • Meister A. New developments in glutathione metabolism and their potential application in therapy. Hepatology 4 (1984) 739-742
    • (1984) Hepatology , vol.4 , pp. 739-742
    • Meister, A.1
  • 46
    • 0028157817 scopus 로고
    • Phase I clinical trial of intravenous l-buthionine sulfoximine and melphalan: an attempt at modulation of glutathione
    • Bailey H.H., Mulcahy R.T., Tutsch K.D., Arzoomanian R.Z., Alberti D., Tombes M.B., et al. Phase I clinical trial of intravenous l-buthionine sulfoximine and melphalan: an attempt at modulation of glutathione. J Clin Oncol 12 (1994) 194-205
    • (1994) J Clin Oncol , vol.12 , pp. 194-205
    • Bailey, H.H.1    Mulcahy, R.T.2    Tutsch, K.D.3    Arzoomanian, R.Z.4    Alberti, D.5    Tombes, M.B.6
  • 48
    • 0033565557 scopus 로고    scopus 로고
    • The mitochondrial permeability transition pore and its role in cell death
    • Crompton M. The mitochondrial permeability transition pore and its role in cell death. Biochem J 341 Pt. 2 (1999) 233-249
    • (1999) Biochem J , vol.341 , Issue.PART 2 , pp. 233-249
    • Crompton, M.1
  • 49
    • 0025732732 scopus 로고
    • Dose-dependent induction of apoptosis in human tumour cell lines by widely diverging stimuli
    • Lennon S.V., Martin S.J., and Cotter T.G. Dose-dependent induction of apoptosis in human tumour cell lines by widely diverging stimuli. Cell Prolif 24 (1991) 203-214
    • (1991) Cell Prolif , vol.24 , pp. 203-214
    • Lennon, S.V.1    Martin, S.J.2    Cotter, T.G.3
  • 50
    • 0037082357 scopus 로고    scopus 로고
    • Hypothesis: the mitochondrial NO(*) signaling pathway, and the transduction of nitrosative to oxidative cell signals: an alternative function for cytochrome C oxidase
    • Brookes P., and Darley-Usmar V.M. Hypothesis: the mitochondrial NO(*) signaling pathway, and the transduction of nitrosative to oxidative cell signals: an alternative function for cytochrome C oxidase. Free Radic Biol Med 32 (2002) 370-374
    • (2002) Free Radic Biol Med , vol.32 , pp. 370-374
    • Brookes, P.1    Darley-Usmar, V.M.2
  • 51
    • 0037105335 scopus 로고    scopus 로고
    • Mitochondria: regulators of signal transduction by reactive oxygen and nitrogen species
    • Brookes P.S., Levonen A.L., Shiva S., Sarti P., and Darley-Usmar V.M. Mitochondria: regulators of signal transduction by reactive oxygen and nitrogen species. Free Radic Biol Med 33 (2002) 755-764
    • (2002) Free Radic Biol Med , vol.33 , pp. 755-764
    • Brookes, P.S.1    Levonen, A.L.2    Shiva, S.3    Sarti, P.4    Darley-Usmar, V.M.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.