-
1
-
-
1242338758
-
Selective estrogen receptor modulators: Discrimination of agonistic versus antagonistic activities by gene expression profiling in breast cancer cells
-
Frasor J, Stossi F, Danes JM, Komm B, Lyttle CR, Katzenellenbogen BS. Selective estrogen receptor modulators: Discrimination of agonistic versus antagonistic activities by gene expression profiling in breast cancer cells. Cancer Res. 64(4), 1522-1533 (2004)
-
(2004)
Cancer Res.
, vol.64
, Issue.4
, pp. 1522-1533
-
-
Frasor, J.1
Stossi, F.2
Danes, J.M.3
Komm, B.4
Lyttle, C.R.5
Katzenellenbogen, B.S.6
-
2
-
-
0037441550
-
Membrane receptors for steroid hormones: Signal transduction and physiological significance
-
Nemere I, Pietras RJ, Blackmore PF. Membrane receptors for steroid hormones: Signal transduction and physiological significance. J. Cell. Biochem. 88(3), 438-445 (2003)
-
(2003)
J. Cell. Biochem.
, vol.88
, Issue.3
, pp. 438-445
-
-
Nemere, I.1
Pietras, R.J.2
Blackmore, P.F.3
-
3
-
-
15544379599
-
Estrogen-receptor biology: Continuing progress and therapeutic implications
-
Osborne CK, Schiff R. Estrogen-receptor biology: Continuing progress and therapeutic implications. J. Clin. Oncol. 23(8), 1616-1622 (2005
-
(2005)
J. Clin. Oncol.
, vol.23
, Issue.8
, pp. 1616-1622
-
-
Osborne, C.K.1
Schiff, R.2
-
4
-
-
33744943264
-
Signaling regulation of genomic and nongenomic functions of estrogen receptors
-
Acconcia F, Kumar R. Signaling regulation of genomic and nongenomic functions of estrogen receptors. Cancer Lett. 238(1), 1-14 (2006
-
(2006)
Cancer Lett.
, vol.238
, Issue.1
, pp. 1-14
-
-
Acconcia, F.1
Kumar, R.2
-
5
-
-
0035878743
-
Estrogen receptor interaction with estrogen response elements
-
Klinge CM. Estrogen receptor interaction with estrogen response elements. Nucleic Acids Res. 29(14), 2905-2919 (2001
-
(2001)
Nucleic Acids Res.
, vol.29
, Issue.14
, pp. 2905-2919
-
-
Klinge, C.M.1
-
7
-
-
15444368857
-
Mechanisms of estrogen receptor signaling: Convergence of genomic and nongenomic actions on target genes
-
Bjornstrom L, Sjoberg M. Mechanisms of estrogen receptor signaling: Convergence of genomic and nongenomic actions on target genes. Mol. Endocrinol. 19(4), 833-842 (2005
-
(2005)
Mol. Endocrinol.
, vol.19
, Issue.4
, pp. 833-842
-
-
Bjornstrom, L.1
Sjoberg, M.2
-
8
-
-
0028886694
-
Activation of the estrogen receptor through phosphorylation by mitogen-activated protein kinase
-
Kato S, Endoh H, Masuhiro Y et al. Activation of the estrogen receptor through phosphorylation by mitogen-activated protein kinase. Science 270(5241), 1491-1494 (1995
-
(1995)
Science
, vol.270
, Issue.5241
, pp. 1491-1494
-
-
Kato, S.1
Endoh, H.2
Masuhiro, Y.3
-
9
-
-
0037237481
-
Breast cancer endocrine resistance: How growth factor signaling and estrogen receptor coregulators modulate response
-
Schiff R, Massarweh S, Shou J, Osborne CK. Breast cancer endocrine resistance: How growth factor signaling and estrogen receptor coregulators modulate response. Clin. Cancer Res. 9(1 Pt 2), S447-S454 (2003
-
(2003)
Clin. Cancer Res.
, vol.9
, Issue.1 PART 2
-
-
Schiff, R.1
Massarweh, S.2
Shou, J.3
Osborne, C.K.4
-
10
-
-
9144256614
-
Cross-talk between estrogen receptor and growth factor pathways as a molecular target for overcoming endocrine resistance
-
Schiff R, Massarweh SA, Shou J, Bharwani L, Mohsin SK, Osborne CK. Cross-talk between estrogen receptor and growth factor pathways as a molecular target for overcoming endocrine resistance. Clin. Cancer Res. 10(1 Pt 2), 331S-336S (2004
-
(2004)
Clin. Cancer Res.
, vol.10
, Issue.1 PART 2
-
-
Schiff, R.1
Massarweh, S.A.2
Shou, J.3
Bharwani, L.4
Mohsin, S.K.5
Osborne, C.K.6
-
11
-
-
2942652871
-
Mechanisms of tamoxifen resistance: Increased estrogen receptor-HER2/neu cross-talk in ER/HER2-positive breast cancer
-
Shou J, Massarweh S, Osborne CK et al. Mechanisms of tamoxifen resistance: Increased estrogen receptor-HER2/neu cross-talk in ER/HER2-positive breast cancer. J. Natl Cancer Inst. 96(12), 926-935 (2004
-
(2004)
J. Natl Cancer Inst.
, vol.96
, Issue.12
, pp. 926-935
-
-
Shou, J.1
Massarweh, S.2
Osborne, C.K.3
-
12
-
-
18844373937
-
Transcriptional regulation by steroid receptor coactivator phosphorylation
-
Wu RC, Smith CL, O'Malley BW. Transcriptional regulation by steroid receptor coactivator phosphorylation. Endocr. Rev. 26(3), 393-399 (2005
-
(2005)
Endocr. Rev.
, vol.26
, Issue.3
, pp. 393-399
-
-
Wu, R.C.1
Smith, C.L.2
O'Malley, B.W.3
-
13
-
-
0029877913
-
Activation of the unliganded estrogen receptor by EGF involves the MAP kinase pathway and direct phosphorylation
-
Bunone G, Briand PA, Miksicek RJ, Picard D. Activation of the unliganded estrogen receptor by EGF involves the MAP kinase pathway and direct phosphorylation. EMBO J. 15(9), 2174-2183 (1996
-
(1996)
EMBO J.
, vol.15
, Issue.9
, pp. 2174-2183
-
-
Bunone, G.1
Briand, P.A.2
Miksicek, R.J.3
Picard, D.4
-
14
-
-
69249137029
-
Biological determinants of endocrine resistance in breast cancer
-
Musgrove EA, Sutherland RL. Biological determinants of endocrine resistance in breast cancer. Nat. Rev. Cancer 9(9), 631-643 (2009
-
(2009)
Nat. Rev. Cancer
, vol.9
, Issue.9
, pp. 631-643
-
-
Musgrove, E.A.1
Sutherland, R.L.2
-
15
-
-
79551576468
-
Mechanisms of endocrine resistance in breast cancer
-
Osborne CK, Schiff R. Mechanisms of endocrine resistance in breast cancer. Annu. Rev. Med. 62, 233-247 (2011
-
(2011)
Annu. Rev. Med.
, vol.62
, pp. 233-247
-
-
Osborne, C.K.1
Schiff, R.2
-
16
-
-
80054087160
-
ErbB family receptor inhibitors as therapeutic agents in breast cancer: Current status and future clinical perspective
-
doi:0.1002/med.20209 (Epub ahead of print
-
Saxena R, Dwivedi A. ErbB family receptor inhibitors as therapeutic agents in breast cancer: Current status and future clinical perspective. Med. Res. Rev. doi:0.1002/med.20209 (2010) (Epub ahead of print
-
(2010)
Med. Res. Rev.
-
-
Saxena, R.1
Dwivedi, A.2
-
17
-
-
0028955388
-
Epidermal growth factor-related peptides and their receptors in human malignancies
-
Salomon DS, Brandt R, Ciardiello F, Normanno N. Epidermal growth factor-related peptides and their receptors in human malignancies. Crit. Rev. Oncol. Hematol. 19(3), 183-232 (1995
-
(1995)
Crit. Rev. Oncol. Hematol.
, vol.19
, Issue.3
, pp. 183-232
-
-
Salomon, D.S.1
Brandt, R.2
Ciardiello, F.3
Normanno, N.4
-
18
-
-
77952338791
-
ErbB3/HER3 intracellular domain is competent to bind ATP and catalyze autophosphorylation
-
Shi F, Telesco SE, Liu Y, Radhakrishnan R, Lemmon MA. ErbB3/HER3 intracellular domain is competent to bind ATP and catalyze autophosphorylation. Proc. Natl Acad. Sci. USA 107(17), 7692-7697 (2010
-
(2010)
Proc. Natl Acad. Sci. USA
, vol.107
, Issue.17
, pp. 7692-7697
-
-
Shi, F.1
Telesco, S.E.2
Liu, Y.3
Radhakrishnan, R.4
Lemmon, M.A.5
-
19
-
-
0034600849
-
The ErbB signaling network: Receptor heterodimerization in development and cancer
-
Olayioye MA, Neve RM, Lane HA, Hynes NE. The ErbB signaling network: Receptor heterodimerization in development and cancer. EMBO J. 19(13), 3159-3167 (2000
-
(2000)
EMBO J.
, vol.19
, Issue.13
, pp. 3159-3167
-
-
Olayioye, M.A.1
Neve, R.M.2
Lane, H.A.3
Hynes, N.E.4
-
20
-
-
77951967101
-
Roles for growth factors in cancer progression
-
Witsch E, Sela M, Yarden Y. Roles for growth factors in cancer progression. Physiology (Bethesda) 25(2), 85-101 (2010
-
(2010)
Physiology (Bethesda
, vol.25
, Issue.2
, pp. 85-101
-
-
Witsch, E.1
Sela, M.2
Yarden, Y.3
-
21
-
-
48649092620
-
A central role for HER3 in HER2-amplified breast cancer: Implications for targeted therapy
-
Lee-Hoeflich ST, Crocker L, Yao E et al. A central role for HER3 in HER2-amplified breast cancer: Implications for targeted therapy. Cancer Res. 68(14), 5878-5887 (2008
-
(2008)
Cancer Res.
, vol.68
, Issue.14
, pp. 5878-5887
-
-
Lee-Hoeflich, S.T.1
Crocker, L.2
Yao, E.3
-
22
-
-
0037226817
-
Heregulin is sufficient for the promotion of tumorigenicity and metastasis of breast cancer cells in vivo
-
Atlas E, Cardillo M, Mehmi I, Zahedkargaran H, Tang C, Lupu R. Heregulin is sufficient for the promotion of tumorigenicity and metastasis of breast cancer cells in vivo. Mol. Cancer Res. 1(3), 165-175 (2003
-
(2003)
Mol. Cancer Res.
, vol.1
, Issue.3
, pp. 165-175
-
-
Atlas, E.1
Cardillo, M.2
Mehmi, I.3
Zahedkargaran, H.4
Tang, C.5
Lupu, R.6
-
23
-
-
77953435123
-
The ERalpha coactivator, HER4/4ICD, regulates progesterone receptor expression in normal and malignant breast epithelium
-
Rokicki J, Das PM, Giltnane JM et al. The ERalpha coactivator, HER4/4ICD, regulates progesterone receptor expression in normal and malignant breast epithelium. Mol. Cancer 9, 150 (2010
-
(2010)
Mol. Cancer
, vol.9
, Issue.150
-
-
Rokicki, J.1
Das, P.M.2
Giltnane, J.M.3
-
24
-
-
84862914692
-
Pertuzumab plus trastuzumab plus docetaxel for metastatic breast cancer
-
Baselga J, Cortes J, Kim SB et al. Pertuzumab plus trastuzumab plus docetaxel for metastatic breast cancer. N. Engl. J. Med. 366(2), 109-119 (2012
-
(2012)
N. Engl. J. Med.
, vol.366
, Issue.2
, pp. 109-119
-
-
Baselga, J.1
Cortes, J.2
Kim, S.B.3
-
25
-
-
77949884661
-
Randomized study of lapatinib alone or in combination with trastuzumab in women with ErbB2-positive, trastuzumab-refractory metastatic breast cancer
-
Blackwell KL, Burstein HJ, Storniolo AM et al. Randomized study of lapatinib alone or in combination with trastuzumab in women with ErbB2-positive, trastuzumab-refractory metastatic breast cancer. J. Clin. Oncol. 28(7), 1124-1130 (2010
-
(2010)
J. Clin. Oncol.
, vol.28
, Issue.7
, pp. 1124-1130
-
-
Blackwell, K.L.1
Burstein, H.J.2
Storniolo, A.M.3
-
26
-
-
0242721567
-
CI-1033, an irreversible pan-ErbB receptor inhibitor and its potential application for the treatment of breast cancer
-
Allen LF, Eiseman IA, Fry DW, Lenehan PF. CI-1033, an irreversible pan-ErbB receptor inhibitor and its potential application for the treatment of breast cancer. Semin. Oncol. 30(5 Suppl. 16), 65-78 (2003
-
(2003)
Semin. Oncol.
, vol.30
, Issue.5 SUPPL. 16
, pp. 65-78
-
-
Allen, L.F.1
Eiseman, I.A.2
Fry, D.W.3
Lenehan, P.F.4
-
27
-
-
0035168761
-
CI-1033, a pan-ErbB tyrosine kinase inhibitor
-
Slichenmyer WJ, Elliott WL, Fry DW. CI-1033, a pan-ErbB tyrosine kinase inhibitor. Semin. Oncol. 28(5 Suppl. 16), 80-85 (2001
-
(2001)
Semin. Oncol.
, vol.28
, Issue.5 SUPPL. 16
, pp. 80-85
-
-
Slichenmyer, W.J.1
Elliott, W.L.2
Fry, D.W.3
-
28
-
-
0034794636
-
Overexpression of HER-2 as a resistance mechanism to hormonal therapy for breast cancer
-
Dowsett M. Overexpression of HER-2 as a resistance mechanism to hormonal therapy for breast cancer. Endocr. Relat. Cancer 8(3), 191-195 (2001
-
(2001)
Endocr. Relat. Cancer
, vol.8
, Issue.3
, pp. 191-195
-
-
Dowsett, M.1
-
29
-
-
0034667395
-
Inhibition of HER2/neu (ErbB-2) and mitogen-activated protein kinases enhances tamoxifen action against HER2-overexpressing, tamoxifen-resistant breast cancer cells
-
Kurokawa H, Lenferink AE, Simpson JF et al. Inhibition of HER2/neu (ErbB-2) and mitogen-activated protein kinases enhances tamoxifen action against HER2-overexpressing, tamoxifen-resistant breast cancer cells. Cancer Res. 60(20), 5887-5894 (2000
-
(2000)
Cancer Res.
, vol.60
, Issue.20
, pp. 5887-5894
-
-
Kurokawa, H.1
Lenferink, A.E.2
Simpson, J.F.3
-
30
-
-
0028997307
-
HER-2 tyrosine kinase pathway targets estrogen receptor and promotes hormone-independent growth in human breast cancer cells
-
Pietras RJ, Arboleda J, Reese DM et al. HER-2 tyrosine kinase pathway targets estrogen receptor and promotes hormone-independent growth in human breast cancer cells. Oncogene 10(12), 2435-2446 (1995
-
(1995)
Oncogene
, vol.10
, Issue.12
, pp. 2435-2446
-
-
Pietras, R.J.1
Arboleda, J.2
Reese, D.M.3
-
31
-
-
0033651439
-
MEKK1 activation of human estrogen receptor alpha and stimulation of the agonistic activity of4-hydroxytamoxifen in endometrial and ovarian cancer cells
-
Lee H, Jiang F, Wang Q et al. MEKK1 activation of human estrogen receptor alpha and stimulation of the agonistic activity of4-hydroxytamoxifen in endometrial and ovarian cancer cells. Mol. Endocrinol. 14(11), 1882-1896 (2000
-
(2000)
Mol. Endocrinol.
, vol.14
, Issue.11
, pp. 1882-1896
-
-
Lee, H.1
Jiang, F.2
Wang, Q.3
-
32
-
-
34548014786
-
Activated AKT signaling pathway in invasive ductal carcinoma of the breast: Correlation with HER2 overexpression
-
Park SS, Kim SW. Activated AKT signaling pathway in invasive ductal carcinoma of the breast: Correlation with HER2 overexpression. Oncol. Rep. 18(1), 139-143 (2007
-
(2007)
Oncol. Rep.
, vol.18
, Issue.1
, pp. 139-143
-
-
Park, S.S.1
Kim, S.W.2
-
33
-
-
33746832533
-
Activation of PI3K/AKT signaling and hormone resistance in breast cancer
-
Tokunaga E, Kimura Y, Mashino K et al. Activation of PI3K/AKT signaling and hormone resistance in breast cancer. Breast Cancer 13(2), 137-144 (2006
-
(2006)
Breast Cancer
, vol.13
, Issue.2
, pp. 137-144
-
-
Tokunaga, E.1
Kimura, Y.2
Mashino, K.3
-
34
-
-
2942565669
-
Overcoming endocrine therapy resistance by signal transduction inhibition
-
Ellis M. Overcoming endocrine therapy resistance by signal transduction inhibition. Oncologist 9(Suppl. 3), 20-26 (2004
-
(2004)
Oncologist
, vol.9
, Issue.SUPPL. 3
, pp. 20-26
-
-
Ellis, M.1
-
35
-
-
33745988573
-
Estrogen-independent proliferation is present in estrogen-receptor HER2-positive primary breast cancer after neoadjuvant letrozole
-
Ellis MJ, Tao Y, Young O et al. Estrogen-independent proliferation is present in estrogen-receptor HER2-positive primary breast cancer after neoadjuvant letrozole. J. Clin. Oncol. 24(19), 3019-3025 (2006
-
(2006)
J. Clin. Oncol.
, vol.24
, Issue.19
, pp. 3019-3025
-
-
Ellis, M.J.1
Tao, Y.2
Young, O.3
-
36
-
-
33947510501
-
Five years of letrozole compared with tamoxifen as initial adjuvant therapy for postmenopausal women with endocrine-responsive early breast cancer: Update of study BIG 1-98
-
Coates AS, Keshaviah A, Thurlimann B et al. Five years of letrozole compared with tamoxifen as initial adjuvant therapy for postmenopausal women with endocrine-responsive early breast cancer: Update of study BIG 1-98. J. Clin. Oncol. 25(5), 486-492 (2007
-
(2007)
J. Clin. Oncol.
, vol.25
, Issue.5
, pp. 486-492
-
-
Coates, A.S.1
Keshaviah, A.2
Thurlimann, B.3
-
37
-
-
84856195419
-
Prognostic and predictive role of ESR1 status for postmenopausal patients with endocrine-responsive early breast cancer in the Danish cohort of the BIG 1-98 trial
-
Ejlertsen B, Aldridge J, Nielsen KV et al. Prognostic and predictive role of ESR1 status for postmenopausal patients with endocrine-responsive early breast cancer in the Danish cohort of the BIG 1-98 trial. Ann. Oncol. (2011
-
(2011)
Ann. Oncol.
-
-
Ejlertsen, B.1
Aldridge, J.2
Nielsen, K.V.3
-
38
-
-
73949105921
-
Trastuzumab plus anastrozole versus anastrozole alone for the treatment of postmenopausal women with human epidermal growth factor receptor 2-positive, hormone receptor-positive metastatic breast cancer. results from the randomized Phase III TAnDEM study
-
Kaufman B, Mackey JR, Clemens MR et al. Trastuzumab plus anastrozole versus anastrozole alone for the treatment of postmenopausal women with human epidermal growth factor receptor 2-positive, hormone receptor-positive metastatic breast cancer. results from the randomized Phase III TAnDEM study. J. Clin. Oncol. 27(33), 5529-5537 (2009
-
(2009)
J. Clin. Oncol.
, vol.27
, Issue.33
, pp. 5529-5537
-
-
Kaufman, B.1
Mackey, J.R.2
Clemens, M.R.3
-
39
-
-
33847147996
-
The combination of letrozole and trastuzumab as first or second-line biological therapy produces durable responses in a subset of HER2 positive and ER positive advanced breast cancers
-
Marcom PK, Isaacs C, Harris L et al. The combination of letrozole and trastuzumab as first or second-line biological therapy produces durable responses in a subset of HER2 positive and ER positive advanced breast cancers. Breast Cancer Res. Treat. 102(1), 43-49 (2007
-
(2007)
Breast Cancer Res. Treat.
, vol.102
, Issue.1
, pp. 43-49
-
-
Marcom, P.K.1
Isaacs, C.2
Harris, L.3
-
40
-
-
77649100030
-
Lapatinib plus letrozole as first-line therapy for HER-2+ hormone receptor-positive metastatic breast cancer
-
Schwartzberg LS, Franco SX, Florance A, O'Rourke L, Maltzman J, Johnston S. Lapatinib plus letrozole as first-line therapy for HER-2+ hormone receptor-positive metastatic breast cancer. Oncologist 15(2), 122-129 (2010
-
(2010)
Oncologist
, vol.15
, Issue.2
, pp. 122-129
-
-
Schwartzberg, L.S.1
Franco, S.X.2
Florance, A.3
O'Rourke, L.4
Maltzman, J.5
Johnston, S.6
-
41
-
-
17844398046
-
Molecular changes in tamoxifen-resistant breast cancer: Relationship between estrogen receptor, HER-2, and p38 mitogen-activated protein kinase
-
Gutierrez MC, Detre S, Johnston S et al. Molecular changes in tamoxifen-resistant breast cancer: Relationship between estrogen receptor, HER-2, and p38 mitogen-activated protein kinase. J. Clin. Oncol. 23(11), 2469-2476 (2005
-
(2005)
J. Clin. Oncol.
, vol.23
, Issue.11
, pp. 2469-2476
-
-
Gutierrez, M.C.1
Detre, S.2
Johnston, S.3
-
42
-
-
76949089720
-
Understanding resistance to endocrine agents: Molecular mechanisms and potential for intervention
-
Sabnis G, Brodie A. Understanding resistance to endocrine agents: Molecular mechanisms and potential for intervention. Clin. Breast Cancer 10(1), e6-e15 (2010
-
(2010)
Clin. Breast Cancer
, vol.10
, Issue.1
-
-
Sabnis, G.1
Brodie, A.2
-
43
-
-
57349113761
-
Regulation of ErbB2 by oestrogen receptor-PAX2 determines response to tamoxifen
-
Hurtado A, Holmes KA, Geistlinger TR et al. Regulation of ErbB2 by oestrogen receptor-PAX2 determines response to tamoxifen. Nature 456(7222), 663-666 (2008
-
(2008)
Nature
, vol.456
, Issue.7222
, pp. 663-666
-
-
Hurtado, A.1
Holmes, K.A.2
Geistlinger, T.R.3
-
44
-
-
58249105933
-
ErbB2 influences the subcellular localization of the estrogen receptor in tamoxifen-resistant MCF-7 cells leading to the activation of AKT and RPS6KA2
-
Pancholi S, Lykkesfeldt AE, Hilmi C et al. ErbB2 influences the subcellular localization of the estrogen receptor in tamoxifen-resistant MCF-7 cells leading to the activation of AKT and RPS6KA2. Endocr. Relat. Cancer 15(4), 985-1002 (2008
-
(2008)
Endocr. Relat. Cancer
, vol.15
, Issue.4
, pp. 985-1002
-
-
Pancholi, S.1
Lykkesfeldt, A.E.2
Hilmi, C.3
-
45
-
-
84858393716
-
Progression-free survival (PFS) of patients with HER2-negative, estrogen-receptor (ER)-low metastatic breast cancer (MBC) with the addition of lapatinib to letrozole. Biomarker results of EGF30008
-
Presented at: 45th Annual Meeting. Orlando, FL, USA, 29 May-2 June
-
Finn RS, Press M, Dring J et al. Progression-free survival (PFS) of patients with HER2-negative, estrogen-receptor (ER)-low metastatic breast cancer (MBC) with the addition of lapatinib to letrozole. Biomarker results of EGF30008. Presented at: American Society of Clinical Oncology (ASCO) 45th Annual Meeting. Orlando, FL, USA, 29 May-2 June 2009.
-
(2009)
American Society of Clinical Oncology (ASCO
-
-
Finn, R.S.1
Press, M.2
Dring, J.3
-
46
-
-
33645234316
-
Bidirectional cross talk between ERalpha and EGFR signalling pathways regulates tamoxifen-resistant growth
-
Britton DJ, Hutcheson IR, Knowlden JM et al. Bidirectional cross talk between ERalpha and EGFR signalling pathways regulates tamoxifen-resistant growth. Breast Cancer Res. Treat. 96(2), 131-146 (2006
-
(2006)
Breast Cancer Res. Treat.
, vol.96
, Issue.2
, pp. 131-146
-
-
Britton, D.J.1
Hutcheson, I.R.2
Knowlden, J.M.3
-
47
-
-
0037373326
-
Elevated levels of epidermal growth factor receptor/c-ErbB2 heterodimers mediate an autocrine growth regulatory pathway in tamoxifen-resistant MCF-7 cells
-
Knowlden JM, Hutcheson IR, Jones HE et al. Elevated levels of epidermal growth factor receptor/c-ErbB2 heterodimers mediate an autocrine growth regulatory pathway in tamoxifen-resistant MCF-7 cells. Endocrinology 144(3), 1032-1044 (2003
-
(2003)
Endocrinology
, vol.144
, Issue.3
, pp. 1032-1044
-
-
Knowlden, J.M.1
Hutcheson, I.R.2
Jones, H.E.3
-
48
-
-
0033765376
-
Role of MAP kinase in the enhanced cell proliferation of long term estrogen deprived human breast cancer cells
-
Jeng MH, Yue W, Eischeid A, Wang JP, Santen RJ. Role of MAP kinase in the enhanced cell proliferation of long term estrogen deprived human breast cancer cells. Breast Cancer Res. Treat. 62(3), 167-175 (2000
-
(2000)
Breast Cancer Res. Treat.
, vol.62
, Issue.3
, pp. 167-175
-
-
Jeng, M.H.1
Yue, W.2
Eischeid, A.3
Wang, J.P.4
Santen, R.J.5
-
49
-
-
29144494969
-
The anti-oestrogen ICI 182,780, but not tamoxifen, inhibits the growth of MCF-7 breast cancer cells refractory to long-term oestrogen deprivation through down-regulation of oestrogen receptor and IGF signalling
-
Martin LA, Pancholi S, Chan CM et al. The anti-oestrogen ICI 182,780, but not tamoxifen, inhibits the growth of MCF-7 breast cancer cells refractory to long-term oestrogen deprivation through down-regulation of oestrogen receptor and IGF signalling. Endocr. Relat. Cancer 12(4), 1017-1036 (2005
-
(2005)
Endocr. Relat. Cancer
, vol.12
, Issue.4
, pp. 1017-1036
-
-
Martin, L.A.1
Pancholi, S.2
Chan, C.M.3
-
50
-
-
38849091433
-
Tamoxifen resistance in breast tumors is driven by growth factor receptor signaling with repression of classic estrogen receptor genomic function
-
Massarweh S, Osborne CK, Creighton CJ et al. Tamoxifen resistance in breast tumors is driven by growth factor receptor signaling with repression of classic estrogen receptor genomic function. Cancer Res. 68(3), 826-833 (2008
-
(2008)
Cancer Res.
, vol.68
, Issue.3
, pp. 826-833
-
-
Massarweh, S.1
Osborne, C.K.2
Creighton, C.J.3
-
51
-
-
0034987631
-
Enhanced epidermal growth factor receptor signaling in MCF7 breast cancer cells after long-term culture in the presence of the pure antiestrogen ICI 182,780 (Faslodex
-
McClelland RA, Barrow D, Madden TA et al. Enhanced epidermal growth factor receptor signaling in MCF7 breast cancer cells after long-term culture in the presence of the pure antiestrogen ICI 182,780 (Faslodex). Endocrinology 142(7), 2776-2788 (2001
-
(2001)
Endocrinology
, vol.142
, Issue.7
, pp. 2776-2788
-
-
McClelland, R.A.1
Barrow, D.2
Madden, T.A.3
-
52
-
-
59449093537
-
Activation of ErbB3, EGFR and Erk is essential for growth of human breast cancer cell lines with acquired resistance to fulvestrant
-
Frogne T, Benjaminsen RV, Sonne-Hansen K et al. Activation of ErbB3, EGFR and Erk is essential for growth of human breast cancer cell lines with acquired resistance to fulvestrant. Breast Cancer Res. Treat. 114(2), 263-275 (2009
-
(2009)
Breast Cancer Res. Treat.
, vol.114
, Issue.2
, pp. 263-275
-
-
Frogne, T.1
Benjaminsen, R.V.2
Sonne-Hansen, K.3
-
53
-
-
17844398046
-
Molecular changes in tamoxifen-resistant breast cancer: Relationship between estrogen receptor, HER-2, and p38 mitogen-activated protein kinase
-
Gutierrez MC, Detre S, Johnston S et al. Molecular changes in tamoxifen-resistant breast cancer: Relationship between estrogen receptor, HER-2, and p38 mitogen-activated protein kinase. J. Clin. Oncol. 23(11), 2469-2476 (2005
-
(2005)
J. Clin. Oncol.
, vol.23
, Issue.11
, pp. 2469-2476
-
-
Gutierrez, M.C.1
Detre, S.2
Johnston, S.3
-
54
-
-
25844500946
-
Consensus statement. Workshop on therapeutic resistance in breast cancer: Impact of growth factor signalling pathways and implications for future treatment
-
Gee JM, Howell A, Gullick WJ et al. Consensus statement. Workshop on therapeutic resistance in breast cancer: Impact of growth factor signalling pathways and implications for future treatment. Endocr. Relat. Cancer 12(Suppl. 1), S1-S7 (2005
-
(2005)
Endocr. Relat. Cancer
, vol.12
, Issue.SUPPL. 1
-
-
Gee, J.M.1
Howell, A.2
Gullick, W.J.3
-
55
-
-
2942652871
-
Mechanisms of tamoxifen resistance: Increased estrogen receptor-HER2/neu cross-talk in ER/HER2-positive breast cancer
-
Shou J, Massarweh S, Osborne CK et al. Mechanisms of tamoxifen resistance: Increased estrogen receptor-HER2/neu cross-talk in ER/HER2-positive breast cancer. J. Natl Cancer Inst. 96(12), 926-935 (2004
-
(2004)
J. Natl Cancer Inst.
, vol.96
, Issue.12
, pp. 926-935
-
-
Shou, J.1
Massarweh, S.2
Osborne, C.K.3
-
56
-
-
0242721012
-
The antiepidermal growth factor receptor agent gefitinib (ZD1839/Iressa) improves antihormone response and prevents development of resistance in breast cancer in vitro
-
Gee JM, Harper ME, Hutcheson IR et al. The antiepidermal growth factor receptor agent gefitinib (ZD1839/Iressa) improves antihormone response and prevents development of resistance in breast cancer in vitro. Endocrinology 144(11), 5105-5117 (2003
-
(2003)
Endocrinology
, vol.144
, Issue.11
, pp. 5105-5117
-
-
Gee, J.M.1
Harper, M.E.2
Hutcheson, I.R.3
-
57
-
-
4444278403
-
HER-2 amplification, HER-1 expression, and tamoxifen response in estrogen receptor-positive metastatic breast cancer: A Southwest Oncology Group study
-
Arpino G, Green SJ, Allred DC et al. HER-2 amplification, HER-1 expression, and tamoxifen response in estrogen receptor-positive metastatic breast cancer: A Southwest Oncology Group study. Clin. Cancer Res. 10(17), 5670-5676 (2004
-
(2004)
Clin. Cancer Res.
, vol.10
, Issue.17
, pp. 5670-5676
-
-
Arpino, G.1
Green, S.J.2
Allred, D.C.3
-
58
-
-
77949882440
-
The effects of gefitinib in tamoxifen-resistant and hormone-insensitive breast cancer: A Phase II study
-
Gutteridge E, Agrawal A, Nicholson R, Leung Cheung K, Robertson J, Gee J. The effects of gefitinib in tamoxifen-resistant and hormone-insensitive breast cancer: A Phase II study. Int. J. Cancer 126(8), 1806-1816 (2010
-
(2010)
Int. J. Cancer
, vol.126
, Issue.8
, pp. 1806-1816
-
-
Gutteridge, E.1
Agrawal, A.2
Nicholson, R.3
Leung Cheung, K.4
Robertson, J.5
Gee, J.6
-
59
-
-
79952259688
-
Gefitinib or placebo in combination with tamoxifen in patients with hormone receptor-positive metastatic breast cancer: A randomized Phase II study
-
Osborne CK, Neven P, Dirix LY et al. Gefitinib or placebo in combination with tamoxifen in patients with hormone receptor-positive metastatic breast cancer: A randomized Phase II study. Clin. Cancer Res. 17(5), 1147-1159 (2011
-
(2011)
Clin. Cancer Res.
, vol.17
, Issue.5
, pp. 1147-1159
-
-
Osborne, C.K.1
Neven, P.2
Dirix, L.Y.3
-
60
-
-
77949754385
-
Phase II, randomized trial to compare anastrozole combined with gefitinib or placebo in postmenopausal women with hormone receptor-positive metastatic breast cancer
-
Cristofanilli M, Valero V, Mangalik A et al. Phase II, randomized trial to compare anastrozole combined with gefitinib or placebo in postmenopausal women with hormone receptor-positive metastatic breast cancer. Clin. Cancer Res. 16(6), 1904-1914 (2010
-
(2010)
Clin. Cancer Res.
, vol.16
, Issue.6
, pp. 1904-1914
-
-
Cristofanilli, M.1
Valero, V.2
Mangalik, A.3
-
61
-
-
19944408390
-
Preoperative gefitinib versus gefitinib and anastrozole in postmenopausal patients with oestrogen-receptor positive and epidermal-growth-factor-receptor- positive primary breast cancer: A double-blind placebo-controlled Phase II randomised trial
-
Polychronis A, Sinnett HD, Hadjiminas D et al. Preoperative gefitinib versus gefitinib and anastrozole in postmenopausal patients with oestrogen-receptor positive and epidermal-growth-factor-receptor-positive primary breast cancer: A double-blind placebo-controlled Phase II randomised trial. Lancet Oncol. 6(6), 383-391 (2005
-
(2005)
Lancet Oncol.
, vol.6
, Issue.6
, pp. 383-391
-
-
Polychronis, A.1
Sinnett, H.D.2
Hadjiminas, D.3
-
62
-
-
34548537574
-
A Phase II placebo-controlled trial of neoadjuvant anastrozole alone or with gefitinib in early breast cancer
-
Smith IE, Walsh G, Skene A et al. A Phase II placebo-controlled trial of neoadjuvant anastrozole alone or with gefitinib in early breast cancer. J. Clin. Oncol. 25(25), 3816-3822 (2007
-
(2007)
J. Clin. Oncol.
, vol.25
, Issue.25
, pp. 3816-3822
-
-
Smith, I.E.1
Walsh, G.2
Skene, A.3
-
63
-
-
39749085432
-
Short preoperative treatment with erlotinib inhibits tumor cell proliferation in hormone receptor-positive breast cancers
-
Guix M, Granja Nde M, Meszoely I et al. Short preoperative treatment with erlotinib inhibits tumor cell proliferation in hormone receptor-positive breast cancers. J. Clin. Oncol. 26(6), 897-906 (2008
-
(2008)
J. Clin. Oncol.
, vol.26
, Issue.6
, pp. 897-906
-
-
Guix, M.1
Granja Nde, M.2
Meszoely, I.3
-
64
-
-
39749130639
-
Of mice and (wo)men: Is this any way to test a new drug?
-
Haddad TC, Yee D. Of mice and (wo)men: Is this any way to test a new drug? J. Clin. Oncol. 26(6), 830-832 (2008
-
(2008)
J. Clin. Oncol.
, vol.26
, Issue.6
, pp. 830-832
-
-
Haddad, T.C.1
Yee, D.2
-
65
-
-
77349114891
-
The role of MAP kinases and MAP kinase phosphatase-1 in resistance to breast cancer treatment
-
Haagenson KK, Wu GS. The role of MAP kinases and MAP kinase phosphatase-1 in resistance to breast cancer treatment. Cancer Metastasis Rev. 29(1), 143-149 (2010
-
(2010)
Cancer Metastasis Rev.
, vol.29
, Issue.1
, pp. 143-149
-
-
Haagenson, K.K.1
Wu, G.S.2
-
66
-
-
77954216113
-
Targeting the MAPK pathway in melanoma: Why some approaches succeed and others fail
-
Inamdar GS, Madhunapantula SV, Robertson GP. Targeting the MAPK pathway in melanoma: Why some approaches succeed and others fail. Biochem. Pharmacol. 80(5), 624-637 (2010
-
(2010)
Biochem. Pharmacol.
, vol.80
, Issue.5
, pp. 624-637
-
-
Inamdar, G.S.1
Madhunapantula, S.V.2
Robertson, G.P.3
-
67
-
-
4644252581
-
Selective phosphorylations of the SRC-3/AIB1 coactivator integrate genomic reponses to multiple cellular signaling pathways
-
Wu RC, Qin J, Yi P et al. Selective phosphorylations of the SRC-3/AIB1 coactivator integrate genomic reponses to multiple cellular signaling pathways. Mol. Cell 15(6), 937-949 (2004
-
(2004)
Mol. Cell
, vol.15
, Issue.6
, pp. 937-949
-
-
Wu, R.C.1
Qin, J.2
Yi, P.3
-
68
-
-
0001392322
-
AIB1 is a conduit for kinase-mediated growth factor signaling to the estrogen receptor
-
Font De Mora J, Brown M. AIB1 is a conduit for kinase-mediated growth factor signaling to the estrogen receptor. Mol. Cell. Biol. 20(14), 5041-5047 (2000
-
(2000)
Mol. Cell. Biol.
, vol.20
, Issue.14
, pp. 5041-5047
-
-
Font De Mora, J.1
Brown, M.2
-
69
-
-
0037205048
-
The phosphoinositide 3-kinase pathway
-
Cantley LC. The phosphoinositide 3-kinase pathway. Science 296(5573), 1655-1657 (2002
-
(2002)
Science
, vol.296
, Issue.5573
, pp. 1655-1657
-
-
Cantley, L.C.1
-
70
-
-
13844312400
-
Phosphorylation and regulation of AKT/PKB by the rictor-mTOR complex
-
Sarbassov DD, Guertin DA, Ali SM, Sabatini DM. Phosphorylation and regulation of AKT/PKB by the rictor-mTOR complex. Science 307(5712), 1098-1101 (2005
-
(2005)
Science
, vol.307
, Issue.5712
, pp. 1098-1101
-
-
Sarbassov, D.D.1
Guertin, D.A.2
Ali, S.M.3
Sabatini, D.M.4
-
71
-
-
1542328927
-
Structure, regulation and function of PKB/AKT - A major therapeutic target
-
Hanada M, Feng J, Hemmings BA. Structure, regulation and function of PKB/AKT - a major therapeutic target. Biochim. Biophys. Acta 1697(1-2), 3-16 (2004
-
(2004)
Biochim. Biophys. Acta
, vol.1697
, Issue.1-2
, pp. 3-16
-
-
Hanada, M.1
Feng, J.2
Hemmings, B.A.3
-
72
-
-
77956329400
-
Potential role of PI3K inhibitors in the treatment of breast cancer
-
Carvalho S, Schmitt F. Potential role of PI3K inhibitors in the treatment of breast cancer. Future Oncol. 6(8), 1251-1263 (2010
-
(2010)
Future Oncol.
, vol.6
, Issue.8
, pp. 1251-1263
-
-
Carvalho, S.1
Schmitt, F.2
-
73
-
-
0036632368
-
The phosphatidylinositol 3-kinase AKT pathway in human cancer
-
Vivanco I, Sawyers CL. The phosphatidylinositol 3-kinase AKT pathway in human cancer. Nat. Rev. Cancer 2(7), 489-501 (2002
-
(2002)
Nat. Rev. Cancer
, vol.2
, Issue.7
, pp. 489-501
-
-
Vivanco, I.1
Sawyers, C.L.2
-
74
-
-
40549113364
-
PIK3CA exon 20 mutation is independently associated with a poor prognosis in breast cancer patients
-
Lai YL, Mau BL, Cheng WH, Chen HM, Chiu HH, Tzen CY. PIK3CA exon 20 mutation is independently associated with a poor prognosis in breast cancer patients. Ann. Surg. Oncol. 15(4), 1064-1069 (2008
-
(2008)
Ann. Surg. Oncol.
, vol.15
, Issue.4
, pp. 1064-1069
-
-
Lai, Y.L.1
Mau, B.L.2
Cheng, W.H.3
Chen, H.M.4
Chiu, H.H.5
Tzen, C.Y.6
-
75
-
-
49349091955
-
Exon 20 PIK3CA mutations decreases survival in aggressive (HER-2 positive) breast carcinomas
-
Lerma E, Catasus L, Gallardo A et al. Exon 20 PIK3CA mutations decreases survival in aggressive (HER-2 positive) breast carcinomas. Virchows Arch. 453(2), 133-139 (2008
-
(2008)
Virchows Arch.
, vol.453
, Issue.2
, pp. 133-139
-
-
Lerma, E.1
Catasus, L.2
Gallardo, A.3
-
76
-
-
33846854921
-
Clinicopathologic analysis of breast cancers with PIK3CA mutations in Japanese women
-
Maruyama N, Miyoshi Y, Taguchi T, Tamaki Y, Monden M, Noguchi S. Clinicopathologic analysis of breast cancers with PIK3CA mutations in Japanese women. Clin. Cancer Res. 13(2 Pt 1), 408-414 (2007
-
(2007)
Clin. Cancer Res.
, vol.13
, Issue.2 PART 1
, pp. 408-414
-
-
Maruyama, N.1
Miyoshi, Y.2
Taguchi, T.3
Tamaki, Y.4
Monden, M.5
Noguchi, S.6
-
77
-
-
34250749822
-
PIK3CA mutations and PTEN loss correlate with similar prognostic factors and are not mutually exclusive in breast cancer
-
Perez-Tenorio G, Alkhori L, Olsson B et al. PIK3CA mutations and PTEN loss correlate with similar prognostic factors and are not mutually exclusive in breast cancer. Clin. Cancer Res. 13(12), 3577-3584 (2007
-
(2007)
Clin. Cancer Res.
, vol.13
, Issue.12
, pp. 3577-3584
-
-
Perez-Tenorio, G.1
Alkhori, L.2
Olsson, B.3
-
78
-
-
44349170604
-
Insights into the oncogenic effects of PIK3CA mutations from the structure of p110alpha/p85alpha
-
Huang CH, Mandelker D, Gabelli SB, Amzel LM. Insights into the oncogenic effects of PIK3CA mutations from the structure of p110alpha/p85alpha. Cell Cycle 7(9), 1151-1156 (2008
-
(2008)
Cell Cycle
, vol.7
, Issue.9
, pp. 1151-1156
-
-
Huang, C.H.1
Mandelker, D.2
Gabelli, S.B.3
Amzel, L.M.4
-
79
-
-
37249056471
-
The structure of a human p110alpha/p85alpha complex elucidates the effects of oncogenic PI3Kalpha mutations
-
Huang CH, Mandelker D, Schmidt-Kittler O et al. The structure of a human p110alpha/p85alpha complex elucidates the effects of oncogenic PI3Kalpha mutations. Science 318(5857), 1744-1748 (2007
-
(2007)
Science
, vol.318
, Issue.5857
, pp. 1744-1748
-
-
Huang, C.H.1
Mandelker, D.2
Schmidt-Kittler, O.3
-
80
-
-
70350126139
-
A frequent kinase domain mutation that changes the interaction between PI3Kalpha and the membrane
-
Mandelker D, Gabelli SB, Schmidt-Kittler O et al. A frequent kinase domain mutation that changes the interaction between PI3Kalpha and the membrane. Proc. Natl Acad. Sci. USA 106(40), 16996-17001 (2009
-
(2009)
Proc. Natl Acad. Sci. USA
, vol.106
, Issue.40
, pp. 16996-17001
-
-
Mandelker, D.1
Gabelli, S.B.2
Schmidt-Kittler, O.3
-
81
-
-
34447503808
-
Mechanism of two classes of cancer mutations in the phosphoinositide 3-kinase catalytic subunit
-
Miled N, Yan Y, Hon WC et al. Mechanism of two classes of cancer mutations in the phosphoinositide 3-kinase catalytic subunit. Science 317(5835), 239-242 (2007
-
(2007)
Science
, vol.317
, Issue.5835
, pp. 239-242
-
-
Miled, N.1
Yan, Y.2
Hon, W.C.3
-
82
-
-
74849112055
-
Phosphatidyl-inositol-3-kinase alpha catalytic subunit mutation and response to neoadjuvant endocrine therapy for estrogen receptor positive breast cancer
-
Ellis MJ, Lin L, Crowder R et al. Phosphatidyl-inositol-3-kinase alpha catalytic subunit mutation and response to neoadjuvant endocrine therapy for estrogen receptor positive breast cancer. Breast Cancer Res. Treat. 119(2), 379-390 (2010
-
(2010)
Breast Cancer Res. Treat.
, vol.119
, Issue.2
, pp. 379-390
-
-
Ellis, M.J.1
Lin, L.2
Crowder, R.3
-
83
-
-
34547172596
-
A transforming mutation in the pleckstrin homology domain of AKT1 in cancer
-
Carpten JD, Faber AL, Horn C et al. A transforming mutation in the pleckstrin homology domain of AKT1 in cancer. Nature 448(7152), 439-444 (2007
-
(2007)
Nature
, vol.448
, Issue.7152
, pp. 439-444
-
-
Carpten, J.D.1
Faber, A.L.2
Horn, C.3
-
84
-
-
65949110376
-
PIK3CA and PIK3CB inhibition produce synthetic lethality when combined with estrogen deprivation in estrogen receptor-positive breast cancer
-
Crowder RJ, Phommaly C, Tao Y et al. PIK3CA and PIK3CB inhibition produce synthetic lethality when combined with estrogen deprivation in estrogen receptor-positive breast cancer. Cancer Res. 69(9), 3955-3962 (2009
-
(2009)
Cancer Res.
, vol.69
, Issue.9
, pp. 3955-3962
-
-
Crowder, R.J.1
Phommaly, C.2
Tao, Y.3
-
85
-
-
27544515272
-
Somatic mutation and gain of copy number of PIK3CA in human breast cancer
-
Wu G, Xing M, Mambo E et al. Somatic mutation and gain of copy number of PIK3CA in human breast cancer. Breast Cancer Res. 7(5), R609-R616 (2005
-
(2005)
Breast Cancer Res.
, vol.7
, Issue.5
-
-
Wu, G.1
Xing, M.2
Mambo, E.3
-
86
-
-
0032506011
-
The lipid phosphatase activity of PTEN is critical for its tumor supressor function
-
Myers MP, Pass I, Batty IH et al. The lipid phosphatase activity of PTEN is critical for its tumor supressor function. Proc. Natl Acad. Sci. USA 95(23), 13513-13518 (1998
-
(1998)
Proc. Natl Acad. Sci. USA
, vol.95
, Issue.23
, pp. 13513-13518
-
-
Myers, M.P.1
Pass, I.2
Batty, I.H.3
-
87
-
-
84860390340
-
Preclinical modeling of combined phosphatidylinositol-3-kinase inhibition with endocrine therapy for estrogen receptor-positive breast cancer
-
Sanchez CG, Ma CX, Crowder RJ et al. Preclinical modeling of combined phosphatidylinositol-3-kinase inhibition with endocrine therapy for estrogen receptor-positive breast cancer. Breast Cancer Res. 13(2), R21 (2011
-
(2011)
Breast Cancer Res.
, vol.13
, Issue.2
-
-
Sanchez, C.G.1
Ma, C.X.2
Crowder, R.J.3
-
88
-
-
18244391514
-
Activation of AKT/PKB in breast cancer predicts a worse outcome among endocrine treated patients
-
Perez-Tenorio G, Stal O. Activation of AKT/PKB in breast cancer predicts a worse outcome among endocrine treated patients. Br. J. Cancer 86(4), 540-545 (2002
-
(2002)
Br. J. Cancer
, vol.86
, Issue.4
, pp. 540-545
-
-
Perez-Tenorio, G.1
Stal, O.2
-
89
-
-
0038700565
-
AKT kinases in breast cancer and the results of adjuvant therapy
-
Stal O, Perez-Tenorio G, Akerberg L et al. AKT kinases in breast cancer and the results of adjuvant therapy. Breast Cancer Res. 5(2), R37-R44 (2003
-
(2003)
Breast Cancer Res.
, vol.5
, Issue.2
-
-
Stal, O.1
Perez-Tenorio, G.2
Akerberg, L.3
-
90
-
-
33644755478
-
The association between AKT activation and resistance to hormone therapy in metastatic breast cancer
-
Tokunaga E, Kataoka A, Kimura Y et al. The association between AKT activation and resistance to hormone therapy in metastatic breast cancer. Eur. J. Cancer 42(5), 629-635 (2006
-
(2006)
Eur. J. Cancer
, vol.42
, Issue.5
, pp. 629-635
-
-
Tokunaga, E.1
Kataoka, A.2
Kimura, Y.3
-
91
-
-
6944238452
-
Reduced PTEN expression in breast cancer cells confers susceptibility to inhibitors of the PI3 kinase/AKT pathway
-
Degraffenried LA, Fulcher L, Friedrichs WE, Grunwald V, Ray RB, Hidalgo M. Reduced PTEN expression in breast cancer cells confers susceptibility to inhibitors of the PI3 kinase/AKT pathway. Ann. Oncol. 15(10), 1510-1516 (2004
-
(2004)
Ann. Oncol.
, vol.15
, Issue.10
, pp. 1510-1516
-
-
Degraffenried, L.A.1
Fulcher, L.2
Friedrichs, W.E.3
Grunwald, V.4
Ray, R.B.5
Hidalgo, M.6
-
92
-
-
77954974573
-
Hyperactivation of phosphatidylinositol-3 kinase promotes escape from hormone dependence in estrogen receptor-positive human breast cancer
-
Miller TW, Hennessy BT, Gonzalez-Angulo AM et al. Hyperactivation of phosphatidylinositol-3 kinase promotes escape from hormone dependence in estrogen receptor-positive human breast cancer. J. Clin. Invest. 120(7), 2406-2413 (2010
-
(2010)
J. Clin. Invest.
, vol.120
, Issue.7
, pp. 2406-2413
-
-
Miller, T.W.1
Hennessy, B.T.2
Gonzalez-Angulo, A.M.3
-
93
-
-
54949142523
-
MTOR inhibition reverses acquired endocrine therapy resistance of breast cancer cells at the cell proliferation and gene-expression levels
-
Ghayad SE, Bieche I, Vendrell JA et al. mTOR inhibition reverses acquired endocrine therapy resistance of breast cancer cells at the cell proliferation and gene-expression levels. Cancer Sci. 99(10), 1992-2003 (2008
-
(2008)
Cancer Sci.
, vol.99
, Issue.10
, pp. 1992-2003
-
-
Ghayad, S.E.1
Bieche, I.2
Vendrell, J.A.3
-
94
-
-
84863078767
-
Everolimus in postmenopausal hormone-receptor-positive advanced breast cancer
-
Baselga J, Campone M, Piccart M et al. Everolimus in postmenopausal hormone-receptor-positive advanced breast cancer. N. Engl. J. Med. 366(6), 520-529 (2012
-
(2012)
N. Engl. J. Med.
, vol.366
, Issue.6
, pp. 520-529
-
-
Baselga, J.1
Campone, M.2
Piccart, M.3
-
95
-
-
79951814007
-
TAMRAD: A GINECO randomized Phase II trial of everolimus in combination with tamoxifen versus tamoxifen alone in patients (pts) with hormone-receptor positive, HER2 negative metastatic breast cancer (MBC) with prior exposure to aromatase inhibitors (AI
-
Presented at:. San Antonio, TX, USA, 8-12 December 2010
-
Bachelot T, Bourgier C, Cropet C et al. TAMRAD: A GINECO randomized Phase II trial of everolimus in combination with tamoxifen versus tamoxifen alone in patients (pts) with hormone-receptor positive, HER2 negative metastatic breast cancer (MBC) with prior exposure to aromatase inhibitors (AI). Presented at: 33rd Annual San Antonio Breast Cancer Symposium. San Antonio, TX, USA, 8-12 December 2010.
-
33rd Annual San Antonio Breast Cancer Symposium
-
-
Bachelot, T.1
Bourgier, C.2
Cropet, C.3
-
96
-
-
66849136781
-
Phase II randomized study of neoadjuvant everolimus plus letrozole compared with placebo plus letrozole in patients with estrogen receptor-positive breast cancer
-
Baselga J, Semiglazov V, Van Dam P et al. Phase II randomized study of neoadjuvant everolimus plus letrozole compared with placebo plus letrozole in patients with estrogen receptor-positive breast cancer. J. Clin. Oncol. 27(16), 2630-2637 (2009
-
(2009)
J. Clin. Oncol.
, vol.27
, Issue.16
, pp. 2630-2637
-
-
Baselga, J.1
Semiglazov, V.2
Van Dam, P.3
-
97
-
-
34447106387
-
Phase 3 study of temsirolimus with letrozole or letrozole alone in postmenopausal women with locally advanced or metastatic breast cancer
-
(Abstract 6091
-
Chow LWC, Sun Y, Jassem J et al. Phase 3 study of temsirolimus with letrozole or letrozole alone in postmenopausal women with locally advanced or metastatic breast cancer. Breast Cancer Res. Treat. 100(Suppl. 1), S286 (Abstract 6091) (2006
-
(2006)
Breast Cancer Res. Treat.
, vol.100
, Issue.SUPPL. 1
-
-
Chow, L.W.C.1
Sun, Y.2
Jassem, J.3
-
98
-
-
79960605738
-
Targeting phosphatidylinositol 3 kinase (PI3K)-AKT beyond rapalogs
-
Ogita S, Lorusso P. Targeting phosphatidylinositol 3 kinase (PI3K)-AKT beyond rapalogs. Target. Oncol. 6(2), 103-117 (2011
-
(2011)
Target. Oncol.
, vol.6
, Issue.2
, pp. 103-117
-
-
Ogita, S.1
Lorusso, P.2
-
99
-
-
0027264523
-
Insulin-like growth factor-I receptors are overexpressed and predict a low risk in human breast cancer
-
Papa V, Gliozzo B, Clark GM et al. Insulin-like growth factor-I receptors are overexpressed and predict a low risk in human breast cancer. Cancer Res. 53(16), 3736-3740 (1993
-
(1993)
Cancer Res.
, vol.53
, Issue.16
, pp. 3736-3740
-
-
Papa, V.1
Gliozzo, B.2
Clark, G.M.3
-
100
-
-
0025066641
-
Elevated insulin receptor content in human breast cancer
-
Papa V, Pezzino V, Costantino A et al. Elevated insulin receptor content in human breast cancer. J. Clin. Invest. 86(5), 1503-1510 (1990
-
(1990)
J. Clin. Invest.
, vol.86
, Issue.5
, pp. 1503-1510
-
-
Papa, V.1
Pezzino, V.2
Costantino, A.3
-
101
-
-
0032800850
-
Insulin and insulin-like growth factor-I (IGF-I) receptor overexpression in breast cancers leads to insulin/IGF-I hybrid receptor overexpression: Evidence for a second mechanism of IGF-I signaling
-
Pandini G, Vigneri R, Costantino A et al. Insulin and insulin-like growth factor-I (IGF-I) receptor overexpression in breast cancers leads to insulin/IGF-I hybrid receptor overexpression: Evidence for a second mechanism of IGF-I signaling. Clin. Cancer Res. 5(7), 1935-1944 (1999
-
(1999)
Clin. Cancer Res.
, vol.5
, Issue.7
, pp. 1935-1944
-
-
Pandini, G.1
Vigneri, R.2
Costantino, A.3
-
102
-
-
10944249457
-
Expression of insulin-like growth factor 1 receptor in primary breast cancer: Immunohistochemical analysis
-
Shimizu C, Hasegawa T, Tani Y et al. Expression of insulin-like growth factor 1 receptor in primary breast cancer: Immunohistochemical analysis. Hum. Pathol. 35(12), 1537-1542 (2004
-
(2004)
Hum. Pathol.
, vol.35
, Issue.12
, pp. 1537-1542
-
-
Shimizu, C.1
Hasegawa, T.2
Tani, Y.3
-
103
-
-
0032827420
-
Multiple signaling pathways of the insulin-like growth factor 1 receptor in protection from apoptosis
-
Peruzzi F, Prisco M, Dews M et al. Multiple signaling pathways of the insulin-like growth factor 1 receptor in protection from apoptosis. Mol. Cell. Biol. 19(10), 7203-7215 (1999
-
(1999)
Mol. Cell. Biol.
, vol.19
, Issue.10
, pp. 7203-7215
-
-
Peruzzi, F.1
Prisco, M.2
Dews, M.3
-
104
-
-
0027366338
-
Simian virus 40 large tumor antigen is unable to transform mouse embryonic fibroblasts lacking type 1 insulin-like growth factor receptor
-
Sell C, Rubini M, Rubin R, Liu JP, Efstratiadis A, Baserga R. Simian virus 40 large tumor antigen is unable to transform mouse embryonic fibroblasts lacking type 1 insulin-like growth factor receptor. Proc. Natl Acad. Sci. USA 90(23), 11217-11221 (1993
-
(1993)
Proc. Natl Acad. Sci. USA
, vol.90
, Issue.23
, pp. 11217-11221
-
-
Sell, C.1
Rubini, M.2
Rubin, R.3
Liu, J.P.4
Efstratiadis, A.5
Baserga, R.6
-
105
-
-
77958067823
-
Compensatory insulin receptor (IR) activation on inhibition of insulin-like growth factor-1 receptor (IGF-1R): Rationale for cotargeting IGF-1R and IR in cancer
-
Buck E, Gokhale PC, Koujak S et al. Compensatory insulin receptor (IR) activation on inhibition of insulin-like growth factor-1 receptor (IGF-1R): Rationale for cotargeting IGF-1R and IR in cancer. Mol. Cancer Ther. 9(10), 2652-2664 (2010
-
(2010)
Mol. Cancer Ther.
, vol.9
, Issue.10
, pp. 2652-2664
-
-
Buck, E.1
Gokhale, P.C.2
Koujak, S.3
-
106
-
-
57149146434
-
The role of endocrine insulin-like growth factor-I and insulin in breast cancer
-
Lann D, Leroith D. The role of endocrine insulin-like growth factor-I and insulin in breast cancer. J. Mammary Gland Biol. Neoplasia 13(4), 371-379 (2008
-
(2008)
J. Mammary Gland Biol. Neoplasia
, vol.13
, Issue.4
, pp. 371-379
-
-
Lann, D.1
Leroith, D.2
-
107
-
-
80155131176
-
A kinome-wide screen identifies the insulin/IGF-I receptor pathway as a mechanism of escape from hormone dependence in breast cancer
-
Fox EM, Miller TW, Balko JM et al. A kinome-wide screen identifies the insulin/IGF-I receptor pathway as a mechanism of escape from hormone dependence in breast cancer. Cancer Res. 71(21), 6773-6784 (2011
-
(2011)
Cancer Res.
, vol.71
, Issue.21
, pp. 6773-6784
-
-
Fox, E.M.1
Miller, T.W.2
Balko, J.M.3
-
108
-
-
0031238774
-
Growth-promoting interaction of IGF-II with the insulin receptor during mouse embryonic development
-
Louvi A, Accili D, Efstratiadis A. Growth-promoting interaction of IGF-II with the insulin receptor during mouse embryonic development. Dev. Biol. 189(1), 33-48 (1997
-
(1997)
Dev. Biol.
, vol.189
, Issue.1
, pp. 33-48
-
-
Louvi, A.1
Accili, D.2
Efstratiadis, A.3
-
109
-
-
34548479484
-
Disruption of the insulin-like growth factor type 1 receptor in osteoblasts enhances insulin signaling and action
-
Fulzele K, Digirolamo DJ, Liu Z, Xu J, Messina JL, Clemens TL. Disruption of the insulin-like growth factor type 1 receptor in osteoblasts enhances insulin signaling and action. J. Biol. Chem. 282(35), 25649-25658 (2007
-
(2007)
J. Biol. Chem.
, vol.282
, Issue.35
, pp. 25649-25658
-
-
Fulzele, K.1
Digirolamo, D.J.2
Liu, Z.3
Xu, J.4
Messina, J.L.5
Clemens, T.L.6
-
110
-
-
33846458639
-
Down-regulation of type I insulin-like growth factor receptor increases sensitivity of breast cancer cells to insulin
-
Zhang H, Pelzer AM, Kiang DT, Yee D. Down-regulation of type I insulin-like growth factor receptor increases sensitivity of breast cancer cells to insulin. Cancer Res. 67(1), 391-397 (2007
-
(2007)
Cancer Res.
, vol.67
, Issue.1
, pp. 391-397
-
-
Zhang, H.1
Pelzer, A.M.2
Kiang, D.T.3
Yee, D.4
-
111
-
-
77953973648
-
Insulin receptor functionally enhances multistage tumor progression and conveys intrinsic resistance to IGF-1R targeted therapy
-
Ulanet DB, Ludwig DL, Kahn CR, Hanahan D. Insulin receptor functionally enhances multistage tumor progression and conveys intrinsic resistance to IGF-1R targeted therapy. Proc. Natl Acad. Sci. USA 107(24), 10791-10798 (2010
-
(2010)
Proc. Natl Acad. Sci. USA
, vol.107
, Issue.24
, pp. 10791-10798
-
-
Ulanet, D.B.1
Ludwig, D.L.2
Kahn, C.R.3
Hanahan, D.4
-
112
-
-
79958863370
-
Efficacy of and resistance to anti-IGF-1R therapies in Ewing's sarcoma is dependent on insulin receptor signaling
-
Garofalo C, Manara MC, Nicoletti G et al. Efficacy of and resistance to anti-IGF-1R therapies in Ewing's sarcoma is dependent on insulin receptor signaling. Oncogene 30(24), 2730-2740 (2011
-
(2011)
Oncogene
, vol.30
, Issue.24
, pp. 2730-2740
-
-
Garofalo, C.1
Manara, M.C.2
Nicoletti, G.3
-
113
-
-
79953647468
-
Small molecule inhibitors of the IGF-1R/IR axis for the treatment of cancer
-
Buck E, Mulvihill M. Small molecule inhibitors of the IGF-1R/IR axis for the treatment of cancer. Expert Opin Investig. Drugs 20(5), 605-621 (2011
-
(2011)
Expert Opin Investig. Drugs
, vol.20
, Issue.5
, pp. 605-621
-
-
Buck, E.1
Mulvihill, M.2
-
114
-
-
65349165810
-
Customizing the targeting of IGF-1 receptor
-
Baserga R. Customizing the targeting of IGF-1 receptor. Future Oncol. 5(1), 43-50 (2009
-
(2009)
Future Oncol.
, vol.5
, Issue.1
, pp. 43-50
-
-
Baserga, R.1
-
115
-
-
70450182195
-
Clinical development of inhibitors of the insulin-like growth factor receptor in oncology
-
Gualberto A, Pollak M. Clinical development of inhibitors of the insulin-like growth factor receptor in oncology. Curr. Drug Targets 10(10), 923-936 (2009
-
(2009)
Curr. Drug Targets
, vol.10
, Issue.10
, pp. 923-936
-
-
Gualberto, A.1
Pollak, M.2
-
116
-
-
43349088787
-
Targeting the type 1 insulin-like growth factor receptor as a treatment for cancer
-
Yuen JS, Macaulay VM. Targeting the type 1 insulin-like growth factor receptor as a treatment for cancer. Expert Opin Ther. Targets 12(5), 589-603 (2008
-
(2008)
Expert Opin Ther. Targets
, vol.12
, Issue.5
, pp. 589-603
-
-
Yuen, J.S.1
Macaulay, V.M.2
-
117
-
-
57749089652
-
Phosphorylated insulin-like growth factor-I/insulin receptor is present in all breast cancer subtypes and is related to poor survival
-
Law JH, Habibi G, Hu K et al. Phosphorylated insulin-like growth factor-I/insulin receptor is present in all breast cancer subtypes and is related to poor survival. Cancer Res. 68(24), 10238-10246 (2008
-
(2008)
Cancer Res.
, vol.68
, Issue.24
, pp. 10238-10246
-
-
Law, J.H.1
Habibi, G.2
Hu, K.3
-
118
-
-
57149137029
-
Crosstalk between IGF1R and estrogen receptor signaling in breast cancer
-
Fagan DH, Yee D. Crosstalk between IGF1R and estrogen receptor signaling in breast cancer. J. Mammary Gland Biol. Neoplasia 13(4), 423-429 (2008
-
(2008)
J. Mammary Gland Biol. Neoplasia
, vol.13
, Issue.4
, pp. 423-429
-
-
Fagan, D.H.1
Yee, D.2
-
119
-
-
57149127369
-
IGF-1 receptor inhibitors in clinical trials - early lessons
-
Weroha SJ, Haluska P. IGF-1 receptor inhibitors in clinical trials - early lessons. J. Mammary Gland Biol. Neoplasia 13(4), 471-483 (2008
-
(2008)
J. Mammary Gland Biol. Neoplasia
, vol.13
, Issue.4
, pp. 471-483
-
-
Weroha, S.J.1
Haluska, P.2
-
120
-
-
8544284095
-
Role of estrogen receptor alpha in modulating IGF-I receptor signaling and function in breast cancer
-
Surmacz E, Bartucci M. Role of estrogen receptor alpha in modulating IGF-I receptor signaling and function in breast cancer. J. Exp. Clin. Cancer Res. 23(3), 385-394 (2004
-
(2004)
J. Exp. Clin. Cancer Res.
, vol.23
, Issue.3
, pp. 385-394
-
-
Surmacz, E.1
Bartucci, M.2
-
121
-
-
68849128275
-
Molecular predictors of response to a humanized anti-insulin-like growth factor-I receptor monoclonal antibody in breast and colorectal cancer
-
Zha J, O'Brien C, Savage H et al. Molecular predictors of response to a humanized anti-insulin-like growth factor-I receptor monoclonal antibody in breast and colorectal cancer. Mol. Cancer Ther. 8(8), 2110-2121 (2009
-
(2009)
Mol. Cancer Ther.
, vol.8
, Issue.8
, pp. 2110-2121
-
-
Zha, J.1
O'Brien, C.2
Savage, H.3
-
122
-
-
0024359816
-
Insulin-like growth factor-1 receptors and insulin-like growth factor-1-like activity in human primary breast cancer
-
Foekens JA, Portengen H, Janssen M, Klijn JG. Insulin-like growth factor-1 receptors and insulin-like growth factor-1-like activity in human primary breast cancer. Cancer 63(11), 2139-2147 (1989
-
(1989)
Cancer
, vol.63
, Issue.11
, pp. 2139-2147
-
-
Foekens, J.A.1
Portengen, H.2
Janssen, M.3
Klijn, J.G.4
-
123
-
-
0023779434
-
Insulin-like growth factor 1 receptors in human breast cancer and their relation to estradiol and progesterone receptors
-
Peyrat JP, Bonneterre J, Beuscart R, Djiane J, Demaille A. Insulin-like growth factor 1 receptors in human breast cancer and their relation to estradiol and progesterone receptors. Cancer Res. 48(22), 6429-6433 (1988
-
(1988)
Cancer Res.
, vol.48
, Issue.22
, pp. 6429-6433
-
-
Peyrat, J.P.1
Bonneterre, J.2
Beuscart, R.3
Djiane, J.4
Demaille, A.5
-
124
-
-
0037478605
-
Repeated observation of breast tumor subtypes in independent gene expression data sets
-
Sorlie T, Tibshirani R, Parker J et al. Repeated observation of breast tumor subtypes in independent gene expression data sets. Proc. Natl Acad. Sci. USA 100(14), 8418-8423 (2003
-
(2003)
Proc. Natl Acad. Sci. USA
, vol.100
, Issue.14
, pp. 8418-8423
-
-
Sorlie, T.1
Tibshirani, R.2
Parker, J.3
-
125
-
-
0033842834
-
Crosstalk between the insulin-like growth factors and estrogens in breast cancer
-
Yee D, Lee AV. Crosstalk between the insulin-like growth factors and estrogens in breast cancer. J. Mammary Gland Biol. Neoplasia 5(1), 107-115 (2000
-
(2000)
J. Mammary Gland Biol. Neoplasia
, vol.5
, Issue.1
, pp. 107-115
-
-
Yee, D.1
Lee, A.V.2
-
126
-
-
0037937417
-
Interactions between estrogen and insulin-like growth factor signaling pathways in human breast tumor cells
-
Hamelers IHL, Steenbergh PH. Interactions between estrogen and insulin-like growth factor signaling pathways in human breast tumor cells. Endocr. Relat. Cancer 10(2), 331-345 (2003
-
(2003)
Endocr. Relat. Cancer
, vol.10
, Issue.2
, pp. 331-345
-
-
Hamelers, I.H.L.1
Steenbergh, P.H.2
-
127
-
-
0033305004
-
Enhancement of insulin-like growth factor signaling in human breast cancer. Estrogen regulation of insulin receptor substrate-1expression in vitro and in vivo
-
Lee AV, Jackson JG, Gooch JL et al. Enhancement of insulin-like growth factor signaling in human breast cancer. Estrogen regulation of insulin receptor substrate-1expression in vitro and in vivo. Mol. Endocrinol. 13(5), 787-796 (1999
-
(1999)
Mol. Endocrinol.
, vol.13
, Issue.5
, pp. 787-796
-
-
Lee, A.V.1
Jackson, J.G.2
Gooch, J.L.3
-
128
-
-
25844468319
-
Epidermal growth factor receptor/HER2/insulin-like growth factor receptor signalling and oestrogen receptor activity in clinical breast cancer
-
Gee JM, Robertson JF, Gutteridge E et al. Epidermal growth factor receptor/HER2/insulin-like growth factor receptor signalling and oestrogen receptor activity in clinical breast cancer. Endocr. Relat. Cancer 12(Suppl. 1), S99-S111 (2005
-
(2005)
Endocr. Relat. Cancer
, vol.12
, Issue.SUPPL. 1
-
-
Gee, J.M.1
Robertson, J.F.2
Gutteridge, E.3
-
129
-
-
33846846385
-
Estrogen receptor regulates insulin-like growth factor-I receptor gene expression in breast tumor cells. involvement of transcription factor Sp1
-
Maor S, Mayer D, Yarden RI et al. Estrogen receptor regulates insulin-like growth factor-I receptor gene expression in breast tumor cells. involvement of transcription factor Sp1. J. Endocrinol. 191(3), 605-612 (2006
-
(2006)
J. Endocrinol.
, vol.191
, Issue.3
, pp. 605-612
-
-
Maor, S.1
Mayer, D.2
Yarden, R.I.3
-
130
-
-
0030067106
-
Estradiol and antiestrogens regulate a growth inhibitory insulin-like growth factor binding protein 3 autocrine loop in human breast cancer cells
-
Huynh H, Yang X, Pollak M. Estradiol and antiestrogens regulate a growth inhibitory insulin-like growth factor binding protein 3 autocrine loop in human breast cancer cells. J. Biol. Chem. 271(2), 1016-1021 (1996
-
(1996)
J. Biol. Chem.
, vol.271
, Issue.2
, pp. 1016-1021
-
-
Huynh, H.1
Yang, X.2
Pollak, M.3
-
131
-
-
0031589538
-
Insulin-like growth factor binding protein-3 induces apoptosis in MCF7 breast cancer cells
-
Nickerson T, Huynh H, Pollak M. Insulin-like growth factor binding protein-3 induces apoptosis in MCF7 breast cancer cells. Biochem. Biophys. Res. Commun. 237(3), 690-693 (1997
-
(1997)
Biochem. Biophys. Res. Commun.
, vol.237
, Issue.3
, pp. 690-693
-
-
Nickerson, T.1
Huynh, H.2
Pollak, M.3
-
132
-
-
3543020345
-
The role of adapter protein Shc in estrogen non-genomic action
-
Zhang Z, Kumar R, Santen RJ, Song RX. The role of adapter protein Shc in estrogen non-genomic action. Steroids 69(8-9), 523-529 (2004
-
(2004)
Steroids
, vol.69
, Issue.8-9
, pp. 523-529
-
-
Zhang, Z.1
Kumar, R.2
Santen, R.J.3
Song, R.X.4
-
133
-
-
0027385551
-
Recombinant insulin-like growth factor binding protein-1 inhibits IGF-I, serum, and estrogen-dependent growth of MCF-7 human breast cancer cells
-
Figueroa JA, Sharma J, Jackson JG, McDermott MJ, Hilsenbeck SG, Yee D. Recombinant insulin-like growth factor binding protein-1 inhibits IGF-I, serum, and estrogen-dependent growth of MCF-7 human breast cancer cells. J. Cell. Physiol. 157(2), 229-236 (1993
-
(1993)
J. Cell. Physiol.
, vol.157
, Issue.2
, pp. 229-236
-
-
Figueroa, J.A.1
Sharma, J.2
Jackson, J.G.3
McDermott, M.J.4
Hilsenbeck, S.G.5
Yee, D.6
-
134
-
-
26844487041
-
Insulin-like growth factor-I receptor signaling in tamoxifen-resistant breast cancer: A supporting role to the epidermal growth factor receptor
-
Knowlden JM, Hutcheson IR, Barrow D, Gee JM, Nicholson RI. Insulin-like growth factor-I receptor signaling in tamoxifen-resistant breast cancer: A supporting role to the epidermal growth factor receptor. Endocrinology 146(11), 4609-4618 (2005
-
(2005)
Endocrinology
, vol.146
, Issue.11
, pp. 4609-4618
-
-
Knowlden, J.M.1
Hutcheson, I.R.2
Barrow, D.3
Gee, J.M.4
Nicholson, R.I.5
-
135
-
-
0033001742
-
Altered expression of the IGF-1 receptor in a tamoxifen-resistant human breast cancer cell line
-
Parisot JP, Hu XF, Deluise M, Zalcberg JR. Altered expression of the IGF-1 receptor in a tamoxifen-resistant human breast cancer cell line. Br. J. Cancer 79(5-6), 693-700 (1999
-
(1999)
Br. J. Cancer
, vol.79
, Issue.5-6
, pp. 693-700
-
-
Parisot, J.P.1
Hu, X.F.2
Deluise, M.3
Zalcberg, J.R.4
-
136
-
-
63649117164
-
Estrogen signals via an extra-nuclear pathway involving IGF-1R and EGFR in tamoxifen-sensitive and -resistant breast cancer cells
-
Santen RJ, Fan P, Zhang Z, Bao Y, Song RXD, Yue W. Estrogen signals via an extra-nuclear pathway involving IGF-1R and EGFR in tamoxifen-sensitive and -resistant breast cancer cells. Steroids 74(7), 586-594 (2009
-
(2009)
Steroids
, vol.74
, Issue.7
, pp. 586-594
-
-
Santen, R.J.1
Fan, P.2
Zhang, Z.3
Bao, Y.4
Song, R.X.D.5
Yue, W.6
-
137
-
-
77950346929
-
Estrogen utilization of IGF-1-R and EGF-R to signal in breast cancer cells
-
Song RX, Chen Y, Zhang Z et al. Estrogen utilization of IGF-1-R and EGF-R to signal in breast cancer cells. J. Steroid Biochem. Mol. Biol. 118(4-5), 219-230 (2010
-
(2010)
J. Steroid Biochem. Mol. Biol.
, vol.118
, Issue.4-5
, pp. 219-230
-
-
Song, R.X.1
Chen, Y.2
Zhang, Z.3
-
138
-
-
84860390217
-
Elevated insulin-like growth factor 1 receptor signaling induces antiestrogen resistance through the MAPK/ERK and PI3K/AKT signaling routes
-
Zhang Y, Moerkens M, Ramaiahgari S et al. Elevated insulin-like growth factor 1 receptor signaling induces antiestrogen resistance through the MAPK/ERK and PI3K/AKT signaling routes. Breast Cancer Res. 13(3), R52 (2011
-
(2011)
Breast Cancer Res.
, vol.13
, Issue.3
-
-
Zhang, Y.1
Moerkens, M.2
Ramaiahgari, S.3
-
139
-
-
80052157331
-
A randomized, double-blind, placebo-controlled, Phase 2 study of AMG 479 with exemestane (E) or fulvestrant (F) in postmenopausal women with hormone-receptor positive (HR+) metastatic (M) or locally advanced (LA) breast cancer (BC
-
Presented at:. San Antonio, TX, USA, 8-12 December
-
Kaufman PA, Ferrero JM, Bourgeois H et al. A randomized, double-blind, placebo-controlled, Phase 2 study of AMG 479 with exemestane (E) or fulvestrant (F) in postmenopausal women with hormone-receptor positive (HR+) metastatic (M) or locally advanced (LA) breast cancer (BC). Presented at: 33rd Annual San Antonio Breast Cancer Symposium. San Antonio, TX, USA, 8-12 December 2010.
-
(2010)
33rd Annual San Antonio Breast Cancer Symposium
-
-
Kaufman, P.A.1
Ferrero, J.M.2
Bourgeois, H.3
-
140
-
-
69449091019
-
Safety of the anti-IGF-1R antibody CP-751,871 in combination with exemestane in patients with advanced breast cancer
-
Presented at:. San antonio, TX, USA, 10-14 December (Abstract 2136
-
Ryan PD, Neven P, Dirix LY et al. Safety of the anti-IGF-1R antibody CP-751,871 in combination with exemestane in patients with advanced breast cancer. Presented at: San Antonio Breast Cancer Symposium. San antonio, TX, USA, 10-14 December (Abstract 2136) (2008
-
(2008)
San Antonio Breast Cancer Symposium
-
-
Ryan, P.D.1
Neven, P.2
Dirix, L.Y.3
-
141
-
-
78649679778
-
Roles of fibroblast growth factor receptors in carcinogenesis
-
Haugsten EM, Wiedlocha A, Olsnes S, Wesche J. Roles of fibroblast growth factor receptors in carcinogenesis. Mol. Cancer Res. 8(11), 1439-1452 (2010
-
(2010)
Mol. Cancer Res.
, vol.8
, Issue.11
, pp. 1439-1452
-
-
Haugsten, E.M.1
Wiedlocha, A.2
Olsnes, S.3
Wesche, J.4
-
142
-
-
0027344852
-
Structural and functional diversity in the FGF receptor multigene family
-
Johnson DE, Williams LT. Structural and functional diversity in the FGF receptor multigene family. Adv. Cancer Res. 60, 1-41 (1993
-
(1993)
Adv. Cancer Res.
, vol.60
, pp. 1-41
-
-
Johnson, D.E.1
Williams, L.T.2
-
143
-
-
77954365472
-
Potential for targeting the fibroblast growth factor receptors in breast cancer
-
Hynes NE, Dey JH. Potential for targeting the fibroblast growth factor receptors in breast cancer. Cancer Res. 70(13), 5199-5202 (2010
-
(2010)
Cancer Res.
, vol.70
, Issue.13
, pp. 5199-5202
-
-
Hynes, N.E.1
Dey, J.H.2
-
144
-
-
75149170979
-
Fibroblast growth factor signalling: From development to cancer
-
Turner N, Grose R. Fibroblast growth factor signalling: From development to cancer. Nat. Rev. Cancer 10(2), 116-129 (2010
-
(2010)
Nat. Rev. Cancer
, vol.10
, Issue.2
, pp. 116-129
-
-
Turner, N.1
Grose, R.2
-
145
-
-
34447325266
-
FGFR1 amplification in breast carcinomas: A chromogenic in situ hybridisation analysis
-
Elbauomy Elsheikh S, Green AR, Lambros MB et al. FGFR1 amplification in breast carcinomas: A chromogenic in situ hybridisation analysis. Breast Cancer Res. 9(2), R23 (2007
-
(2007)
Breast Cancer Res.
, vol.9
, Issue.2
-
-
Elbauomy Elsheikh, S.1
Green, A.R.2
Lambros, M.B.3
-
146
-
-
77950278598
-
FGFR1 amplification drives endocrine therapy resistance and is a therapeutic target in breast cancer
-
Turner N, Pearson A, Sharpe R et al. FGFR1 amplification drives endocrine therapy resistance and is a therapeutic target in breast cancer. Cancer Res. 70(5), 2085-2094 (2010
-
(2010)
Cancer Res.
, vol.70
, Issue.5
, pp. 2085-2094
-
-
Turner, N.1
Pearson, A.2
Sharpe, R.3
-
147
-
-
84858396997
-
Mechanisms of FGFR3 actions in endocrine resistant breast cancer
-
doi:10.1002/ijc.26304 ( Epub ahead of print
-
Tomlinson D, Knowles M, Speirs V. Mechanisms of FGFR3 actions in endocrine resistant breast cancer. Int. J. Cancer doi:10.1002/ijc.26304 (2011) (Epub ahead of print
-
(2011)
Int. J. Cancer
-
-
Tomlinson, D.1
Knowles, M.2
Speirs, V.3
-
148
-
-
41349112108
-
Fibroblast growth factor receptor 4 predicts failure on tamoxifen therapy in patients with recurrent breast cancer
-
Meijer D, Sieuwerts AM, Look MP, Van Agthoven T, Foekens JA, Dorssers LC. Fibroblast growth factor receptor 4 predicts failure on tamoxifen therapy in patients with recurrent breast cancer. Endocr. Relat. Cancer 15(1), 101-111 (2008
-
(2008)
Endocr. Relat. Cancer
, vol.15
, Issue.1
, pp. 101-111
-
-
Meijer, D.1
Sieuwerts, A.M.2
Look, M.P.3
Van Agthoven, T.4
Foekens, J.A.5
Dorssers, L.C.6
-
149
-
-
0031439247
-
Cellular functions regulated by Src family kinases
-
Thomas SM, Brugge JS. Cellular functions regulated by Src family kinases. Annu. Rev. Cell Dev. Biol. 13, 513-609 (1997
-
(1997)
Annu. Rev. Cell Dev. Biol.
, vol.13
, pp. 513-609
-
-
Thomas, S.M.1
Brugge, J.S.2
-
150
-
-
0041513490
-
C-SRC tyrosine kinase activity is associated with tumor colonization in bone and lung in an animal model of human breast cancer metastasis
-
Myoui A, Nishimura R, Williams PJ et al. C-SRC tyrosine kinase activity is associated with tumor colonization in bone and lung in an animal model of human breast cancer metastasis. Cancer Res. 63(16), 5028-5033 (2003
-
(2003)
Cancer Res.
, vol.63
, Issue.16
, pp. 5028-5033
-
-
Myoui, A.1
Nishimura, R.2
Williams, P.J.3
-
151
-
-
48249132499
-
Signal transducer and activator of transcription 5b, c-Src, and epidermal growth factor receptor signaling play integral roles in estrogen-stimulated proliferation of estrogen receptor-positive breast cancer cells
-
Fox EM, Bernaciak TM, Wen J, Weaver AM, Shupnik MA, Silva CM. Signal transducer and activator of transcription 5b, c-Src, and epidermal growth factor receptor signaling play integral roles in estrogen-stimulated proliferation of estrogen receptor-positive breast cancer cells. Mol. Endocrinol. 22(8), 1781-1796 (2008
-
(2008)
Mol. Endocrinol.
, vol.22
, Issue.8
, pp. 1781-1796
-
-
Fox, E.M.1
Bernaciak, T.M.2
Wen, J.3
Weaver, A.M.4
Shupnik, M.A.5
Silva, C.M.6
-
152
-
-
31044447246
-
Role of c-Src and focal adhesion kinase in progression and metastasis of estrogen receptor-positive breast cancer
-
Planas-Silva MD, Bruggeman RD, Grenko RT, Stanley Smith J. Role of c-Src and focal adhesion kinase in progression and metastasis of estrogen receptor-positive breast cancer. Biochem. Biophys. Res. Commun. 341(1), 73-81 (2006
-
(2006)
Biochem. Biophys. Res. Commun.
, vol.341
, Issue.1
, pp. 73-81
-
-
Planas-Silva, M.D.1
Bruggeman, R.D.2
Grenko, R.T.3
Stanley Smith, J.4
-
153
-
-
77955708280
-
Combining Src inhibitors and aromatase inhibitors: A novel strategy for overcoming endocrine resistance and bone loss
-
Hiscox S, Barrett-Lee P, Borley AC, Nicholson RI. Combining Src inhibitors and aromatase inhibitors: A novel strategy for overcoming endocrine resistance and bone loss. Eur. J. Cancer 46(12), 2187-2195 (2010
-
(2010)
Eur. J. Cancer
, vol.46
, Issue.12
, pp. 2187-2195
-
-
Hiscox, S.1
Barrett-Lee, P.2
Borley, A.C.3
Nicholson, R.I.4
-
154
-
-
17944375553
-
PI3-kinase in concert with Src promotes the S-phase entry of oestradiol-stimulated MCF-7 cells
-
Castoria G, Migliaccio A, Bilancio A et al. PI3-kinase in concert with Src promotes the S-phase entry of oestradiol-stimulated MCF-7 cells. EMBO J. 20(21), 6050-6059 (2001
-
(2001)
EMBO J.
, vol.20
, Issue.21
, pp. 6050-6059
-
-
Castoria, G.1
Migliaccio, A.2
Bilancio, A.3
-
155
-
-
25144517216
-
Estrogen rapid action via protein complex formation involving ERalpha and Src
-
Song RX, Zhang Z, Santen RJ. Estrogen rapid action via protein complex formation involving ERalpha and Src. Trends Endocrinol. Metab. 16(8), 347-353 (2005
-
(2005)
Trends Endocrinol. Metab.
, vol.16
, Issue.8
, pp. 347-353
-
-
Song, R.X.1
Zhang, Z.2
Santen, R.J.3
-
156
-
-
0035134504
-
Potentiation of estrogen receptor activation function 1 (AF-1) by Src/JNK through a serine 118-independent pathway
-
Feng W, Webb P, Nguyen P et al. Potentiation of estrogen receptor activation function 1 (AF-1) by Src/JNK through a serine 118-independent pathway. Mol. Endocrinol. 15(1), 32-45 (2001
-
(2001)
Mol. Endocrinol.
, vol.15
, Issue.1
, pp. 32-45
-
-
Feng, W.1
Webb, P.2
Nguyen, P.3
-
157
-
-
8344223854
-
Crosstalk between steroid receptors and the c-Src-receptor tyrosine kinase pathways: Implications for cell proliferation
-
Shupnik MA. Crosstalk between steroid receptors and the c-Src-receptor tyrosine kinase pathways: Implications for cell proliferation. Oncogene 23(48), 7979-7989 (2004
-
(2004)
Oncogene
, vol.23
, Issue.48
, pp. 7979-7989
-
-
Shupnik, M.A.1
-
158
-
-
34548462552
-
Mechanisms of acquired resistance to endocrine therapy in hormone-dependent breast cancer cells
-
Yue W, Fan P, Wang J, Li Y, Santen RJ. Mechanisms of acquired resistance to endocrine therapy in hormone-dependent breast cancer cells. J. Steroid Biochem. Mol. Biol. 106(1-5), 102-110 (2007
-
(2007)
J. Steroid Biochem. Mol. Biol.
, vol.106
, Issue.1-5
, pp. 102-110
-
-
Yue, W.1
Fan, P.2
Wang, J.3
Li, Y.4
Santen, R.J.5
-
159
-
-
48749118203
-
Targeting Src in breast cancer
-
Finn RS. Targeting Src in breast cancer. Ann. Oncol. 19(8), 1379-1386 (2008
-
(2008)
Ann. Oncol.
, vol.19
, Issue.8
, pp. 1379-1386
-
-
Finn, R.S.1
-
160
-
-
82955234094
-
Significance of ER-Src axis in hormonal therapy resistance
-
Vallabhaneni S, Nair BC, Cortez V et al. Significance of ER-Src axis in hormonal therapy resistance. Breast Cancer Res. Treat. 130(2), 377-385 (2011
-
(2011)
Breast Cancer Res. Treat.
, vol.130
, Issue.2
, pp. 377-385
-
-
Vallabhaneni, S.1
Nair, B.C.2
Cortez, V.3
-
161
-
-
85046914922
-
Elevated Src kinase activity attenuates tamoxifen response in vitro and is associated with poor prognosis clinically
-
Morgan L, Gee J, Pumford S et al. Elevated Src kinase activity attenuates tamoxifen response in vitro and is associated with poor prognosis clinically. Cancer Biol. Ther. 8(16), 1550-1558 (2009
-
(2009)
Cancer Biol. Ther.
, vol.8
, Issue.16
, pp. 1550-1558
-
-
Morgan, L.1
Gee, J.2
Pumford, S.3
-
162
-
-
84857048945
-
Shorter disease-specific survival of ER-positive breast cancer patients with high cytoplasmic Src kinase expression after tamoxifen treatment
-
Elsberger B, Paravasthu DM, Tovey SM, Edwards J. Shorter disease-specific survival of ER-positive breast cancer patients with high cytoplasmic Src kinase expression after tamoxifen treatment. J. Cancer Res. Clin. Oncol. 138(2), 327-332 (2012
-
(2012)
J. Cancer Res. Clin. Oncol.
, vol.138
, Issue.2
, pp. 327-332
-
-
Elsberger, B.1
Paravasthu, D.M.2
Tovey, S.M.3
Edwards, J.4
-
163
-
-
33745402375
-
Elevated Src activity promotes cellular invasion and motility in tamoxifen resistant breast cancer cells
-
Hiscox S, Morgan L, Green TP, Barrow D, Gee J, Nicholson RI. Elevated Src activity promotes cellular invasion and motility in tamoxifen resistant breast cancer cells. Breast Cancer Res. Treat. 97(3), 263-274 (2006
-
(2006)
Breast Cancer Res. Treat.
, vol.97
, Issue.3
, pp. 263-274
-
-
Hiscox, S.1
Morgan, L.2
Green, T.P.3
Barrow, D.4
Gee, J.5
Nicholson, R.I.6
-
164
-
-
34249776956
-
Src kinase promotes adhesion-independent activation of FAK and enhances cellular migration in tamoxifen-resistant breast cancer cells
-
Hiscox S, Jordan NJ, Morgan L, Green TP, Nicholson RI. Src kinase promotes adhesion-independent activation of FAK and enhances cellular migration in tamoxifen-resistant breast cancer cells. Clin. Exp. Metastasis 24(3), 157-167 (2007
-
(2007)
Clin. Exp. Metastasis
, vol.24
, Issue.3
, pp. 157-167
-
-
Hiscox, S.1
Jordan, N.J.2
Morgan, L.3
Green, T.P.4
Nicholson, R.I.5
-
165
-
-
34447503864
-
Targeting c-Src kinase enhances tamoxifen's inhibitory effect on cell growth by modulating expression of cell cycle and survival proteins
-
Planas-Silva MD, Hamilton KN. Targeting c-Src kinase enhances tamoxifen's inhibitory effect on cell growth by modulating expression of cell cycle and
-
(2007)
Cancer Chemother. Pharmacol.
, vol.60
, Issue.4
, pp. 535-543
-
-
Planas-Silva, M.D.1
Hamilton, K.N.2
-
166
-
-
33846235881
-
Cooperative action of tamoxifen and c-Src inhibition in preventing the growth of estrogen receptor-positive human breast cancer cells
-
Herynk MH, Beyer AR, Cui Y et al. Cooperative action of tamoxifen and c-Src inhibition in preventing the growth of estrogen receptor-positive human breast cancer cells. Mol. Cancer Ther. 5(12), 3023-3031 (2006
-
(2006)
Mol. Cancer Ther.
, vol.5
, Issue.12
, pp. 3023-3031
-
-
Herynk, M.H.1
Beyer, A.R.2
Cui, Y.3
-
167
-
-
85028101671
-
KX-01, a novel Src kinase inhibitor directed toward the peptide substrate site, synergizes with tamoxifen in estrogen receptor alpha positive breast cancer
-
doi:10.1007/s10549-011-1513-3 (Epub ahead of print
-
Anbalagan M, Carrier L, Glodowski S, Hangauer D, Shan B, Rowan BG. KX-01, a novel Src kinase inhibitor directed toward the peptide substrate site, synergizes with tamoxifen in estrogen receptor alpha positive breast cancer. Breast Cancer Res. Treat. doi:10.1007/s10549-011-1513-3 (2011) (Epub ahead of print
-
(2011)
Breast Cancer Res. Treat.
-
-
Anbalagan, M.1
Carrier, L.2
Glodowski, S.3
Hangauer, D.4
Shan, B.5
Rowan, B.G.6
-
168
-
-
67349143116
-
Dual targeting of Src and ER prevents acquired antihormone resistance in breast cancer cells
-
Hiscox S, Jordan NJ, Smith C et al. Dual targeting of Src and ER prevents acquired antihormone resistance in breast cancer cells. Breast Cancer Res. Treat. 115(1), 57-67 (2009
-
(2009)
Breast Cancer Res. Treat.
, vol.115
, Issue.1
, pp. 57-67
-
-
Hiscox, S.1
Jordan, N.J.2
Smith, C.3
-
169
-
-
66149160364
-
Combined Src and aromatase inhibition impairs human breast cancer growth in vivo and bypass pathways are activated in AZD0530-resistant tumors
-
Chen Y, Guggisberg N, Jorda M et al. Combined Src and aromatase inhibition impairs human breast cancer growth in vivo and bypass pathways are activated in AZD0530-resistant tumors. Clin. Cancer Res. 15(10), 3396-3405 (2009
-
(2009)
Clin. Cancer Res.
, vol.15
, Issue.10
, pp. 3396-3405
-
-
Chen, Y.1
Guggisberg, N.2
Jorda, M.3
-
170
-
-
80455132309
-
A Phase 2 trial of dasatinib in patients with advanced HER2-positive and/or hormone receptor-positive breast cancer
-
Mayer EL, Baurain JF, Sparano J et al. A Phase 2 trial of dasatinib in patients with advanced HER2-positive and/or hormone receptor-positive breast cancer. Clin. Cancer Res. 17(21), 6897-6904 (2011
-
(2011)
Clin. Cancer Res.
, vol.17
, Issue.21
, pp. 6897-6904
-
-
Mayer, E.L.1
Baurain, J.F.2
Sparano, J.3
-
171
-
-
77149122714
-
Epigenetic regulation in estrogen receptor positive breast cancer - role in treatment response
-
Pathiraja TN, Stearns V, Oesterreich S. Epigenetic regulation in estrogen receptor positive breast cancer - role in treatment response. J. Mammary Gland Biol. Neoplasia 15(1), 35-47 (2010
-
(2010)
J. Mammary Gland Biol. Neoplasia
, vol.15
, Issue.1
, pp. 35-47
-
-
Pathiraja, T.N.1
Stearns, V.2
Oesterreich, S.3
-
172
-
-
62549106985
-
ER re-expression and re-sensitization to endocrine therapies in ER-negative breast cancers
-
Brinkman JA, El-Ashry D. ER re-expression and re-sensitization to endocrine therapies in ER-negative breast cancers. J. Mammary Gland Biol. Neoplasia 14(1), 67-78 (2009
-
(2009)
J. Mammary Gland Biol. Neoplasia
, vol.14
, Issue.1
, pp. 67-78
-
-
Brinkman, J.A.1
El-Ashry, D.2
-
173
-
-
0028318783
-
Methylation of the estrogen receptor gene CpG island marks loss of estrogen receptor expression in human breast cancer cells
-
Ottaviano YL, Issa JP, Parl FF, Smith HS, Baylin SB, Davidson NE. Methylation of the estrogen receptor gene CpG island marks loss of estrogen receptor expression in human breast cancer cells. Cancer Res. 54(10), 2552-2555 (1994
-
(1994)
Cancer Res.
, vol.54
, Issue.10
, pp. 2552-2555
-
-
Ottaviano, Y.L.1
Issa, J.P.2
Parl, F.F.3
Smith, H.S.4
Baylin, S.B.5
Davidson, N.E.6
-
174
-
-
1542787625
-
Specific inhibition of DNMT1 by antisense oligonucleotides induces re-expression of estrogen receptor-alpha (ER) in ER-negative human breast cancer cell lines
-
Yan L, Nass SJ, Smith D, Nelson WG, Herman JG, Davidson NE. Specific inhibition of DNMT1 by antisense oligonucleotides induces re-expression of estrogen receptor-alpha (ER) in ER-negative human breast cancer cell lines. Cancer Biol. Ther. 2(5), 552-556 (2003
-
(2003)
Cancer Biol. Ther.
, vol.2
, Issue.5
, pp. 552-556
-
-
Yan, L.1
Nass, S.J.2
Smith, D.3
Nelson, W.G.4
Herman, J.G.5
Davidson, N.E.6
-
175
-
-
0242330341
-
A novel histone deacetylase inhibitor, scriptaid, enhances expression of functional estrogen receptor alpha (ER) in ER negative human breast cancer cells in combination with 5-aza 2'-deoxycytidine
-
Keen JC, Yan L, Mack KM et al. A novel histone deacetylase inhibitor, scriptaid, enhances expression of functional estrogen receptor alpha (ER) in ER negative human breast cancer cells in combination with 5-aza 2'-deoxycytidine. Breast Cancer Res. Treat. 81(3), 177-186 (2003
-
(2003)
Breast Cancer Res. Treat.
, vol.81
, Issue.3
, pp. 177-186
-
-
Keen, J.C.1
Yan, L.2
Mack, K.M.3
-
176
-
-
0035477320
-
Synergistic activation of functional estrogen receptor (ER)-alpha by DNA methyltransferase and histone deacetylase inhibition in human ER-alpha-negative breast cancer cells
-
Yang X, Phillips DL, Ferguson AT, Nelson WG, Herman JG, Davidson NE. Synergistic activation of functional estrogen receptor (ER)-alpha by DNA methyltransferase and histone deacetylase inhibition in human ER-alpha-negative breast cancer cells. Cancer Res. 61(19), 7025-7029 (2001
-
(2001)
Cancer Res.
, vol.61
, Issue.19
, pp. 7025-7029
-
-
Yang, X.1
Phillips, D.L.2
Ferguson, A.T.3
Nelson, W.G.4
Herman, J.G.5
Davidson, N.E.6
-
177
-
-
33847111684
-
Histone deacetylase inhibitor LBH589 reactivates silenced estrogen receptor alpha (ER) gene expression without loss of DNA hypermethylation
-
Zhou Q, Atadja P, Davidson NE. Histone deacetylase inhibitor LBH589 reactivates silenced estrogen receptor alpha (ER) gene expression without loss of DNA hypermethylation. Cancer Biol. Ther. 6(1), 64-69 (2007
-
(2007)
Cancer Biol. Ther.
, vol.6
, Issue.1
, pp. 64-69
-
-
Zhou, Q.1
Atadja, P.2
Davidson, N.E.3
-
178
-
-
79952237710
-
Functional activation of the estrogen receptor-alpha and aromatase by the HDAC inhibitor entinostat sensitizes ER-negative tumors to letrozole
-
Sabnis GJ, Goloubeva O, Chumsri S, Nguyen N, Sukumar S, Brodie AM. Functional activation of the estrogen receptor-alpha and aromatase by the HDAC inhibitor entinostat sensitizes ER-negative tumors to letrozole. Cancer Res. 71(5), 1893-1903 (2011
-
(2011)
Cancer Res.
, vol.71
, Issue.5
, pp. 1893-1903
-
-
Sabnis, G.J.1
Goloubeva, O.2
Chumsri, S.3
Nguyen, N.4
Sukumar, S.5
Brodie, A.M.6
-
179
-
-
44749085668
-
ER alpha negative breast cancer cells restore response to endocrine therapy by combination treatment with both HDAC inhibitor and DNMT inhibitor
-
Fan J, Yin WJ, Lu JS et al. ER alpha negative breast cancer cells restore response to endocrine therapy by combination treatment with both HDAC inhibitor and DNMT inhibitor. J. Cancer Res. Clin. Oncol. 134(8), 883-890 (2008
-
(2008)
J. Cancer Res. Clin. Oncol.
, vol.134
, Issue.8
, pp. 883-890
-
-
Fan, J.1
Yin, W.J.2
Lu, J.S.3
-
180
-
-
33745685866
-
Restoration of tamoxifen sensitivity in estrogen receptor-negative breast cancer cells: Tamoxifen-bound reactivated ER recruits distinctive corepressor complexes
-
Sharma D, Saxena NK, Davidson NE, Vertino PM. Restoration of tamoxifen sensitivity in estrogen receptor-negative breast cancer cells: Tamoxifen-bound reactivated ER recruits distinctive corepressor complexes. Cancer Res. 66(12), 6370-6378 (2006
-
(2006)
Cancer Res.
, vol.66
, Issue.12
, pp. 6370-6378
-
-
Sharma, D.1
Saxena, N.K.2
Davidson, N.E.3
Vertino, P.M.4
-
181
-
-
33846207899
-
Diverse gene expression and DNA methylation profiles correlate with differential adaptation of breast cancer cells to the antiestrogens tamoxifen and fulvestrant
-
Fan M, Yan PS, Hartman-Frey C et al. Diverse gene expression and DNA methylation profiles correlate with differential adaptation of breast cancer cells to the antiestrogens tamoxifen and fulvestrant. Cancer Res. 66(24), 11954-11966 (2006
-
(2006)
Cancer Res.
, vol.66
, Issue.24
, pp. 11954-11966
-
-
Fan, M.1
Yan, P.S.2
Hartman-Frey, C.3
-
182
-
-
79958084461
-
A Phase II study of the histone deacetylase inhibitor vorinostat combined with tamoxifen for the treatment of patients with hormone therapy-resistant breast cancer
-
Munster PN, Thurn KT, Thomas S et al. A Phase II study of the histone deacetylase inhibitor vorinostat combined with tamoxifen for the treatment of patients with hormone therapy-resistant breast cancer. Br. J. Cancer 104(12), 1828-1835 (2011
-
(2011)
Br. J. Cancer
, vol.104
, Issue.12
, pp. 1828-1835
-
-
Munster, P.N.1
Thurn, K.T.2
Thomas, S.3
-
183
-
-
84866063116
-
Entinostat, a novel histone deacetylase inhibitor, added to exemestane improves PFS in advanced breast cancer in a randomized, Phase II, double-blind study
-
Presented at:. San Antonio, TX, USA, 7 December
-
Yardley DA, Ismail-Khan RR, Klein PM et al. Entinostat, a novel histone deacetylase inhibitor, added to exemestane improves PFS in advanced breast cancer in a randomized, Phase II, double-blind study. Presented at: 34th Annual San Antonio Breast Cancer Symposium. San Antonio, TX, USA, 7 December 2011.
-
(2011)
34th Annual San Antonio Breast Cancer Symposium
-
-
Yardley, D.A.1
Ismail-Khan, R.R.2
Klein, P.M.3
-
184
-
-
79958767367
-
MicroRNA signatures: Clinical biomarkers for the diagnosis and treatment of breast cancer
-
Andorfer CA, Necela BM, Thompson EA, Perez EA. MicroRNA signatures: Clinical biomarkers for the diagnosis and treatment of breast cancer. Trends Mol. Med. 17(6), 313-319 (2011
-
(2011)
Trends Mol. Med.
, vol.17
, Issue.6
, pp. 313-319
-
-
Andorfer, C.A.1
Necela, B.M.2
Thompson, E.A.3
Perez, E.A.4
-
185
-
-
0347444723
-
MicroRNAs: Genomics, biogenesis, mechanism, and function
-
Bartel DP. MicroRNAs: Genomics, biogenesis, mechanism, and function. Cell 116(2), 281-297 (2004
-
(2004)
Cell
, vol.116
, Issue.2
, pp. 281-297
-
-
Bartel, D.P.1
-
186
-
-
0041691111
-
MicroRNAs and small interfering RNAs can inhibit mRNA expression by similar mechanisms
-
Zeng Y, Yi R, Cullen BR. MicroRNAs and small interfering RNAs can inhibit mRNA expression by similar mechanisms. Proc. Natl Acad. Sci. USA 100(17), 9779-9784 (2003
-
(2003)
Proc. Natl Acad. Sci. USA
, vol.100
, Issue.17
, pp. 9779-9784
-
-
Zeng, Y.1
Yi, R.2
Cullen, B.R.3
-
187
-
-
69949189728
-
MicroRNA signatures predict oestrogen receptor, progesterone receptor and HER2/neu receptor status in breast cancer
-
Lowery AJ, Miller N, Devaney A et al. MicroRNA signatures predict oestrogen receptor, progesterone receptor and HER2/neu receptor status in breast cancer. Breast Cancer Res. 11(3), R27 (2009
-
(2009)
Breast Cancer Res.
, vol.11
, Issue.3
-
-
Lowery, A.J.1
Miller, N.2
Devaney, A.3
-
188
-
-
33748624597
-
Optimized high-throughput microRNA expression profiling provides novel biomarker assessment of clinical prostate and breast cancer biopsies
-
Mattie MD, Benz CC, Bowers J et al. Optimized high-throughput microRNA expression profiling provides novel biomarker assessment of clinical prostate and breast cancer biopsies. Mol. Cancer 5, 24 (2006)
-
(2006)
Mol. Cancer
, vol.5
, pp. 24
-
-
Mattie, M.D.1
Benz, C.C.2
Bowers, J.3
-
189
-
-
79954748720
-
MicroRNA-30c expression level is an independent predictor of clinical benefit of endocrine therapy in advanced estrogen receptor positive breast cancer
-
Rodriguez-Gonzalez FG, Sieuwerts AM, Smid M et al. MicroRNA-30c expression level is an independent predictor of clinical benefit of endocrine therapy in advanced estrogen receptor positive breast cancer. Breast Cancer Res. Treat. 127(1), 43-51 (2011)
-
(2011)
Breast Cancer Res. Treat.
, vol.127
, Issue.1
, pp. 43-51
-
-
Rodriguez-Gonzalez, F.G.1
Sieuwerts, A.M.2
Smid, M.3
|