-
1
-
-
0027309375
-
Relationship between EGF-R, c-erbB-2 protein expression and Ki67 immunostaining in breast cancer and hormone sensitivity
-
NicholsonRI,McClellandRA,FinlayP,EatonCL,GullickWJ,DixonAR,RobertsonJF, EllisIO,BlarneyRW.RelationshipbetweenEGF-R,c-erbB- 2proteinexpressionandKi67immunostaininginbreastcancerandhormonesensitivity. EurJCancer1993;29A:1018-1023(Pubitemid23126705)
-
(1993)
European Journal of Cancer Part A: General Topics
, vol.29
, Issue.7
, pp. 1018-1023
-
-
Nicholson, R.I.1
McClelland, R.A.2
Finlay, P.3
Eaton, C.L.4
Gullick, W.J.5
Dixon, A.R.6
Robertson, J.F.R.7
Ellis, I.O.8
Blamey, R.W.9
-
2
-
-
0028293921
-
Epidermal growth factor receptor expression in breast cancer: Association with response to endocrine therapy
-
NicholsonRI,McClellandRA,GeeJM,ManningDL,CannonP,RobertsonJF,EllisIO, BlarneyRW.Epidermalgrowthfactorreceptorexpressioninbreastcancer: associationwithresponse-endocrinetherapy.BreastCancerResTreat1994;29: 117-125(Pubitemid24104843)
-
(1994)
Breast Cancer Research and Treatment
, vol.29
, Issue.1
, pp. 117-125
-
-
Nicholson, R.I.1
McClelland, R.A.2
Gee, J.M.W.3
Manning, D.L.4
Cannon, P.5
Robertson, J.F.R.6
Ellis, I.O.7
Blamey, R.W.8
-
3
-
-
0022374645
-
Presence of epidermal growth factor receptor as an indicator of poor prognosis in patients with breast cancer
-
SainsburyJR,MalcolmAJ,AppletonDR,FarndonJR,HarrisAL. Presenceofepidermalgrowthfactorreceptorasanindicatorofpoorprognosisinpatients withbreastcancer.JClinPathol1985;38:1225-1228(Pubitemid16215034)
-
(1985)
Journal of Clinical Pathology
, vol.38
, Issue.11
, pp. 1225-1228
-
-
Sainsbury, J.R.C.1
Malcolm, A.J.2
Appleton, D.R.3
-
4
-
-
0025211332
-
Expression of epidermal growth factor receptor in breast carcinoma
-
Lewis S, Locker A, Todd JH, Bell JA, Nicholson R, Elst.on CW, Blarney RW, Ellis IO. Expression of epidermal growth factor receptor in breast carcinoma. J Clin Pathol 1990; 43: 385-389
-
(1990)
J Clin Pathol
, vol.43
, pp. 385-389
-
-
Lewis, S.1
Locker, A.2
Todd, J.H.3
Bell, J.A.4
Nicholson, R.5
Elston, C.W.6
Blarney, R.W.7
Ellis, I.O.8
-
6
-
-
0034795433
-
Studies of epidermal growth factor receptor inhibition in breast cancer
-
DOI 10.1677/erc.0.0080183
-
Bundred NJ, Chan K, Anderson NG. Studies of epidermal growth factor receptor inhibition in breast cancer. Endocr Relat Cancer 2001; 8: 183-189 (Pubitemid 32947640)
-
(2001)
Endocrine-Related Cancer
, vol.8
, Issue.3
, pp. 183-189
-
-
Bundred, N.J.1
Chan, K.2
Anderson, N.G.3
-
7
-
-
0036143027
-
Effect of epidermal growth factor receptor tyrosine kinase inhibition on epithelial proliferation in normal and premalignant breast
-
ChanKC,KnoxWF,GeeJM,MorrisJ,NicholsonRI,PottenCS,BundredNJ. Effectofepidermalgrowthfactorreceptortyrosinekinaseinhibitiononepithelialprolif erationinnormalandpremalignantbreast.CancerRes2002;62:122-128(Pubitemid34073995)
-
(2002)
Cancer Research
, vol.62
, Issue.1
, pp. 122-128
-
-
Chan, K.C.1
Knox, W.F.2
Gee, J.M.3
Morris, J.4
Nicholson, R.I.5
Potten, C.S.6
Bundred, N.J.7
-
8
-
-
0348230978
-
Effect of epidermal growth factor receptor inhibitor on development of estrogen receptor-negative mammary tumors
-
LuC,SpeersC,ZhangY,XuX,HillJ,SteinbisE,CelestinoJ,ShenQ,KimH,HilsenbeckS, MohsinSK,WakelingA,etal. Effectofepidermalgrowthfactorreceptorinhibitorondevelopmentofestrogenreceptor- negativemammarytumors.JNatlCancerInst2003;95:1825-1833(Pubitemid38054683)
-
(2003)
Journal of the National Cancer Institute
, vol.95
, Issue.24
, pp. 1825-1833
-
-
Lu, C.1
Speers, C.2
Zhang, Y.3
Xu, X.4
Hill, J.5
Steinbis, E.6
Celestino, J.7
Shen, Q.8
Kim, H.9
Hilsenbeck, S.10
Mohsin, S.K.11
Wakeling, A.12
Osborne, C.K.13
Brown, P.W.14
-
9
-
-
17844398046
-
Molecular changes in tamoxifen-resistant breast cancer: Relationship between estrogen receptor, HER-2, and p38 mitogen-activated protein kinase
-
DOI 10.1200/JCO.2005.01.172
-
Gutierrez MC, Detre S, Johnston S, Mohsin SK, Shou J, Allred DC, Schiff R, Osborne CK, Dowsett M. Molecular changes in tamoxifen-resistant breast cancer: relationship between estrogen receptor, HER-2, and p38 mitogenactivated protein kinase. J Clin Oncol 2005; 23: 2469-2476 (Pubitemid 47050837)
-
(2005)
Journal of Clinical Oncology
, vol.23
, Issue.11
, pp. 2469-2476
-
-
Gutierrez, M.C.1
Detre, S.2
Johnston, S.3
Mohsin, S.K.4
Shou, J.5
Alfred, D.C.6
Schiff, R.7
Osborne, C.K.8
Dowsett, M.9
-
10
-
-
25844500946
-
Consensus statement. Workshop on therapeutic resistance in breast cancer: Impact of growth factor signalling pathways and implications for future treatment
-
Gee JM, Howell A, Gullick WJ, Benz CC, Sutherland RL, Santen RJ, Martin LA, Ciardiello F, Miller WR, Dowsett M, Barrett-Lee P, Robertson JF, et al. Consensus statement. Workshop on therapeutic resistance in breast cancer: impact of growth factor signalling pathways and implications for future treatment. Endocr Relat Cancer 2005;12 Suppl l:S1-7.
-
(2005)
Endocr Relat Cancer
, vol.12
, Issue.SUPPL. L
-
-
Gee, J.M.1
Howell, A.2
Gullick, W.J.3
Benz, C.C.4
Sutherland, R.L.5
Santen, R.J.6
Martin, L.A.7
Ciardiello, F.8
Miller, W.R.9
Dowsett, M.10
Barrett-Lee, P.11
Robertson, J.F.12
-
11
-
-
0037373326
-
Elevated levels of epidermal growth factor receptor/c-erbB2 heterodimers mediate an autocrine growth regulatory pathway in tamoxifen-resistant MCF-7 cells
-
DOI 10.1210/en.2002-220620
-
Knowlden JM, Hutcheson IR, Jones HE, Madden T, Gee JM, Harper ME, Barrow D, Wakeling AE, Nicholson RI. Elevated levels of epidermal growth factor receptor/ c-erbB2 heterodimers mediate an autocrine growth regulatory pathway in tamoxifenresistant MCF-7 cells. Endocrinology 2003; 144:1032-1044 (Pubitemid 36262870)
-
(2003)
Endocrinology
, vol.144
, Issue.3
, pp. 1032-1044
-
-
Knowlden, J.M.1
Hutcheson, I.R.2
Jones, H.E.3
Madden, T.4
Gee, J.M.W.5
Harper, M.E.6
Barrow, D.7
Wakeling, A.E.8
Nicholson, R.I.9
-
12
-
-
0242721012
-
The Antiepidermal Growth Factor Receptor Agent Gefitinib (ZD1839/Iressa) Improves Antihormone Response and Prevents Development of Resistance in Breast Cancer in Vitro
-
DOI 10.1210/en.2003-0705
-
Gee JM, Harper ME, Hutcheson IR, Madden TA, Barrow D, Knowlden JM, McClelland RA, Jordan N, Wakeling AE, Nicholson RI. The antiepidermal growth factor receptor agent gefitinib (ZD 1839/ Iressa) improves antihormone response and prevents development of resistance in breast cancer in vitro. Endocrinology 2003; 144: 5105-5117 (Pubitemid 37378426)
-
(2003)
Endocrinology
, vol.144
, Issue.11
, pp. 5105-5117
-
-
Gee, J.M.W.1
Harper, M.E.2
Hutcheson, I.R.3
Madden, T.A.4
Barrow, D.5
Knowlden, J.M.6
McClelland, R.A.7
Jordan, N.8
Wakeling, A.E.9
Nicholson, R.I.10
-
13
-
-
0034500428
-
Zd 1839 "Iressa"
-
in French.
-
Meric JB, Faivre S, Monnerat C, Adi Vago N, Le Chevalier T, Armand JP, Raymond E. [Zd 1839 "Iressa"]. Bull Cancer 2000;87: 873-876 (in French).
-
(2000)
Bull Cancer
, vol.87
, pp. 873-876
-
-
Meric, J.B.1
Faivre, S.2
Monnerat, C.3
Adi Vago, N.4
Le Chevalier, T.5
Armand, J.P.6
Raymond, E.7
-
14
-
-
0035892346
-
ZD1839 (Iressa), a novel epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor, potently inhibits the growth of EGFR-positive cancer cell lines with or without erbB2 overexpression
-
DOI 10.1002/ijc.1557
-
Anderson NG, Ahmad T, Chan K, Dobson R, Bundred NJ. Z.D1839 (Iressa), a novel epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor, potently inhibits the growth of EGFR-positive cancer cell lines with or without erbB2 overexpression. Int J Cancer 2001;94:774-782 (Pubitemid 33032823)
-
(2001)
International Journal of Cancer
, vol.94
, Issue.6
, pp. 774-782
-
-
Anderson, N.G.1
Ahmad, T.2
Chan, K.3
Dobson, R.4
Bundred, N.J.5
-
15
-
-
0034489914
-
Efficacy of cytotoxic agents against human tumor xenografts is markedly enhanced by coadministration of ZD1839 (Iressa), an inhibitor of EGFR tyrosine kinase
-
Sirotnak FM, Zakowski MF, Miller VA, Scher HI, Kris MG. Efficacy of cytotoxic agents against human tumor xenografts is markedly enhanced by coadministration of ZD1839 (Iressa), an inhibitor of EGFR tyrosine kinase. Clin Cancer Res 2000;6: 4885-4892
-
(2000)
Clin Cancer Res
, vol.6
, pp. 4885-4892
-
-
Sirotnak, F.M.1
Zakowski, M.F.2
Miller, V.A.3
Scher, H.I.4
Kris, M.G.5
-
16
-
-
2942652871
-
Mechanisms of tamoxifen resistance: Increased estrogen receptor-HER2/neu cross-talk in ER/HER2-positive breast cancer
-
ShouJ,MassarwehS,OsborneCK,WakelingAE,AliS,WeissH,SchiffR. Mechanismsoftamoxifenresistance:increasedestrogenreceptor-HER2/ neucross-talkinER/HER2-positivebreastcancer.JNatlCancerInst2004;96: 926-935(Pubitemid38868139)
-
(2004)
Journal of the National Cancer Institute
, vol.96
, Issue.12
, pp. 926-935
-
-
Shou, J.1
Massarweh, S.2
Osborne, C.K.3
Wakeling, A.E.4
Ali, S.5
Weiss, H.6
Schiff, R.7
-
17
-
-
0036842170
-
Phase i safety, pharmacokinetic, and pharmacodynamic trial of ZD1839, a selective oral epidermal growth factor receptor tyrosine kinase inhibitor, in patients with five selected solid tumor types
-
DOI 10.1200/JCO.2002.03.100
-
Baselga J, Rischin D, Ranson M, Calvert H, Raymond E, Kieback DG, Kaye SB, Gianni L, Harris A, Bjork T, Averbuch SD, Feyereislova A, et al. Phase I safety, pharmacokinetic, and pharmacodynamic trial of ZD1839, a selective oral epidermal growth factor receptor tyrosine kinase inhibitor, in patients with five selected solid tumor types. J Clin Oncol 2002; 20: 4292-4302 (Pubitemid 35266289)
-
(2002)
Journal of Clinical Oncology
, vol.20
, Issue.21
, pp. 4292-4302
-
-
Baselga, J.1
Rischin, D.2
Ranson, M.3
Calvert, H.4
Raymond, E.5
Kieback, D.G.6
Kaye, S.B.7
Gianni, L.8
Harris, A.9
Bjork, T.10
Averbuch, S.D.11
Feyereislova, A.12
Swaisland, H.13
Rojo, F.14
Albanell, J.15
-
18
-
-
0012381722
-
Multi-institutional randomized phase II trial of gefitinib for previously treated patients with advanced non-small-cell lung cancer
-
DOI 10.1200/JCO.2003.10.038
-
Fukuoka M, Yano S, Giaccone G, Tamura T, Nakagawa K, Douillard JY, Nishiwaki Y, Vansteenkiste J, Kudoh S, Rischin. D, Eek R, Horai T, et al. Multi-institutional randomized phase II trial of gefitinib for previously treated patients with advanced non-small-cell lung cancer (The IDEAL 1 Trial) [corrected]. J Clin Oncol 2003; 21: 2237-2246 (Pubitemid 46621858)
-
(2003)
Journal of Clinical Oncology
, vol.21
, Issue.12
, pp. 2237-2246
-
-
Fukuoka, M.1
Yano, S.2
Giaccone, G.3
Tamura, T.4
Nakagawa, K.5
Douillard, J.-Y.6
Nishiwaki, Y.7
Vansteenkiste, J.8
Kudoh, S.9
Rischin, D.10
Eek, R.11
Horai, T.12
Noda, K.13
Takata, I.14
Smit, E.15
Averbuch, S.16
Macleod, A.17
Feyereislova, A.18
Dong, R.-P.19
Baselga, J.20
more..
-
19
-
-
0037296417
-
Dose-comparative monotherapy trials of ZD1839 in previously treated non-small cell lung cancer patients
-
DOI 10.1053/sonc.2003.50030
-
Herbst RS. Dose-comparative monotherapy trials of ZD1839 in previously treated nonsmall cell lung cancer patients. Semin Oncol 2003:30(1 Suppl l):30-38 (Pubitemid 36307615)
-
(2003)
Seminars in Oncology
, vol.30
, Issue.1 SUPPL. 1
, pp. 30-38
-
-
Herbst, R.S.1
-
20
-
-
0142055937
-
Efficacy of Gefitinib, an Inhibitor of the Epidermal Growth Factor Receptor Tyrosine Kinase, in Symptomatic Patients with Non-Small Cell Lung Cancer: A Randomized Trial
-
DOI 10.1001/jama.290.16.2149
-
Kris MG, Natale RB, Herbst RS, Lynch TJ, Jr, Prager D, Belani CP, Schiller JH, Kelly K, Spiridonidis H, Sandler A, Albain KS, Celia D, et al. Efficacy of gefitinib, an inhibitor of the epidermal growth factor receptor tyrosine kinase, in symptomatic patients with non-small cell lung cancer: a randomized trial. JAMA 2003; 290: 2149-2158 (Pubitemid 37432975)
-
(2003)
Journal of the American Medical Association
, vol.290
, Issue.16
, pp. 2149-2158
-
-
Kris, M.G.1
Natale, R.B.2
Herbst, R.S.3
Lynch Jr., T.J.4
Prager, D.5
Belani, C.P.6
Schiller, J.H.7
Kelly, K.8
Spiridonidis, H.9
Sandler, A.10
Albain, K.S.11
Cella, D.12
Wolf, M.K.13
Averbuch, S.D.14
Ochs, J.J.15
Kay, A.C.16
-
21
-
-
0042675500
-
Open-label, phase II, multicenter trial of ZD1839 ('Iressa') in patients with advanced breast cancer
-
Albain K, Elledge R, Gradishar WJ, Hayes DF, Rowinsky E, Hudis C, Pusztai L, Tripathy D, Modi S, Rubi S. Open-label, phase II, multicenter trial of ZD1839 ('Iressa') in patients with advanced breast cancer. Breast Cancer Res Treat 2002; 76(Suppl):S33.
-
(2002)
Breast Cancer Res Treat
, vol.76
, Issue.SUPPL.
-
-
Albain, K.1
Elledge, R.2
Gradishar, W.J.3
Hayes, D.F.4
Rowinsky, E.5
Hudis, C.6
Pusztai, L.7
Tripathy, D.8
Modi, S.9
Rubi, S.10
-
22
-
-
20844456577
-
A multicentre phase II study on gefitinib in taxane- And anthracycline-pretreated metastatic breast cancer
-
von Minckwitz G, Jonat W, Fasching P, du Bois A, Kleeberg U, Luck HJ, Kettner E, Hilfrich J, Eiermann W, Torode J, Schneeweiss A. A multicentre phase II study on gefitinib in taxane- and anthracycline-pretreated metastatic breast cancer. Breast Cancer Res Treat 2005;89: 165-172
-
(2005)
Breast Cancer Res Treat
, vol.89
, pp. 165-172
-
-
Von Minckwitz, G.1
Jonat, W.2
Fasching, P.3
Du Bois, A.4
Kleeberg, U.5
Luck, H.J.6
Kettner, E.7
Hilfrich, J.8
Eiermann, W.9
Torode, J.10
Schneeweiss, A.11
-
23
-
-
19944427176
-
Insulin-like growth factor-I receptor signalling and acquired resistance to gefitinib (ZD1839; Iresa) in human breast and prostate cancer cells
-
DOI 10.1677/erc.1.00799
-
Jones HE, Goddard L, Gee JM, Hiscox. S, Rubini M, Barrow D, Knowlden JM, Williams S, Wakeling AE, Nicholson RI. Insulin-like growth factor-I receptor signalling and acquired resistance to gefitinib (ZD1839; Iressa) in human breast and prostate cancer cells. Endocr Relat Cancer 2004; 11: 793-814. (Pubitemid 40065552)
-
(2004)
Endocrine-Related Cancer
, vol.11
, Issue.4
, pp. 793-814
-
-
Jones, H.E.1
Goddard, L.2
Gee, J.M.W.3
Hiscox, S.4
Rubini, M.5
Barrow, D.6
Knowlden, J.M.7
Williams, S.8
Wakeling, A.E.9
Nicholson, R.I.10
-
24
-
-
4544352393
-
Increased constitutive activity of PKB/Akt in tamoxifen resistant breast cancer MCF-7 cells
-
DOI 10.1023/B:BREA.0000041623.21338.47
-
Jordan NJ, Gee JM, Barrow D, Wakeling AE, Nicholson RI. Increased constitutive activity of PKB/Akt in tamoxifen resistant breast cancer MCF-7 cells. Breast Cancer Res Treat 2004; 87: 167-180 (Pubitemid 39237793)
-
(2004)
Breast Cancer Research and Treatment
, vol.87
, Issue.2
, pp. 167-180
-
-
Jordan, N.J.1
Gee, J.M.W.2
Barrow, D.3
Wakeling, A.E.4
Nicholson, R.I.5
-
25
-
-
0035805546
-
Epidermal Growth Factor (EGF) Receptor Kinase-independent Signaling by EGF
-
DOI 10.1074/jbc.M100928200
-
Deb TB, Su L, Wong L, Bonvini E, Wells A, David M, Johnson GR. Epidermal growth factor (EGF) receptor kinaseindependent signaling by EGF. J Biol Chem 2001; 276: 15554-15560 (Pubitemid 37373452)
-
(2001)
Journal of Biological Chemistry
, vol.276
, Issue.18
, pp. 15554-15560
-
-
Deb, T.B.1
Su, L.2
Wong, L.3
Bonvini, E.4
Wells, A.5
David, M.6
Johnson, G.R.7
-
26
-
-
0037616593
-
Loss of PTEN/MMAC1/TEP in EGF receptor-expressing tumor cells counteracts the antitumor action of EGFR tyrosine kinase inhibitors
-
DOI 10.1038/sj.onc.1206388
-
Bianco R, Shin I, Ritter CA, Yakes FM, Basso A, Rosen N, Tsurutani J, Dennis PA, Mills GB, Arteaga CL. Loss of PTEN/ MMAC1/TEP in EGF receptor-expressing tumor cells counteracts the antitumor action of EGFR tyrosine kinase inhibitors. Oncogene 2003; 22: 2812-2822 (Pubitemid 36609595)
-
(2003)
Oncogene
, vol.22
, Issue.18
, pp. 2812-2822
-
-
Bianco, R.1
Shin, I.2
Ritter, C.A.3
Yakes, F.M.4
Basso, A.5
Rosen, N.6
Tsurutani, J.7
Dennis, P.A.8
Mills, G.B.9
Arteaga, C.L.10
-
27
-
-
0027076295
-
Southwest Oncology Group standard response criteria, endpoint definitions and toxicity criteria
-
DOI 10.1007/BF00944177
-
Green S, Weiss GR. Southwest Oncology Group standard response criteria, endpoint definitions and toxicity criteria. Invest New Drugs 1992; 10: 239-253 (Pubitemid 23008970)
-
(1992)
Investigational New Drugs
, vol.10
, Issue.4
, pp. 239-253
-
-
Green, S.1
Weiss, G.R.2
-
28
-
-
0037106377
-
Selective oral epidermal growth factor receptor tyrosine kinase inhibitor ZD1839 is generally welltolerated and has activity in non-small-cell lung cancer and other solid tumors: Results of a phase i trial
-
Herbst RS, Maddox AM, Rothenberg ML, Small EJ, Rubin EH, Baselga J, Rojo F, Hong WK, Swaisland H, Averbuch SD, Ochs J, LoRusso PM. Selective oral epidermal growth factor receptor tyrosine kinase inhibitor ZD1839 is generally welltolerated and has activity in non-small-cell lung cancer and other solid tumors: results of a phase I trial. J Clin Oncol 2002; 20: 3815-3825
-
(2002)
J Clin Oncol
, vol.20
, pp. 3815-3825
-
-
Herbst, R.S.1
Maddox, A.M.2
Rothenberg, M.L.3
Small, E.J.4
Rubin, E.H.5
Baselga, J.6
Rojo, F.7
Hong, W.K.8
Swaisland, H.9
Averbuch, S.D.10
Ochs, J.11
Lorusso, P.M.12
-
29
-
-
23944476155
-
Phase i safety, pharmacokinetics, and clinical activity study of lapatinib (GW572016), a reversible dual inhibitor of epidermal growth factor receptor tyrosine kinases, in heavily pretreated patients with metastatic carcinomas
-
DOI 10.1200/JCO.2005.16.584
-
Burris HA, Hurwitz HI, Dees EC, Dowlati A, Blackwell KL, O'Neil B, Marcom PK, Ellis MJ, Overmoyer B, Jones SF, Harris JL, Smith DA, et al. Phase I safety, pharmacokinetics, and clinical activity study of lapatinib (GW572016), a reversible dual inhibitor of epidermal growth factor receptor tyrosine kinases, in heavily pretreated patients with metastatic carcinomas. J Clin Oncol 2005; 23: 5305-5313 (Pubitemid 46206984)
-
(2005)
Journal of Clinical Oncology
, vol.23
, Issue.23
, pp. 5305-5313
-
-
Burris III, H.A.1
Hurwitz, H.I.2
Dees, E.C.3
Dowlati, A.4
Blackwell, K.L.5
O'Neil, B.6
Marcom, P.K.7
Ellis, M.J.8
Overmoyer, B.9
Jones, S.F.10
Harris, J.L.11
Smith, D.A.12
Koch, K.M.13
Stead, A.14
Mangum, S.15
Spector, N.L.16
-
30
-
-
57149096463
-
Phase III, double-blind, randomized study comparing lapatinib plus paclitaxei with placebo plus paclitaxei as first-line treatment for metastatic breast cancer
-
Di Leo A, Gomez HL, Aziz Z, Zvirbule Z, Bines J, Arbushites MC, Guerrera SF, Koehler M, Oliva C, Stein SH, Williams LS, Dering J, et al. Phase III, double-blind, randomized study comparing lapatinib plus paclitaxei with placebo plus paclitaxei as first-line treatment for metastatic breast cancer. J Clin Oncol 2008; 26: 5544-5552
-
(2008)
J Clin Oncol
, vol.26
, pp. 5544-5552
-
-
Di Leo, A.1
Gomez, H.L.2
Aziz, Z.3
Zvirbule, Z.4
Bines, J.5
Arbushites, M.C.6
Guerrera, S.F.7
Koehler, M.8
Oliva, C.9
Stein, S.H.10
Williams, L.S.11
Dering, J.12
-
31
-
-
61649118623
-
Single-agent lapatinib for HER2-overexpressing advanced or metastatic breast cancer that progressed on first- Or second-line trastuzumabcontaining regimens
-
Blackwell KL, Pegram MD, Tan-Chiu E, Schwartzberg LS, Arbushites MC, Maltzman JD, Forster JK, Rubin SD, Stein SH, Burstein HJ. Single-agent lapatinib for HER2-overexpressing advanced or metastatic breast cancer that progressed on first- or second-line trastuzumabcontaining regimens. Ann Oncol 2009;20: 1026-1031
-
(2009)
Ann Oncol
, vol.20
, pp. 1026-1031
-
-
Blackwell, K.L.1
Pegram, M.D.2
Tan-Chiu, E.3
Schwartzberg, L.S.4
Arbushites, M.C.5
Maltzman, J.D.6
Forster, J.K.7
Rubin, S.D.8
Stein, S.H.9
Burstein, H.J.10
-
32
-
-
33748170780
-
Gentinib has a low clinical benefit rate in advanced breast cancer patients
-
for Australian New Zealand Breast Cancer Trials Group (ANZ BCTG), Newcastle, NSW, Australia. Presented at the San Antonio, TX, December 10
-
Francis P, GM, Gebski V, Harvey V, Karapetis C, Chan A, Snyder R, Forbes J;for Australian New Zealand Breast Cancer Trials Group (ANZ BCTG), Newcastle, NSW, Australia.Gentinib has a low clinical benefit rate in advanced breast cancer patients. Presented at the 28th Annual San Antonio Breast Cancer Symposium (SABCS), San Antonio, TX, December 10, 2005.
-
(2005)
28th Annual San Antonio Breast Cancer Symposium (SABCS)
-
-
Francis, P.1
Gebski V, G.M.2
Harvey, V.3
Karapetis, C.4
Chan, A.5
Snyder, R.6
Forbes, J.7
-
33
-
-
0038700004
-
Phase II multicenter study to evaluate the efficacy and safety of Tarceva (erlotinib) in women with previously treated locally advanced or metastatic breast cancer
-
Winer E, Cobleigh M, Dickler M, Miller K, Fehrenbacher L, Jones C, Justice R. Phase II multicenter study to evaluate the efficacy and safety of Tarceva (erlotinib) in women with previously treated locally advanced or metastatic breast cancer. Breast Cancer Res Treat 2002; 76(Suppl 1): S115.
-
(2002)
Breast Cancer Res Treat
, vol.76
, Issue.SUPPL. 1
-
-
Winer, E.1
Cobleigh, M.2
Dickler, M.3
Miller, K.4
Fehrenbacher, L.5
Jones, C.6
Justice, R.7
-
34
-
-
34547199941
-
Endocrine therapy for breast cancer: An overview
-
DOI 10.1016/j.breast.2007.03.004, PII S0960977607000719
-
Cheung KL. Endocrine therapy for breast cancer: an overview. Breast 2007; 16: 327-343 (Pubitemid 47109203)
-
(2007)
Breast
, vol.16
, Issue.4
, pp. 327-343
-
-
Cheung, K.L.1
-
35
-
-
0035127466
-
Selection of primary breast cancer patients for adjuvant endocrine therapy-is oestrogen receptor alone adequate?
-
Cheung KL, Nicholson RI, Blarney RW, Robertson JF. Selection of primary breast cancer patients for adjuvant endocrine therapy-is oestrogen receptor alone adequate? Breast Cancer Res Treat 2001;65: 155-162
-
(2001)
Breast Cancer Res Treat
, vol.65
, pp. 155-162
-
-
Cheung, K.L.1
Nicholson, R.I.2
Blarney, R.W.3
Robertson, J.F.4
-
36
-
-
0029870691
-
Oestrogen and progesterone receptors as prognostic variables in hormonally treated breast cancer
-
Robertson JF, Cannon PM, Nicholson RI, Blarney RW. Oestrogen and progesterone receptors as prognostic variables in hormonally treated breast cancer. Int J Biol Markers 1996; 11: 29-35.
-
(1996)
Int J Biol Markers
, vol.11
, pp. 29-35
-
-
Robertson, J.F.1
Cannon, P.M.2
Nicholson, R.I.3
Blarney, R.W.4
-
37
-
-
0018250503
-
Relationship between oestrogen-receptor content and histological grade in human primary breast tumours
-
Maynard PV, Davies CJ, Blarney RW, Elston CW, Johnson J, Griffiths K. Relationship between oestrogen-receptor content and histological grade in human primary breast tumours. Br J Cancer 1978; 38: 745-748
-
(1978)
Br J Cancer
, vol.38
, pp. 745-748
-
-
Maynard, P.V.1
Davies, C.J.2
Blarney, R.W.3
Elston, C.W.4
Johnson, J.5
Griffiths, K.6
-
38
-
-
33745277110
-
Phase II study of gefitinib in combination with docetaxel as first-line therapy in metastatic breast cancer
-
DOI 10.1038/sj.bjc.6603141, PII 6603141
-
Ciardiello F, Troiani T, Caputo F, De Laurentiis M, Tortora G, Palmieri G, De Vita F, Diadema MR, Orditura M, Colantuoni G, Gridelli C, Catalano G, et al. Phase II study of gefitinib in combination with docetaxel as first-line therapy in metastatic breast cancer. Br J Cancer 2006; 94: 1604-1609 (Pubitemid 43924921)
-
(2006)
British Journal of Cancer
, vol.94
, Issue.11
, pp. 1604-1609
-
-
Ciardiello, F.1
Troiani, T.2
Caputo, F.3
De Laurentiis, M.4
Tortora, G.5
Palmieri, G.6
De Vita, F.7
Diadema, M.R.8
Orditura, M.9
Colantuoni, G.10
Gridelli, C.11
Catalano, G.12
Bianco, A.R.13
-
39
-
-
65549098841
-
Epidermal growth factor receptor as a potential therapeutic target in triplenegative breast cancer
-
Corkery B, Crown J, Clynes M, O'Donovan N. Epidermal growth factor receptor as a potential therapeutic target in triplenegative breast cancer. Ann Oncol 2009; 20: 862-867
-
(2009)
Ann Oncol
, vol.20
, pp. 862-867
-
-
Corkery, B.1
Crown, J.2
Clynes, M.3
O'Donovan, N.4
-
40
-
-
0030988729
-
New EGF-R selective tyrosine kinase inhibitor reveals variable growth responses in prostate carcinoma cell lines PC-3 and DU-145
-
DOI 10.1002/(SICI)1097-0215(19970611)71:6<1010::AID-IJC17>3.0.CO;2- H
-
Jones HE, Dutkowski CM, Barrow D, Harper ME, Wakeling AE, Nicholson RI. New EGF-R selective tyrosine kinase inhibitor reveals variable growth responses in prostate carcinoma cell lines PC-3 and DU-145. Int J Cancer 1997;71:1010-1018 (Pubitemid 27252884)
-
(1997)
International Journal of Cancer
, vol.71
, Issue.6
, pp. 1010-1018
-
-
Jones, H.E.1
Dutkowski, C.M.2
Barrow, D.3
Harper, M.E.4
Wakeling, A.E.5
Nicholson, R.I.6
-
41
-
-
36549089022
-
Heregulin β1 drives gefitinib-resistant growth and invasion in tamoxifen-resistant MCF-7 breast cancer cells
-
DOI 10.1186/bcr1754
-
Hutcheson IR, Knowlden JM, Hiscox SE, Barrow D, Gee JM, Robertson. JF, Ellis IO, Nicholson RI. Heregulin betal drives gefitinib-resistant growth and invasion in tamoxifen-resistant MCF-7 breast cancer cells. Breast Cancer Res 2007:9:R50. (Pubitemid 350187472)
-
(2007)
Breast Cancer Research
, vol.9
, Issue.4
-
-
Hutcheson, I.R.1
Knowlden, J.M.2
Hiscox, S.E.3
Barrow, D.4
Gee, J.M.W.5
Robertson, J.F.6
Ellis, I.O.7
Nicholson, R.I.8
-
42
-
-
33645234316
-
Bidirectional cross talkbetween ERalpha and EGFR signalling pathways regulates tamoxifen-resistant growth
-
Brltton DJ, Hutcheson IR, Knowlden JM, Barrow D, Giles M, McClelland RA, Gee JM, Nicholson RI, Bidirectional cross talkbetween ERalpha and EGFR signalling pathways regulates tamoxifen-resistant growth. Breast Cancer Res Treat 2006;96: 131-146
-
(2006)
Breast Cancer Res Treat
, vol.96
, pp. 131-146
-
-
Brltton, D.J.1
Hutcheson, I.R.2
Knowlden, J.M.3
Barrow, D.4
Giles, M.5
McClelland, R.A.6
Gee, J.M.7
Nicholson, R.I.8
-
43
-
-
0242668485
-
Tumor EGFR membrane staining is not clinically relevant for predicting response in patients receiving Gefitinib (Iressa, ZD1839) monotherapy for pretreated advanced non-small-cell lung cancer: IDEAL 1 and 2
-
Bailey LR, Kris M, Wolf M, Kay A, Averbuch S, Askaa J, Janas M, Schmidt K, Fukuoka M. Tumor EGFR membrane staining is not clinically relevant for predicting response in patients receiving Gefitinib (Iressa, ZD1839) monotherapy for pretreated advanced non-small-cell lung cancer: IDEAL 1 and 2. Proc Am Assoc Cancer Res 2003; 44: 1362.
-
(2003)
Proc Am Assoc Cancer Res
, vol.44
, pp. 1362
-
-
Bailey, L.R.1
Kris, M.2
Wolf, M.3
Kay, A.4
Averbuch, S.5
Askaa, J.6
Janas, M.7
Schmidt, K.8
Fukuoka, M.9
-
44
-
-
0031881602
-
Changes in hormone receptors and proliferation markers in tamoxifen treated breast cancer patients and the relationship with response
-
DOI 10.1023/A:1005973529921
-
Makris A, Powles TJ, Allred DC, Ashley S, Ormerod MG, Titley JC, Dowsett M. Changes in hormone receptors and proliferation markers in tamoxifen treated breast cancer patients and the relationship with response. Breast Cancer Res Treat 1998; 48: 11-20. (Pubitemid 28073529)
-
(1998)
Breast Cancer Research and Treatment
, vol.48
, Issue.1
, pp. 11-20
-
-
Makris, A.1
Powles, T.J.2
Allred, D.C.3
Ashley, S.4
Ormerod, M.G.5
Titley, J.C.6
Dowsett, M.7
-
45
-
-
0033969483
-
Prediction of clinical outcome from primary tamoxifen by expression of biologic markers in breast cancer patients
-
ChangJ,PowlesTJ,AllredDC,AshleySE,MakrisA,GregoryRK,OsborneCK,DowsettM. Predictionofclinicaloutcomefromprimarytamoxifenbyexpressionofbiologicmarker sinbreastcancerpatients.ClinCancerRes2000;6:616-621(Pubitemid30111487)
-
(2000)
Clinical Cancer Research
, vol.6
, Issue.2
, pp. 616-621
-
-
Chang, J.1
Powles, T.J.2
Allred, D.C.3
Ashley, S.E.4
Makris, A.5
Gregory, R.K.6
Osborne, C.K.7
Dowsett, M.8
-
46
-
-
0035127192
-
Change in expression of ER, bcl-2 and MIB1 on primary tamoxifen and relation to response in ER positive breast cancer
-
DOI 10.1023/A:1006469627067
-
Kenny FS, Willsher PC, Gee JM, Nicholson R, Pinder SE, Ellis IO, Robertson JF. Change in expression of ER, bcl-2 and MIBl on primary tamoxifen and relation to response in ER positive breast cancer. Breast Cancer Res Treat 2001; 65: 135-144 (Pubitemid 32193617)
-
(2001)
Breast Cancer Research and Treatment
, vol.65
, Issue.2
, pp. 135-144
-
-
Kenny, F.S.1
Willsher, P.C.2
Gee, J.M.W.3
Nicholson, R.I.4
Pinder, S.E.5
Ellis, I.O.6
Robertson, J.F.R.7
-
47
-
-
34447285253
-
Response: Re: Prognostic value of Ki67 expression after short-term presurgical endocrine therapy for primary breast cancer [6]
-
DOI 10.1093/jnci/djm020, Pdf Contents
-
Dowsett M, Smith IE, Ebbs SR, Dixon JM, Skene A, A'Hern R, Salter J, Detre S, Hills M, Walsh G. Prognostic value of Ki67 expression after short-term presurgical endocrine therapy for primary breast cancer. J Natl Cancer Inst 2007; 99: 167-170 (Pubitemid 47232611)
-
(2007)
Journal of the National Cancer Institute
, vol.99
, Issue.13
, pp. 1053-1054
-
-
Dowsett, M.1
Smith, I.E.2
-
48
-
-
19944408390
-
Preoperative gefitinib versus gefitinib and anastrozole in postmenopausal patients with oestrogen-receptor positive and epidermal-growth-factor-receptor- positive primary breast cancer: A double-blind placebo-controlled phase II randomised trial
-
DOI 10.1016/S1470-2045(05)70176-5, PII S1470204505701765
-
Polychrome A, Sinnett HD, Hadjiminas D, Singhal H, Mansi JL, Shivapatham D, Shousha S, Jiang J, Peston D, Barrett N, Vigushin D, Morrison K, et al. Preoperative gefitinib versus gefitinib and anastrozole in postmenopausal patients with oestrogen-receptor positive and epidermal-growth-factor-receptor- positive primary breast cancer: a double-blind placebo-controlled phase II randomised trial. Lancet Oncol 2005; 6: 383-391 (Pubitemid 40753744)
-
(2005)
Lancet Oncology
, vol.6
, Issue.6
, pp. 383-391
-
-
Polychronis, A.1
Sinnett, H.D.2
Hadjiminas, D.3
Singhal, H.4
Mansi, J.L.5
Shivapatham, D.6
Shousha, S.7
Jiang, J.8
Peston, D.9
Barrett, N.10
Vigushin, D.11
Morrison, K.12
Beresford, E.13
Ali, S.14
Slade, M.J.15
Coombes, R.C.16
-
49
-
-
39749085432
-
Short preoperative treatment with erlotinib inhibits tumor cell proliferation in hormone receptor-positive breast cancers
-
DOI 10.1200/JCO.2007.13.5939
-
Guix M, Granja Nde M, Meszoely I, Adkins TB, Wieman BM, Frierson KE, Sanchez V, Sanders ME, Grau AM, Mayer IA, Pestano G, Shyr Y, et al. Short preoperative treatment with erlotinib inhibits tumor cell proliferation in hormone receptor-positive breast cancers. J Clin Oncol 2008; 26: 897-906. (Pubitemid 351398082)
-
(2008)
Journal of Clinical Oncology
, vol.26
, Issue.6
, pp. 897-906
-
-
Guix, M.1
Granja, N.D.M.2
Meszoely, I.3
Adkins, T.B.4
Wieman, B.M.5
Frierson, K.E.6
Sanchez, V.7
Sanders, M.E.8
Grau, A.M.9
Mayer, I.A.10
Pestano, G.11
Shyr, Y.12
Muthuswamy, S.13
Calvo, B.14
Krontiras, H.15
Krop, I.E.16
Kelley, M.C.17
Arteaga, C.L.18
-
50
-
-
26844487041
-
Insulin-like growth factor-I receptor signaling in tamoxifen-resistant breast cancer: A supporting role to the epidermal growth factor receptor
-
DOI 10.1210/en.2005-0247
-
Knowlden JM, Hutcheson IR, Barrow D, Gee JM, Nicholson RI. Insulin-like growth factor-I receptor signaling in tamoxifenresistant breast cancer: a supporting role to the epidermal growth factor receptor. Endocrinology 2005; 146: 4609-4618 (Pubitemid 41446598)
-
(2005)
Endocrinology
, vol.146
, Issue.11
, pp. 4609-4618
-
-
Knowlden, J.M.1
Hutcheson, I.R.2
Barrow, D.3
Gee, J.M.W.4
Nicholson, R.I.5
-
51
-
-
0029837782
-
Prognostic significance of serum c-erbB-2 protein in breast cancer patients
-
DOI 10.1007/BF01806813
-
Willsher PC, Beaver J, Pinder S, Bell JA, Ellis IO, Blarney RW, Robertson JF. Prognostic significance of serum c-erbB-2 proteinin breast cancer patients. Breast Cancer Res Treat 1996; 40: 251-255 (Pubitemid 26336120)
-
(1996)
Breast Cancer Research and Treatment
, vol.40
, Issue.3
, pp. 251-255
-
-
Willsher, P.C.1
Beaver, J.2
Pinder, S.3
Bell, J.A.4
Ellis, I.O.5
Blamey, R.W.6
Robertson, J.F.R.7
-
52
-
-
0031699459
-
C-erbB2 expression predicts response to preoperative chemotherapy for locally advanced breast cancer
-
WillsherPC,PinderSE,GeeJM,EllisIO,ChanSY,NicholsonRI,BlarneyRW, RobertsonJF.C-erbB2expressionpredictsresponse- preoperativechemotherapyforlocallyadvancedbreastcancer.AnticancerRes1998;18(5B): 3695-3698(Pubitemid28564249)
-
(1998)
Anticancer Research
, vol.18
, Issue.5 B
, pp. 3695-3698
-
-
Willsher, P.C.1
Pinder, S.E.2
Gee, J.M.W.3
Ellis, I.O.4
Chan, S.Y.5
Nicholson, R.I.6
Blamey, R.W.7
Robertson, J.F.R.8
-
53
-
-
58149153020
-
A phase I-II study of combined blockade of the ErbB receptor network with trastuzumab and gefitinib in patients with HER2 (ErbB2)-overexpressing metastatic breast cancer
-
Arteaga CL, O'Neill A, Moulder SL, Pins M, Sparano JA, Sledge GW, Davidson NE. A phase I-II study of combined blockade of the ErbB receptor network with trastuzumab and gefitinib in patients with HER2 (ErbB2)-overexpressing metastatic breast cancer. Clin Cancer Res 2008;14: 6277-6283
-
(2008)
Clin Cancer Res
, vol.14
, pp. 6277-6283
-
-
Arteaga, C.L.1
O'Neill, A.2
Moulder, S.L.3
Pins, M.4
Sparano, J.A.5
Sledge, G.W.6
Davidson, N.E.7
-
54
-
-
23944464495
-
Phase II and tumor pharmacodynamic study of gefitinib in patients with advanced breast cancer
-
DOI 10.1200/JCO.2005.08.326
-
Baselga J, Albanell J, Ruiz A, Lluch A, Gascon. P, Guillem V, Gonzalez S, Sauleda S, Marimon I, Tabernero JM, Koehler MT, Rojo F. Phase II and tumor pharmacodynamic study of gefitinib in patients with advanced breast cancer. J Clin Oncol 2005; 23: 5323-5333 (Pubitemid 46206986)
-
(2005)
Journal of Clinical Oncology
, vol.23
, Issue.23
, pp. 5323-5333
-
-
Baselga, J.1
Albanell, J.2
Ruiz, A.3
Lluch, A.4
Gascon, P.5
Guillem, V.6
Gonzalez, S.7
Sauleda, S.8
Marimon, I.9
Tabernero, J.M.10
Koehler, M.T.11
Rojo, F.12
-
55
-
-
0033305004
-
Enhancement of insulin-like growth factor signaling in human breast cancer: Estrogen regulation of insulin receptor substrate-1 expression in vitro and in vivo
-
LeeAV,JacksonJG,GoochJL,HilsenbeckSG,Coronado-HeinsohnE,OsborneCK,YeeD. Enhancementofinsulin-likegrowthfactorsignalinginhumanbreastcancer: estrogenregulationofinsulinreceptorsubstrate-1expressioninvitroandinvivo. MolEndocrinol1999;13:787-796(Pubitemid30645331)
-
(1999)
Molecular Endocrinology
, vol.13
, Issue.5
, pp. 787-796
-
-
Lee, A.V.1
Jackson, J.G.2
Gooch, J.L.3
Hilsenbeck, S.G.4
Coronado-Heinsohn, E.5
Osborne, C.K.6
Yee, D.7
-
56
-
-
0020676410
-
Response of metastatic breast cancer to tamoxifen withdrawal: Report of a case
-
DOI 10.1002/jso.2930220112
-
Stein W, Hortobagyi GN, Blumenschein GR. Response of metastatic breast cancer to tamoxifen withdrawal: report of a case. J Surg Oncol 1983; 22: 45-46 (Pubitemid 13179723)
-
(1983)
Journal of Surgical Oncology
, vol.22
, Issue.1
, pp. 45-46
-
-
Stein III, W.1
Hortobagyi, G.N.2
Blumenschein, G.R.3
-
57
-
-
68549137434
-
Randomized Phase II study of gefitinib (IRESSA) or placebo in combination with tamoxifen in patients with hormone receptor positive metastatic breast cancer
-
Osborne K, Neven P, Dirix L, Mackey J, Robert J, Underbill C, Gutierrez C, Magill P, Hargreaves L. Randomized Phase II study of gefitinib (IRESSA) or placebo in combination with tamoxifen in patients with hormone receptor positive metastatic breast cancer. Breast Cancer Res Treat 2007;106(Suppl 1): S107.
-
(2007)
Breast Cancer Res Treat
, vol.106
, Issue.SUPPL. 1
-
-
Osborne, K.1
Neven, P.2
Dirix, L.3
Mackey, J.4
Robert, J.5
Underbill, C.6
Gutierrez, C.7
Magill, P.8
Hargreaves, L.9
-
58
-
-
34548537574
-
A phase II placebo-controlled trial of neoadjuvant anastrozole alone or with gefitinib in early breast cancer
-
DOI 10.1200/JCO.2006.09.6578
-
Smith IE, Walsh G, Skene A, Llombart A, Mayordomo JI, Detre S, Salter J, Clark E, Magill P, Dowsett M. A phase II placebo-controlled trial of neoadjuvant anastrozole alone or with gefitinib in early breast cancer. J Clin Oncol 2007; 25: 3816-3822 (Pubitemid 47477255)
-
(2007)
Journal of Clinical Oncology
, vol.25
, Issue.25
, pp. 3816-3822
-
-
Smith, I.E.1
Walsh, G.2
Skene, A.3
Llombart, A.4
Mayordomo, J.I.5
Detre, S.6
Salter, J.7
Clark, E.8
Magill, P.9
Dowsett, M.10
-
59
-
-
66249139315
-
A phase II multicenter, double-blind, randomized trial to compare anastrozole plus gefitinib with anastrozole plus placebo in postmenopausal women with hormone receptor-positive (HR+) metastatic breast cancer (MBC)
-
abstr 1012.
-
Cristofanilli M, Valero V, Mangalik A, Rabinowitz I, Arena FP, Kroener JF, Curcio E, Watkins C, Magill P. A phase II multicenter, double-blind, randomized trial to compare anastrozole plus gefitinib with anastrozole plus placebo in postmenopausal women with hormone receptor-positive (HR+) metastatic breast cancer (MBC). J Clin Oncol 2008; 26(Suppl):abstr 1012.
-
(2008)
J Clin Oncol
, vol.26
, Issue.SUPPL.
-
-
Cristofanilli, M.1
Valero, V.2
Mangalik, A.3
Rabinowitz, I.4
Arena, F.P.5
Kroener, J.F.6
Curcio, E.7
Watkins, C.8
Magill, P.9
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