Beneficial effects of propolis on human health and neurological diseases

Frontiers in Bioscience - Elite

Volumn 4 E, Issue 2, 2012, Pages 779-793

  Farooqui, Tahira ^a   Farooqui, Akhlaq A ^a  

^a OHIO STATE UNIVERSITY   (United States)

Author keywords

Anti Inflammatory; Anti Oxidant; Apis mellifera; Flavonoids; Immunomodulatory; Neurological Disorders; Phenolic Acid Esters; Phenolic Acids; Polyphenols

Indexed keywords

APIGENIN; CAFFEIC ACID; CAFFEIC ACID PHENETHYL ESTER; CARBOHYDRATE; CHLOROGENIC ACID; CHRYSIN; CINNAMIC ACID; CINNAMYL ALCOHOL; FERULIC ACID; FLAVONOID; GALANGIN; ISOFERULIC ACID; KAEMPFEROL; LUTEOLIN; MINERAL; MYRICETIN; PINOCEMBRINE; PROPOLIS; QUERCETIN; QUINIC ACID; RUTOSIDE; VANILLIN; VITAMIN;

ALLERGY; ALZHEIMER DISEASE; ANTIINFLAMMATORY ACTIVITY; ANTIMICROBIAL ACTIVITY; ANTINEOPLASTIC ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; ASTHMA; BIOLOGICAL ACTIVITY; BRAIN ISCHEMIA; BRAIN PROTECTION; CHEMICAL COMPOSITION; DIABETES MELLITUS; DIET SUPPLEMENTATION; DRUG BIOAVAILABILITY; DRUG MECHANISM; DRUG TRANSFORMATION; EPILEPSY; HEART PROTECTION; HUMAN; HYPERTENSION; IMMUNOMODULATION; IN VITRO STUDY; IN VIVO STUDY; INFECTION; INFLAMMATORY DISEASE; MULTIPLE SCLEROSIS; NERVOUS SYSTEM INFLAMMATION; NEUROLOGIC DISEASE; NEUROPATHOLOGY; NEUROPROTECTION; NONHUMAN; OXIDATIVE STRESS; PARKINSON DISEASE; PHYTOGEOGRAPHY; UNSPECIFIED SIDE EFFECT; HEALTH STATUS; REVIEW;

APIS MELLIFERA;

HEALTH STATUS; HUMANS; NERVOUS SYSTEM DISEASES; OXIDATIVE STRESS; PROPOLIS;

EID: 84858327443     PISSN: 19450494     EISSN: 19450508     Source Type: Journal    
DOI: 10.2741/e418     Document Type: Article

References (82)

1. GA Burdock. Review of the biological properties and toxicity of bee propolis (Propolis) Food Chem Toxicol, 36, 347-63 (1998)
2. E De Vecchi, L Drago. Propolis' antimicrobial activity: what's new? Infez Med, 15, 7-15 (2007)
3. P Molan. Why honey is effective as a medicine. Part 2. The scientific explanation of its effects. Bee World, 82, 22-40 (2001)
4. K Salomão, PR Pereira, LC Campos, CM Borba, PH Cabello, MC Marcucci, SL de Castro SL. Brazilian propolis: Correlation between chemical composition and antimicrobial activity. Evid Based Complement Alternat Med, 5, 317-24 (2008)
5. A Daugsch, CS Moraes, P Fort, YK Park. Brazilian Red Propolis-Chemical composition and botanical origin. Evid Based Complement Alternat Med, 5, 435-41 (2008)
6. VS Bankova, SL DcCastro, MC Marucci. Propolis recent advances in chemistry and plant origin. Apidologic 31, 3- 15 (2000)
7. AH Banskota, Y Tezuka, S Kadota. Recent progress in pharmacological research of propolis. Phytother Res, 15, 561-71 (2001)
8. T Farooqui, AA Farooqui. Beneficial effects of propolis on human Health: pharmacological and molecular aspects. In: Phytochemicals and Human Health: Pharmacological and Molecular Aspects, Eds: Farooqui AA, Farooqui T, Nova Science Publishers, Hauppage, New York, (in press)
9. S Castalado, F Capasso. Propolis, an old remedy used in modern medicine. Fitoterapia 73(Suppl 1), S1-6 (2002)
10. EL Ghisalberti. Propolis: a review. Bee World, 60, 59-84 (1979)
11. MC Marcucci. Propolis: chemical composition, biological properties and therapeutic activity. Apidologie 26, 83-99 (1995)
12. MC Marcucci, V Bankova. Chemical composition, plant origin and biological activity of Brazilian propolis. Curr Top Phytochem, 2, 115-23 (1999)
13. T Farooqui, AA Farooqui. Molecular mechanism underlying the therapeutic activities of propolis: a critical review. Curr Nutr Food Sci, 6, 186-99 (2010)
14. AA Farooqui, LA Horrocks. Glycerophospholipid Metabolism in Brain. Springer, New York, (2007)
15. AA Farooqui. Hot Topics in Neural Membrane Lipidology. Springer New York, (2009)
16. ME Altuǧ, Y Serarslan, R Bal, T Kontaş, F Ekici, IM Melek, H Aslan, T Duman. Caffeic acid phenethyl ester protects rabbit brains against permanent focal ischemia by antioxidant action: a biochemical and planimetric study. Brain Res, 1201, 135-42 (2008)
17. D Choi, J Han, Y Lee, J Choi, S Han, S Hong, H Jeon, YM Kim, Y Jung. Caffeic acid phenethyl ester is a potent inhibitor of HIF prolyl hydroxylase: structural analysis and pharmacological implication. J Nutr Biochem, 21, 809-17 (2010)
18. X Wei, Z Ma, CV Fontanilla, L Zhao L, ZC Xu, V Taggliabraci, BH Johnstoe, RC Dodel, MR Farlow, Y Du. Caffeic acid phenethyl ester prevents cerebellar granule neurons (CGNs) against glutamate-induced neurotoxicity. Neuroscience 155, 1098-10105 (2008)
19. P Montpied, F de Bock, G Rondouin, G Niel, L Briant, AS Courseau, M Lerner-Natoli, J Bockaert. Caffeic acid phenethyl ester (CAPE) prevents inflammatory stress in organotypic hippocampal slice cultures. Brain Res Mol Brain Res, 115, 111-20 (2003)
20. R Liu, M Gao, ZH Yang, GH Du. Pinocembrin protects rat brain against oxidation and apoptosis induced by ischemia-reperfusion both in vivo and in vitro. Brain Res, 1216, 104-15 (2008)
21. H Ichikawa, K Satoh, T Tobe, I Yasuda, F Ushio, K Matsumoto, K Endo, C Ookubo. Free radical scavenging activity of propolis. Redox Rep, 7, 347-50 (2002)
22. YS Kwon, DH Park, EJ Shin, MS Kwon, KH Ko, WK Kim, JH Jhoo, WK Jhoo, MB Wie, BD Jung, HC Kim. Antioxidant propolis attenuates kainate-induced neurotoxicity via adenosine A1 receptor modulation in the rat. Neurosci Lett, 355 (3), 231-5 (2004)
23. V Bankova. Chemical diversity of propolis and the problem of standardization. J Ethnopharmacol, 100, 114-7 (2005)
24. V Bankova, M Popova, S Bogdanov, AG Sabatini. Chemical composition of European propolis: expected and unexpected results. Zeitschrift für Naturforschung, 57c, 530-3 (2002)
25. A Salatino, EW Teixeira, G Negri, D Message. Origin and Chemical Variation of Brazilian Propolis. Evid Based Complement Alternat Med, 2, 33-8 (2005)
26. AH Banskota, Y Tezuka, JK Prasain, K Matsushige, I Saiki, S Kadota. Chemical constituents of Brazilian propolis and their cytotoxic activities. J Nat Prod, 61, 896- 900 (1998)
27. V Bankova. Recent trends and important developments in propolis research. eCAM, 2, 29-32 (2005)
28. CN Chen, M-S Weng, C-L Wu, JK Lin. Comparison of radical scavenging activity, cytotoxic effects and apoptosis induction in human melanoma cells by Taiwanese propolis from different sources. eCAM, 1, 175-85 (2004)
29. BH Havsteen. The biochemistry and medical significance of the flavonoids. Pharmacol Ther, 96, 67-202 (2002)
30. AM G'mez-Caravaca, M G'mez-Romero, D Arráez- Román, A Segura-Carretero, A Fernández-Gutiérrez. Advances in the analysis of phenolic compounds in products derived from bees. J Pharm Biomed Anal, 41, 1220-34 (2006)
31. S Surveswaron, YZ Cai, H Carke, M Sun. Systematic evaluation of natural phenolic antioxidants from 133 Indian medicinal plant. Food Chem, 102, 938-53 (2007)
32. F Borrelli, P Maffia, L Pinto, A Ianaro, A Russo, F Capasso, A Ialenti. Phytochemical compounds involved in the anti-inflammatory effect of propolis extract. Fitoterapia 73, 53-63 (2002)
33. A dos Santos Pereira, AF de Miranda Pereira, LC Trugo, FR de Aquino Neto FR. Distribution of quinic acid derivatives and other phenolic compounds in Brazilian propolis. Z Naturforsch C, 58, 590-3 (2003)
34. SC Grace, MG Salgo, WA Pryor. Scavenging of peroxynitrite by a phenolic/peroxidase system prevents oxidative damage DNA. FEBS Lett, 426, 24-8 (1998)
35. Y Nakajima, M Shimazawa, S Mishima, H Hara. Neuroprotective effects of Brazilian green propolis and its main constituents against oxygen-glucose deprivation stress, with a gene-expression analysis. Phtother Res, 23, 1431-8 (2009)
36. OK Mirzoeva, PC Calder. The effect of propolis and its components on eicosanoid production during the inflammatory response. Prostaglandins Leukot Essent Fatty Acids, 55, 441-9 (1996)
37. KJ Woo, YJ Jeong, H Inoue, JW Park, TK Kwon. Chrysin suppresses lipopolysaccharide-induced cyclooxygenase-2 expression through the inhibition of nuclear factor for IL-6 (NF-IL6) DNA-binding activity. FEBS Lett, 579, 705-11 (2005)
38. SB Lotito, B Frei. Dietary flavonoids attenuate tumor necrosis factor alpha-induced adhesion molecule expression in human aortic endothelial cells. Structure-function relationships and activity after first pass metabolism. J Biol Chem, 281, 37102-10 (2006)
39. MR Ahn, K Kunimasa, S Kumazawa, T Nakayama, K Kaji, Y Uto, H Hori, H Nagasawa, T Ohta T. Correlation between antiangiogenic activity and antioxidant activity of various components from propolis. Mol Nutr Food Res, 53, 643-51 (2009)
40. S Kumazawa, T Hamasaka, T Nakayama. Antioxidant activity of propolis of various geographic origins. Food Chem, 84, 329-39 (2004)
41. SA van Acker, DJ van Den Berg, MN Tromp, DH Griffioen, WP van Bennekom, WJ van der Vijgh, A Bast. Structural aspects of antioxidant activity of flavonoids. Free Radic Biol Med, 20, 331-42 (1996)
42. SV Jovanovic, S Steenken, M Tosic, B Marjanovic, MG Simic MG. Flavonoids as antioxidants. J Am Chem Soc, 116, 4846-51 (1994)
43. D Amić, D Davidovic-Amić, D Baselo, V Rastija, B Lucić, N Trinajstić. SAR and QSAR of the antioxidant activity of flavonoids. Curr Med Chem, 14, 827-45 (2007)
44. S Kumazawa, R Ueda, T Hamasaka, S Fukumoto, T Fujimoto, T Nakayama. Antioxidant prenylated flavonoids from propolis collected in Okinawa, Japan. J Agric Food Chem, 55, 7722-5 (2007)
45. F Attalla, El-Kott, AA Owayss. Protective effects of propolis against the amitraz hepatotoxicity in mice. J Pharmacol Toxicol, 3, 402-8 (2008)
46. T Farooqui, AA Farooqui. Aging: an important factor for the pathogenesis of neurodegenerative diseases. Mech Ageing Dev, 130, 203-15 (2009)
47. AA Farooqui. Neurochemical Aspects of Neurotraumatic and Neurodegenerative Diseases. Springer New York, (2010)
48. C Noelker, M Bacher, P Gocke, X Wei, T Klockgether, Y Du, R Dodel. The flavanoide caffeic acid phenethyl ester blocks 6-hydroxydopamine-induced neurotoxicity. Neurosci Lett, 383, 39-43 (2005)
49. SK Tsai, MJ Lin, PH Liao, CY Yang, SM Lin, SM Liu, RH Lin, CL Chih, SS Huang. Caffeic acid phenethyl ester ameliorates cerebral infarction in rats subjected to focal cerebral ischemia. Life Sci, 78, 2758-62 (2006)
50. ME Altuǧ, Y Serarslan, R Bal, T Kontaş, F Ekici, IM Melek, H Aslan, T Duman. Caffeic acid phenethyl ester protects rabbit brains against permanent focal ischemia by antioxidant action: a biochemical and planimetric study. Brain Res, 1201, 135-42 (2008)
51. D Choi, J Han, Y Lee, J Choi, S Han, S Hong, H Jeon, YM Kim, Y Jung. Caffeic acid phenethyl ester is a potent inhibitor of HIF prolyl hydroxylase: structural analysis and pharmacological implication. J Nutr Biochem, 21, 809-17 (2010)
52. SK Ha, P Lee, JA Park, HR Oh, SY Lee, J-H Park, E-H Lee, JH Ryu, KR Lee, SY Kim. Apigenin inhibits the production of NO and PGE2 in microglia and inhibits neuronal cell death in a middle cerebral artery occlusioninduced focal ischemia mice model. Neurochem Int, 52, 878-86 (2008)
53. J Chen, Y Long, M Han, T Wang, Q Chen, R Wang. Water-soluble derivative of propolis mitigates scopolamine-induced learning and memory impairment in mice. Pharmacol Biochem Behav, 90, 441-46 (2008)
54. SK Ha, E Moon, SY Kim. Chrysin suppresses LPSstimulated proinflammatory responses by blocking NFkappaB and JNK activations in microglia cells. Neurosci Lett, 485 (3), 143-7 (2010)
55. P Montpied, F de Bock, G Rondouin, G Niel, L Briant, AS Courseau, M Lerner-Natoli, J Bockaert. Caffeic acid phenethyl ester (CAPE) prevents inflammatory stress in organotypic hippocampal slice cultures. Brain Res Mol Brain Res, 115, 111-20 (2003)
56. FA Khalil, NM El-Sheikh. The effects of dietary Egyptian propolis and bee pollen supplementation against toxicity if sodium fluoride in rats. J Am Sci, 2010; 6 (11), 310-6 (2010)
57. R Liu, M Gao, ZH Yang, GH Du. Pinocembrin protects rat brain against oxidation and apoptosis induced by ischemia-reperfusion both in vivo and in vitro. Brain Res, 1216, 104-15 (2008)
58. G Filomeni, I Graziani, D De Zio, L Dini, D Centonze, G Rotilio, MR Ciriolo. Neuroprotection of kaempferol by autophagy in models of rotenone-mediated acute toxicity: possible implications for Parkinson's disease. Neurobiol Aging, (2011)
59. T Tong-un, P Wannanon, J Wattanathorn, W Phachonpai. Cognitive-Enhancing and Antioxidant Activities of Quercetin Liposomes in Animal Model of Alzheimer's Disease. J Biol Sci, 10, 84-91 (2010)
60. H-Q Chen, ZY Jin, XJ Wang, XM Xu, L Deng, JW Zhao. Luteolin protects dopaminergic neurons from inflammation-induced injury through inhibition of microglial activation. Neurosci Lett, 448, 175-9 (2008)
61. S Akira, S Uematsu, O Takeuchi. Pathogen recognition and innate immunity. Cell 124, 783-801 (2006)
62. G Liu, L Zhang, Y Zhao. Modulation of immune responses through direct activation of Toll-like receptors to T cells. Clin Exp Immunol, 160, 168-75 (2010)
63. G Trinchieri, A Sher. Cooperation of Toll-like receptor signals in innate immune defence. Nat Rev Immunol, 7, 179-90 (2007)
64. B Beutler. Inferences, questions and possibilities in Toll-like receptor signalling. Nature, 430, 257-63 (2004)
65. CL Orsatti, F Missima, AC Pagliarone, TF Bachiega, MC Búfalo, JP Araújo Jr, JM Sforcin. Propolis immunomodulatory action in vivo on Toll-like receptors 2 and 4 expression and on pro-inflammatory cytokines production in mice. Phytother Res, 24, 1141-6 (2010)
66. K Rezai-Zadeh, J Ehrhart, Y Bai, PR Sanberg, P Bickford, J Tan, RD Shytle. Apigenin and luteolin modulate microglial activation via inhibition of STAT1- induced CD40 expression. J Neuroinflammation, 5, 41 (2008)
67. JK Lee, SY Kim, YS Kim, E-H Lee, DH Hwang, JY Lee. Suppression of the TRIF-dependent signaling pathway of Toll-like receptor by luteolin. Biochem Pharmacol, 77, 1391-400 (2009)
68. J-C Chen, F-M Ho, P-DL Chao, C-P Chen, K-CG Jeng, H-B Hsu, HB, S-T Lee, WT Wu, W-W Lin. Inhibition of iNOS gene expression by quercetin is mediated by the inhibition of IκB kinase, nuclear factor-κB and STAT1, and depends on heme oxygenase-1 induction in mouse BV-2 microglia. Eur J Pharmacol, 521, 9-20 (2005)
69. Y Lee, DH Shin, JH Kim, S Hong, D Choi, YJ Kim, MK Kwak, Y Jung. Caffeic acid phenethyl ester-mediated Nrf2 activation and IkappaB kinase inhibition are involved in NFkappaB inhibitory effect: structural analysis for NFkappaB inhibition. Eur J Pharmacol, 643, 21-8 (2010)
70. L Rossi, S Mazzitell, M Arciello, CR Capo, G Rotillo. Benefits from dietary polyphenols for brain aging and Alzheimer's disease. Neurochem Res, 33, 2390-400 (2008)
71. JY Wang, LL Wen, YN Huang, YT Chen, MC Ku. Dual effects of antioxidants in neurodegeneration: direct neuroprotection against oxidative stress and indirect protection via suppression of glia-mediated inflammation. Curr Pharm Des, 12, 3521-33 (2006)
72. AA Farooqui, LA Horrocks, T Farooqui. Modulation of inflammation in brain: a matter of fat. J Neurochem, 101, 577-99 (2007)
73. AA Farooqui. Neurochemical Aspects of Inflammation in Brain. In: Molecular Aspects of Neurodegeneration and Neuroprotection, Eds: Farooqui AA, Farooqui, T, Bentham Science Publishers Ltd, Dubai, (in press)
74. S Lehnardt, P Henneke, E Lien, DL Kasper, JJ Volpe, I Bechmann, R Nitch, JR Weber, DT Golenbock, T Vartanian. A mechanism for neurodegeneration induced by group B streptococci through activation of the TLR2/MyD88 pathway in microglia. J Immunol, 177, 583- 92 (2006)
75. MD Nguyen, JP Julien, S Rivest. Innate immunity: the missing link in neuroprotection and neurodegeneration? Nat Rev Neurosci, 3, 216-27 (2002)
76. JM van Noort, M Bsibsi. Toll-like receptors in the CNS: implications for neurodegeneration and repair. Prog Brain Res, 175, 139-48 (2009)
77. GW Konat, T Kielian, I Marriott. The role of Toll-like receptors in CNS response to microbial challenge. J Neurochem, 99, 1-12 (2006)
78. D Trudler, D Farfara, D Frenkel. Toll-like receptors expression and signaling in glia cells in neuro amyloidogenic diseases: towards future therapeutic application. Mediators Inflamm, 2010: 497987 (2010)
79. PG Pietta. Flavonoids as antioxidants. J Nat Prod, 63, 1035-42 (2000)
80. J Robak, RJ Gryglewski. Bioactivity of flavonoids. Pol J Pharmacol, 48, 555-64 (1996)
81. WC Chang, FL Hsu. Inhibition of platelet activation and endothelial cell injury by polyphenolic compounds isolated from Lonicera japonica Thunb. Prostaglandins Leukot Essent Fatty Acids, 45, 307-12 (1992)
82. T Hirano, S Higa, J Arimitsu, T Naka, Y Shima, S Ohshima, M Fujimoto, T Yamadori, I Kawase, T Tanaka. Flavonoids such as luteolin, fisetin and apigenin are inhibitors of interleukin-4 and interleukin-13 production by activated human basophils. Int Arch Allergy Immunol, 134, 135-40 (2004)