Cognitive-enhancing and antioxidant activities of quercetin liposomes in animal model of alzheimer’s disease

OnLine Journal of Biological Sciences

Volumn 10, Issue 2, 2010, Pages 84-91

  Tong un, Terdthai ^a   Wannanon, Panakaporn ^a   Wattanathorn, Jintanaporn ^a   Phachonpai, Wathita ^a  

^a KHON KAEN UNIVERSITY   (Thailand)

Author keywords

Nasal administration; Oxidative stress; Quercetin liposomes; Spatial memory

Indexed keywords

ANIMALIA; RATTUS; RATTUS NORVEGICUS;

EID: 79959858325     PISSN: None     EISSN: 16084217     Source Type: Journal    
DOI: 10.3844/ojbsci.2010.84.91     Document Type: Article

References (39)

1. Andres-Lacueva, C., B. Shukitt-Hale, R. L. Galli O. Jauregui and R. M. Lamuela-Raventos et al., 2005. Anthocyanins in aged blueberry-fed rats are found centrally and may enhance memory. Nutr. Neurosci., 8: 111-120. PMID: 16053243.
2. Auld, D. S., T. J. Kornecook, S. Bastianetto and R. Quirion, 2002. Alzheimer's disease and the basal forebrain cholinergic system: Relations to β-amyloid peptides cognition and treatment strategies. Prog. Neurobiol., 68: 209-245. PMID: 12450488.
3. Boer, V. C. J., A. A. Dihal, H. van Derwoude, I. C. W. Arts and S. Wolffram et al., 2005. Tissue distribution of quercetin in rats and pigs. J. Nutr., 135: 1617-1618. PMID: 15987855.
4. Bokov, A., A. Chaudhuri and A. Richardson, 2004. The role of oxidative damage and stress in aging. Mech. Ageing Dev., 125: 811-826. PMID: 15541775.
5. Boots, A. W., G. R. Haenen and A. Bast, 2008. Health effects of quercetin: From antioxidant to nutraceutical. Eur. J. Pharmacol., 585: 325-337. DOI: 10. 1016/j. ejphar. 2008. 03. 008.
6. Cho, J. Y., I. S. Kim, Y. H. Jang, A. R. Kim and S. R. Lee, 2006. Protective effect of quercetin, a natural flavonoid against neuronal damage after transient global cerebral ischemia. Neurosci. Lett., 404: 330-335. PMID: 16806698 DOI: 10. 1016/j. neulet. 2006. 06. 010.
7. Chrobak, J. J., I. Hanin, D. E. Schmechel and T. J. Walsh, 1988. AF64Ainduced working memory impairment: Behavioral, neurochemical and histological correlates. Brain Res., 463: 107-117. DOI: 10. 1016/0006-8993(88)90532-X.
8. Ellman, G. L., 1959. Tissue sulfhydryl groups. Arch. Biochem. Biophys., 82: 70-77. PMID: 13650640.
9. Formica, J. V. and W. Regelson, 1995. Review of the biology of quercetin and related bioflavonoids. Food Chem. Toxicol., 33: 1061-1080. PMID: 8847003.
10. Galli, R. L., B. Shukitt-Hale, K. A. Youdim and J. A. Joseph, 2002. Fruit polyphenolics and brain aging: Nutritional interventions targeting age-related neuronal and behavioral deficits. Ann. N. Y. Acad. Sci., 959: 128-132. PMID: 11976192.
11. Goldblith, S. A. and B. E. Proctor, 1950. Photometric determination of catalase activity. J. Biol. Chem., 187: 705-709. PMID: 14803454.
12. Graf, B. A., C. Ameho, G. G. Dolnikowski, P. E. Milbury and C. Y. Chen et al., 2006. Rat gastrointestinal tissues metabolized quercetin. J. Nutr., 136: 39-44. PMID: 16365056.
13. Gulyaeva, N., N. Lazareva, M. Libe, O. Mitrokhina and M. Onufriev et al., 1996. Oxidative stress in the brain following intraventricular administration of ethylcholine aziridinium (AF64A). Brain Res., 726: 174-180. DOI: 10. 1016/0006-8993(96)00330-7.
14. Guo, J., Q. Ping, G. Jiang, L. Huang and Y. Tong, 2003. Chitosan-coated liposomes: Characterization and interaction with leuprolide. Int. J. Pharm., 260: 167-173. DOI: 10. 1016/S0378-5173(03)00254-0.
15. Hanin, I., 1996. The AF64A model of cholinergic hypofunction: An update. Life Sci., 58: 1955-1964. DOI: 10. 1016/0024-3205(96)00185-3.
16. Jabeen, B., M. Badaruddin, R. Ali and D. J. Haleem, 2007. Attenuation of restraint induced behavioral deficits and serotonergic responses by stabilized rice bran in rats. Nutr. Neurosci., 10: 11-16. PMID: 17539478.
17. Jamal, T., S. Jean-Michel, R. R. Anthony and K. Michel, 2000. Brain drug delivery technologies: Novel approaches for transporting therapeutics. Pharm. Sci. Technol., 3: 155-162. PMID: 10785657.
18. Keller, B. C., 2001. Liposomes in nutrition. Trends. Food Sci. Technol., 12: 25-31. DOI: 10. 1016/S0924-2244(01)00044.
19. Krauze, L., 2006. Real-time imaging and quantification of brain delivery of liposomes. Pharm. Res., 23: 2493-2504. DOI: 10. 1007/s11095-006-9103-5.
20. Liang, M. T., N. M. Davies and I. Toth, 2005. Encapsulation of lipopeptides within liposomes: Effect of number of lipid chains, chain length and method of liposome preparation. Int. J. Pharm., 301: 247-254. PMID: 16054787.
21. Lowry, O. H., N. J. Rosenbrough, A. L. Farr and R. J. Randall, 1951. Protein measurement with folin phenol reagent. J. Biol. Chem., 193: 265-75. PMID: 14907713.
22. Manach, C., C. Morand, V. Crespy, C. Demignee and O. Texier et al., 1998. Quercetin is recovered in human plasma as conjugated derivatives which retain antioxidant properties. FEBS Lett., 426: 331-336. PMID: 9600261.
23. Manach, C., A. Scalbert, C. Morand, C. Remesy and L. Jimenez, 2004. Polyphenols: Food sources and bioavailability. Am. J. Clin. Nutr., 79: 727-747. PMID: 15113710.
24. Markesbery, W. R., 1999. Oxidative stress hypothesis in Alzheimer's disease. Free Radic. Biol. Med., 23: 134-147. PMID: 9165306.
25. Mattson, M. P., 2004. Pathways towards and away from Alzheimer's disease. Nature, 430: 631-639.
26. McCord, J. M. and I. Fridovich, 1969. Superoxide dismutase. An enzymic function for erythrocuprein (hemocuprein). J. Biol. Chem., 244: 6049-6055. PMID: 5389100 DOI: 10. 1038/nature02621.
27. McDonald, M. D. and J. B. Overmier, 1998. Present imperfect: A critical review of animal models of the mnemonic impairments in Alzheimer's disease. Neurosci. Biobehav. Rev., 22: 99-120. DOI: 10. 1016/S0149-7634(97)00024-9.
28. Metodiewa, D., A. K. Jaiswal, N. Cenas, E. Dickancaite and J. Segura-Aguilar, 1999. Quercetin may act as a cytotoxic prooxidant after its methanolic activation to semiquinone and quinoidal product. Free Radic. Biol. Med., 26: 107-116. PMID: 9890646.
29. Nagata, H., S. Takekoshi, T. Honna and K. Watanabe, 1999. Antioxidative action of flavonoids quercetin and catachin mediated by the activation of glutathione peroxidase. J. Exp. Clin. Med., 24: 1-11. PMID: 10530620.
30. Naumenko, V. S. and A. V. Kulikov, 2006. Quantitative assay of 5-HT (1A) serotonin receptor gene expression in the brain. Molekuliarnaia Biol., 40: 37-44. PMID: 16523690.
31. Ohkawa, H., N. Ohishi and K. Yagi, 1979. Assay for lipid peroxide in animal tissues by thiobarbituric acid reaction. Anal. Biochem., 95: 351-358. DOI: 10. 1016/0003-2697(79)90738-3.
32. Raghavendra, V. and S. K. Kulkarni, 2001. Possible antioxidant mechanism in melatonin reversal of aging and chronic ethanol-induced amnesia in plusmaze and passive avoidance memory tasks. Free Radic. Biol. Med., 30: 595-602. PMID: 11295357.
33. Reiter, M., K. Rupp, P. Baumeister, S. Zieger and U. Harreus, 2009. Antioxidant effects of quercetin and coenzyme Q10 in mini organ cultures of human nasal mucosa cells. Anticancer Res., 29: 33-39. PMID: 19331131.
34. Sarkar, S. and N. Das, 2006. Mannosylated liposomal flavonoid in combating age-related ischemiareperfusion induced oxidative damage in rat brain. Mech. Ageing Dev., 127: 391-397. DOI: 10. 1016/j. mad. 2005. 12. 010.
35. Wang, X., H. He, W. Leng and X. Tang, 2006. Evaluation of brain-targeting for the nasal delivery of estradiol by the microdialysis method. Int. J. Pharm., 317: 40-46. DOI: 10. 1016/j. ijpharm. 2006. 02. 055.
36. Weinstock, M. and S. Shoham, 2004. Rat models of dementia based on reductions in regional glucose metabolism, cerebral blood flow and cytochrome oxidase activity. J. Neural Transm., 111: 347-366. PMID: 14991459.
37. Wu, H., K. Hu and X. Jiang, 2008. From nose to brain: Understanding transport capacity and transport rate of drugs. Expert Opin. Drug Deliv., 5: 1159-1168. PMID: 18817519.
38. Youdim, K. A., M. Z. Qaiser, D. J. Begley, C. A. Rice-Evans and N. J. Abbott, 2004. Flavonoid permeability across an in situ model of the blood-brain barrier. Free. Radic. Biol. Med., 36: 592-604. PMID: 14980703.
39. Zu, Y., C. Li, Y. Fu and C. Zhao, 2006. Simultaneous determination of catechin, rutin, quercetin kaempferol and isorhamnetin in the extract of sea buckthorn (Hippophae rhamnoides L.) leaves by RP-HPLC with DAD. J. Pharm. Biomed. Anal., 41: 714-719. PMID: 16520013 DOI: 10. 1016/j. jpba. 2005. 04. 052.