Comparative potency approach based on H2AX assay for estimating the genotoxicity of polycyclic aromatic hydrocarbons

Toxicology and Applied Pharmacology

Volumn 260, Issue 1, 2012, Pages 58-64

  Audebert, M ^a   Zeman, F ^b   Beaudoin, R ^b   Pery A ^b   Cravedi, J P ^a  

^a TOXALIM RESEARCH CENTRE IN FOOD TOXICOLOGY   (France)

^b INSTITUT NATIONAL DE L ENVIRONNEMENT INDUSTRIEL ET DES RISQUES INERIS   (France)

Author keywords

Genotoxicity; H2AX; HepG2; LS 174T; Modelization; Polycyclic aromatic hydrocarbons; Toxic Equivalent Factor

Indexed keywords

7,12 DIMETHYL BENZ[A]ANTHRACENE; BENZ[A]ANTHRACENE; BENZO[A]PYRENE; BENZO[B]FLUORANTHENE; BENZO[GHI]PERYLENE; BENZO[K]FLUOROANTHENE; CHRYSENE; DIBENZ[A,H]ANTHRACENE; DIBENZO[A,L]PYRENE; FLUORANTHENE; HISTONE H2AX; INDENO[1,2,3 CD]PYRENE; POLYCYCLIC AROMATIC HYDROCARBON; PYRENE; UNCLASSIFIED DRUG;

ARTICLE; ASSAY; CELL LINE; CELL STRAIN HEPG2; DOSE RESPONSE; GENOTOXICITY; HUMAN; HUMAN CELL; IN VITRO STUDY; RISK ASSESSMENT;

CARCINOGENS, ENVIRONMENTAL; CELL LINE, TUMOR; DOSE-RESPONSE RELATIONSHIP, DRUG; HEP G2 CELLS; HISTONES; HUMANS; MODELS, THEORETICAL; MUTAGENICITY TESTS; POLYCYCLIC HYDROCARBONS, AROMATIC;

EID: 84858294203     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2012.01.022     Document Type: Article

References (49)

1. Audebert M., Dolo L., Perdu E., Cravedi J.P., Zalko D. Use of the gammaH2AX assay for assessing the genotoxicity of bisphenol A and bisphenol F in human cell lines. Arch. Toxicol. 2011, 85:1463-1473.
2. Audebert M., Riu A., Jacques C., Hillenweck A., Jamin E.L., Zalko D., Cravedi J.P. Use of the gammaH2AX assay for assessing the genotoxicity of polycyclic aromatic hydrocarbons in human cell lines. Toxicol. Lett. 2010, 199:182-192.
3. Baird W.M., Hooven L.A., Mahadevan B. Carcinogenic polycyclic aromatic hydrocarbon-DNA adducts and mechanism of action. Environ. Mol. Mutagen. 2005, 45:106-114.
4. Bostrom C.E., Gerde P., Hanberg A., Jernstrom B., Johansson C., Kyrklund T., Rannug A., Tornqvist M., Victorin K., Westerholm R. Cancer risk assessment, indicators, and guidelines for polycyclic aromatic hydrocarbons in the ambient air. Environ. Health Perspect. 2002, 110(Suppl 3):451-488.
5. 7H-benzo[c]fluorene, manufactured gas plant residue (MGP), and MGP fractions. Environ. Mol. Mutagen. 2004, 43:159-168.
6. Collins J.F., Brown J.P., Alexeeff G.V., Salmon A.G. Potency equivalency factors for some polycyclic aromatic hydrocarbons and polycyclic aromatic hydrocarbon derivatives. Regul. Toxicol. Pharmacol. 1998, 28:45-54.
7. European Commission Opinion of the Scientific Committee on Food on the Risks to Human Health of Polycyclic Aromatic Hydrocarbons in food 2002, http://ec.europa.eu/food/fs/sc/scf/out153_en.pdf.
8. Durant J.L., Busby W.F., Lafleur A.L., Penman B.W., Crespi C.L. Human cell mutagenicity of oxygenated, nitrated and unsubstituted polycyclic aromatic hydrocarbons associated with urban aerosols. Mutat. Res. 1996, 371:123-157.
9. EFSA Polycyclic aromatic hydrocarbons in food. The EFSA journal 2008, 724:1-114.
10. FAO/WHO Joint FAO/WHO Expert Committee on Food Additives (JECFA). Sixtyfourth meeting, Rome, 8-17 February 2005. Summary and Conclusions 2005, http://www.who.int/ipcs/food/jecfa/summaries/summary_report_64_final.pdf.
11. Graillot V., Takakura N., Le Hegarat L., Fessard V., Audebert M., Cravedi J.P. Genotoxicity of pesticide mixtures present in the diet of the French population. Environ. Mol. Mutagen. 2012, 10.1002/em.21676.
12. Grisham J.W. Interspecies comparison of liver carcinogenesis: implications for cancer risk assessment. Carcinogenesis 1997, 18:59-81.
13. 32P-postlabelling analysis of the covalent binding of benzo[ghi]perylene to DNA in vivo and in vitro. Carcinogenesis 1993, 14:127-133.
14. IARC Some non-heterocyclic polycyclic aromatic hydrocarbons and some related exposures. IARC Monographs on the Evaluation of Carcinogenic Risks to Humans 2010, V92.
15. Ismail I.H., Wadhra T.I., Hammarsten O. An optimized method for detecting gamma-H2AX in blood cells reveals a significant interindividual variation in the gamma-H2AX response among humans. Nucleic Acids Res. 2007, 35:e36.
16. Iwanari M., Nakajima M., Kizu R., Hayakawa K., Yokoi T. Induction of CYP1A1, CYP1A2, and CYP1B1 mRNAs by nitropolycyclic aromatic hydrocarbons in various human tissue-derived cells: chemical-, cytochrome P450 isoform-, and cell-specific differences. Arch. Toxicol. 2002, 76:287-298.
17. Koganti A., Singh R., Rozett K., Modi N., Goldstein L.S., Roy T.A., Zhang F.J., Harvey R.G., Weyand E.H. 7H-benzo[c]fluorene: a major DNA adduct-forming component of coal tar. Carcinogenesis 2000, 21:1601-1609.
18. Lavoie E.J., Tulley L., Bedenko V., Hoffmann D. Mutagenicity of methylated fluorenes and benzofluorenes. Mutat. Res. 1981, 91:167-176.
19. Leopardi P., Cordelli E., Villani P., Cremona T.P., Conti L., De Luca G., Crebelli R. Assessment of in vivo genotoxicity of the rodent carcinogen furan: evaluation of DNA damage and induction of micronuclei in mouse splenocytes. Mutagenesis 2010, 25:57-62.
20. Li W., Harper P.A., Tang B.K., Okey A.B. Regulation of cytochrome P450 enzymes by aryl hydrocarbon receptor in human cells: CYP1A2 expression in the LS180 colon carcinoma cell line after treatment with 2,3,7,8-tetrachlorodibenzo-p-dioxin or 3-methylcholanthrene. Biochem. Pharmacol. 1998, 56:599-612.
21. Louiz I., Kinani S., Gouze M.E., Ben-Attia M., Menif D., Bouchonnet S., Porcher J.M., Ben-Hassine O.K., Ait-Aissa S. Monitoring of dioxin-like, estrogenic and anti-androgenic activities in sediments of the Bizerta lagoon (Tunisia) by means of in vitro cell-based bioassays: contribution of low concentrations of polynuclear aromatic hydrocarbons (PAHs). Sci. Total Environ. 2008, 402:318-329.
22. Lutz W.K. Dose-response relationship for chemical carcinogenesis by genotoxic agents. Soz. Praventivmed. 1991, 36:243-248.
23. Medvedeva N.G., Panyutin I.V., Panyutin I.G., Neumann R.D. Phosphorylation of histone H2AX in radiation-induced micronuclei. Radiat. Res. 2007, 168:493-498.
24. Nisbet I.C., LaGoy P.K. Toxic equivalency factors (TEFs) for polycyclic aromatic hydrocarbons (PAHs). Regul. Toxicol. Pharmacol. 1992, 16:290-300.
25. O'Brien P.J., Irwin W., Diaz D., Howard-Cofield E., Krejsa C.M., Slaughter M.R., Gao B., Kaludercic N., Angeline A., Bernardi P., Brain P., Hougham C. High concordance of drug-induced human hepatotoxicity with in vitro cytotoxicity measured in a novel cell-based model using high content screening. Arch. Toxicol. 2006, 80:580-604.
26. Plazar J., Hreljac I., Pirih P., Filipic M., Groothuis G.M. Detection of xenobiotic-induced DNA damage by the comet assay applied to human and rat precision-cut liver slices. Toxicol. In Vitro 2007, 21:1134-1142.
27. Rodriguez L.V., Dunsford H.A., Steinberg M., Chaloupka K.K., Zhu L., Safe S., Womack J.E., Goldstein L.S. Carcinogenicity of benzo[a]pyrene and manufactured gas plant residues in infant mice. Carcinogenesis 1997, 18:127-135.
28. Safe S.H. Hazard and risk assessment of chemical mixtures using the toxic equivalency factor approach. Environ. Health Perspect. 1998, 106(Suppl 4):1051-1058.
29. Sjogren M., Ehrenberg L., Rannug U. Relevance of different biological assays in assessing initiating and promoting properties of polycyclic aromatic hydrocarbons with respect to carcinogenic potency. Mutat. Res. 1996, 358:97-112.
30. Stocker K.J., Howard W.R., Statham J., Proudlock R.J. Assessment of the potential in vivo genotoxicity of fluoranthene. Mutagenesis 1996, 11:493-496.
31. Tarantini A., Maitre A., Lefebvre E., Marques M., Marie C., Ravanat J.L., Douki T. Relative contribution of DNA strand breaks and DNA adducts to the genotoxicity of benzo[a]pyrene as a pure compound and in complex mixtures. Mutat. Res. 2009, 671:67-75.
32. Team R.D.C. R: a language and environment for statistical computing. R Foundation for Statistical Computing, Vienna, Austria 2008, ISBN 3-900051-07-0, URL. http://www.R-project.org.
33. Terradas M., Martin M., Tusell L., Genesca A. DNA lesions sequestered in micronuclei induce a local defective-damage response. DNA Repair (Amst) 2009, 8:1225-1234.
34. Trouiller B., Reliene R., Westbrook A., Solaimani P., Schiestl R.H. Titanium dioxide nanoparticles induce DNA damage and genetic instability in vivo in mice. Cancer Res. 2009, 69:8784-8789.
35. US-EPA Development of a Relative Potency Factor (RPF) Approach for Polycyclic Aromatic Hydrocarbon (PAH) Mixtures (External Review Draft) 2010, U.S. Environmental Protection Agency, Washington, DC, EPA/635/R-08/012A.
36. Vaca C., Tornqvist M., Rannug U., Lindahl-Kiessling K., Ahnstrom G., Ehrenberg L. On the bioactivation and genotoxic action of fluoranthene. Arch. Toxicol. 1992, 66:538-545.
37. Van den Berg M., Birnbaum L., Bosveld A.T., Brunstrom B., Cook P., Feeley M., Giesy J.P., Hanberg A., Hasegawa R., Kennedy S.W., Kubiak T., Larsen J.C., van Leeuwen F.X., Liem A.K., Nolt C., Peterson R.E., Poellinger L., Safe S., Schrenk D., Tillitt D., Tysklind M., Younes M., Waern F., Zacharewski T. Toxic equivalency factors (TEFs) for PCBs, PCDDs, PCDFs for humans and wildlife. Environ. Health Perspect. 1998, 106:775-792.
38. Walker N.J., Yang J.H. Complexities in understanding the nature of the dose-response for dioxins and related compounds. Dose Response 2005, 3:267-272.
39. Wang J.S., Busby W.F. Induction of lung and liver tumors by fluoranthene in a preweanling CD-1 mouse bioassay. Carcinogenesis 1993, 14:1871-1874.
40. Wang J.S., Busby W.F., Wogan G.N. Formation and persistence of DNA adducts in organs of CD-1 mice treated with a tumorigenic dose of fluoranthene. Carcinogenesis 1995, 16:2609-2616.
41. Watters G.P., Smart D.J., Harvey J.S., Austin C.A. H2AX phosphorylation as a genotoxicity endpoint. Mutat. Res. 2009, 679:50-58.
42. Weyand E.H., Modi N., Parimoo B., Mauro D.M., Craig D.R. Evaluation of PAH:DNA adduct formation in rats fed coal tar-contamined diets. Polycyclic Aromat. Compd. 2002, 22:911-921.
43. Weyand E.H., Parimoo B., Reuhl K.R., Goldstein L.S., Wang J.Q., Harvey R.G. 7H-benzo[c]fluorene: a potent systemic lung carcinogen. Polycyclic Aromat. Compd. 2004, 24:1-20.
44. Winter H.K., Ehrlich V.A., Grusch M., Lackner A., Schulte-Hermann R., Grasl-Kraupp B., Mikulits W., Knasmuller S. Use of four new human-derived liver-cell lines for the detection of genotoxic compounds in the single-cell gel electrophoresis (SCGE) assay. Mutat. Res. 2008, 657:133-139.
45. Wynder E.L., Hoffmann D. The carcinogenicity of benzofluoranthenes. Cancer 1959, 12:1194-1199.
46. Wynder E.L., Hoffmann D. Carcinogenicity of dibenzo(a, l)pyrene. Nature 1961, 192:1092-1093.
47. Xue W., Warshawsky D. Metabolic activation of polycyclic and heterocyclic aromatic hydrocarbons and DNA damage: a review. Toxicol. Appl. Pharmacol. 2005, 206:73-93.
48. Yoshikawa T., Kashino G., Ono K., Watanabe M. Phosphorylated H2AX foci in tumor cells have no correlation with their radiation sensitivities. J. Radiat. Res. (Tokyo) 2009, 50:151-160.
49. Zhou C., Li Z., Diao H., Yu Y., Zhu W., Dai Y., Chen F.F., Yang J. DNA damage evaluated by gammaH2AX foci formation by a selective group of chemical/physical stressors. Mutat. Res. 2006, 604:8-18.