Assessment of the potential in vivo genotoxicity of fluoranthene

Mutagenesis

Volumn 11, Issue 5, 1996, Pages 493-496

  Stocker, Karen J ^a   Howard, Wayne R ^a   Statham, Joanne ^a   Proudlock, Raymond J ^a  

^a HUNTINGDON LIFE SCIENCES   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

FLUORANTHENE; MUTAGENIC AGENT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BONE MARROW; CARCINOGENESIS; CONTROLLED STUDY; GENOTOXICITY; LIVER METABOLISM; MALE; METABOLIC ACTIVATION; MICRONUCLEUS; MOUSE; NONHUMAN; POLLUTANT; PRIORITY JOURNAL; RAT; UNSCHEDULED DNA SYNTHESIS;

ANIMALIA; BACTERIA (MICROORGANISMS); MAMMALIA;

EID: 0029832551     PISSN: 02678357     EISSN: None     Source Type: Journal    
DOI: 10.1093/mutage/11.5.493     Document Type: Article

References (24)

1. Ashby, J. (1986) The prospects for a simplified and internationally harmonized approach to the detection of possible human carcinogens and mutagens. Mutagenesis, 1, 3-16.
2. Barfknecht, T.R., Hites, R.A., Cavalieri, E.L. and Thilly, W.G. (1982) Human cell mutagenicity of polycyclic aromatic hydrocarbon components of diesel emissions. In Lewtas, J. (ed.), Toxicological Effects of Emissions from Diesel Engines. Elsevier Science Publishing Co. Inc., New York, pp. 277-294.
3. Bos, R.P. (1987) Fluoranthene, a carcinogen? (Letter.) Mutat. Res., 189, 187.
4. Butterworth, B.E., Ashby, J., Bermudez, E., Casciano, D., Mirsalis, J., Probsl, G. and Williams, G. (1987) A protocol and guide for the in vivo rat hepatocyte DNA-repair assay. Mutat. Res., 189, 123-133.
5. Busby, W.F.Jr., Goldman, M.E., Newberne, P.M. and Wogan, G.N. (1984) Tumorigenicily of fluoranthene in a newborn mouse lung adenoma bioassay. Carcinogenesis, 5, 1311-1316.
6. Drinking Water Inspectorate (1994) Rouse, M., (ed.), Drinking water 1993, A report of the Chief Inspector Drinking Water Inspectorate, HMSO, London.
7. Gorelick, N.J., Hutchins, D.A., Tannenbaum, S.R. and Wogan, G.N. (1989) Formation of DNA and haemoglobin adducts of fluoranthene after single and multiple exposures. Carcinogenesis, 10, 1579-1587.
8. International Agency for Research on Cancer (1983) IARC Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans. Polynuclear Aromatic Compounds, Part 1, Chemical, Environmental and Experimental Data. Vol. 32. International Agency for Research on Cancer, Lyon, France, pp. 355-364.
9. Kaden, D.A., Hites, R.A. and Thilly, W.G. (1979) Mutagenicity of soot and associated polycyclic aromatic hydrocarbons to Salmonella typhimurium. Cancer Res., 39, 4152-4159.
10. Kennelly, J.C., Waters, R., Ashby, J., Lefevre, P.A., Burlinson, B., Benford, D.J, Dean, S.W. and Mitchell, I. de G. (1993) In vivo rat liver UDS assay. In Kirkland, D.J. and Fox, M. (eds), Supplementary Mutagenicity Tests: UKEMS Recommended Procedures. Cambridge University Press, Cambridge.
11. Kornburst, D. and Dietz, D. (1985) Aroclor pretreatment effects on DNA repair in rat hepatocytes elicited by in vivo and in vitro exposure to various chemicals. Environ. Mutagen. 7, 857-870.
12. LaVoie, E.J., Hecht, S.S., Bedenko, V. and Hoffmann, D. (1982) Identification of the mutagenic metabolites of fluoranthene, 2-methylfluoranthene, and 3-methylfluoranthene. Carcinogenesis, 3, 841-846.
13. LaVoie, E.J., Cai, Z.-W., Meschter, C.L. and Weyand, E.H. (1994) Tumorigenic activity of fluoranthene, 2-methylfluoranthene and 3-methylfluoranthene in newborn CD-1 mice. Carcinogenesis, 15, 2131-2135.
14. Organisation for Economic Co-Operation and Development (1995a) OECD Guideline for the Testing of Chemicals. Revised Draft Document. Proposal for Updating Guideline 474. Mammalian Erythrocyte Micronucleus Test. Organisation for Economic Co-Operation and Development, Paris.
15. Organisation for Economic Co-Operation and Development (1995b) OECD Guideline for the Testing of Chemicals. Revised Draft Document. Proposal for a New Guideline. Unscheduled DNA Synthesis (UDS) Test with Mammalian Liver Cells in vivo. Organisation for Economic Co-Operation and Development, Paris.
16. Palitti, F., Cozzi, R., Fiore, M., Palombo, F., Polcaro, C., Perez, G. and Possagno, E. (1986) An in vitro and in vivo study on mutagenic activity of fluoranthene: comparison between cytogenetic studies and HPLC analysis. Mutat. Res., 174, 125-130.
17. Richold, M., Ashby, J., Bootman, J., Chandley, A., Gatehouse, D.G. and Henderson, L. (1990) In vivo cytogenetics assays. In Kirkland, D.J.(ed.), Basic Mutagenicity Tests: UKEMS Recommended Procedures. Cambridge University Press, Cambridge, pp. 115-141.
18. Rogers, A.W. (1973) Techniques in Autoradiography. Elsevier, Amsterdam.
19. Seglen, P.O. (1976) Preparation of isolated liver cells. In Prescot, D.M. (ed.), Methods in Cell Biology. Vol. XIII. Academic Press, New York, pp. 29-83.
20. Snedecor, G.W. and Cochran, W.G. (1967) Statistical Methods. 6th edn. Iowa State University Press.
21. Thilly, W.G., DeLuca, J.G., Furth, E.E., Hoppe IV,H., Kaden, D.A., Krolewski, J.J., Liber, H.L., Skopek, T.R., Slapikoff, S.A., Tizard, R.J. and Penman, B.W. (1980) Gene-locus mutation assays in diploid human lymphoblast lines. In de Serres, F.J. and Hollaender, A. (eds), Chemical Mutagens, Principles and Methods for their Detection. Vol. 6. Plenum, New York, pp. 331-364.
22. Vaca, C., Törnqvist, M., Rannug, U., Lindahl-Kiessling, K., Ahnström, G. and Ehrenberg, L. (1992) On the bioactivation and genotoxic action of fluoranthene. Arch. Toxicol., 66, 538-545.
23. Wang, J.-S. and Busby Jr., W.F. (1993) Induction of lung and liver tumours by fluoranthene in a pre-weanling CD-1 mouse bioassay. Carcinogenesis, 14, 1871-1874.
24. Wang, J.-S., Busby Jr., W.F. and Wogan, G.N. (1995) Formation and persistence of DNA adducts in organs of CD-1 mice treated with a tumorigenic dose of fluoranthene. Carcinogenesis, 16, 2609-2616.