7H-benzo[c]fluorene: A major DNA adduct-forming component of coal tar

Carcinogenesis

Volumn 21, Issue 8, 2000, Pages 1601-1609

  Koganti, Aruna ^a   Singh, Renu ^a   Rozett, Kimberly ^a   Modi, Nehal ^a   Goldstein, Lawrence S ^b   Roy, Tim A ^c   Zhang, Fang Jie ^d   Harvey, Ronald G ^d   Weyand, Eric H ^a  

^a RUTGERS UNIVERSITY   (United States)

^b ELECTRIC POWER RESEARCH INSTITUTE   (United States)

^c Petrotec Inc   (United States)

^d UNIVERSITY OF CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BENZO[A]FLUORENE; BENZO[A]PYRENE; BENZO[B]FLUORENE; BENZO[C]FLUORENE; COAL TAR; FLUORENE DERIVATIVE; PHOSPHORUS 32; POLYCYCLIC AROMATIC HYDROCARBON; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CAPILLARY GAS CHROMATOGRAPHY; CHEMICAL CARCINOGENESIS; CONTROLLED STUDY; DNA ADDUCT; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; ISOTOPE LABELING; LIVER MICROSOME; LUNG CARCINOGENESIS; LUNG CARCINOMA; MASS SPECTROMETRY; MOUSE; NONHUMAN; PRIORITY JOURNAL; RAT; THIN LAYER CHROMATOGRAPHY;

EID: 0033865643     PISSN: 01433334     EISSN: None     Source Type: Journal    
DOI: 10.1093/carcin/21.8.1601     Document Type: Article

References (32)

1. Toxic equivalency factor approach for risk assessment of combustion byproducts
2. Differences in the tumorigenic activity of a pure hydrocarbon and a complex mixture following ingestion: Benzo[a]pyrene vs manufactured gas plant residue
3. Carcinogenicity of benzo[a]pyrene and manufactured gas plant residues in infant mice
4. A comparison of the tumors induced by coal tar and benzo[a]pyrene in a 2-year bioassay
5. Carcinogenicity of coal tars: A multidisciplinary approach
6. Benzo[a]pyrene diol epoxide-I-DNA adduct formation in the epidermis and lung of sencar mice following topical application of crude coal tar
7. Influences of complex mixtures on tumor-initiating activity, DNA binding and adducts of benzo[a]pyrene
8. Induction of cyp1a-1 and cyp1a-2 gene expression by a reconstituted mixture of polynuclear aromatic hydrocarbons in B6C3F1 mice
9. Arylhydrocarbon (AH) receptor-independent induction of cypla2 gene expression by acenapthylene and related compounds in B6C3F1 mice
10. Genotoxicity of manufactured gas plant residue (MGP) in skin and lung of mice following MGP ingestion or topical administration
11. Relationship between DNA adduct levels and tumor incidence in mice fed coal tar or benzo[a]pyrene for two years
12. DNA adduct measurements, cell proliferation and tumor mutation induction in relation to tumor formation in B6C3F1 mice fed coal tar or benzo[a]pyrene
13. Covalent binding of polycyclic aromatic hydrocarbon components of manufactured gas plant residue to mouse lung and forestomach DNA
14. A new general synthesis of polycyclic aromatic compounds based on enamine chemistry
15. The use of in vitro DNA adduct formation to estimate the genotoxicity of residues at contaminated sites
16. Relevance of polycyclic aromatic hydrocarbons as environmental carcinogens
17. 32P-postlabeling analysis of DNA adducts from non-alternate PAH using thin-layer and high performance liquid chromatography
18. Non-random binding of the carcinogen N-hydroxy-2-acetylaminofluorene to repetitive sequence of rat liver DNA in vivo
19. A procedure for the isolation of deoxyribonucleic acid from microorganisms
20. Mutagenicity of methylated fluorenes and benzofluorenes
21. Comparative studies on the tumor initiating activity and metabolism of methylfluorenes and methylbenzofluorenes
22. The production of cancer by pure hydrocarbons-IV
23. Tumorigenic activity of fluoranthene, 2 methylfluoranthene and 3-methylfluoranthene in newborn CD-1 mice
24. Exceptionally high tumor-initiating activity of benzo[c]phenanthrene bay-region diol-epoxides on mouse skin
25. Benzo[c]phenanthrene is activated to DNA-binding diol epoxides in the human mammary carcinoma cell line MCF-7 but only limited activation occurs in mouse skin
26. DNA binding of manufactured gas site waste components in mouse skin and lung tissue following oral and topical routes of administration
27. Doserelated differences in DNA adduct levels in rodent tissues following skin application of complex mixtures from air pollution sources
28. 32p-postlabelling
29. Covalent binding of polycyclic aromatic hydrocarbon components of coal tar to DNA in mouse skin