A Computational Analysis of the Dynamic Roles of Talin, Dok1, and PIPKI for Integrin Activation

PLoS ONE

Volumn 6, Issue 11, 2011, Pages

  Geier, Florian ^a,b   Fengos, Georgios ^a   Iber, Dagmar ^a  

^a ETH ZURICH   (Switzerland)

^b UNIVERSITY OF BASEL   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

DOCKING PROTEIN; DOK1 PROTEIN; INTEGRIN; LIGAND; PHOSPHATIDYLINOSITOL 4 PHOSPHATE KINASE; PROTEIN TYROSINE KINASE; TALIN; UNCLASSIFIED DRUG; DNA BINDING PROTEIN; PHOSPHOTRANSFERASE;

ARTICLE; BINDING AFFINITY; BIOCHEMISTRY; COMPLEX FORMATION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; ENZYME ACTIVATION; MATHEMATICAL ANALYSIS; MOLECULAR INTERACTION; PROTEIN BINDING; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN STABILITY; SIGNAL TRANSDUCTION; BIOLOGICAL MODEL; CELL MEMBRANE; COMPUTER SIMULATION; METABOLISM; PHOSPHORYLATION; PROTEIN TRANSPORT; UNCERTAINTY;

CELL MEMBRANE; COMPUTER SIMULATION; DNA-BINDING PROTEINS; INTEGRINS; MODELS, BIOLOGICAL; PHOSPHORYLATION; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR); PROTEIN TRANSPORT; SIGNAL TRANSDUCTION; TALIN; UNCERTAINTY;

EID: 84858237475     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0024808     Document Type: Article

References (44)

1. Horwitz R, Webb D, (2003) Cell migration. Curr Biol 13: R756-9.
2. Arnaout MA, Mahalingam B, Xiong JP, (2005) Integrin structure, allostery, and bidirectional signaling. Annu Rev Cell Dev Biol 21: 381-410.
3. Banno A, Ginsberg MH, (2008) Integrin activation. Biochem Soc Trans 36: 229-34.
4. Campbell ID, (2008) Studies of focal adhesion assembly. Biochem Soc Trans 36: 263-6.
5. Hynes RO, Lively JC, McCarty JH, Taverna D, Francis SE, et al.(2002) The diverse roles of integrins and their ligands in angiogenesis. Cold Spring Harb Symp Quant Biol 67: 143-53.
6. Harburger DS, Bouaouina M, Calderwood DA, (2009) Kindlin-1 and-2 directly bind the c-terminal region of beta integrin cytoplasmic tails and exert integrin-specific activation effects. J Biol Chem 284: 11485-97.
7. Moser M, Legate KR, Zent R, Fassler R, (2009) The tail of integrins, talin, and kindlins. Science 324: 895-899.
8. Zhang X, Jiang G, Cai Y, Monkley SJ, Critchley DR, et al.(2008) Talin depletion reveals independence of initial cell spreading from integrin activation and traction. Nat Cell Biol 10: 1062-8.
9. Tadokoro S, Shattil SJ, Eto K, Tai V, Liddington RC, et al.(2003) Talin binding to integrin beta tails: a final common step in integrin activation. Science 302: 103-6.
10. Goksoy E, Ma YQ, Wang X, Kong X, Perera D, et al.(2008) Structural basis for the autoinhibition of talin in regulating integrin activation. Mol Cell 31: 124-33.
11. Martel V, Racaud-Sultan C, Dupe S, Marie C, Paulhe F, et al.(2001) Conformation, localization, and integrin binding of talin depend on its interaction with phosphoinositides. J Biol Chem 276: 21217-27.
12. Paolo GD, Pellegrini L, Letinic K, Cestra G, Zoncu R, et al.(2002) Recruitment and regulation of phosphatidylinositol phosphate kinase type 1 gamma by the ferm domain of talin. Nature 420: 85-9.
13. Ling K, Doughman RL, Iyer VV, Firestone AJ, Bairstow SF, et al.(2003) Tyrosine phosphorylation of type igamma phosphatidylinositol phosphate kinase by src regulates an integrin-talin switch. J Cell Biol 163: 1339-1349.
14. de Pereda JM, Wegener KL, Santelli E, Bate N, Ginsberg MH, et al.(2005) Structural basis for phosphatidylinositol phosphate kinase type igamma binding to talin at focal adhesions. J Biol Chem 280: 8381-8386.
15. Ling K, Doughman RL, Firestone AJ, Bunce MW, Anderson RA, (2002) Type i gamma phosphatidylinositol phosphate kinase targets and regulates focal adhesions. Nature 420: 89-93.
16. Arias-Salgado EG, Lizano S, Shattil SJ, Ginsberg MH, (2005) Specification of the direction of adhesive signaling by the integrin beta cytoplasmic domain. J Biol Chem 280: 29699-707.
17. Arias-Salgado EG, Lizano S, Sarkar S, Brugge JS, Ginsberg MH, et al.(2003) Src kinase activation by direct interaction with the integrin beta cytoplasmic domain. Proc Natl Acad Sci U S A 100: 13298-13302.
18. Barsukov IL, Prescot A, Bate N, Patel B, Floyd DN, et al.(2003) Phosphatidylinositol phosphate kinase type 1gamma and beta1-integrin cytoplasmic domain bind to the same region in the talin ferm domain. J Biol Chem 278: 31202-9.
19. Oxley CL, Anthis NJ, Lowe ED, Vakonakis I, Campbell ID, et al.(2008) An integrin phosphorylation switch: the effect of beta3 integrin tail phosphorylation on dok1 and talin binding. J Biol Chem 283: 5420-5426.
20. Wegener KL, Partridge AW, Han J, Pickford AR, Liddington RC, et al.(2007) Structural basis of integrin activation by talin. Cell 128: 171-82.
21. Faeder JR, Blinov ML, Hlavacek WS, (2009) Rule-based modeling of biochemical systems with bionetgen. Methods Mol Biol 500: 113-67.
22. Nag A, Monine MI, Blinov ML, Goldstein B, (2010) A detailed mathematical model predicts that serial engagement of ige-fcepsilonri complexes can enhance syk activation in mast cells. J Immunol 185: 3268-76.
23. Geier F, Fengos G, Iber D, (2011) A computational analysis of the dynamic roles of talin, Dok1, and PIPKI for integrin activation- Supplementary Text. Plos One.
24. Geier F, Fengos G, Iber D, (2011) A computational analysis of the dynamic roles of talin, Dok1, and PIPKI for integrin activation- Supplementary Table. Plos One.
25. Rao VD, Misra S, Boronenkov IV, Anderson RA, Hurley JH, (1998) Structure of type iibeta phosphatidylinositol phosphate kinase: a protein kinase fold attened for interfacial phosphorylation. Cell 94: 829-39.
26. Ling Y, Maile LA, Badley-Clarke J, Clemmons DR, (2005) Dok1 mediates shp-2 binding to the alphavbeta3 integrin and thereby regulates insulin-like growth factor i signaling in cultured vascular smooth muscle cells. J Biol Chem 280: 3151-8.
27. Melke P, Jönsson H, Pardali E, ten Dijke P, Peterson C, (2006) A rate equation approach to elucidate the kinetics and robustness of the tgf-beta pathway. Biophysical Journal 91: 4368-80.
28. Kuepfer L, Peter M, Sauer U, Stelling J, (2007) Ensemble modeling for analysis of cell signaling dynamics. Nat Biotechnol 25: 1001-6.
29. Gutenkunst RN, Waterfall JJ, Casey FP, Brown KS, Myers CR, et al.(2007) Universally sloppy parameter sensitivities in systems biology models. PLoS Comput Biol 3: 1871-78.
30. Spencer SL, Gaudet S, Albeck JG, Burke JM, Sorger PK, (2009) Non-genetic origins of cell-to-cell variability in trail-induced apoptosis. Nature 459: 428-32.
31. Pampori N, Hato T, Stupack DG, Aidoudi S, Cheresh DA, et al.(1999) Mechanisms and consequences of affinity modulation of integrin alpha(v)beta(3) detected with a novel patch-engineered monovalent ligand. J Biol Chem 274: 21609-16.
32. Suehiro K, Mizuguchi J, Nishiyama K, Iwanaga S, Farrell DH, et al.(2000) Fibrinogen binds to integrin alpha(5)beta(1) via the carboxyl-terminal rgd site of the aalpha-chain. J Biochem 128: 705-10.
33. Faull RJ, Kovach NL, Harlan JM, Ginsberg MH, (1993) Affinity modulation of integrin alpha 5 beta 1: regulation of the functional response by soluble fibronectin. J Cell Biol 121: 155-62.
34. Iber D, Campbell ID, (2006) Integrin activation-the importance of a positive feedback. Bull Math Biol 68: 945-56.
35. Yan B, Calderwood DA, Yaspan B, Ginsberg MH, (2001) Calpain cleavage promotes talin binding to the beta 3 integrin cytoplasmic domain. The Journal of biological chemistry 276: 28164-70.
36. Calderwood DA, Yan B, de Pereda JM, Alvarez BG, Fujioka Y, et al.(2002) The phosphotyrosine binding-like domain of talin activates integrins. J Biol Chem 277: 21749-21758.
37. Roskoski R Jr, (2004) Src protein-tyrosine kinase structure and regulation. Biochem Biophys Res Commun 324: 1155-64.
38. Songyang Z, Carraway KL 3rd, Eck MJ, Harrison SC, Feldman RA, et al.(1995) Catalytic specificity of protein-tyrosine kinases is critical for selective signalling. Nature 373: 536-9.
39. Goldmann WH, Senger R, Kaufmann S, Isenberg G, (1995) Determination of the affinity of talin and vinculin to charged lipid vesicles: a light scatter study. FEBS Lett 368: 516-8.
40. Giudici ML, Lee K, Lim R, Irvine RF, (2006) The intracellular localisation and mobility of type igamma phosphatidylinositol 4p 5-kinase splice variants. FEBS Lett 580: 6933-7.
41. Neff NT, Lowrey C, Decker C, Tovar A, Damsky C, et al.(1982) A monoclonal antibody detaches embryonic skeletal muscle from extracellular matrices. J Cell Biol 95: 654-66.
42. Akiyama SK, Hasegawa E, Hasegawa T, Yamada KM, (1985) The interaction of fibronectin fragments with fibroblastic cells. J Biol Chem 260: 13256-60.
43. Wiseman PW, Brown CM, Webb DJ, Hebert B, Johnson NL, et al.(2004) Spatial mapping of integrin interactions and dynamics during cell migration by image correlation microscopy. J Cell Sci 117: 5521-34.
44. Vitte J, Benoliel AM, Eymeric P, Bongrand P, Pierres A, (2004) Beta-1 integrin-mediated adhesion may be initiated by multiple incomplete bonds, thus accounting for the functional importance of receptor clustering. Biophys J 86: 4059-74.