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1
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80052271501
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Advancing asthma care: The glass is only half full!
-
This article reviews trends in asthma morbidity and morality over the past 20 years as well as remaining gaps in asthma knowledge and treatment
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Szefler SJ. Advancing asthma care: the glass is only half full! J Allergy Clin Immunol 2011; 128:485-494. This article reviews trends in asthma morbidity and morality over the past 20 years as well as remaining gaps in asthma knowledge and treatment.
-
(2011)
J Allergy Clin Immunol
, vol.128
, pp. 485-494
-
-
Szefler, S.J.1
-
2
-
-
33845191620
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Features of severe asthma in school-age children: Atopy and increased exhaled nitric oxide
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DOI 10.1016/j.jaci.2006.08.019, PII S0091674906017702
-
Fitzpatrick AM, Gaston BM, Erzurum SC, Teague WG. Features of severe asthma in school-age children: atopy and increased exhaled nitric oxide. J Allergy Clin Immunol 2006; 118:1218-1225. (Pubitemid 44854125)
-
(2006)
Journal of Allergy and Clinical Immunology
, vol.118
, Issue.6
, pp. 1218-1225
-
-
Fitzpatrick, A.M.1
Gaston, B.M.2
Erzurum, S.C.3
Teague, W.G.4
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3
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33845987340
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Characterization of the severe asthma phenotype by the National Heart, Lung, and Blood Institute's Severe Asthma Research Program
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DOI 10.1016/j.jaci.2006.11.639, PII S0091674906030302
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Moore WC, Bleecker ER, Curran-Everett D, et al. Characterization of the severe asthma phenotype by the National Heart, Lung, and Blood Institute's Severe Asthma Research Program. J Allergy Clin Immunol 2007; 119:405-413. (Pubitemid 46210080)
-
(2007)
Journal of Allergy and Clinical Immunology
, vol.119
, Issue.2
, pp. 405-413
-
-
Moore, W.C.1
Bleecker, E.R.2
Curran-Everett, D.3
Erzurum, S.C.4
Ameredes, B.T.5
Bacharier, L.6
Calhoun, W.J.7
Castro, M.8
Chung, K.F.9
Clark, M.P.10
Dweik, R.A.11
Fitzpatrick, A.M.12
Gaston, B.13
Hew, M.14
Hussain, I.15
Jarjour, N.N.16
Israel, E.17
Levy, B.D.18
Murphy, J.R.19
Peters, S.P.20
Teague, W.G.21
Meyers, D.A.22
Busse, W.W.23
Wenzel, S.E.24
more..
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4
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71749107897
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Consistently very poorly controlled asthma, as defined by the impairment domain of the Expert Panel Report 3 guidelines, increases risk for future severe asthma exacerbations in the Epidemiology and Natural History of Asthma: Outcomes and Treatment Regimens (TENOR) study
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Haselkorn T, Fish JE, Zeiger RS, et al. Consistently very poorly controlled asthma, as defined by the impairment domain of the Expert Panel Report 3 guidelines, increases risk for future severe asthma exacerbations in The Epidemiology and Natural History of Asthma: Outcomes and Treatment Regimens (TENOR) study. J Allergy Clin Immunol 2009; 124:895-902; e1-e4.
-
(2009)
J Allergy Clin Immunol
, vol.124
-
-
Haselkorn, T.1
Fish, J.E.2
Zeiger, R.S.3
-
5
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34248575381
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Association of control and risk of severe asthma-related events in severe or difficult-to-treat asthma patients
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DOI 10.1111/j.1398-9995.2007.01383.x
-
Sullivan SD, Wenzel SE, Bresnahan BW, et al. Association of control and risk of severe asthma-related events in severe or difficult-to-treat asthma patients. Allergy 2007; 62:655-660. (Pubitemid 46763446)
-
(2007)
Allergy: European Journal of Allergy and Clinical Immunology
, vol.62
, Issue.6
, pp. 655-660
-
-
Sullivan, S.D.1
Wenzel, S.E.2
Bresnahan, B.W.3
Zheng, B.4
Lee, J.H.5
Pritchard, M.6
Kamath, T.V.7
Weiss, S.T.8
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6
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78650915946
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Costs of asthma in the United States: 2002-2007
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This article presents current estimates of the incremental direct costs of asthma and productivity losses due to asthma as determined by the Medical Expenditure Panel Survey
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Barnett SB, Nurmagambetov TA. Costs of asthma in the United States: 2002-2007. J Allergy Clin Immunol 2011; 127:145-152. This article presents current estimates of the incremental direct costs of asthma and productivity losses due to asthma as determined by the Medical Expenditure Panel Survey.
-
(2011)
J Allergy Clin Immunol
, vol.127
, pp. 145-152
-
-
Barnett, S.B.1
Nurmagambetov, T.A.2
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7
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79960916856
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Economic burden of impairment in children with severe or difficult-to-treat asthma
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This article presents mean total annual asthma costs for children with severe or difficult-to-treat asthma enrolled in The Epidemiology and Natural History of Asthma: Outcomes and Treatment Regimens study according to the level of asthma control
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Szefler SJ, Zeiger RS, Haselkorn T, et al. Economic burden of impairment in children with severe or difficult-to-treat asthma. Ann Allergy Asthma Immunol 2011; 107:110-119; e1. This article presents mean total annual asthma costs for children with severe or difficult-to-treat asthma enrolled in The Epidemiology and Natural History of Asthma: Outcomes and Treatment Regimens study according to the level of asthma control.
-
(2011)
Ann Allergy Asthma Immunol
, vol.107
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-
Szefler, S.J.1
Zeiger, R.S.2
Haselkorn, T.3
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8
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10744231300
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The ENFUMOSA cross-sectional European multicentre study of the clinical phenotype of chronic severe asthma
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European Network for Understanding Mechanisms of Severe Asthma
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The ENFUMOSA cross-sectional European multicentre study of the clinical phenotype of chronic severe asthma. European Network for Understanding Mechanisms of Severe Asthma. Eur Respir J 2003; 22:470-477.
-
(2003)
Eur Respir J
, vol.22
, pp. 470-477
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9
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9144268928
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Design and baseline characteristics of The Epidemiology and Natural History of Asthma: Outcomes and Treatment Regimens (TENOR) study: A large cohort of patients with severe or difficult-to-treat asthma
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Dolan CM, Fraher KE, Bleecker ER, et al. Design and baseline characteristics of the epidemiology and natural history of asthma: Outcomes and Treatment Regimens (TENOR) study: a large cohort of patients with severe or difficult-totreat asthma. Ann Allergy Asthma Immunol 2004; 92:32-39. (Pubitemid 38113629)
-
(2004)
Annals of Allergy, Asthma and Immunology
, vol.92
, Issue.1
, pp. 32-39
-
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Dolan, C.M.1
Fraher, K.E.2
Bleecker, E.R.3
Borish, L.4
Chipps, B.5
Hayden, M.L.6
Weiss, S.7
Zheng, B.8
Johnson, C.9
Wenzel, S.10
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10
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66749089841
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GA2LEN (Global Allergy and Asthma European Network) addresses the allergy and asthma 'epidemic'
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Bousquet J, Burney PG, Zuberbier T, et al. GA2LEN (Global Allergy and Asthma European Network) addresses the allergy and asthma 'epidemic'. Allergy 2009; 64:969-977.
-
(2009)
Allergy
, vol.64
, pp. 969-977
-
-
Bousquet, J.1
Burney, P.G.2
Zuberbier, T.3
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11
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33846017302
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Severe asthma: Lessons from the Severe Asthma Research Program
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quiz 2-3
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Wenzel SE, Busse WW. Severe asthma: lessons from the Severe Asthma Research Program. J Allergy Clin Immunol 2007; 119:14-21; quiz 2-3.
-
(2007)
J Allergy Clin Immunol
, vol.119
, pp. 14-21
-
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Wenzel, S.E.1
Busse, W.W.2
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13
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63449135734
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Status of childhood asthma in the United States, 1980-2007
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Akinbami LJ, Moorman JE, Garbe PL, Sondik EJ. Status of childhood asthma in the United States, 1980-2007. Pediatrics 2009; 123 (Suppl 3):S131-S145.
-
(2009)
Pediatrics
, vol.123
, Issue.SUPPL. 3
-
-
Akinbami, L.J.1
Moorman, J.E.2
Garbe, P.L.3
Sondik, E.J.4
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14
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84855283737
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Asthma prevalence, healthcare use, and mortality: United States, 2005-2009
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This article presents data from several national surveys on recent trends in asthma prevalence healthcare use, school and work absences, and asthma management practices
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Akinbami LJ, Moorman JE, Liu X. Asthma prevalence, healthcare use, and mortality: United States, 2005-2009. Natl Health Stat Report 2011:1-14. This article presents data from several national surveys on recent trends in asthma prevalence healthcare use, school and work absences, and asthma management practices.
-
(2011)
Natl Health Stat Report
, pp. 1-14
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Akinbami, L.J.1
Moorman, J.E.2
Liu, X.3
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16
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77956366627
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Management of severe asthma in children
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This article reviews clinical diagnostic approaches and therapeutic management strategies for children with severe and difficult-to-treat asthma
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Bush A, Saglani S. Management of severe asthma in children. Lancet 2010; 376:814-825. This article reviews clinical diagnostic approaches and therapeutic management strategies for children with severe and difficult-to-treat asthma.
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(2010)
Lancet
, vol.376
, pp. 814-825
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Bush, A.1
Saglani, S.2
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17
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79953652383
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Assessment of problematic severe asthma in children
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This article presents recommendations for clinical diagnostic approaches for children with severe and difficult-to-treat asthma and reviews relevant practice gaps
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Lodrup Carlsen KC, Hedlin G, Bush A, et al. Assessment of problematic severe asthma in children. Eur Respir J 2011; 37:432-440. This article presents recommendations for clinical diagnostic approaches for children with severe and difficult-to-treat asthma and reviews relevant practice gaps.
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(2011)
Eur Respir J
, vol.37
, pp. 432-440
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Lodrup Carlsen, K.C.1
Hedlin, G.2
Bush, A.3
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18
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77954639445
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Problematic severe asthma in children, not one problem but many: A GA2LEN initiative
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This consensus statement from the Problematic Severe Asthma in Childhood Initiative Group discusses recommended nomenclature and clinical approaches to the child with problematic severe asthma
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Hedlin G, Bush A, Lodrup Carlsen K, et al. Problematic severe asthma in children, not one problem but many: a GA2LEN initiative. Eur Respir J 2010; 36:196-201. This consensus statement from the Problematic Severe Asthma in Childhood Initiative Group discusses recommended nomenclature and clinical approaches to the child with problematic severe asthma.
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(2010)
Eur Respir J
, vol.36
, pp. 196-201
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Hedlin, G.1
Bush, A.2
Lodrup Carlsen, K.3
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19
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80053498278
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Pharmacological treatment of severe, therapy-resistant asthma in children: What can we learn from where?
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This article reviews pharmacological treatment options for children with severe, therapy-resistant asthma
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Bush A, Pedersen S, Hedlin G, et al. Pharmacological treatment of severe, therapy-resistant asthma in children: what can we learn from where? Eur Respir J 2011; 38:947-958. This article reviews pharmacological treatment options for children with severe, therapy-resistant asthma.
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(2011)
Eur Respir J
, vol.38
, pp. 947-958
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Bush, A.1
Pedersen, S.2
Hedlin, G.3
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20
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76149146032
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Identification of asthma phenotypes using cluster analysis in the Severe Asthma Research Program
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This article presents findings from an unbiased cluster analysis of adolescents and adults enrolled in the Severe Asthma Research Program, which identified five distinct clusters or 'phenotypes' of asthma with shared clinical characteristics
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Moore WC, Meyers DA, Wenzel SE, et al. Identification of asthma phenotypes using cluster analysis in the Severe Asthma Research Program. Am J Respir Crit Care Med 2010; 181:315-323. This article presents findings from an unbiased cluster analysis of adolescents and adults enrolled in the Severe Asthma Research Program, which identified five distinct clusters or 'phenotypes' of asthma with shared clinical characteristics.
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(2010)
Am J Respir Crit Care Med
, vol.181
, pp. 315-323
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Moore, W.C.1
Meyers, D.A.2
Wenzel, S.E.3
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21
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77954637790
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Different definitions in childhood asthma: How dependable is the dependent variable?
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This article describes differences in the epidemiological definition of asthma in children and how this may affect prediction of asthma at age 6 years
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Van Wonderen KE, Van Der Mark LB, Mohrs J, et al. Different definitions in childhood asthma: how dependable is the dependent variable? Eur Respir J 2010; 36:48-56. This article describes differences in the epidemiological definition of asthma in children and how this may affect prediction of asthma at age 6 years.
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(2010)
Eur Respir J
, vol.36
, pp. 48-56
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Van Wonderen, K.E.1
Van Der Mark, L.B.2
Mohrs, J.3
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22
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67649805319
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An official American Thoracic Society/European Respiratory Society statement: Asthma control and exacerbations: standardizing endpoints for clinical asthma trials and clinical practice
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Reddel HK, Taylor DR, Bateman ED, et al. An official American Thoracic Society/European Respiratory Society statement: asthma control and exacerbations: standardizing endpoints for clinical asthma trials and clinical practice. Am J Respir Crit Care Med 2009; 180:59-99.
-
(2009)
Am J Respir Crit Care Med
, vol.180
, pp. 59-99
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Reddel, H.K.1
Taylor, D.R.2
Bateman, E.D.3
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23
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53049084809
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A new perspective on concepts of asthma severity and control
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Taylor DR, Bateman ED, Boulet LP, et al. A new perspective on concepts of asthma severity and control. Eur Respir J 2008; 32:545-554.
-
(2008)
Eur Respir J
, vol.32
, pp. 545-554
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Taylor, D.R.1
Bateman, E.D.2
Boulet, L.P.3
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24
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78049457548
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Uniform definition of asthma severity, control, and exacerbations: Document presented for the World Health Organization Consultation on Severe Asthma
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This position statement from the World Health Organization provides a uniform definition for asthma severity, control and exacerbations with important implications for global health
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Bousquet J, Mantzouranis E, Cruz AA, et al. Uniform definition of asthma severity, control, and exacerbations: document presented for the World Health Organization Consultation on Severe Asthma. J Allergy Clin Immunol 2010; 126:926-938. This position statement from the World Health Organization provides a uniform definition for asthma severity, control and exacerbations with important implications for global health.
-
(2010)
J Allergy Clin Immunol
, vol.126
, pp. 926-938
-
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Bousquet, J.1
Mantzouranis, E.2
Cruz, A.A.3
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25
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79952443277
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WHO universal definition of severe asthma
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This article reviews the World Health Organization's definition of asthma severity and control, with emphasis on the relevance to children
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Bush A, Zar HJ. WHO universal definition of severe asthma. Curr Opin Allergy Clin Immunol 2011; 11:115-121. This article reviews the World Health Organization's definition of asthma severity and control, with emphasis on the relevance to children.
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(2011)
Curr Opin Allergy Clin Immunol
, vol.11
, pp. 115-121
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Bush, A.1
Zar, H.J.2
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26
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0034526865
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Proceedings of the ATS workshop on refractory asthma: Current understanding, recommendations, and unanswered questions
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American Thoracic Society
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Proceedings of the ATS workshop on refractory asthma: current understanding, recommendations, and unanswered questions. American Thoracic Society. Am J Respir Crit Care Med 2000; 162:2341-2351.
-
(2000)
Am J Respir Crit Care Med
, vol.162
, pp. 2341-2351
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27
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79551505136
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Asthma endotypes: A new approach to classification of disease entities within the asthma syndrome
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This PRACTALL (PRACtical ALLergy) consensus report proposes definitions for asthma phenotypes versus endotypes and discusses how these terms can be used in the context of clinical research and drug development
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Lotvall J, Akdis CA, Bacharier LB, et al. Asthma endotypes: a new approach to classification of disease entities within the asthma syndrome. J Allergy Clin Immunol 2011; 127:355-360. This PRACTALL (PRACtical ALLergy) consensus report proposes definitions for asthma phenotypes versus endotypes and discusses how these terms can be used in the context of clinical research and drug development.
-
(2011)
J Allergy Clin Immunol
, vol.127
, pp. 355-360
-
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Lotvall, J.1
Akdis, C.A.2
Bacharier, L.B.3
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28
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77954366044
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Phenotypes of childhood asthma: Are they real?
-
This article reviews definitions and approaches to asthma phenotyping with an emphasis on applicability and relevance to clinical practice
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Spycher BD, Silverman M, Kuehni CE. Phenotypes of childhood asthma: are they real? Clin Exp Allergy 2010; 40:1130-1141. This article reviews definitions and approaches to asthma phenotyping with an emphasis on applicability and relevance to clinical practice.
-
(2010)
Clin Exp Allergy
, vol.40
, pp. 1130-1141
-
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Spycher, B.D.1
Silverman, M.2
Kuehni, C.E.3
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29
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79959731559
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Phenotypes of refractory/severe asthma
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This article reviews current understanding of asthma phenotypes and provides suggestions for the approach to asthma 'phenotypes' in the clinical setting
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Bush A, Fleming L. Phenotypes of refractory/severe asthma. Paediatr Respir Rev 2011; 12:177-181. This article reviews current understanding of asthma phenotypes and provides suggestions for the approach to asthma 'phenotypes' in the clinical setting.
-
(2011)
Paediatr Respir Rev
, vol.12
, pp. 177-181
-
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Bush, A.1
Fleming, L.2
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30
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80051739899
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Genetic studies of the etiology of asthma
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This article reviews progress on the study of genes as they relate to asthma cause, including genome-wide association studies
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Barnes KC. Genetic studies of the etiology of asthma. Proc Am Thorac Soc 2011; 8:143-148. This article reviews progress on the study of genes as they relate to asthma cause, including genome-wide association studies.
-
(2011)
Proc Am Thorac Soc
, vol.8
, pp. 143-148
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Barnes, K.C.1
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31
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77956361115
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Genetics of asthma and allergy: What have we learned?
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quiz 47-8. This article reviews progress on understanding of the genetic basis of disease severity with a focus on asthma and also discusses future approaches to personalized medicine
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Meyers DA. Genetics of asthma and allergy: what have we learned? J Allergy Clin Immunol 2010; 126:439-446; quiz 47-8. This article reviews progress on understanding of the genetic basis of disease severity with a focus on asthma and also discusses future approaches to personalized medicine.
-
(2010)
J Allergy Clin Immunol
, vol.126
, pp. 439-446
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Meyers, D.A.1
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32
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84858156027
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Use of sputum eosinophil counts to guide management in children with severe asthma
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Epub ahead of print. This study found that incorporating sputum eosinophil counts into the management of children with severe asthma was not useful in the clinical setting
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Fleming L, Wilson N, Regamey N, Bush A. Use of sputum eosinophil counts to guide management in children with severe asthma. Thorax 2011 [Epub ahead of print]. This study found that incorporating sputum eosinophil counts into the management of children with severe asthma was not useful in the clinical setting.
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(2011)
Thorax
-
-
Fleming, L.1
Wilson, N.2
Regamey, N.3
Bush, A.4
-
33
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79960429165
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Predictors of symptoms are different from predictors of severe exacerbations from asthma in children
-
This study found that children with persistent symptoms were more likely to have severe exacerbations, although the predictors of symptoms and exacerbations differed
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Wu AC, Tantisira K, Li L, et al. Predictors of symptoms are different from predictors of severe exacerbations from asthma in children. Chest 2011; 140:100-107. This study found that children with persistent symptoms were more likely to have severe exacerbations, although the predictors of symptoms and exacerbations differed.
-
(2011)
Chest
, vol.140
, pp. 100-107
-
-
Wu, A.C.1
Tantisira, K.2
Li, L.3
-
34
-
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71049144979
-
Corticosteroid responsiveness and clinical characteristics in childhood difficult asthma
-
Bossley CJ, Saglani S, Kavanagh C, et al. Corticosteroid responsiveness and clinical characteristics in childhood difficult asthma. Eur Respir J 2009; 34:1052-1059.
-
(2009)
Eur Respir J
, vol.34
, pp. 1052-1059
-
-
Bossley, C.J.1
Saglani, S.2
Kavanagh, C.3
-
35
-
-
70449632913
-
Adherence to combined montelukast and fluticasone treatment in economically disadvantaged african american youth with asthma
-
McNally KA, Rohan J, Schluchter M, et al. Adherence to combined montelukast and fluticasone treatment in economically disadvantaged african american youth with asthma. J Asthma 2009; 46:921-927.
-
(2009)
J Asthma
, vol.46
, pp. 921-927
-
-
McNally, K.A.1
Rohan, J.2
Schluchter, M.3
-
36
-
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78649889729
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Health experiences of adolescents with uncontrolled severe asthma
-
This study found that adolescents with uncontrolled severe asthma were often nonadherent with their asthma therapy and also had a poor understanding of their medication
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Edgecombe K, Latter S, Peters S, Roberts G. Health experiences of adolescents with uncontrolled severe asthma. Arch Dis Child 2010; 95:985-991. This study found that adolescents with uncontrolled severe asthma were often nonadherent with their asthma therapy and also had a poor understanding of their medication.
-
(2010)
Arch Dis Child
, vol.95
, pp. 985-991
-
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Edgecombe, K.1
Latter, S.2
Peters, S.3
Roberts, G.4
-
37
-
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61449122947
-
Tablet and inhaled controller medication refill frequencies in children with asthma
-
Fitzpatrick AM, Kir T, Naeher LP, et al. Tablet and inhaled controller medication refill frequencies in children with asthma. J Pediatr Nurs 2009; 24:81-89.
-
(2009)
J Pediatr Nurs
, vol.24
, pp. 81-89
-
-
Fitzpatrick, A.M.1
Kir, T.2
Naeher, L.P.3
-
38
-
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0035888740
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Relationship between exhaled nitric oxide and mucosal eosinophilic inflammation in children with difficult asthma, after treatment with oral prednisolone
-
Payne DN, Adcock IM, Wilson NM, et al. Relationship between exhaled nitric oxide and mucosal eosinophilic inflammation in children with difficult asthma, after treatment with oral prednisolone. Am J Respir Crit Care Med 2001; 164 (8 Pt 1):1376-1381. (Pubitemid 33124013)
-
(2001)
American Journal of Respiratory and Critical Care Medicine
, vol.164
, Issue.8 I
, pp. 1376-1381
-
-
Payne, D.N.R.1
Adcock, I.M.2
Wilson, N.M.3
Oates, T.4
Scallan, M.5
Bush, A.6
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39
-
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0037214337
-
Early thickening of the reticular basement membrane in children with difficult asthma
-
DOI 10.1164/rccm.200205-414OC
-
Payne DN, Rogers AV, Adelroth E, et al. Early thickening of the reticular basement membrane in children with difficult asthma. Am J Respir Crit Care Med 2003; 167:78-82. (Pubitemid 36015921)
-
(2003)
American Journal of Respiratory and Critical Care Medicine
, vol.167
, Issue.1
, pp. 78-82
-
-
Payne, D.N.R.1
Rogers, A.V.2
Adelroth, E.3
Bandi, V.4
Guntupalli, K.K.5
Bush, A.6
Jeffery, P.K.7
-
40
-
-
0035051608
-
Evidence for different subgroups of difficult asthma in children
-
DOI 10.1136/thorax.56.5.345
-
Payne DN, Wilson NM, James A, et al. Evidence for different subgroups of difficult asthma in children. Thorax 2001; 56:345-350. (Pubitemid 32398123)
-
(2001)
Thorax
, vol.56
, Issue.5
, pp. 345-350
-
-
Payne, D.N.R.1
Wilson, N.M.2
James, A.3
Hablas, H.4
Agrafioti, C.5
Bush, A.6
-
41
-
-
4544317118
-
Classifying asthma severity in children: Mismatch between symptoms, medication use, and lung function
-
DOI 10.1164/rccm.200308-1178OC
-
Bacharier LB, Strunk RC, Mauger D, et al. Classifying asthma severity in children: mismatch between symptoms, medication use, and lung function. Am J Respir Crit Care Med 2004; 170:426-432. (Pubitemid 39214618)
-
(2004)
American Journal of Respiratory and Critical Care Medicine
, vol.170
, Issue.4
, pp. 426-432
-
-
Bacharier, L.B.1
Strunk, R.C.2
Mauger, D.3
White, D.4
Lemanske Jr., R.F.5
Sorkness, C.A.6
-
42
-
-
34247489402
-
Demographic and clinical characteristics of children and adolescents with severe or difficult-to-treat asthma
-
DOI 10.1016/j.jaci.2006.12.668, PII S0091674907002369
-
Chipps BE, Szefler SJ, Simons FE, et al. Demographic and clinical characteristics of children and adolescents with severe or difficult-to-treat asthma. J Allergy Clin Immunol 2007; 119:1156-1163. (Pubitemid 46654173)
-
(2007)
Journal of Allergy and Clinical Immunology
, vol.119
, Issue.5
, pp. 1156-1163
-
-
Chipps, B.E.1
Szefler, S.J.2
Simons, F.E.R.3
Haselkorn, T.4
Mink, D.R.5
Deniz, Y.6
Lee, J.H.7
-
43
-
-
78649261484
-
Severe asthma in children: Insights from the National Heart, Lung, and Blood Institute's Severe Asthma Research Program
-
This article reviews findings on severe asthma in children from the Severe Asthma Research Program
-
Fitzpatrick AM, Teague WG. Severe asthma in children: insights from the National Heart, Lung, and Blood Institute's Severe Asthma Research Program. Pediatr Allergy Immunol Pulmonol 2010; 23:131-138. This article reviews findings on severe asthma in children from the Severe Asthma Research Program.
-
(2010)
Pediatr Allergy Immunol Pulmonol
, vol.23
, pp. 131-138
-
-
Fitzpatrick, A.M.1
Teague, W.G.2
-
44
-
-
78449265774
-
Allergy, total serum immunoglobulin E, and airflow in children and adolescents in TENOR
-
This article presents findings on the relationship between allergic sensitization and airflow limitation un children with severe or difficult-to-treat asthma enrolled in The Epidemiology and Natural History of Asthma: Outcomes and Treatment Regimens study
-
Haselkorn T, Szefler SJ, Simons FE, et al. Allergy, total serum immunoglobulin E, and airflow in children and adolescents in TENOR. Pediatr Allergy Immunol 2010; 21:1157-1165. This article presents findings on the relationship between allergic sensitization and airflow limitation un children with severe or difficult-to-treat asthma enrolled in The Epidemiology and Natural History of Asthma: Outcomes and Treatment Regimens study.
-
(2010)
Pediatr Allergy Immunol
, vol.21
, pp. 1157-1165
-
-
Haselkorn, T.1
Szefler, S.J.2
Simons, F.E.3
-
45
-
-
77952206441
-
Use of exhaled nitric oxide measurement to identify a reactive, at-risk phenotype among patients with asthma
-
This study fron the Severe Asthma Research Program found that although exhaled nitric oxide did not differentiate patients with severe versus nonsevere asthma, it did identify a group of patients with severe asthma with significant airflow limitation and exacerbations
-
Dweik RA, Sorkness RL, Wenzel S, et al. Use of exhaled nitric oxide measurement to identify a reactive, at-risk phenotype among patients with asthma. Am J Respir Crit Care Med 2010; 181:1033-1041. This study fron the Severe Asthma Research Program found that although exhaled nitric oxide did not differentiate patients with severe versus nonsevere asthma, it did identify a group of patients with severe asthma with significant airflow limitation and exacerbations.
-
(2010)
Am J Respir Crit Care Med
, vol.181
, pp. 1033-1041
-
-
Dweik, R.A.1
Sorkness, R.L.2
Wenzel, S.3
-
46
-
-
38949165471
-
Lung function in adults with stable but severe asthma: Air trapping and incomplete reversal of obstruction with bronchodilation
-
DOI 10.1152/japplphysiol.00329.2007
-
Sorkness RL, Bleecker ER, Busse WW, et al. Lung function in adults with stable but severe asthma: air trapping and incomplete reversal of obstruction with bronchodilation. J Appl Physiol 2008; 104:394-403. (Pubitemid 351231486)
-
(2008)
Journal of Applied Physiology
, vol.104
, Issue.2
, pp. 394-403
-
-
Sorkness, R.L.1
Bleecker, E.R.2
Busse, W.W.3
Calhoun, W.J.4
Castro, M.5
Chung, K.F.6
Curran-Everett, D.7
Erzurum, S.C.8
Gaston, B.M.9
Israel, E.10
Jarjour, N.N.11
Moore, W.C.12
Peters, S.P.13
Teague, W.G.14
Wenzel, S.E.15
-
47
-
-
79953670552
-
Sex dependence of airflow limitation and air trapping in children with severe asthma
-
This study from the Severe Asthma Research Program describes differences in pre and postbronchodilator airflow limitation and air trapping in asthmatic children according to sex
-
Sorkness RL, Teague WG, Penugonda M, Fitzpatrick AM. Sex dependence of airflow limitation and air trapping in children with severe asthma. J Allergy Clin Immunol 2011; 127:1073-1074. This study from the Severe Asthma Research Program describes differences in pre and postbronchodilator airflow limitation and air trapping in asthmatic children according to sex.
-
(2011)
J Allergy Clin Immunol
, vol.127
, pp. 1073-1074
-
-
Sorkness, R.L.1
Teague, W.G.2
Penugonda, M.3
Fitzpatrick, A.M.4
-
48
-
-
78650921930
-
Progressive airflow limitation is a feature of children with severe asthma
-
This small cohort study from the Severe Asthma Research Program descibes accelerated loss of lung function in children with severe asthma associated with daily symptoms and allergic sensitization
-
Fitzpatrick AM, Teague WG. Progressive airflow limitation is a feature of children with severe asthma. J Allergy Clin Immunol 2011; 127:282-284. This small cohort study from the Severe Asthma Research Program descibes accelerated loss of lung function in children with severe asthma associated with daily symptoms and allergic sensitization.
-
(2011)
J Allergy Clin Immunol
, vol.127
, pp. 282-284
-
-
Fitzpatrick, A.M.1
Teague, W.G.2
-
49
-
-
3242743550
-
Progression of asthma measured by lung function in the childhood asthma management program
-
Covar RA, Spahn JD, Murphy JR, Szefler SJ. Progression of asthma measured by lung function in the childhood asthma management program. Am J Respir Crit Care Med 2004; 170:234-241. (Pubitemid 38971407)
-
(2004)
American Journal of Respiratory and Critical Care Medicine
, vol.170
, Issue.3
, pp. 234-241
-
-
Covar, R.A.1
Spahn, J.D.2
Murphy, J.R.3
Szefler, S.J.4
-
50
-
-
75849136559
-
Predictors of remitting, periodic, and persistent childhood asthma
-
This article from the Childhood Asthma Management Program found that allergic sensitization and exposure, low lung function, and airway hyper-responsiveness are associated with asthma persistence in childhood
-
Covar RA, Strunk R, Zeiger RS, et al. Predictors of remitting, periodic, and persistent childhood asthma. J Allergy Clin Immunol 2010; 125:359-366; e3. This article from the Childhood Asthma Management Program found that allergic sensitization and exposure, low lung function, and airway hyper-responsiveness are associated with asthma persistence in childhood.
-
(2010)
J Allergy Clin Immunol
, vol.125
-
-
Covar, R.A.1
Strunk, R.2
Zeiger, R.S.3
-
51
-
-
0036606480
-
1/vital capacity ratio: A longitudinal population study from childhood to adulthood
-
DOI 10.1164/rccm.2108009
-
Rasmussen F, Taylor DR, Flannery EM, et al. Risk factors for airway remodeling in asthma manifested by a low postbronchodilator FEV1/vital capacity ratio: a longitudinal population study from childhood to adulthood. Am J Respir Crit Care Med 2002; 165:1480-1488. (Pubitemid 34606661)
-
(2002)
American Journal of Respiratory and Critical Care Medicine
, vol.165
, Issue.11
, pp. 1480-1488
-
-
Rasmussen, F.1
Robin, T.D.2
Flannery, E.M.3
Cowan, J.O.4
Greene, J.M.5
Peter, H.G.6
Sears, M.R.7
-
52
-
-
0141639949
-
A longitudinal, population-based, cohort study of childhood asthma followed to adulthood
-
DOI 10.1056/NEJMoa022363
-
Sears MR, Greene JM, Willan AR, et al. A longitudinal, population-based, cohort study of childhood asthma followed to adulthood. N Engl J Med 2003; 349:1414-1422. (Pubitemid 37211056)
-
(2003)
New England Journal of Medicine
, vol.349
, Issue.15
, pp. 1414-1422
-
-
Sears, M.R.1
Greene, J.M.2
Willan, A.R.3
Wiecek, E.M.4
Taylor, D.R.5
Flannery, E.M.6
Cowan, J.O.7
Herbison, G.P.8
Silva, P.A.9
Poulton, R.10
-
53
-
-
0037460725
-
Longitudinal study of childhood wheezy bronchitis and asthma: Outcome at age 42
-
Horak E, Lanigan A, Roberts M, et al. Longitudinal study of childhood wheezy bronchitis and asthma: outcome at age 42. Br Med J 2003; 326:422-423. (Pubitemid 36246312)
-
(2003)
British Medical Journal
, vol.326
, Issue.7386
, pp. 422-423
-
-
Horak, E.1
Lanigan, A.2
Roberts, M.3
Welsh, L.4
Wilson, J.5
Carlin, J.B.6
Olinsky, A.7
Robertson, C.F.8
-
55
-
-
33750526051
-
Mild to moderate asthma affects lung growth in children and adolescents
-
DOI 10.1016/j.jaci.2006.07.053, PII S0091674906017155
-
Strunk RC, Weiss ST, Yates KP, et al. Mild to moderate asthma affects lung growth in children and adolescents. J Allergy Clin Immunol 2006; 118:1040-1047. (Pubitemid 44666990)
-
(2006)
Journal of Allergy and Clinical Immunology
, vol.118
, Issue.5
, pp. 1040-1047
-
-
Strunk, R.C.1
Weiss, S.T.2
Yates, K.P.3
Tonascia, J.4
Zeiger, R.S.5
Szefler, S.J.6
-
56
-
-
42649096323
-
Increased airway smooth muscle mass in children with asthma, cystic fibrosis, and non-cystic fibrosis bronchiectasis
-
DOI 10.1164/rccm.200707-977OC
-
Regamey N, Ochs M, Hilliard TN, et al. Increased airway smooth muscle mass in children with asthma, cystic fibrosis, and noncystic fibrosis bronchiectasis. Am J Respir Crit Care Med 2008; 177:837-843. (Pubitemid 351600661)
-
(2008)
American Journal of Respiratory and Critical Care Medicine
, vol.177
, Issue.8
, pp. 837-843
-
-
Regamey, N.1
Ochs, M.2
Hilliard, T.N.3
Muhlfeld, C.4
Cornish, N.5
Fleming, L.6
Saglani, S.7
Alton, E.W.F.W.8
Bush, A.9
Jeffery, P.K.10
Davies, J.C.11
-
57
-
-
6344250580
-
Airway inflammation in children with difficult asthma: Relationships with airflow limitation and persistent symptoms
-
DOI 10.1136/thx.2003.017244
-
Payne DN, Qiu Y, Zhu J, et al. Airway inflammation in children with difficult asthma: relationships with airflow limitation and persistent symptoms. Thorax 2004; 59:862-869. (Pubitemid 39389626)
-
(2004)
Thorax
, vol.59
, Issue.10
, pp. 862-869
-
-
Payne, D.N.R.1
Qiu, Y.2
Zhu, J.3
Peachey, L.4
Scallan, M.5
Bush, A.6
Jeffery, P.K.7
-
58
-
-
33750592575
-
Epithelial damage and angiogenesis in the airways of children with asthma
-
DOI 10.1164/rccm.200602-189OC
-
Barbato A, Turato G, Baraldo S, et al. Epithelial damage and angiogenesis in the airways of children with asthma. Am J Respir Crit Care Med 2006; 174:975-981. (Pubitemid 44684445)
-
(2006)
American Journal of Respiratory and Critical Care Medicine
, vol.174
, Issue.9
, pp. 975-981
-
-
Barbato, A.1
Turato, G.2
Baraldo, S.3
Bazzan, E.4
Calabrese, F.5
Panizzolo, C.6
Zanin, M.E.7
Zuin, R.8
Maestrelli, P.9
Fabbri, L.M.10
Saetta, M.11
-
59
-
-
80053087268
-
Noneosinophilic asthma in children: Relation with airway remodelling
-
This study found evidence of airway remodeling in children with noneosinophilic asthma that was not significantly different from that observed in children with eosinophilic asthma
-
Baraldo S, Turato G, Bazzan E, et al. Noneosinophilic asthma in children: relation with airway remodelling. Eur Respir J 2011; 38:575-583. This study found evidence of airway remodeling in children with noneosinophilic asthma that was not significantly different from that observed in children with eosinophilic asthma.
-
(2011)
Eur Respir J
, vol.38
, pp. 575-583
-
-
Baraldo, S.1
Turato, G.2
Bazzan, E.3
-
60
-
-
36049007283
-
Early detection of airway wall remodeling and eosinophilic inflammation in preschool wheezers
-
DOI 10.1164/rccm.200702-212OC
-
Saglani S, Payne DN, Zhu J, et al. Early detection of airway wall remodeling and eosinophilic inflammation in preschool wheezers. Am J Respir Crit Care Med 2007; 176:858-864. (Pubitemid 350097074)
-
(2007)
American Journal of Respiratory and Critical Care Medicine
, vol.176
, Issue.9
, pp. 858-864
-
-
Saglani, S.1
Payne, D.N.2
Zhu, J.3
Wang, Z.4
Nicholson, A.G.5
Bush, A.6
Jeffery, P.K.7
-
61
-
-
20144387227
-
Airway remodeling and inflammation in symptomatic infants with reversible airflow obstruction
-
DOI 10.1164/rccm.200410-1404OC
-
Saglani S, Malmstrom K, Pelkonen AS, et al. Airway remodeling and inflammation in symptomatic infants with reversible airflow obstruction. Am J Respir Crit Care Med 2005; 171:722-727. (Pubitemid 40471142)
-
(2005)
American Journal of Respiratory and Critical Care Medicine
, vol.171
, Issue.7
, pp. 722-727
-
-
Saglani, S.1
Malmstrom, K.2
Pelkonen, A.S.3
Malmberg, L.P.4
Lindahl, H.5
Kajosaari, M.6
Turpeinen, M.7
Rogers, A.V.8
Payne, D.N.9
Bush, A.10
Haahtela, T.11
Makela, M.J.12
Jeffery, P.K.13
-
62
-
-
79953027095
-
Development of the bronchial epithelial reticular basement membrane: Relationship to epithelial height and age
-
This study found that the reticular basement membrane was microscopically identifiable by 30 weeks' gestation and thickened further in early childhood and adolescence
-
Tsartsali L, Hislop AA, McKay K, et al. Development of the bronchial epithelial reticular basement membrane: relationship to epithelial height and age. Thorax 2011; 66:280-285. This study found that the reticular basement membrane was microscopically identifiable by 30 weeks' gestation and thickened further in early childhood and adolescence.
-
(2011)
Thorax
, vol.66
, pp. 280-285
-
-
Tsartsali, L.1
Hislop, A.A.2
McKay, K.3
-
63
-
-
0141504373
-
Airway inflammation in childhood asthma
-
DOI 10.1164/rccm.200305-650OC
-
Barbato A, Turato G, Baraldo S, et al. Airway inflammation in childhood asthma. Am J Respir Crit Care Med 2003; 168:798-803. (Pubitemid 37188303)
-
(2003)
American Journal of Respiratory and Critical Care Medicine
, vol.168
, Issue.7
, pp. 798-803
-
-
Barbato, A.1
Turato, G.2
Baraldo, S.3
Bazzan, E.4
Calabrese, F.5
Tura, M.6
Zuin, R.7
Beghe, B.8
Maestrelli, P.9
Fabbri, L.M.10
Saetta, M.11
-
64
-
-
79251608789
-
Lung function, airway remodelling and inflammation in symptomatic infants: Outcome at 3 years
-
This study found that infants with decreased pulmonary function, increased reticular basement membrane thickening, and increased mucosal mast cells had more asthma symptoms and greater inhaled asthma medication requirements at 3 years of age
-
Malmstrom K, Pelkonen AS, Malmberg LP, et al. Lung function, airway remodelling and inflammation in symptomatic infants: outcome at 3 years. Thorax 2011; 66:157-162. This study found that infants with decreased pulmonary function, increased reticular basement membrane thickening, and increased mucosal mast cells had more asthma symptoms and greater inhaled asthma medication requirements at 3 years of age.
-
(2011)
Thorax
, vol.66
, pp. 157-162
-
-
Malmstrom, K.1
Pelkonen, A.S.2
Malmberg, L.P.3
-
65
-
-
50849122094
-
Neutrophilic airway inflammation and association with bacterial lipopolysaccharide in children with asthma and wheezing
-
Hauk PJ, Krawiec M, Murphy J, et al. Neutrophilic airway inflammation and association with bacterial lipopolysaccharide in children with asthma and wheezing. Pediatr Pulmonol 2008; 43:916-923.
-
(2008)
Pediatr Pulmonol
, vol.43
, pp. 916-923
-
-
Hauk, P.J.1
Krawiec, M.2
Murphy, J.3
-
66
-
-
38849096425
-
Neutrophil but not eosinophil inflammation is related to the severity of a first acute epidemic bronchiolitis in young infants
-
DOI 10.1111/j.1399-3038.2007.00600.x
-
Marguet C, Bocquel N, Benichou J, et al. Neutrophil but not eosinophil inflammation is related to the severity of a first acute epidemic bronchiolitis in young infants. Pediatr Allergy Immunol 2008; 19:157-165. (Pubitemid 351197287)
-
(2008)
Pediatric Allergy and Immunology
, vol.19
, Issue.2
, pp. 157-165
-
-
Marguet, C.1
Bocquel, N.2
Benichou, J.3
Basuyau, J.P.4
Hellot, M.F.5
Couderc, L.6
Mallet, E.7
Mace, B.8
-
67
-
-
0032933252
-
Bronchoalveolar cell profiles in children with asthma, infantile wheeze, chronic cough, or cystic fibrosis
-
Marguet C, Jouen-Boedes F, Dean TP, Warner JO. Bronchoalveolar cell profiles in children with asthma, infantile wheeze, chronic cough, or cystic fibrosis. Am J Respir Crit Care Med 1999; 159:1533-1540. (Pubitemid 29227865)
-
(1999)
American Journal of Respiratory and Critical Care Medicine
, vol.159
, Issue.5 I
, pp. 1533-1540
-
-
Marguet, C.1
Jouen-Boedes, F.2
Dean, T.P.3
Warner, J.O.4
-
68
-
-
33747811511
-
Ultrastructure of the reticular basement membrane in asthmatic adults, children and infants
-
DOI 10.1183/09031936.06.00056405
-
Saglani S, Molyneux C, Gong H, et al. Ultrastructure of the reticular basement membrane in asthmatic adults, children and infants. Eur Respir J 2006; 28:505-512. (Pubitemid 44794664)
-
(2006)
European Respiratory Journal
, vol.28
, Issue.3
, pp. 505-512
-
-
Saglani, S.1
Molyneux, C.2
Gong, H.3
Rogers, A.4
Malmstrom, K.5
Pelkonen, A.6
Makela, M.7
Adelroth, E.8
Bush, A.9
Payne, D.N.R.10
Jeffery, P.K.11
-
69
-
-
58149181699
-
Airway glutathione homeostasis is altered in children with severe asthma: Evidence for oxidant stress
-
Fitzpatrick AM, Teague WG, Holguin F, et al. Airway glutathione homeostasis is altered in children with severe asthma: evidence for oxidant stress. J Allergy Clin Immunol 2009; 123:146-152; e8.
-
(2009)
J Allergy Clin Immunol
, vol.123
-
-
Fitzpatrick, A.M.1
Teague, W.G.2
Holguin, F.3
-
70
-
-
79951659624
-
Glutathione oxidation is associated with airway macrophage functional impairment in children with severe asthma
-
This substudy from the Severe Asthma Research Program found that children with severe asthma have oxidation of the antioxidant, glutathione, which is associated with impaired airway macrophage function including apoptosis and phagocytosis of infectious particles
-
Fitzpatrick AM, Teague WG, Burwell L, et al. Glutathione oxidation is associated with airway macrophage functional impairment in children with severe asthma. Pediatr Res 2011; 69:154-159. This substudy from the Severe Asthma Research Program found that children with severe asthma have oxidation of the antioxidant, glutathione, which is associated with impaired airway macrophage function including apoptosis and phagocytosis of infectious particles.
-
(2011)
Pediatr Res
, vol.69
, pp. 154-159
-
-
Fitzpatrick, A.M.1
Teague, W.G.2
Burwell, L.3
-
71
-
-
71749084479
-
Levels of nitric oxide oxidation products are increased in the epithelial lining fluid of children with persistent asthma
-
Fitzpatrick AM, Brown LA, Holguin F, Teague WG. Levels of nitric oxide oxidation products are increased in the epithelial lining fluid of children with persistent asthma. J Allergy Clin Immunol 2009; 124:990-996; e1-e9.
-
(2009)
J Allergy Clin Immunol
, vol.124
-
-
Fitzpatrick, A.M.1
Brown, L.A.2
Holguin, F.3
Teague, W.G.4
-
72
-
-
77955644592
-
Breath formate is a marker of airway S-nitrosothiol depletion in severe asthma
-
This study found that exhaled breath condensate concentrations of formate were higher in children with severe versus nonsevere asthma, suggestive of increased catabolism of S-nitrosothiols
-
Greenwald R, Fitzpatrick AM, Gaston B, et al. Breath formate is a marker of airway S-nitrosothiol depletion in severe asthma. PLoS One 2010; 5:e11919. This study found that exhaled breath condensate concentrations of formate were higher in children with severe versus nonsevere asthma, suggestive of increased catabolism of S-nitrosothiols.
-
(2010)
PLoS One
, vol.5
-
-
Greenwald, R.1
Fitzpatrick, A.M.2
Gaston, B.3
-
73
-
-
44649183243
-
Alveolar macrophage phagocytosis is impaired in children with poorly controlled asthma
-
Fitzpatrick AM, Holguin F, Teague WG, Brown LA. Alveolar macrophage phagocytosis is impaired in children with poorly controlled asthma. J Allergy Clin Immunol 2008; 1211372-1378, 8 e1-e3.
-
(2008)
J Allergy Clin Immunol
, vol.121
-
-
Fitzpatrick, A.M.1
Holguin, F.2
Teague, W.G.3
Brown, L.A.4
-
74
-
-
77950215411
-
The molecular phenotype of severe asthma in children
-
This substudy from the Severe Asthma Research Program found that children with severe asthma have a unique airway molecular phenotype that is not clearly associated with a Th1 or Th2 phenotype
-
Fitzpatrick AM, Higgins M, Holguin F, et al. The molecular phenotype of severe asthma in children. J Allergy Clin Immunol 2010; 125:851-857; e18. This substudy from the Severe Asthma Research Program found that children with severe asthma have a unique airway molecular phenotype that is not clearly associated with a Th1 or Th2 phenotype.
-
(2010)
J Allergy Clin Immunol
, vol.125
-
-
Fitzpatrick, A.M.1
Higgins, M.2
Holguin, F.3
-
75
-
-
79957849132
-
Thiol redox disturbances in children with severe asthma are associated with posttranslational modification of the transcription factor nuclear factor (erythroid-derived 2)-like 2
-
This study found that children with severe asthma have impaired activation of the transcription factor Nrf2 associated with glutathione depletion and increased oxidant stress
-
Fitzpatrick AM, Stephenson ST, Hadley GR, et al. Thiol redox disturbances in children with severe asthma are associated with posttranslational modification of the transcription factor nuclear factor (erythroid-derived 2)-like 2. J Allergy Clin Immunol 2011; 127:1604-1611. This study found that children with severe asthma have impaired activation of the transcription factor Nrf2 associated with glutathione depletion and increased oxidant stress.
-
(2011)
J Allergy Clin Immunol
, vol.127
, pp. 1604-1611
-
-
Fitzpatrick, A.M.1
Stephenson, S.T.2
Hadley, G.R.3
-
77
-
-
79551500941
-
Heterogeneity of severe asthma in childhood: Confirmation by cluster analysis of children in the National Institutes of Health/National Heart, Lung, and Blood Institute Severe Asthma Research Program
-
This article describes the results of an unbiased cluster analysis of children enrolled in the Severe Asthma Research Program and identified four distinct phenotypic clusters differentiated by lung function, the age of asthma onset, and controller medication use
-
Fitzpatrick AM, Teague WG, Meyers DA, et al. Heterogeneity of severe asthma in childhood: confirmation by cluster analysis of children in the National Institutes of Health/National Heart, Lung, and Blood Institute Severe Asthma Research Program. J Allergy Clin Immunol 2011; 127:382-389; e13. This article describes the results of an unbiased cluster analysis of children enrolled in the Severe Asthma Research Program and identified four distinct phenotypic clusters differentiated by lung function, the age of asthma onset, and controller medication use.
-
(2011)
J Allergy Clin Immunol
, vol.127
-
-
Fitzpatrick, A.M.1
Teague, W.G.2
Meyers, D.A.3
-
79
-
-
42149161351
-
Guidelines for the Diagnosis and Management of Asthma-Summary Report 2007
-
Expert Panel Report 3 (EPR-3)
-
Expert Panel Report 3 (EPR-3). Guidelines for the Diagnosis and Management of Asthma-Summary Report 2007. J Allergy Clin Immunol NHLBI, 2007; 120(5 Suppl):S94-S138.
-
(2007)
J Allergy Clin Immunol NHLBI
, vol.120
, Issue.5 SUPPL.
-
-
-
80
-
-
77954827460
-
The path to personalized medicine
-
This article reviews obstacles to personalized medicine and strategies that have been put into place to help promote its use in the clinical setting
-
Hamburg MA, Collins FS. The path to personalized medicine. N Engl J Med 2010; 363:301-304. This article reviews obstacles to personalized medicine and strategies that have been put into place to help promote its use in the clinical setting.
-
(2010)
N Engl J Med
, vol.363
, pp. 301-304
-
-
Hamburg, M.A.1
Collins, F.S.2
-
81
-
-
80055076171
-
Is it time to revise the asthma guidelines?
-
Epub ahead of print. This article reviews the development of the National Asthma Education and Prevention Program's asthma treatment guidelines and current knowledge gaps remaining related to the care of patients with asthma
-
Szefler SJ. Is it time to revise the asthma guidelines? J Allergy Clin Immunol 2011 [Epub ahead of print]. This article reviews the development of the National Asthma Education and Prevention Program's asthma treatment guidelines and current knowledge gaps remaining related to the care of patients with asthma.
-
(2011)
J Allergy Clin Immunol
-
-
Szefler, S.J.1
-
82
-
-
80053084755
-
Lebrikizumab treatment in adults with asthma
-
This clinical trial found that lebrikizumab, an anti-IL-13 monoclonal antibody, improved lung function in adult patients with poorly controlled asthma despite high-dose ICS therapy
-
Corren J, Lemanske RF, Hanania NA, et al. Lebrikizumab treatment in adults with asthma. N Engl J Med 2011; 365:1088-1098. This clinical trial found that lebrikizumab, an anti-IL-13 monoclonal antibody, improved lung function in adult patients with poorly controlled asthma despite high-dose ICS therapy.
-
(2011)
N Engl J Med
, vol.365
, pp. 1088-1098
-
-
Corren, J.1
Lemanske, R.F.2
Hanania, N.A.3
-
83
-
-
77949576423
-
Step-up therapy for children with uncontrolled asthma receiving inhaled corticosteroids
-
This clinical trial found that for children with asthma that was poorly controlled despite low-dose ICS, LABA step up was more likely to provide the best response compared to higher-dose ICS or LTRA, although overall responses were highly differential
-
Lemanske RF Jr, Mauger DT, Sorkness CA, et al. Step-up therapy for children with uncontrolled asthma receiving inhaled corticosteroids. N Engl J Med 2010; 362:975-985. This clinical trial found that for children with asthma that was poorly controlled despite low-dose ICS, LABA step up was more likely to provide the best response compared to higher-dose ICS or LTRA, although overall responses were highly differential.
-
(2010)
N Engl J Med
, vol.362
, pp. 975-985
-
-
Lemanske Jr., R.F.1
Mauger, D.T.2
Sorkness, C.A.3
-
84
-
-
77957768543
-
Tiotropium bromide step-up therapy for adults with uncontrolled asthma
-
This clinical trial found that triotrium added to ICS improved symptoms and lung function in adult patients with asthma poorly controlled on low doses of ICS
-
Peters SP, Kunselman SJ, Icitovic N, et al. Tiotropium bromide step-up therapy for adults with uncontrolled asthma. N Engl J Med 2010; 363:1715-1726. This clinical trial found that triotrium added to ICS improved symptoms and lung function in adult patients with asthma poorly controlled on low doses of ICS.
-
(2010)
N Engl J Med
, vol.363
, pp. 1715-1726
-
-
Peters, S.P.1
Kunselman, S.J.2
Icitovic, N.3
-
85
-
-
79960991918
-
Urinary leukotriene E4 levels identify children with tobacco smoke exposure at risk for asthma exacerbation
-
This study found that children with second-hand tobacco smoke exposure with severe asthma exacerbations were differentiated by high urinary leukotriene levels
-
Rabinovitch N, Reisdorph N, Silveira L, Gelfand EW. Urinary leukotriene E4 levels identify children with tobacco smoke exposure at risk for asthma exacerbation. J Allergy Clin Immunol 2011; 128:323-327. This study found that children with second-hand tobacco smoke exposure with severe asthma exacerbations were differentiated by high urinary leukotriene levels.
-
(2011)
J Allergy Clin Immunol
, vol.128
, pp. 323-327
-
-
Rabinovitch, N.1
Reisdorph, N.2
Silveira, L.3
Gelfand, E.W.4
-
86
-
-
77956378266
-
Urinary leukotriene E4/exhaled nitric oxide ratio and montelukast response in childhood asthma
-
This study found that the ratio of urinary leukotriene E4 to exhaled nitric oxide predicted asthmatic children with a better response to montelukast than fluticasone
-
Rabinovitch N, Graber NJ, Chinchilli VM, et al. Urinary leukotriene E4/exhaled nitric oxide ratio and montelukast response in childhood asthma. J Allergy Clin Immunol 2010; 126:545-551; e1-e4. This study found that the ratio of urinary leukotriene E4 to exhaled nitric oxide predicted asthmatic children with a better response to montelukast than fluticasone.
-
(2010)
J Allergy Clin Immunol
, vol.126
-
-
Rabinovitch, N.1
Graber, N.J.2
Chinchilli, V.M.3
-
87
-
-
84455204862
-
Relationship between serum vitamin D, disease severity and airway remodeling in children with asthma
-
Epub ahead of print. This study found that low serum 25-hydroxyvitamin D [25(OH)D3] was associated with increased symptoms, lower pulmonary function, more exacerbations and asthma medication requirements, and increased airway smooth muscle mass
-
Gupta A, Sjoukes A, Richards D, et al. Relationship between serum vitamin D, disease severity and airway remodeling in children with asthma. Am J Respir Crit Care Med 2011 [Epub ahead of print]. This study found that low serum 25-hydroxyvitamin D [25(OH)D3] was associated with increased symptoms, lower pulmonary function, more exacerbations and asthma medication requirements, and increased airway smooth muscle mass.
-
(2011)
Am J Respir Crit Care Med
-
-
Gupta, A.1
Sjoukes, A.2
Richards, D.3
-
88
-
-
78650477607
-
Allergy diagnostics in the GDR
-
[Review] German
-
Adolph J, Stiller D, Schubert HJ. Allergy diagnostics in the GDR [Review] [German]. Allergologie 2010; 33:481-488.
-
(2010)
Allergologie
, vol.33
, pp. 481-488
-
-
Adolph, J.1
Stiller, D.2
Schubert, H.J.3
-
89
-
-
84855283737
-
Asthma prevalence, healthcare use, and mortality: United States, 2005-2009
-
14
-
Akinbami LJ, Moorman JE, Liu X. Asthma prevalence, healthcare use, and mortality: United States, 2005-2009. Natl Health Stat Report 2011:1-14. [14]
-
(2011)
Natl Health Stat Report
, pp. 1-14
-
-
Akinbami, L.J.1
Moorman, J.E.2
Liu, X.3
-
90
-
-
78650870285
-
BCG vaccination and allergy: A systematic review and meta-analysis
-
Review.
-
Arnoldussen DL, Linehan M, Sheikh A. BCG vaccination and allergy: A systematic review and meta-analysis [Review]. J Allergy Clin Immunol 2011; 127:246-NIL-404.
-
(2011)
J Allergy Clin Immunol
, vol.127
-
-
Arnoldussen, D.L.1
Linehan, M.2
Sheikh, A.3
-
91
-
-
80053087268
-
Noneosinophilic asthma in children: Relation with airway remodelling
-
Baraldo S, Turato G, Bazzan E, Ballarin A, et al. Noneosinophilic asthma in children: relation with airway remodelling. Eur Respir J 2011; 38:575-583.
-
(2011)
Eur Respir J
, vol.38
, pp. 575-583
-
-
Baraldo, S.1
Turato, G.2
Bazzan, E.3
Ballarin, A.4
-
92
-
-
80053087268
-
Noneosinophilic asthma in children: Relation with airway remodelling
-
59
-
Baraldo S, Turato G, Bazzan E, et al. Noneosinophilic asthma in children: relation with airway remodelling. Eur Respir J 2011; 38:575-583. [59]
-
(2011)
Eur Respir J
, vol.38
, pp. 575-583
-
-
Baraldo, S.1
Turato, G.2
Bazzan, E.3
-
93
-
-
80051739899
-
Genetic studies of the etiology of asthma
-
30
-
Barnes KC. Genetic studies of the etiology of asthma. Proc Am Thorac Soc 2011; 8:143-148. [30]
-
(2011)
Proc Am Thorac Soc
, vol.8
, pp. 143-148
-
-
Barnes, K.C.1
-
95
-
-
78049457548
-
Uniform definition of asthma severity, control, and exacerbations: Document presented for the World Health Organization Consultation on Severe Asthma
-
24
-
Bousquet J, Mantzouranis E, Cruz AA, et al. Uniform definition of asthma severity, control, and exacerbations: document presented for the World Health Organization Consultation on Severe Asthma. J Allergy Clin Immunol 2010; 126:926-938. [24]
-
(2010)
J Allergy Clin Immunol
, vol.126
, pp. 926-938
-
-
Bousquet, J.1
Mantzouranis, E.2
Cruz, A.A.3
-
96
-
-
79959731559
-
Phenotypes of refractory/severe asthma
-
29
-
Bush A, Fleming L. Phenotypes of refractory/severe asthma. Paediatr Respir Rev 2011; 12:177-181. [29]
-
(2011)
Paediatr Respir Rev
, vol.12
, pp. 177-181
-
-
Bush, A.1
Fleming, L.2
-
97
-
-
80053498278
-
Pharmacological treatment of severe, therapy-resistant asthma in children: What can we learn from where?
-
19
-
Bush A, Pedersen S, Hedlin G, et al. Pharmacological treatment of severe, therapy-resistant asthma in children: what can we learn from where? Eur Respir J 2011; 38:947-958. [19]
-
(2011)
Eur Respir J
, vol.38
, pp. 947-958
-
-
Bush, A.1
Pedersen, S.2
Hedlin, G.3
-
98
-
-
77956366627
-
Management of severe asthma in children
-
16
-
Bush A, Saglani S. Management of severe asthma in children. Lancet 2010; 376:814-825. [16]
-
(2010)
Lancet
, vol.376
, pp. 814-825
-
-
Bush, A.1
Saglani, S.2
-
99
-
-
79952443277
-
WHO universal definition of severe asthma
-
25
-
Bush A, Zar HJ. WHO universal definition of severe asthma. Curr Opin Allergy Clin Immunol 2011; 11:115-121. [25]
-
(2011)
Curr Opin Allergy Clin Immunol
, vol.11
, pp. 115-121
-
-
Bush, A.1
Zar, H.J.2
-
100
-
-
79960456869
-
Associations of the Single-Nucleotide Polymorphisms of the Mina Gene with the Development of Asthma in Chinese Han Children: A Case-Control Study
-
Chen Y, Yang XQ, Huang Y, Liu EM, et al. Associations of the Single-Nucleotide Polymorphisms of the Mina Gene with the Development of Asthma in Chinese Han Children: A Case-Control Study. Genet Test Mol Biomark 2011; 15:531-536.
-
(2011)
Genet Test Mol Biomark
, vol.15
, pp. 531-536
-
-
Chen, Y.1
Yang, X.Q.2
Huang, Y.3
Liu, E.M.4
-
101
-
-
80053084755
-
Lebrikizumab treatment in adults with asthma
-
[82]
-
Corren J, Lemanske RF, Hanania NA, et al. Lebrikizumab treatment in adults with asthma. N Engl J Med 2011; 365:1088-1098. [82]
-
(2011)
N Engl J Med
, vol.365
, pp. 1088-1098
-
-
Corren, J.1
Lemanske, R.F.2
Hanania, N.A.3
-
102
-
-
75849136559
-
Predictors of remitting, periodic, and persistent childhood asthma
-
50
-
Covar RA, Strunk R, Zeiger RS, et al. Predictors of remitting, periodic, and persistent childhood asthma. J Allergy Clin Immunol 2010; 125:359-366. e3 [50]
-
(2010)
J Allergy Clin Immunol
, vol.125
-
-
Covar, R.A.1
Strunk, R.2
Zeiger, R.S.3
-
103
-
-
79960841553
-
Maternal and childhood asthma: Risk factors, interactions, and ramifications
-
Dietert RR. Maternal and childhood asthma: Risk factors, interactions, and ramifications. Reprod Toxicol 2011; 32:198-204.
-
(2011)
Reprod Toxicol
, vol.32
, pp. 198-204
-
-
Dietert, R.R.1
-
104
-
-
77952206441
-
Use of exhaled nitric oxide measurement to identify a reactive, at-risk phenotype among patients with asthma
-
45
-
Dweik RA, Sorkness RL, Wenzel S, et al. Use of exhaled nitric oxide measurement to identify a reactive, at-risk phenotype among patients with asthma. Am J Respir Crit Care Med 2010; 181:1033-1041. [45]
-
(2010)
Am J Respir Crit Care Med
, vol.181
, pp. 1033-1041
-
-
Dweik, R.A.1
Sorkness, R.L.2
Wenzel, S.3
-
105
-
-
78649889729
-
Health experiences of adolescents with uncontrolled severe asthma
-
36
-
Edgecombe K, Latter S, Peters S, Roberts G. Health experiences of adolescents with uncontrolled severe asthma. Arch Dis Child 2010; 95:985-991. [36]
-
(2010)
Arch Dis Child
, vol.95
, pp. 985-991
-
-
Edgecombe, K.1
Latter, S.2
Peters, S.3
Roberts, G.4
-
107
-
-
79957849132
-
Thiol redox disturbances in children with severe asthma are associated with posttranslational modification of the transcription factor nuclear factor (erythroid-derived 2)-like 2
-
75
-
Fitzpatrick AM, Stephenson ST, Hadley GR, et al. Thiol redox disturbances in children with severe asthma are associated with posttranslational modification of the transcription factor nuclear factor (erythroid-derived 2)-like 2. J Allergy Clin Immunol 2011; 127:1604-1611. [75]
-
(2011)
J Allergy Clin Immunol
, vol.127
, pp. 1604-1611
-
-
Fitzpatrick, A.M.1
Stephenson, S.T.2
Hadley, G.R.3
-
108
-
-
78649261484
-
Severe asthma in children: Insights from the National Heart, Lung, and Blood Institute's Severe Asthma Research Program
-
43
-
Fitzpatrick AM, Teague WG. Severe asthma in children: insights from the National Heart, Lung, and Blood Institute's Severe Asthma Research Program. Pediatr Allergy Immunol Pulmonol 2010; 23:131-138. [43]
-
(2010)
Pediatr Allergy Immunol Pulmonol
, vol.23
, pp. 131-138
-
-
Fitzpatrick, A.M.1
Teague, W.G.2
-
109
-
-
78650921930
-
Progressive airflow limitation is a feature of children with severe asthma
-
48
-
Fitzpatrick AM, Teague WG. Progressive airflow limitation is a feature of children with severe asthma. J Allergy Clin Immunol 2011; 127:282-284. [48]
-
(2011)
J Allergy Clin Immunol
, vol.127
, pp. 282-284
-
-
Fitzpatrick, A.M.1
Teague, W.G.2
-
110
-
-
79951659624
-
Glutathione oxidation is associated with airway macrophage functional impairment in children with severe asthma
-
70
-
Fitzpatrick AM, Teague WG, Burwell L, et al. Glutathione oxidation is associated with airway macrophage functional impairment in children with severe asthma. Pediatr Res 2011; 69:154-159. [70]
-
(2011)
Pediatr Res
, vol.69
, pp. 154-159
-
-
Fitzpatrick, A.M.1
Teague, W.G.2
Burwell, L.3
-
111
-
-
79551500941
-
Heterogeneity of severe asthma in childhood: Confirmation by cluster analysis of children in the National Institutes of Health/National Heart, Lung, and Blood Institute Severe Asthma Research Program
-
77
-
Fitzpatrick AM, Teague WG, Meyers DA, et al. Heterogeneity of severe asthma in childhood: confirmation by cluster analysis of children in the National Institutes of Health/National Heart, Lung, and Blood Institute Severe Asthma Research Program. J Allergy Clin Immunol 2011; 127:382-389. e13 [77]
-
(2011)
J Allergy Clin Immunol
, vol.127
-
-
Fitzpatrick, A.M.1
Teague, W.G.2
Meyers, D.A.3
-
112
-
-
84858156027
-
Use of sputum eosinophil counts to guide management in children with severe asthma
-
Epub ahead of print. 32
-
Fleming L, Wilson N, Regamey N, Bush A. Use of sputum eosinophil counts to guide management in children with severe asthma. Thorax 2011 [Epub ahead of print]. [32]
-
(2011)
Thorax
-
-
Fleming, L.1
Wilson, N.2
Regamey, N.3
Bush, A.4
-
113
-
-
77955644592
-
Breath formate is a marker of airway S-nitrosothiol depletion in severe asthma
-
72
-
Greenwald R, Fitzpatrick AM, Gaston B, et al. Breath formate is a marker of airway S-nitrosothiol depletion in severe asthma. PLoS One 2010; 5:e11919. [72]
-
(2010)
PLoS One
, vol.5
-
-
Greenwald, R.1
Fitzpatrick, A.M.2
Gaston, B.3
-
114
-
-
84455204862
-
Relationship between serum vitamin D, disease severity and airway remodeling in children with asthma
-
Epub ahead of print. 87
-
Gupta A, Sjoukes A, Richards D, et al. Relationship between serum vitamin D, disease severity and airway remodeling in children with asthma. Am J Respir Crit Care Med 2011 [Epub ahead of print]. [87]
-
(2011)
Am J Respir Crit Care Med
-
-
Gupta, A.1
Sjoukes, A.2
Richards, D.3
-
115
-
-
77954827460
-
The path to personalized medicine
-
80
-
Hamburg MA, Collins FS. The path to personalized medicine. N Engl J Med 2010; 363:301-304. [80]
-
(2010)
N Engl J Med
, vol.363
, pp. 301-304
-
-
Hamburg, M.A.1
Collins, F.S.2
-
116
-
-
78449265774
-
Allergy, total serum immunoglobulin E, and airflow in children and adolescents in TENOR
-
44
-
Haselkorn T, Szefler SJ, Simons FE, et al. Allergy, total serum immunoglobulin E, and airflow in children and adolescents in TENOR. Pediatr Allergy Immunol 2010; 21:1157-1165. [44]
-
(2010)
Pediatr Allergy Immunol
, vol.21
, pp. 1157-1165
-
-
Haselkorn, T.1
Szefler, S.J.2
Simons, F.E.3
-
117
-
-
79959726036
-
Inflammatory Phenotypes in Stable and Acute Childhood Asthma
-
He XY, Simpson JL, Wang F. Inflammatory Phenotypes in Stable and Acute Childhood Asthma. Paediatr Respir Rev 2011; 12:165-169.
-
(2011)
Paediatr Respir Rev
, vol.12
, pp. 165-169
-
-
He, X.Y.1
Simpson, J.L.2
Wang, F.3
-
118
-
-
77954639445
-
Problematic severe asthma in children, not one problem but many: A GA2LEN initiative
-
18
-
Hedlin G, Bush A, Lodrup Carlsen K, et al. Problematic severe asthma in children, not one problem but many: a GA2LEN initiative. Eur Respir J 2010; 36:196-201. [18]
-
(2010)
Eur Respir J
, vol.36
, pp. 196-201
-
-
Hedlin, G.1
Bush, A.2
Lodrup Carlsen, K.3
-
119
-
-
77956234325
-
Joint influences of Acidic-Mammalian-Chitinase with Interleukin-4 and Toll-like receptor-10 with Interleukin-13 in the genetics of asthma
-
Heinzmann A, Brugger M, Bierbaum S, Mailaparambil B, et al. Joint influences of Acidic-Mammalian-Chitinase with Interleukin-4 and Toll-like receptor-10 with Interleukin-13 in the genetics of asthma. Pediatr Allergy Immunol 2010; 21:E679-E686.
-
(2010)
Pediatr Allergy Immunol
, vol.21
-
-
Heinzmann, A.1
Brugger, M.2
Bierbaum, S.3
Mailaparambil, B.4
-
120
-
-
79955763980
-
Interaction between Adaptive and Innate Immune Pathways in the Pathogenesis of Atopic Asthma Operation of a Lung/Bone Marrow Axis
-
Holt PG, Sly PD. Interaction Between Adaptive and Innate Immune Pathways in the Pathogenesis of Atopic Asthma Operation of a Lung/Bone Marrow Axis. Chest 2011; 139:1165-1171.
-
(2011)
Chest
, vol.139
, pp. 1165-1171
-
-
Holt, P.G.1
Sly, P.D.2
-
121
-
-
79951471976
-
The Relevance of U.S. Ratification of the Convention on the Rights of the Child for Child Health: A Matter of Equity and Social Justice
-
Kasper J. The Relevance of U.S. Ratification of the Convention on the Rights of the Child for Child Health: A Matter of Equity and Social Justice. Child Welfare 2010; 89:21-36.
-
(2010)
Child Welfare
, vol.89
, pp. 21-36
-
-
Kasper, J.1
-
122
-
-
79955756501
-
The CC16 A38G polymorphism is associated with the development of asthma in children with allergic rhinitis
-
Ku MS, Sun HL, Lu KH, Sheu JN, et al. The CC16 A38G polymorphism is associated with the development of asthma in children with allergic rhinitis. Clin Exp Allergy 2011; 41:794-800.
-
(2011)
Clin Exp Allergy
, vol.41
, pp. 794-800
-
-
Ku, M.S.1
Sun, H.L.2
Lu, K.H.3
Sheu, J.N.4
-
123
-
-
79951676875
-
Childhood disadvantage and emergency admission rates for common presentations in London: An exploratory analysis
-
Kyle RG, Kukanova M, Campbell M, Wolfe I, et al. Childhood disadvantage and emergency admission rates for common presentations in London: an exploratory analysis. Arch Dis Child 2011; 96:221-226.
-
(2011)
Arch Dis Child
, vol.96
, pp. 221-226
-
-
Kyle, R.G.1
Kukanova, M.2
Campbell, M.3
Wolfe, I.4
-
124
-
-
77949576423
-
Step-up therapy for children with uncontrolled asthma receiving inhaled corticosteroids
-
83
-
Lemanske Jr RF, Mauger DT, Sorkness CA, et al. Step-up therapy for children with uncontrolled asthma receiving inhaled corticosteroids. N Engl J Med 2010; 362:975-985. [83]
-
(2010)
N Engl J Med
, vol.362
, pp. 975-985
-
-
Lemanske Jr., R.F.1
Mauger, D.T.2
Sorkness, C.A.3
-
125
-
-
79953652383
-
Assessment of problematic severe asthma in children
-
17
-
Lodrup Carlsen KC, Hedlin G, Bush A, et al. Assessment of problematic severe asthma in children. Eur Respir J 2011; 37:432-440. [17]
-
(2011)
Eur Respir J
, vol.37
, pp. 432-440
-
-
Lodrup Carlsen, K.C.1
Hedlin, G.2
Bush, A.3
-
126
-
-
79551505136
-
Asthma endotypes: A new approach to classification of disease entities within the asthma syndrome
-
27
-
Lotvall J, Akdis CA, Bacharier LB, et al. Asthma endotypes: a new approach to classification of disease entities within the asthma syndrome. J Allergy Clin Immunol 2011; 127:355-360. [27]
-
(2011)
J Allergy Clin Immunol
, vol.127
, pp. 355-360
-
-
Lotvall, J.1
Akdis, C.A.2
Bacharier, L.B.3
-
127
-
-
79251608789
-
Lung function, airway remodelling and inflammation in symptomatic infants: Outcome at 3 years
-
64
-
Malmstrom K, Pelkonen AS, Malmberg LP, et al. Lung function, airway remodelling and inflammation in symptomatic infants: outcome at 3 years. Thorax 2011; 66:157-162. [64]
-
(2011)
Thorax
, vol.66
, pp. 157-162
-
-
Malmstrom, K.1
Pelkonen, A.S.2
Malmberg, L.P.3
-
128
-
-
77956361115
-
Genetics of asthma and allergy: What have we learned?
-
quiz 47-8 31
-
Meyers DA. Genetics of asthma and allergy: what have we learned? J Allergy Clin Immunol 2010; 126:439-446. quiz 47-8 [31]
-
(2010)
J Allergy Clin Immunol
, vol.126
, pp. 439-446
-
-
Meyers, D.A.1
-
129
-
-
76149146032
-
Identification of asthma phenotypes using cluster analysis in the Severe Asthma Research Program
-
20
-
Moore WC, Meyers DA, Wenzel SE, et al. Identification of asthma phenotypes using cluster analysis in the Severe Asthma Research Program. Am J Respir Crit Care Med 2010; 181:315-323. [20]
-
(2010)
Am J Respir Crit Care Med
, vol.181
, pp. 315-323
-
-
Moore, W.C.1
Meyers, D.A.2
Wenzel, S.E.3
-
130
-
-
80051863038
-
Fulminant hepatitis and glomerulonephritis-a rare presentation of Hepatitis A virus infection
-
Pal RB, Saha P, Das I, Sinha MK. Fulminant hepatitis and glomerulonephritis-a rare presentation of Hepatitis A virus infection. Acta Paediatr 2011; 100:E132-E134.
-
(2011)
Acta Paediatr
, vol.100
-
-
Pal, R.B.1
Saha, P.2
Das, I.3
Sinha, M.K.4
-
131
-
-
77957768543
-
Tiotropium bromide step-up therapy for adults with uncontrolled asthma
-
84
-
Peters SP, Kunselman SJ, Icitovic N, et al. Tiotropium bromide step-up therapy for adults with uncontrolled asthma. N Engl J Med 2010; 363:1715-1726. [84]
-
(2010)
N Engl J Med
, vol.363
, pp. 1715-1726
-
-
Peters, S.P.1
Kunselman, S.J.2
Icitovic, N.3
-
132
-
-
79955734609
-
Fraction of Exhaled Nitric Oxide and Asthma Predictive Index in Infants Less Than Two Years-Old
-
Spanish
-
Prado OS, Perez-Yarza EG, Ruiz AA, Murua JK, et al. Fraction of Exhaled Nitric Oxide and Asthma Predictive Index in Infants Less Than Two Years-Old [Spanish]. Arch Bronconeumol 2011; 47:234-238.
-
(2011)
Arch Bronconeumol
, vol.47
, pp. 234-238
-
-
Prado, O.S.1
Perez-Yarza, E.G.2
Ruiz, A.A.3
Murua, J.K.4
-
133
-
-
77956378266
-
Urinary leukotriene E4/exhaled nitric oxide ratio and montelukast response in childhood asthma
-
86
-
Rabinovitch N, Graber NJ, Chinchilli VM, et al. Urinary leukotriene E4/exhaled nitric oxide ratio and montelukast response in childhood asthma. J Allergy Clin Immunol 2010; 126:545-551. e1-e4 [86]
-
(2010)
J Allergy Clin Immunol
, vol.126
-
-
Rabinovitch, N.1
Graber, N.J.2
Chinchilli, V.M.3
-
134
-
-
79960991918
-
Urinary leukotriene E4 levels identify children with tobacco smoke exposure at risk for asthma exacerbation
-
85
-
Rabinovitch N, Reisdorph N, Silveira L, Gelfand EW. Urinary leukotriene E4 levels identify children with tobacco smoke exposure at risk for asthma exacerbation. J Allergy Clin Immunol 2011; 128:323-327. [85]
-
(2011)
J Allergy Clin Immunol
, vol.128
, pp. 323-327
-
-
Rabinovitch, N.1
Reisdorph, N.2
Silveira, L.3
Gelfand, E.W.4
-
135
-
-
79960533286
-
Factors Associated with the Development of Severe Asthma Exacerbations in Children
-
Sala KA, Carroll CL, Tang YS, Aglio T, et al. Factors Associated with the Development of Severe Asthma Exacerbations in Children. J Asthma 2011; 48:558-564.
-
(2011)
J Asthma
, vol.48
, pp. 558-564
-
-
Sala, K.A.1
Carroll, C.L.2
Tang, Y.S.3
Aglio, T.4
-
136
-
-
78651376729
-
Don't forget other causes of wheeze. ABPA in a boy with asthma. A case report and review of the literature
-
Review
-
Schwerk N, Rochwalsky U, Brinkmann F, Hansen G. Don't forget other causes of wheeze. ABPA in a boy with asthma. A case report and review of the literature [Review]. Acta Paediatr 2011; 100:307-310.
-
(2011)
Acta Paediatr
, vol.100
, pp. 307-310
-
-
Schwerk, N.1
Rochwalsky, U.2
Brinkmann, F.3
Hansen, G.4
-
137
-
-
79955977402
-
Keratinocytes play a role in the immunity to Herpes simplex virus type 2 infection
-
Praha
-
Shao Y, Zhang W, Dong X, Liu W, et al. Keratinocytes play a role in the immunity to Herpes simplex virus type 2 infection. Acta Virol (Praha) 2010; 54:261-267.
-
(2010)
Acta Virol
, vol.54
, pp. 261-267
-
-
Shao, Y.1
Zhang, W.2
Dong, X.3
Liu, W.4
-
140
-
-
80052271501
-
Advancing asthma care: The glass is only half full!
-
01
-
Szefler SJ. Advancing asthma care: the glass is only half full! J Allergy Clin Immunol 2011; 128:485-494. [01]
-
(2011)
J Allergy Clin Immunol
, vol.128
, pp. 485-494
-
-
Szefler, S.J.1
-
141
-
-
80055076171
-
Is it time to revise the asthma guidelines?
-
Epub ahead of print. 81
-
Szefler SJ. Is it time to revise the asthma guidelines? J Allergy Clin Immunol 2011 [Epub ahead of print]. [81]
-
(2011)
J Allergy Clin Immunol
-
-
Szefler, S.J.1
-
142
-
-
79960916856
-
Economic burden of impairment in children with severe or difficult-to-treat asthma
-
07
-
Szefler SJ, Zeiger RS, Haselkorn T, et al. Economic burden of impairment in children with severe or difficult-to-treat asthma. Ann Allergy Asthma Immunol 2011; 107:110-119. e1 [07]
-
(2011)
Ann Allergy Asthma Immunol
, vol.107
-
-
Szefler, S.J.1
Zeiger, R.S.2
Haselkorn, T.3
-
143
-
-
79953027095
-
Development of the bronchial epithelial reticular basement membrane: Relationship to epithelial height and age
-
62
-
Tsartsali L, Hislop AA, McKay K, et al. Development of the bronchial epithelial reticular basement membrane: relationship to epithelial height and age. Thorax 2011; 66:280-285. [62]
-
(2011)
Thorax
, vol.66
, pp. 280-285
-
-
Tsartsali, L.1
Hislop, A.A.2
McKay, K.3
-
144
-
-
77954637790
-
Different definitions in childhood asthma: How dependable is the dependent variable?
-
21
-
Van Wonderen KE, Van Der Mark LB, Mohrs J, et al. Different definitions in childhood asthma: how dependable is the dependent variable? Eur Respir J 2010; 36:48-56. [21]
-
(2010)
Eur Respir J
, vol.36
, pp. 48-56
-
-
Van Wonderen, K.E.1
Van Der Mark, L.B.2
Mohrs, J.3
-
145
-
-
78650869168
-
A genome-wide association study to identify genetic determinants of atopy in subjects from the United Kingdom
-
Wan YZI, Strachan DP, Evans DM, Henderson J, et al. A genome-wide association study to identify genetic determinants of atopy in subjects from the United Kingdom. J Allergy Clin Immunol 2011; 127:223-NIL-358.
-
(2011)
J Allergy Clin Immunol
, vol.127
-
-
Wan, Y.Z.I.1
Strachan, D.P.2
Evans, D.M.3
Henderson, J.4
-
146
-
-
79960429165
-
Predictors of symptoms are different from predictors of severe exacerbations from asthma in children
-
33
-
Wu AC, Tantisira K, Li L, et al. Predictors of symptoms are different from predictors of severe exacerbations from asthma in children. Chest 2011; 140:100-107. [33]
-
(2011)
Chest
, vol.140
, pp. 100-107
-
-
Wu, A.C.1
Tantisira, K.2
Li, L.3
-
147
-
-
79955073541
-
Epithelial Apoptosis and Loss in Airways of Children with Asthma
-
Zhou CJ, Yin GQ, Liu JR, Liu XC, et al. Epithelial Apoptosis and Loss in Airways of Children with Asthma. J Asthma 2011; 48:358-365.
-
(2011)
J Asthma
, vol.48
, pp. 358-365
-
-
Zhou, C.J.1
Yin, G.Q.2
Liu, J.R.3
Liu, X.C.4
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