Urinary leukotriene E4 levels identify children with tobacco smoke exposure at risk for asthma exacerbation

Journal of Allergy and Clinical Immunology

Volumn 128, Issue 2, 2011, Pages 323-327

  Rabinovitch, Nathan ^a   Reisdorph, Nichole ^a   Silveira, Lori ^a   Gelfand, Erwin W ^a  

^a DEPARTMENT OF MEDICINE   (United States)

Author keywords

Asthma; biomarker; exacerbation; secondhand smoke

Indexed keywords

CORTICOSTEROID; COTININE; LEUKOTRIENE E4; NITRIC OXIDE; TOBACCO SMOKE;

ADOLESCENT; ARTICLE; ASTHMA; CHILD; CLINICAL ARTICLE; DISEASE EXACERBATION; DISEASE PREDISPOSITION; DISEASE SEVERITY; EMERGENCY WARD; EXPIRED AIR; HUMAN; LUNG FUNCTION; PRESCHOOL CHILD; PRIORITY JOURNAL; PROTEIN URINE LEVEL; QUESTIONNAIRE; RISK FACTOR; SCHOOL CHILD; SENSITIVITY AND SPECIFICITY; SYMPTOM;

EID: 79960991918     PISSN: 00916749     EISSN: 10976825     Source Type: Journal    
DOI: 10.1016/j.jaci.2011.05.035     Document Type: Article

References (31)

1. Kumlin M. Measurement of leukotrienes in humans. Am J Respir Crit Care Med 2000;161(suppl):S102-6.
2. Smith CM, Hawksworth RJ, Thien FC, Christie PE, Lee TH. Urinary leukotriene E4 in bronchial asthma. Eur Respir J 1992;5:693-9.
3. Doucet MY, Jones TR, Ford-Hutchinson AW. Responses of equine trachealis and lung parenchyma to methacholine, histamine, prostanoids, and leukotrienes in vitro. Can J Physiol Pharmacol 1990;68:379-83. (Pubitemid 20130602)
4. Busse W, Kraft M. Cysteinyl leukotrienes in allergic inflammation: strategic target for therapy. Chest 2005;127:1312-26. (Pubitemid 46224296)
5. Gyllfors P, Kumlin M, Dahlén SE, Gaber F, Ehrs PO, Dahlen B. Relation between bronchial responsiveness to inhaled leukotriene D4 and markers of leukotriene biosynthesis. Thorax 2005;60:902-8. (Pubitemid 41598205)
6. Rabinovitch N, Zhang L, Gelfand EW. Urine leukotriene E4 levels are associated with decreased pulmonary function in children with persistent airway obstruction. J Allergy Clin Immunol 2006;118:635-40. (Pubitemid 44301392)
7. Lazarus SC, Chinchilli VM, Rollings NJ, Boushey HA, Cherniack R, Craig TJ, et al. Smoking affects response to inhaled corticosteroids or leukotriene receptor antagonists in asthma. Am J Respir Crit Care Med 2007;175:783-90. (Pubitemid 46631789)
8. Rabinovitch N, Strand M, Stuhlman K, Gelfand EW. Exposure to tobacco smoke increases leukotriene E4-related albuterol usage and response to montelukast. J Allergy Clin Immunol 2008;121:1365-71.
9. Couriel JM. Passive smoking and the health of children. Thorax 1994;49:731-4. (Pubitemid 24250226)
10. Forastiere F, Corbo MG, Michelozzi P, Pistelli R, Agabiti N, Brancato G, et al. Effects of environment and passive smoking on the respiratory health of children. Int J Epidemiol 1992;21:66-73.
11. Stoddard JJ, Miller T. Impact of parental smoking on the prevalence of wheezing respiratory illness in children. Am J Epidemiol 1995;141:96-102.
12. Chilmonczyk BA, Salmun LM, Megathlin KN, Neveaux LM, Palomaki GE, Knight GJ, et al. Association between exposure to environmental tobacco smoke and exacerbations of asthma in children. N Engl J Med 1993;328:1665-9. (Pubitemid 23157348)
13. Armstrong M, Liu AH, Harbeck R, Reisdorph R, Rabinovitch N, Reisdorph N. Leukotriene-E4 in human urine: Comparison of on-line purification and liquid chromatography-tandem mass spectrometry to affinity purification followed by enzyme immunoassay. J Chromatogr B Analyt Technol Biomed Life Sci 2009;877: 3169-74.
14. Muscat JE, Djordjevic MV, Colosimo S, Stellman SD, Richie JP Jr. Racial differences in exposure and glucuronidation of the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK). Cancer 2005;103:1420-6. (Pubitemid 40410738)
15. Buchvald F, Baraldi E, Carraro S, Gaston B, De Jongste J, Pijnenburg MW, et al. Measurements of exhaled nitric oxide in healthy subjects age 4 to 17 years. J Allergy Clin Immunol 2005;115:1130-6. (Pubitemid 40824579)
16. Cornelius MD, Goldschmidt L, Dempsey DA. Environmental tobacco smoke exposure in low-income 6-year-olds: parent report and urine cotinine measures. Nicotine Tob Res 2003;3:333-9. (Pubitemid 36764028)
17. Cohen RT, Raby BA, Van Steen K, Fuhlbrigge AL, Celedón JC, Rosner BA, et al. In utero smoke exposure and impaired response to inhaled corticosteroids in children with asthma. J Allergy Clin Immunol 2010;126:491-7.
18. Pedersen B, Dahl R, Karlstrom R, Peterson CG, Venge P. Eosinophil and neutrophil activity in asthma in a one-year trial with inhaled budesonide. The impact of smoking. Am J Respir Crit Care Med 1996;153:1519-29. (Pubitemid 26141335)
19. Invernizzi G, Ruprecht A, De Marco C, Mazza R, Nicolini G, Boffi R. Inhaled steroid/ tobacco smoke particle interactions: a new light on steroid resistance. Respir Res 2009;10:48.
20. Adenuga D, Yao H, March TH, Seagrave J, Rahman I. Histone deacetylase 2 is phosphorylated, ubiquitinated, and degraded by cigarette smoke. Am J Respir Cell Mol Biol 2009;40:464-73.
21. Bracken M, Fleming L, Hall P, Stephout VN, Bossley C, Biggart E, et al. The importance of nurse-led home visits in the assessment of children with problematic asthma. Arch Dis Child 2009;94:780-4.
22. Fauler J, Frolich JC. Cigarette smoking stimulates cysteinyl leukotriene production in man. Eur J Clin Invest 1997;27:43-7. (Pubitemid 27065172)
23. Rabinovitch N, Strand M, Gelfand EW. Particulate levels are associated with early asthma worsening in children with persistent disease. Am J Respir Crit Care Med 2006;173:1098-105. (Pubitemid 43726890)
24. Fregonese L, Silvestri M, Sabatini F, Rossi GA. Cysteinyl leukotrienes induce human eosinophil locomotion and adhesion molecule expression via a CysLT1 receptor-mediated mechanism. Clin Exp Allergy 2002;32:745-50. (Pubitemid 34534022)
25. Lee TH, Woszczek G, Farooque SP. Leukotriene E4: perspective on the forgotten mediator. J Allergy Clin Immunol 2009;124:417-21.
26. Austen KF, Maekawa A, Kanaoka Y, Boyce JA. The leukotriene E4 puzzle: finding the missing pieces and revealing the pathobiologic implications. J Allergy Clin Immunol 2009;124:406-14.
27. Covar RA, Szefler SJ, Zeiger RS, Sorkness CA, Moss M, Mauger DT, et al. Factors associated with asthma exacerbations during a long-term clinical trial of controller medications in children. J Allergy Clin Immunol 2008;122:741-7.
28. Goldstein MF, Veza BA, Dunsky EH, Dvorin DJ, Belecanech GA, Haralabatos IC. Comparisons of peak diurnal expiratory flow variation, postbronchodilator FEV(1) responses, and methacholine inhalation challenges in the evaluation of suspected asthma. Chest 2001;119:1001-10.
29. Smith AD, Cowan JO, Brassett KP, Herbison GP, Taylor DR. Use of exhaled nitric oxide measurements to guide treatment in chronic asthma. N Engl J Med 2005;352: 2163-73.
30. Szefler SJ, Mitchell H, Sorkness CA, Gergen PJ, O'Connor GT, Morgan WJ, et al. Management of asthma based on exhaled nitric oxide in addition to guideline-based treatment for inner-city adolescents and young adults: a randomised controlled trial. Lancet 2008;372:1065-72.
31. Petsky HL, Cates CJ, Li AM, Kynaston JA, Turner C, Chang AB. Tailored interventions based on exhaled nitric oxide versus clinical symptoms for asthma in children and adults. Cochrane Database Syst Rev 2008;(2):CD006340.