Inflammatory Phenotypes in Stable and Acute Childhood Asthma

Paediatric Respiratory Reviews

Volumn 12, Issue 3, 2011, Pages 165-169

  He, Xiao Yan ^b,c   Simpson, Jodie L ^b,c   Wang, Fang ^a,b,c  

^a Basic Medical College   (China)

^b UNIVERSITY OF NEWCASTLE   (Australia)

^c JOHN HUNTER HOSPITAL   (Australia)

Author keywords

Eosinophilic inflammatory phenotype; Inflammatory phenotype; Paediatric asthma; Peripheral or distal airways

Indexed keywords

CORTICOSTEROID; INTERLEUKIN 5;

ASTHMA; ATOPY; BRONCHUS BIOPSY; CELL PROLIFERATION; CLINICAL FEATURE; CROSS-SECTIONAL STUDY; DISEASE COURSE; DISEASE EXACERBATION; DISEASE SEVERITY; DRUG EFFICACY; EOSINOPHIL; FORCED EXPIRATORY VOLUME; GRANULOCYTE; HUMAN; LUNG FUNCTION; LUNG LAVAGE; NEUTROPHIL; PATHOGENESIS; PHENOTYPE; PRIORITY JOURNAL; RESPIRATORY TRACT INFLAMMATION; REVIEW; TREATMENT RESPONSE;

ACUTE DISEASE; ASTHMA; BIOLOGICAL MARKERS; CHILD; CHRONIC DISEASE; DISEASE PROGRESSION; HUMANS; INFLAMMATION; PHENOTYPE; PROGNOSIS; RESPIRATORY FUNCTION TESTS; SEVERITY OF ILLNESS INDEX;

EID: 79959726036     PISSN: 15260542     EISSN: 15260550     Source Type: Journal    
DOI: 10.1016/j.prrv.2011.04.007     Document Type: Review

References (43)

1. Gerritsen J. Follow up students of asthma from childhood to adulthood. Peadiatr Respir Rev 2002, 3:184-192.
2. Jenkins H.A., Cherniack R., Szefler S.J., Szefler S.J., Covar R., Gelfand E.W. A comparison of the clinical characteristics of children and adults with severe asthma. Chest 2003, 124:1318-1324.
3. Castro-Rodriguez J.A., Holberg C.J., Wright A.L., Martinez F.D. A clinical index to define risk of asthma in young children with recurrent wheezing. Am J Respir Crit Care Med 2000, 162:1403-1406.
4. Martinez F.D. Development of wheezing disorders and asthma in pre-school children. Peadiatrics 2002, 109:362-367.
5. Bush A. How early do airway inflammation and remodeling occur?. Allergology International 2008, 57:11-19.
6. Lex C., Ferreira F., Zacharasewicz A., Nicholson A.G., Haslam P.L., Wilson N.M., Hansel T.T., Payne D.N.R., Bush A. Airway eosinophilia in children with severe asthma. Am J Respir Crit Care Med 2006, 174:1286-1291.
7. Sethi S., Murphy T.F. Infection in the pathogenesis and course of chronic obstructive pulmonary disease. N Engl J Med 2008, 359:2355-2365.
8. Van Alphen L., Janson H.M., Dankert J. Virulence factors in the colonization and persistence of bacteria in the airways. Am J Respir Crit Care Med 1995, 151:2094-2099.
9. Papadopoulos N.G., Christodoulou I., Rohde G., Agache I., Almqvist C., Bruno A., et al. Viruses and bacteria in acute asthma exacerbations-a GA2LEN-DARE systematic review. Allergy 2010, 10.1111/j.1398-9995.2010.02505.x.
10. Harju T.H., Leinonen M., Nokso-Koivisto J., et al. Pathogenic bacteria and viruses in induced sputum of pharyngeal secretions of adults with stable asthma. Thorax 2006, 61:579-584.
11. Gelfand E.W., Kraft M. The importance and features of the distal airways in children and adults. J Allergy Clin Immunol 2009, 124:S84-87.
12. Spahn J.D., Cover R.A., Jain N., Gleason M., Shimamoto R., Szefler S.J., et al. Effect of montelukast on peripheral airway obstruction in children with asthma. Ann Allergy Asthma Immunol 2006, 96:541-549.
13. Bacharier L.B., Strunk R.C., Mauger D., White D., Lemanske R.F., Sorkness C.A. Classifying asthma severity in children: mismatch between symptoms, medication use, and lung function. Am J Respir Crit Care Med 2004, 170:426-432.
14. Spahn J.D., Chemiack R., Paull K., Galfand E.W. Is forced expiratory volume in one second the best measure of severity in childhood asthma?. Am J Respir Crit Care Med 2004, 169:784-786.
15. Hogg J.C., Macklem P.T., Thurlbeck W.M. Site and nature of airway obstruction in chronic obstructive lung disease. N Engl J Med 1968, 278:1355-1360.
16. Carroll N., Cooke C., James A. The distribution of eosinophils and lymphocytes in the large and small airways of asthmatics. Eur Respir J 1997, 10:292-300.
17. Dezateux C., Stocks J. Lung development and early origins of childhood respiratory illness. Br Med Bull 1997, 53:40-57.
18. Taylor D.R., Cowan J.O., Greene J.M., Willian A.R., Sears M.R. Asthma in remission: can relapse in early adulthood be predicted at 18 years of age?. Chest 2005, 127:845-850.
19. Inal A., Kendirli S.G., Yilmaz M., Altintas D.U., Karakoc G.B., Erdogan S. Indices of lower airway inflammation in children monosensitized to house dust mite after nasal allergen challenge. Allergy 2008, 63:1345-1351.
20. Von Mutitus E. Presentation of new GINA guidelines for paediatrics. The global initiative on asthma. Clin Exp Allergy 2000, 30(suppl 1):6-10.
21. Gerritsen J. Follow-up studies of asthma from childhood to adulthood. Paediatr Respir Rev 2002, 3:184-192.
22. Simpson J.L., Scott R., Boyle M.J., Gibson P.G. Inflammatory subtypes in asthma: Assessment and identification using induced sputum. Respirology 2006, 11:54-61.
23. Gibson P.G., Henry P.L., Thomas P. The non-invasive assessment of airway inflammation in chronic corticosteroid-treated symptomatic asthma. Ann Allergy Asthma Immunol 2000, 85:501-507.
24. Gibson P.G., Simpson J.L., Hankin R., et al. Relationship between induced sputum eosinophils and the clinical pattern of childhood asthma. Thorax 2003, 58:116-121.
25. Subrata L.S., Bizzintino J., Mamessier E., Bosco A., McKenna K.L., Wikstrom M.E., et al. Interactions between innate antiviral and atopic immunoinflammatory pathways precipitate and sustain asthma exacerbations in children. The Journal of Immunol 2009, 183:2793-2800.
26. Wang F, He XY, Baines KJ, Gunawardhana L, Simpson JL, Li F, Gibson PG. Different inflammatory phenotypes in adults and children with acute asthma. European Respiratory Journal. 2011; (in press) doi:10.1183/09031936.00170110.
27. Papadopouli E., Tzanakis N., Tsoumakidou M., Kyriakoy D., Plataki M., Mantzouranis E.C., Siafaks N.M. Comparison of induced sputum inflammatory profile between childhood and adult-onset asthma. Respiratory Medicine 2006, 100:1442-1450.
28. Wilson N.M., James A., Uasuf C., et al. Asthma severity and inflammation markers in children. Pediatr Allergy Immunol 2001, 12:125-132.
29. Grootendorst D.C., Van den Bos J.M., romeijn J.J., et al. Induced sputum in adolescents with severe stable asthma. Safety ans the relationship of cell counts and eosinophil cationic protein to clinical severity. Eur Respir J 1999, 13:647-653.
30. Norzila M.Z., Fakes K., Henry R.L., Simpson J., Gibson P.G. Interlukin-8 secretion and neutrophil recruitment accompanies induced sputum eosinophil activation in children with acute asthma. Am J Respir Crit Care Med 2009, 161:769-774.
31. Green R.H., Brightling C.E., McKenna S., Hargadon B., Parker D., Bradding P., Wardlaw A.J., Pavord I.D. Asthma exacerbation and sputum eosinophil counts: a randomised controlled trial. Lancet 2002, 360:1715-1721.
32. Haldar P., Brightling C.E., Hargadon B., Gupta S., Monteiro W., Sousa A., Marshall R.P., Bradding P., Green R.H., Wardlaw A.J., et al. Mepolizumab and exacerbations of refractory eosinophilic asthma. N Engl J Med 2009, 360:973-984.
33. Nair P., Pizzichini M.M., Kjarsgaard M., Inman M.D., Efthimiadis A., Pizzichini E., Hargreave F.E., O'Byrne P.M. Mepolizumab for prednisone-dependent asthma with sputum eosinophilia. N Engl J Med 2009, 360:985-993.
34. Spahn J.D., Cover R. Clinical assessment of asthma progression in children and adults. J Allergy Clin Immunol 2008, 121:548-557.
35. Simpson J.L., Powell H., Boyle M.J., Scott R.J., Gibson P.G. Clarithromycin targets neutrophilic airway inflammation in refractory asthma. Am J Respir Crit Care Med 2008, 177(2):148-155.
36. Porsbjerg C., Lund T.K., Pedersen L., Backer V. Inflammatory subtypes in asthma are related to airway hyperresponsiveness to Mannitol and exhaled NO. Journal of Asthma 2009, 46:606-612.
37. Miranda C., Busacker A., Balzar S., Trudeau J., Wenzel S.E. Distinguishing severe asthma phenotypes: role of age at onset and eosinophilic inflammation. J Allergy Clin Immunol 2004, 113:101-108.
38. Stern D.A., Morgan W.J., Halonen M., Wright A.L., Martinez F.D. Wheezing and bronchial hyper-responsiveness in early childhood as predictors of newly diagnosed asthma in early adulthood: a longitudinal birth-cohort study. Lancet 2008, 372:1058-1064.
39. Murugan A., Prys-Picard C., Calhoun W.J. Biomarkers in asthma. Current Opinion in pulmonary Medicine 2009, 15:12-18.
40. Baines K.L., Simpson J.L., Wood L.G., Scott R.J., Gibson P.G. Transcriptional asthma phenotypes defined by gene expression profiling of induced sputum. J Allergy Clin Immunol 2011, 127:153-160.
41. Woodruff P.G., Modrek B., Choy D.F., Jia G., Abbas A.R., Ellwangner A., Koth J.K., Arron J.R., Fahy J.V. Th2-driven inflammation defines major sub-phenotypes of asthma. Am J Respir Crit Care Med 2009, 180:388-395.
42. Verrills N.M., Irwin J.A., He X.Y., Wood L.G., Powell H., Simpson J.L., McDonald V., Sim A., Gibson P.G. Identification of Novel Diagnostic Biomarkers for Asthma and Chronic Obstructive Pulmonary Disease. Am J Respir Crit Care Med 2011, 183:1-11.
43. DoughertyRH, Fath J.V. Acute exacerbation of asthma: epidemiology, biology and the exacerbation-prone phenotype. Clin exp Allergy 2009, 39:193-202.