Problematic severe asthma in children, not one problem but many: A GA 2LEN initiative

European Respiratory Journal

Volumn 36, Issue 1, 2010, Pages 196-201

  Hedlin, G ^a   Bush, A ^d   Lodrup Carlsen K ^f,g   Wennergren, G ^c   De Benedictis, F M ⁱ   Melen E ^b   Paton, J ^e   Wilson, N ^d   Carlsen, K H ^g,h  

^a Centre for Allergy Research   (Sweden)

^b KAROLINSKA INSTITUTE   (Sweden)

^c QUEEN SILVIA CHILDREN'S HOSPITAL   (Sweden)

^d ROYAL BROMPTON HOSPITAL   (United Kingdom)

^e UNIVERSITY OF GLASGOW   (United Kingdom)

^f ULLEVÅL UNIVERSITY HOSPITAL   (Norway)

^g UNIVERSITY OF OSLO   (Norway)

^h OSLO UNIVERSITY HOSPITAL   (Norway)

ⁱ Salesi Children's Hospital   (Italy)

Author keywords

Child; Genes; Problematic severe asthma; Prognosis

Indexed keywords

AIRWAY OBSTRUCTION; ASTHMA; CHILDHOOD DISEASE; CHRONIC DISEASE; CLINICAL EVALUATION; COMORBIDITY; DISEASE EXACERBATION; DISEASE SEVERITY; GENETICS; GROUPS BY AGE; HOME ENVIRONMENT; HUMAN; INHALER; PATIENT COMPLIANCE; PEDIATRICIAN; PERCEPTION; PHENOTYPE; PRESCRIPTION; PRIORITY JOURNAL; PROBLEMATIC SEVERE ASTHMA; PROGNOSIS; REVIEW; SOCIAL PSYCHOLOGY; SYMPTOMATOLOGY; ADOLESCENT; CHILD; CLASSIFICATION; FEMALE; INFANT; MALE; MEDICATION COMPLIANCE; NEBULIZER; NEWBORN; PRESCHOOL CHILD; PSYCHOLOGY; SEVERITY OF ILLNESS INDEX;

ANTIASTHMATIC AGENT;

ADOLESCENT; ANTI-ASTHMATIC AGENTS; ASTHMA; CHILD; CHILD, PRESCHOOL; FEMALE; HUMANS; INFANT; INFANT, NEWBORN; MALE; MEDICATION ADHERENCE; NEBULIZERS AND VAPORIZERS; SEVERITY OF ILLNESS INDEX;

EID: 77954639445     PISSN: 09031936     EISSN: 13993003     Source Type: Journal    
DOI: 10.1183/09031936.00104809     Document Type: Review

References (55)

1. Fleming L, Wilson N, Bush A. Difficult to control asthma in children. Curr Opin Allergy Clin Immunol 2007; 7: 190-195.
2. Lang A, Carlsen KH, Haaland G, et al. Severe asthma in childhood: assessed in 10 year olds in a birth cohort study. Allergy 2008; 63: 1054-1060.
3. Bush A, Hedlin G, Carlsen KH, et al. Severe asthma in childhood: a common international approach. Lancet 2008; 372: 1019-1021.
4. Brand PL, Baraldi E, Bisgaard H, et al. Definition, assessment and treatment of wheezing disorders in pre-school children: an evidence-based approach. Eur Respir J 2008; 32: 1096-1110.
5. Ayres JG, Miles JF, Barnes PJ. Brittle asthma. Thorax 1998; 53: 315-321.
6. Quanjer PH, Borsboom GJJM, Kivastik J, et al. Cross-sectional and longitudinal spirometry in children and adolescents: interpretative strategies. Am J Respir Crit Care Med 2008; 178: 1262-1270.
7. Casale TB, Stokes JR. Immunomodulators for allergic respiratory disorders. J Allergy Clin Immunol 2008; 121: 288-296.
8. de Benedictis FM, Bush A. Hypothesis paper: rhinosinusitis and asthma - epiphenomenon or causal association? Chest 1999; 115: 550-556.
9. Hellings PW, Hens G. Rhinosinusitis and the lower airways. Immunol Allergy Clin North Am 2009; 29: 733-740.
10. Bourdin A, Gras D, Vachier I, et al. Upper airway 1: Allergic rhinitis and asthma: united disease through epithelial cells. Thorax 2009; 64: 999-1004.
11. Bechard DE, Shumert ML. Gastro-oesophageal reflux-induced asthma: new insights. Gastroenterology 1998; 114: 849-850.
12. Stordal K, Johannesdottir GB, Bentsen BS, et al. Acid suppression does not change respiratory symptoms in children with asthma and gastro-oesophageal reflux disease. Arch Dis Child 2005; 90: 956-960. (Pubitemid 41232350)
13. Beuther DA, Weiss ST, Sutherland ER. Obesity and asthma. Am J Respir Crit Care Med 2006; 174: 112-119.
14. Tantisira KG, Litonjua AA, Weiss ST, et al. Association of body mass with pulmonary function in the Childhood Asthma Management Program (CAMP). Thorax 2003; 58: 1036-1041.
15. Carroll CL, Stoltz P, Raykov N, et al. Childhood overweight increases hospital admission rates for asthma. Pediatrics 2007; 120: 734-740. (Pubitemid 47549560)
16. Sutherland ER, Goleva E, Strand M, et al. Body mass and glucocorticoid response in asthma. Am J Respir Crit Care Med 2008; 178: 682-687.
17. Chanez P, Wenzel SE, Anderson GP, et al. Severe asthma in adults: what are the important questions? J Allergy Clin Immunol 2007; 119: 1337-1348.
18. Robinson DS, Campbell DA, Durham SR, et al. Systematic assessment of difficult-to-treat asthma. Eur Respir J 2003; 22: 478-483.
19. Fleming L, Hall P, van Stiphout N, et al. The importance of nurse-led home visits in the assessment of children with problematic asthma. Arch Dis Child 2009; 94: 780-784.
20. Orrell-Valente JK, Jarlsberg LG, Hill LG, et al. At what age do children start taking daily asthma medicines on their own? Pediatrics 2008; 122: e1186-e1192.
21. Belanger K, Triche EW. Indoor combustion and asthma. Immunol Allergy Clin North Am 2008; 28: 507-519.
22. Howden-Chapman P, Pierse N, Nicholls S, et al. Effects of improved home heating on asthma in community dwelling children: randomised controlled trial. BMJ 2008; 337: a1411.
23. Chalmers GW, Macleod KJ, Little SA, et al. Influence of cigarette smoking on inhaled corticosteroid treatment in mild asthma. Thorax 2002; 57: 226-230. (Pubitemid 34214408)
24. Chaudhuri R, Livingston E, McMahon AD, et al. Cigarette smoking impairs the therapeutic response to oral corticosteroids in chronic asthma. Am J Respir Crit Care Med 2003; 168: 1308-1311. (Pubitemid 37487324)
25. Livingston E, Chaudhuri R, McMahon AD, et al. Systemic sensitivity to corticosteroids in smokers with asthma. Eur Respir J 2007; 29: 64-71.
26. Matsui EC, Hansel NN, McCormack MC, et al. Asthma in the inner city and the indoor environment. Immunol Allergy Clin North Am 2008; 28: 665-686.
27. Nimmagadda SR, Szefler SJ, Spahn JD, et al. Allergen exposure decreases glucocorticoid receptor binding affinity and steroid responsiveness in atopic asthmatics. Am Rev Respir Crit Care Med 1997; 155: 87-93.
28. Kam JC, Szefler SJ, Surs W, et al. Combination IL-2 and IL-4 reduces glucocorticoid receptor-binding affinity and T cell response to glucocorticoids. J Immunol 1993; 151: 3460-3466.
29. Langley SJ, Goldthorpe S, Craven M, et al. Relationship between exposure to domestic allergens and bronchial hyperresponsiveness in non-sensitised, atopic asthmatic subjects. Thorax 2005; 60: 17-21. (Pubitemid 40101012)
30. Chinn S, Heinrich J, Antó JM, et al. Bronchial responsiveness in atopic adults increases with exposure to cat allergen. Am J Respir Crit Care Med 2007; 176: 20-26.
31. Strunk RC, Mrazek DA, Fuhrmann GS, et al. Physiological and psychological characteristics associated with deaths due to asthma in childhood - case-controlled study. JAMA 1985; 254: 1193-1198.
32. Bergström SE, Boman G, Eriksson L, et al. Asthma mortality among Swedish children and young adults, a 10-year study. Respir Med 2008; 102: 1335-1341.
33. Martin AJ, Cambell DA, Gluyas PA, et al. Characteristics of near fatal asthma in children. Pediatr Pulmonol 1995; 20: 1-8.
34. Wright RJ, Cohen S, Carey V, et al. Parental stress as a predictor of wheezing in infancy; a prospective birth cohort study. Am J Respir Crit Care Med 2002; 165: 358-365. (Pubitemid 34118509)
35. Sandberg S, Paton JY, Ahola S, et al. The role of acute and chronic stress in asthma attacks in children. Lancet 2000; 356: 982-987.
36. Sandberg S, McCann DC, Ahola S, et al. Positive experiences and the relationship between stress and asthma in children. Acta Paediatr 2002; 91: 152-158.
37. Wright RJ. Further evidence that the wealthier are healthier: negative life events and asthma-specific quality of life. Thorax 2007; 62: 106-108.
38. 2-adrenergic receptor in children with asthma. Proc Natl Acad Sci USA 2006; 103: 5496-5501.
39. 2LEN and InterAirways document. Allergy 2007; 62: 457-470.
40. Johnston SL, Pattemore PK, Sanderson G, et al. Community study of role of viral infections in exacerbations of asthma in 9-11 year old children. BMJ 1995; 310: 1225-1229.
41. Malmström K, Pitkäranta A, Carpen O, et al. Human rhinovirus in bronchial epithelium of infants with recurrent respiratory symptoms. J Allergy Clin Immunol 2006; 118: 591-596. (Pubitemid 44301384)
42. Hattevig G, Kjellman B, Björkstén B. Appearance of IgE antibodies to ingested and inhaled allergens during the first 12 years of life in atopic and non-atopic children. Pediatr Allergy Immunol 1993; 4: 182-186. (Pubitemid 24004021)
43. Bergström SE, Sundell K, Hedlin G. Adolescents with asthma: Consequences of transition from paediatric to adult healthcare. Respir Med 2010; 104: 180-187.
44. Barton CA, McKenzie DP, Walters EH, et al. Interactions between psychosocial problems and management of asthma: who is at risk of dying? J Asthma 2005; 42: 249-256.
45. Bloomberg GR, Chen E. The relationship of psychologic stress with childhood asthma. Immunol Allergy Clin North Am 2005; 25: 83-105. (Pubitemid 39576679)
46. de Benedicitis D, Bush A. The challenge of asthma in adolescence. Pediatric Pulmonol 2007; 42: 683-692.
47. Wolfe R, Carlin JB, Oswald H, et al. Association between allergy and asthma from childhood to middle adulthood in an Australian cohort study. Am J Respir Crit Care Med 2000; 162: 2177-2181. (Pubitemid 32051683)
48. Phelan PD, Robertson CF, Olinsky A. The Melbourne Asthma Study: 1964-1999. J Allergy Clin Immunol 2002; 109: 189-194.
49. Sears MR, Greene JM, Willan AR, et al. A longitudinal, population-based, cohort study of childhood asthma followed to adulthood. N Engl J Med 2003; 349: 1414-1422.
50. Toelle BG, Xuan W, Peat JK, et al. Childhood factors that predict asthma in young adulthood. Eur Respir J 2004; 23: 66-70. (Pubitemid 38088498)
51. Limb SL, Brown KC, Wood RA, et al. Adult asthma severity in individuals with a history of childhood asthma. J Allergy Clin Immunol 2005; 115: 61-66.
52. Wenzel SE, Balzar S, Ampleford E, et al. IL4Rα mutations are associated with asthma exacerbations and mast cell/IgE expression. Am J Respir Crit Care Med 2007; 175: 570-576.
53. Chagani T, Pare PD, Zhu S, et al. Prevalence of tumor necrosis factor-α and angiotensin converting enzyme polymorphisms in mild/moderate and fatal/near-fatal asthma. Am J Respir Crit Care Med 1999; 160: 278-282.
54. Zhang Y, Leaves NI, Anderson GG, et al. Positional cloning of a quantitative trait locus on chromosome 13q14 that influences immunoglobulin E levels and asthma. Nat Genet 2003; 34: 181-186.
55. Ma SF, Flores C, Wade MS, et al. A common cortactin gene variation confers differential susceptibility to severe asthma. Genet Epidemiol 2008; 32: 757-766.