메뉴 건너뛰기




Volumn 376, Issue 9743, 2010, Pages 814-825

Management of severe asthma in children

Author keywords

[No Author keywords available]

Indexed keywords

ALLERGEN; AZATHIOPRINE; BETA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; BUDESONIDE PLUS FORMOTEROL; CORTICOSTEROID; CYCLOSPORIN; IMMUNOGLOBULIN E ANTIBODY; ITRACONAZOLE; METHOTREXATE; OMALIZUMAB; TERBUTALINE; TOBACCO SMOKE; VORICONAZOLE;

EID: 77956366627     PISSN: 01406736     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0140-6736(10)61054-9     Document Type: Review
Times cited : (195)

References (185)
  • 1
    • 33846032661 scopus 로고    scopus 로고
    • Long-term comparison of 3 controller regimens for mild-moderate persistent childhood asthma: The Pediatric Asthma Controller Trial
    • Childhood Asthma Research and Education Network of the National Heart, Lung, and Blood Institute D.T.
    • CA Sorkness, RF Lemanske Jr, DT Mauger Childhood Asthma Research and Education Network of the National Heart, Lung, and Blood Institute Long-term comparison of 3 controller regimens for mild-moderate persistent childhood asthma: the Pediatric Asthma Controller Trial J Allergy Clin Immunol 119 2007 64 72
    • (2007) J Allergy Clin Immunol , vol.119 , pp. 64-72
    • Sorkness, C.A.1    Mauger2
  • 2
    • 77949576423 scopus 로고    scopus 로고
    • Step-up therapy for children with uncontrolled asthma receiving inhaled corticosteroids
    • Childhood Asthma Research and Education (CARE) Network of the National Heart, Lung, and Blood Institute C.A.
    • RF Lemanske Jr, DT Mauger, CA Sorkness Childhood Asthma Research and Education (CARE) Network of the National Heart, Lung, and Blood Institute Step-up therapy for children with uncontrolled asthma receiving inhaled corticosteroids N Engl J Med 362 2010 975 985
    • (2010) N Engl J Med , vol.362 , pp. 975-985
    • Mauger, D.T.1    Sorkness2
  • 3
    • 70449649943 scopus 로고    scopus 로고
    • Scottish Intercollegiate Guidelines Network. British Guideline on the management of asthma
    • British Thoracic Society
    • British Thoracic Society Scottish Intercollegiate Guidelines Network. British Guideline on the management of asthma Thorax 63 suppl 4 2008 iv1 121
    • (2008) Thorax , vol.63 , Issue.SUPPL. 4 , pp. 1-121
  • 5
    • 16244377444 scopus 로고    scopus 로고
    • Effects of viral respiratory infections on lung development and childhood asthma
    • JE Gern Effects of viral respiratory infections on lung development and childhood asthma J Allergy Clin Immunol 115 2005 668 674
    • (2005) J Allergy Clin Immunol , vol.115 , pp. 668-674
    • Gern, J.E.1
  • 6
    • 16244404577 scopus 로고    scopus 로고
    • Facing the challenges of childhood asthma: What changes are necessary?
    • SJ Szefler Facing the challenges of childhood asthma: what changes are necessary? J Allergy Clin Immunol 115 2005 685 688
    • (2005) J Allergy Clin Immunol , vol.115 , pp. 685-688
    • Szefler, S.J.1
  • 7
    • 57149124346 scopus 로고    scopus 로고
    • Azithromycin or montelukast as inhaled corticosteroid-sparing agents in moderate-to-severe childhood asthma study
    • RC Strunk, LB Bacharier, BR Phillips Azithromycin or montelukast as inhaled corticosteroid-sparing agents in moderate-to-severe childhood asthma study J Allergy Clin Immunol 122 2008 1138 1144
    • (2008) J Allergy Clin Immunol , vol.122 , pp. 1138-1144
    • Strunk, R.C.1    Bacharier, L.B.2    Phillips, B.R.3
  • 8
    • 52049108262 scopus 로고    scopus 로고
    • Management of asthma based on exhaled nitric oxide in addition to guideline-based treatment for inner-city adolescents and young adults: A randomised controlled trial
    • SJ Szefler, H Mitchell, CA Sorkness Management of asthma based on exhaled nitric oxide in addition to guideline-based treatment for inner-city adolescents and young adults: a randomised controlled trial Lancet 372 2008 1065 1072
    • (2008) Lancet , vol.372 , pp. 1065-1072
    • Szefler, S.J.1    Mitchell, H.2    Sorkness, C.A.3
  • 9
    • 58449121138 scopus 로고    scopus 로고
    • Daily telemonitoring of exhaled nitric oxide and symptoms in the treatment of childhood asthma
    • CHARISM Study Group Baraldi E. W.C.
    • JC de Jongste, S Carraro, WC Hop CHARISM Study Group E Baraldi Daily telemonitoring of exhaled nitric oxide and symptoms in the treatment of childhood asthma Am J Respir Crit Care Med 179 2009 93 97
    • (2009) Am J Respir Crit Care Med , vol.179 , pp. 93-97
    • De Jongste, J.C.1    Carraro, S.2
  • 11
    • 57149086352 scopus 로고    scopus 로고
    • Definition, assessment and treatment of wheezing disorders in preschool children: An evidence-based approach
    • PL Brand, E Baraldi, H Bisgaard Definition, assessment and treatment of wheezing disorders in preschool children: an evidence-based approach Eur Respir J 32 2008 1096 1110
    • (2008) Eur Respir J , vol.32 , pp. 1096-1110
    • Brand, P.L.1    Baraldi, E.2    Bisgaard, H.3
  • 12
    • 67649805319 scopus 로고    scopus 로고
    • An official American Thoracic Society/European Respiratory Society statement: Asthma control and exacerbations: Standardizing endpoints for clinical asthma trials and clinical practice
    • American Thoracic Society/European Respiratory Society Task Force on Asthma Control and Exacerbations E.D.
    • HK Reddel, DR Taylor, ED Bateman American Thoracic Society/European Respiratory Society Task Force on Asthma Control and Exacerbations An official American Thoracic Society/European Respiratory Society statement: asthma control and exacerbations: standardizing endpoints for clinical asthma trials and clinical practice Am J Respir Crit Care Med 180 2009 59 99
    • (2009) Am J Respir Crit Care Med , vol.180 , pp. 59-99
    • Reddel, H.K.1    Taylor, D.R.2    Bateman3
  • 14
    • 0031981957 scopus 로고    scopus 로고
    • Difficult-to-control asthma: Clinical characteristics of steroid-insensitive asthma
    • MTS Chan, DYM Leung, SJ Szefler, JD Spahn Difficult-to-control asthma: clinical characteristics of steroid-insensitive asthma J Allergy Clin Immunol 101 1998 594 601
    • (1998) J Allergy Clin Immunol , vol.101 , pp. 594-601
    • Chan, M.T.S.1    Leung, D.Y.M.2    Szefler, S.J.3    Spahn, J.D.4
  • 16
    • 77951966416 scopus 로고    scopus 로고
    • Airway obstruction at time of symptoms prompting use of reliever therapy in children with asthma
    • AF Brouwer, PL Brand, RJ Roorda, EJ Duiverman Airway obstruction at time of symptoms prompting use of reliever therapy in children with asthma Acta Paediatr 99 2010 871 876
    • (2010) Acta Paediatr , vol.99 , pp. 871-876
    • Brouwer, A.F.1    Brand, P.L.2    Roorda, R.J.3    Duiverman, E.J.4
  • 18
    • 38849129311 scopus 로고    scopus 로고
    • Reference ranges for spirometry across all ages: A new approach
    • S Stanojevic, A Wade, J Stocks Reference ranges for spirometry across all ages: a new approach Am J Respir Crit Care Med 177 2008 253 260
    • (2008) Am J Respir Crit Care Med , vol.177 , pp. 253-260
    • Stanojevic, S.1    Wade, A.2    Stocks, J.3
  • 20
    • 76149146032 scopus 로고    scopus 로고
    • Identification of asthma phenotypes using cluster analysis in the severe asthma program
    • WC Moore, DA Meyers, SE Wenzel Identification of asthma phenotypes using cluster analysis in the severe asthma program Am J Respir Crit Care Med 181 2010 315 323
    • (2010) Am J Respir Crit Care Med , vol.181 , pp. 315-323
    • Moore, W.C.1    Meyers, D.A.2    Wenzel, S.E.3
  • 22
    • 33845191620 scopus 로고    scopus 로고
    • National Institutes of Health/National Heart, Lung and Blood Institute Severe Asthma Research Program
    • AM Fitzpatrick, BM Gaston, SC Erzurum, WG Teague National Institutes of Health/National Heart, Lung and Blood Institute Severe Asthma Research Program J Allergy Clin Immunol 118 2006 1218 1225
    • (2006) J Allergy Clin Immunol , vol.118 , pp. 1218-1225
    • Fitzpatrick, A.M.1    Gaston, B.M.2    Erzurum, S.C.3    Teague, W.G.4
  • 23
    • 34247489402 scopus 로고    scopus 로고
    • Demographic and clinical characteristics of children and adolescents with severe or difficult-to-treat asthma
    • TENOR study group E.R.
    • BE Chipps, SJ Szefler, ER Simons TENOR study group Demographic and clinical characteristics of children and adolescents with severe or difficult-to-treat asthma J Allergy Clin Immunol 119 2007 1156 1163
    • (2007) J Allergy Clin Immunol , vol.119 , pp. 1156-1163
    • Chipps, B.E.1    Szefler, S.J.2    Simons3
  • 24
    • 71049144979 scopus 로고    scopus 로고
    • Corticosteroid responsiveness and clinical characteristics in childhood difficult asthma
    • CJ Bossley, S Saglani, C Kavanagh Corticosteroid responsiveness and clinical characteristics in childhood difficult asthma Eur Respir J 34 2009 1052 1059
    • (2009) Eur Respir J , vol.34 , pp. 1052-1059
    • Bossley, C.J.1    Saglani, S.2    Kavanagh, C.3
  • 25
    • 70349388242 scopus 로고    scopus 로고
    • The importance of nurse-led home visits in the assessment of children with problematic asthma
    • M Bracken, L Fleming, P Hall The importance of nurse-led home visits in the assessment of children with problematic asthma Arch Dis Child 94 2009 780 784
    • (2009) Arch Dis Child , vol.94 , pp. 780-784
    • Bracken, M.1    Fleming, L.2    Hall, P.3
  • 26
    • 58349115630 scopus 로고    scopus 로고
    • Randomized controlled trial of oral antifungal sensitization. the fungal asthma sensitization trial (FAST) study
    • DW Denning, BR O'Driscoll, G Powell Randomized controlled trial of oral antifungal sensitization. The fungal asthma sensitization trial (FAST) study Am J Respir Crit Care Med 179 2009 11 18
    • (2009) Am J Respir Crit Care Med , vol.179 , pp. 11-18
    • Denning, D.W.1    O'Driscoll, B.R.2    Powell, G.3
  • 27
    • 68349150858 scopus 로고    scopus 로고
    • Effect of environmental allergen sensitization on asthma morbidity in inner-city asthmatic children
    • J Wang, CM Visness, A Calatroni Effect of environmental allergen sensitization on asthma morbidity in inner-city asthmatic children Clin Exp Allergy 39 2009 1381 1389
    • (2009) Clin Exp Allergy , vol.39 , pp. 1381-1389
    • Wang, J.1    Visness, C.M.2    Calatroni, A.3
  • 28
    • 70350309503 scopus 로고    scopus 로고
    • Comparison of skin prick tests with specific immunoglobulin e in the diagnosis of fungal sensitization in patients with severe asthma
    • BR O'Driscoll, G Powell, F Chew Comparison of skin prick tests with specific immunoglobulin E in the diagnosis of fungal sensitization in patients with severe asthma Clin Exp Allergy 39 2009 1677 1683
    • (2009) Clin Exp Allergy , vol.39 , pp. 1677-1683
    • O'Driscoll, B.R.1    Powell, G.2    Chew, F.3
  • 29
    • 7144263723 scopus 로고    scopus 로고
    • Current allergic asthma and rhinitis: Diagnostic efficiency of three commonly used atopic markers (IgE, skin prick tests, and Phadiatop). Results from 8329 randomized adults from the SAPALDIA Study. Swiss Study on Air Pollution and Lung Diseases in Adults
    • JM Tschopp, D Sistek, C Schindler Current allergic asthma and rhinitis: diagnostic efficiency of three commonly used atopic markers (IgE, skin prick tests, and Phadiatop). Results from 8329 randomized adults from the SAPALDIA Study. Swiss Study on Air Pollution and Lung Diseases in Adults Allergy 53 1998 608 613
    • (1998) Allergy , vol.53 , pp. 608-613
    • Tschopp, J.M.1    Sistek, D.2    Schindler, C.3
  • 30
    • 4544317118 scopus 로고    scopus 로고
    • Classifying asthma severity in children: Mismatch between symptoms, medication use, and lung function
    • LB Bacharier, RC Strunk, D Mauger Classifying asthma severity in children: mismatch between symptoms, medication use, and lung function Am J Respir Crit Care Med 170 2004 426 432
    • (2004) Am J Respir Crit Care Med , vol.170 , pp. 426-432
    • Bacharier, L.B.1    Strunk, R.C.2    Mauger, D.3
  • 31
    • 79959344460 scopus 로고    scopus 로고
    • Expert Panel Report 3 (EPR-3): Guidelines for the diagnosis and management of asthma-summary report 2007
    • Expert Panel Report 3 (EPR-3): guidelines for the diagnosis and management of asthma-summary report 2007 J Allergy Clin Immunol 120 suppl 2007 S94 138
    • (2007) J Allergy Clin Immunol , vol.120 , Issue.SUPPL. , pp. 94-138
  • 32
    • 57149121475 scopus 로고    scopus 로고
    • Suitability of forced expiratory volume in 1 second/forced vital capacity vs percentage of predicted forced expiratory volume in 1 second for the classification of asthma severity in adolescents
    • C van Dalen, E Harding, J Parkin Suitability of forced expiratory volume in 1 second/forced vital capacity vs percentage of predicted forced expiratory volume in 1 second for the classification of asthma severity in adolescents Arch Pediatr Adolesc Med 162 2008 1169 1174
    • (2008) Arch Pediatr Adolesc Med , vol.162 , pp. 1169-1174
    • Van Dalen, C.1    Harding, E.2    Parkin, J.3
  • 33
    • 0141639949 scopus 로고    scopus 로고
    • A longitudinal, population-based, cohort study of childhood asthma followed to adulthood
    • MR Sears, JM Greene, AR Willan A longitudinal, population-based, cohort study of childhood asthma followed to adulthood N Engl J Med 349 2003 1414 1422
    • (2003) N Engl J Med , vol.349 , pp. 1414-1422
    • Sears, M.R.1    Greene, J.M.2    Willan, A.R.3
  • 34
    • 0031034422 scopus 로고    scopus 로고
    • Childhood asthma and lung function in mid-adult life
    • H Oswald, PD Phelan, A Lanigan Childhood asthma and lung function in mid-adult life Pediatr Pulmonol 23 1997 14 20
    • (1997) Pediatr Pulmonol , vol.23 , pp. 14-20
    • Oswald, H.1    Phelan, P.D.2    Lanigan, A.3
  • 35
    • 3242743550 scopus 로고    scopus 로고
    • Progression of asthma measured by lung function in the childhood asthma management program
    • Childhood Asthma Management Program Research Group S.J.
    • RA Covar, JD Spahn, JR Murphy, SJ Szefler Childhood Asthma Management Program Research Group Progression of asthma measured by lung function in the childhood asthma management program Am J Respir Crit Care Med 170 2004 234 241
    • (2004) Am J Respir Crit Care Med , vol.170 , pp. 234-241
    • Covar, R.A.1    Spahn, J.D.2    Murphy, J.R.3    Szefler4
  • 36
    • 58349121851 scopus 로고    scopus 로고
    • Severe exacerbations and decline in lung function in asthma
    • START Investigators Group W.W.
    • PM O'Byrne, S Pedersen, CJ Lamm, WC Tan, WW Busse START Investigators Group Severe exacerbations and decline in lung function in asthma Am J Respir Crit Care Med 179 2009 19 24
    • (2009) Am J Respir Crit Care Med , vol.179 , pp. 19-24
    • O'Byrne, P.M.1    Pedersen, S.2    Lamm, C.J.3    Tan, W.C.4    Busse5
  • 37
    • 0031949780 scopus 로고    scopus 로고
    • Airway wall thickness in patients with near fatal asthma and control groups: Assessment with high resolution computed tomographic scanning
    • N Awadh, NL Muller, CS Park Airway wall thickness in patients with near fatal asthma and control groups: assessment with high resolution computed tomographic scanning Thorax 53 1998 248 253
    • (1998) Thorax , vol.53 , pp. 248-253
    • Awadh, N.1    Muller, N.L.2    Park, C.S.3
  • 38
    • 0030042991 scopus 로고    scopus 로고
    • Computed tomography of the lungs in severe asthma: Influence of disease severity and etiology
    • F Paganin, E Seneterre, P Chanez Computed tomography of the lungs in severe asthma: influence of disease severity and etiology Am J Respir Crit Care Med 153 1996 110 114
    • (1996) Am J Respir Crit Care Med , vol.153 , pp. 110-114
    • Paganin, F.1    Seneterre, E.2    Chanez, P.3
  • 39
    • 0036903388 scopus 로고    scopus 로고
    • High-resolution CT features of severe asthma and bronchiolitis obliterans
    • SP Jensen, DA Lynch, KK Brown, SE Wenzel, JD Newell High-resolution CT features of severe asthma and bronchiolitis obliterans Clin Radiol 57 2002 1078 1085
    • (2002) Clin Radiol , vol.57 , pp. 1078-1085
    • Jensen, S.P.1    Lynch, D.A.2    Brown, K.K.3    Wenzel, S.E.4    Newell, J.D.5
  • 40
    • 0036187873 scopus 로고    scopus 로고
    • Correlation between the bronchial subepithelial layer and whole airway wall thickness in patients with asthma
    • K Kasahara, K Shiba, T Ozawa, K Okuda, M Adachi Correlation between the bronchial subepithelial layer and whole airway wall thickness in patients with asthma Thorax 57 2002 242 246
    • (2002) Thorax , vol.57 , pp. 242-246
    • Kasahara, K.1    Shiba, K.2    Ozawa, T.3    Okuda, K.4    Adachi, M.5
  • 41
    • 73149096712 scopus 로고    scopus 로고
    • Qualitative analysis of high-resolution CT scans in severe asthma
    • S Gupta, S Siddiqui, P Haldar Qualitative analysis of high-resolution CT scans in severe asthma Chest 136 2009 1521 1528
    • (2009) Chest , vol.136 , pp. 1521-1528
    • Gupta, S.1    Siddiqui, S.2    Haldar, P.3
  • 42
    • 0036838921 scopus 로고    scopus 로고
    • Thoracic CT in pediatric patients with difficult-to-treat asthma
    • V Marchac, S Emond, T Mamou-Mani Thoracic CT in pediatric patients with difficult-to-treat asthma Am J Roentgenol 179 2002 1245 1252
    • (2002) Am J Roentgenol , vol.179 , pp. 1245-1252
    • Marchac, V.1    Emond, S.2    Mamou-Mani, T.3
  • 43
    • 33645772482 scopus 로고    scopus 로고
    • Can HRCT be used as a marker of airway remodelling in children with difficult asthma?
    • S Saglani, G Papaioannou, L Khoo Can HRCT be used as a marker of airway remodelling in children with difficult asthma? Respir Res 7 2006 46
    • (2006) Respir Res , vol.7 , pp. 46
    • Saglani, S.1    Papaioannou, G.2    Khoo, L.3
  • 44
    • 25844499733 scopus 로고    scopus 로고
    • High-resolution computed tomography scan and airway remodeling in children with severe asthma
    • J de Blic, I Tillie-Leblond, S Emond High-resolution computed tomography scan and airway remodeling in children with severe asthma J Allergy Clin Immunol 116 2005 750 754
    • (2005) J Allergy Clin Immunol , vol.116 , pp. 750-754
    • De Blic, J.1    Tillie-Leblond, I.2    Emond, S.3
  • 45
    • 34047187392 scopus 로고    scopus 로고
    • The use of imaging techniques for assessing severe childhood asthma
    • J de Blic, P Scheinmann The use of imaging techniques for assessing severe childhood asthma J Allergy Clin Immunol 119 2007 808 810
    • (2007) J Allergy Clin Immunol , vol.119 , pp. 808-810
    • De Blic, J.1    Scheinmann, P.2
  • 46
    • 0036066973 scopus 로고    scopus 로고
    • Low-density areas on high-resolution computed tomograms in chronic pediatric asthma
    • M Pifferi, D Caransella, V Ragazzo, A Pietrobelli, AL Boner Low-density areas on high-resolution computed tomograms in chronic pediatric asthma J Pediatr 141 2002 104 108
    • (2002) J Pediatr , vol.141 , pp. 104-108
    • Pifferi, M.1    Caransella, D.2    Ragazzo, V.3    Pietrobelli, A.4    Boner, A.L.5
  • 48
    • 24344487986 scopus 로고    scopus 로고
    • Quantitative computed tomography detects peripheral airway disease in children
    • N Jain, RA Covar, MC Gleason, JD Newell Jr, EW Gelfand, JD Spahn Quantitative computed tomography detects peripheral airway disease in children Pediatr Pulmonol 40 2005 211 218
    • (2005) Pediatr Pulmonol , vol.40 , pp. 211-218
    • Jain, N.1    Covar, R.A.2    Gleason, M.C.3    Gelfand, E.W.4    Spahn, J.D.5
  • 49
    • 33846815415 scopus 로고    scopus 로고
    • Peripheral airway involvement in CF and asthma compared by inert gas washout
    • PM Gustafsson Peripheral airway involvement in CF and asthma compared by inert gas washout Pediatr Pulmonol 42 2007 168 176
    • (2007) Pediatr Pulmonol , vol.42 , pp. 168-176
    • Gustafsson, P.M.1
  • 50
    • 39049084491 scopus 로고    scopus 로고
    • Multiple-breath inert gas washout and spirometry versus structural lung disease in cystic fibrosis
    • PM Gustafsson, PA De Jong, HA Tiddens, A Lindblad Multiple-breath inert gas washout and spirometry versus structural lung disease in cystic fibrosis Thorax 63 2008 129 134
    • (2008) Thorax , vol.63 , pp. 129-134
    • Gustafsson, P.M.1    De Jong, P.A.2    Tiddens, H.A.3    Lindblad, A.4
  • 51
    • 48949088549 scopus 로고    scopus 로고
    • Asthma education and monitoring: What has been shown to work
    • AF Brouwer, PL Brand Asthma education and monitoring: what has been shown to work Pediatr Respir Rev 9 2008 193 200
    • (2008) Pediatr Respir Rev , vol.9 , pp. 193-200
    • Brouwer, A.F.1    Brand, P.L.2
  • 52
    • 0029114387 scopus 로고
    • Review of prescribed treatment for children with asthma in 1990
    • JO Warner Review of prescribed treatment for children with asthma in 1990 BMJ 311 1995 663 666
    • (1995) BMJ , vol.311 , pp. 663-666
    • Warner, J.O.1
  • 53
    • 1642360751 scopus 로고    scopus 로고
    • Use of asthma medication dispensing patterns to predict risk of adverse health outcomes: A study of Medicaid-insured children in managed care programs
    • HJ Farber, FW Chi, A Capra Use of asthma medication dispensing patterns to predict risk of adverse health outcomes: a study of Medicaid-insured children in managed care programs Ann Allergy Asthma Immunol 92 2004 319 328
    • (2004) Ann Allergy Asthma Immunol , vol.92 , pp. 319-328
    • Farber, H.J.1    Chi, F.W.2    Capra, A.3
  • 54
    • 68849127143 scopus 로고    scopus 로고
    • Severe asthma patients in Korea overestimate their adherence to inhaled corticosteroids
    • YJ Bae, TB Kim, YK Jee Severe asthma patients in Korea overestimate their adherence to inhaled corticosteroids J Asthma 46 2009 591 595
    • (2009) J Asthma , vol.46 , pp. 591-595
    • Bae, Y.J.1    Kim, T.B.2    Jee, Y.K.3
  • 56
    • 0030725199 scopus 로고    scopus 로고
    • Nonadherence in asthmatic patients: Is there a solution to the problem?
    • B Bender, H Milgrom, C Rand Nonadherence in asthmatic patients: is there a solution to the problem? Ann Allergy Asthma Immunol 79 1997 177 185
    • (1997) Ann Allergy Asthma Immunol , vol.79 , pp. 177-185
    • Bender, B.1    Milgrom, H.2    Rand, C.3
  • 58
    • 0033988097 scopus 로고    scopus 로고
    • Poor inhalation technique, even after inhalation instructions, in children with asthma
    • AW Kamps, B van Ewijk, RJ Roorda, PL Brand Poor inhalation technique, even after inhalation instructions, in children with asthma Pediatr Pulmonol 29 2000 39 42
    • (2000) Pediatr Pulmonol , vol.29 , pp. 39-42
    • Kamps, A.W.1    Van Ewijk, B.2    Roorda, R.J.3    Brand, P.L.4
  • 59
    • 0036200007 scopus 로고    scopus 로고
    • Determinants of correct inhalation technique in children attending a hospital-based asthma clinic
    • AW Kamps, PL Brand, RJ Roorda Determinants of correct inhalation technique in children attending a hospital-based asthma clinic Acta Paediatr 91 2002 159 163
    • (2002) Acta Paediatr , vol.91 , pp. 159-163
    • Kamps, A.W.1    Brand, P.L.2    Roorda, R.J.3
  • 60
    • 33750990775 scopus 로고    scopus 로고
    • Assessment of inhalation technique and determinants of incorrect performance among children with asthma
    • M Walia, L Paul, A Satyavani, R Lodha, M Kalaivani, SK Kabra Assessment of inhalation technique and determinants of incorrect performance among children with asthma Pediatr Pulmonol 41 2006 1082 1087
    • (2006) Pediatr Pulmonol , vol.41 , pp. 1082-1087
    • Walia, M.1    Paul, L.2    Satyavani, A.3    Lodha, R.4    Kalaivani, M.5    Kabra, S.K.6
  • 63
    • 16844380860 scopus 로고    scopus 로고
    • Efficacy of low and high dose inhaled corticosteroid in smokers versus non-smokers with mild asthma
    • JE Tomlinson, AD McMahon, R Chaudhuri, JM Thompson, SF Wood, NC Thomson Efficacy of low and high dose inhaled corticosteroid in smokers versus non-smokers with mild asthma Thorax 60 2005 282 287
    • (2005) Thorax , vol.60 , pp. 282-287
    • Tomlinson, J.E.1    McMahon, A.D.2    Chaudhuri, R.3    Thompson, J.M.4    Wood, S.F.5    Thomson, N.C.6
  • 66
    • 33745288561 scopus 로고    scopus 로고
    • Indoor environmental exposures among children with asthma seen in an urban emergency department
    • SJ Teach, EF Crain, DM Quint, ML Hylan, JG Joseph Indoor environmental exposures among children with asthma seen in an urban emergency department Pediatrics 117 2006 S152 S158
    • (2006) Pediatrics , vol.117
    • Teach, S.J.1    Crain, E.F.2    Quint, D.M.3    Hylan, M.L.4    Joseph, J.G.5
  • 67
    • 68049093794 scopus 로고    scopus 로고
    • 'Difficult asthma': Can symptoms be controlled in a structured environment?
    • K De Boeck, M Moens, N Van Der Aa 'Difficult asthma': can symptoms be controlled in a structured environment? Pediatr Pulmonol 44 2009 743 748
    • (2009) Pediatr Pulmonol , vol.44 , pp. 743-748
    • De Boeck, K.1    Moens, M.2    Van Der Aa, N.3
  • 68
    • 33745728358 scopus 로고    scopus 로고
    • Cigarette smoke induces proinflammatory cytokine release by activation of NF-kappaB and posttranslational modifications of histone deacetylase in macrophages
    • SR Yang, AS Chida, MR Bauter Cigarette smoke induces proinflammatory cytokine release by activation of NF-kappaB and posttranslational modifications of histone deacetylase in macrophages Am J Physiol Lung Cell Mol Physiol 291 2006 L46 L57
    • (2006) Am J Physiol Lung Cell Mol Physiol , vol.291
    • Yang, S.R.1    Chida, A.S.2    Bauter, M.R.3
  • 69
    • 0031776403 scopus 로고    scopus 로고
    • Increases in airway eosinophils and interleukin-5 with minimal bronchoconstriction during repeated low-dose allergen challenge in atopic asthmatics
    • I Sulakvelidze, MD Inman, T Rerecich, PM O'Byrne Increases in airway eosinophils and interleukin-5 with minimal bronchoconstriction during repeated low-dose allergen challenge in atopic asthmatics Eur Respir J 11 1998 821 827
    • (1998) Eur Respir J , vol.11 , pp. 821-827
    • Sulakvelidze, I.1    Inman, M.D.2    Rerecich, T.3    O'Byrne, P.M.4
  • 70
    • 0027242280 scopus 로고
    • Combination IL-2 and IL-4 reduces glucocorticoid receptor-binding affinity and T cell response to glucocorticoids
    • JC Kam, SJ Szefler, W Surs, ER Sher, DY Leung Combination IL-2 and IL-4 reduces glucocorticoid receptor-binding affinity and T cell response to glucocorticoids J Immunol 151 1993 3460 3466
    • (1993) J Immunol , vol.151 , pp. 3460-3466
    • Kam, J.C.1    Szefler, S.J.2    Surs, W.3    Sher, E.R.4    Leung, D.Y.5
  • 71
    • 0031018474 scopus 로고    scopus 로고
    • Allergen exposure decreases glucocorticoid receptor binding affinity and steroid responsiveness in atopic asthmatics
    • SR Nimmagadda, SJ Szefler, JD Spahn, W Surs, DYM Leung Allergen exposure decreases glucocorticoid receptor binding affinity and steroid responsiveness in atopic asthmatics Am Rev Respir Crit Care Med 155 1997 87 93
    • (1997) Am Rev Respir Crit Care Med , vol.155 , pp. 87-93
    • Nimmagadda, S.R.1    Szefler, S.J.2    Spahn, J.D.3    Surs, W.4    Leung, D.Y.M.5
  • 72
    • 33646555487 scopus 로고    scopus 로고
    • Study of modifiable risk factors for asthma exacerbations: Virus infection and allergen exposure increase the risk of asthma hospital admissions in children
    • CS Murray, G Poletti, T Kebadze Study of modifiable risk factors for asthma exacerbations: virus infection and allergen exposure increase the risk of asthma hospital admissions in children Thorax 61 2006 376 382
    • (2006) Thorax , vol.61 , pp. 376-382
    • Murray, C.S.1    Poletti, G.2    Kebadze, T.3
  • 73
    • 0035085390 scopus 로고    scopus 로고
    • Worsening of asthma in children allergic to cats, after indirect exposure to cat at school
    • C Almqvist, M Wickman, L Perfetti Worsening of asthma in children allergic to cats, after indirect exposure to cat at school Am J Respir Crit Care Med 163 2001 694 698
    • (2001) Am J Respir Crit Care Med , vol.163 , pp. 694-698
    • Almqvist, C.1    Wickman, M.2    Perfetti, L.3
  • 74
    • 44949099502 scopus 로고    scopus 로고
    • House dust mite avoidance measures for perennial allergic rhinitis
    • A Sheikh, B Hurwitz, Y Shehata House dust mite avoidance measures for perennial allergic rhinitis Cochrane Database Syst Rev 1 2007 CD001563.
    • (2007) Cochrane Database Syst Rev , vol.1
    • Sheikh, A.1    Hurwitz, B.2    Shehata, Y.3
  • 75
    • 42649092143 scopus 로고    scopus 로고
    • Dust-mite control measures of no use
    • Dust-mite control measures of no use Lancet 371 2008 1390
    • (2008) Lancet , vol.371 , pp. 1390
  • 76
    • 53049091432 scopus 로고    scopus 로고
    • Allergen avoidance in the treatment of asthma: Problems with the meta-analyses
    • TA Platts-Mills Allergen avoidance in the treatment of asthma: problems with the meta-analyses J Allergy Clin Immunol 122 2008 694 696
    • (2008) J Allergy Clin Immunol , vol.122 , pp. 694-696
    • Platts-Mills, T.A.1
  • 77
    • 0028803335 scopus 로고
    • Quantitative assessment of exposure to dog (Can f 1) and cat (Fel d 1) allergens: Relationship to sensitization and asthma among children living in Los Alamos, New Mexico
    • J Ingram, R Sporik, G Rose, R Honsinger, M Chapman, TA Platts-Mills Quantitative assessment of exposure to dog (Can f 1) and cat (Fel d 1) allergens: relationship to sensitization and asthma among children living in Los Alamos, New Mexico J Allergy Clin Immunol 96 1995 449 456
    • (1995) J Allergy Clin Immunol , vol.96 , pp. 449-456
    • Ingram, J.1    Sporik, R.2    Rose, G.3    Honsinger, R.4    Chapman, M.5    Platts-Mills, T.A.6
  • 78
    • 20044386127 scopus 로고    scopus 로고
    • Inner City Asthma Study: Relationships among sensitivity, allergen exposure, and asthma morbidity
    • RS Gruchalla, J Pongracic, M Plaut Inner City Asthma Study: relationships among sensitivity, allergen exposure, and asthma morbidity J Allergy Clin Immunol 115 2005 478 485
    • (2005) J Allergy Clin Immunol , vol.115 , pp. 478-485
    • Gruchalla, R.S.1    Pongracic, J.2    Plaut, M.3
  • 79
  • 80
    • 0028879069 scopus 로고
    • Home environment and severe asthma in adolescence: A population based case-control study
    • DP Strachan, IM Carey Home environment and severe asthma in adolescence: a population based case-control study BMJ 311 1995 1053 1056
    • (1995) BMJ , vol.311 , pp. 1053-1056
    • Strachan, D.P.1    Carey, I.M.2
  • 81
    • 5644234169 scopus 로고    scopus 로고
    • Early allergen exposure, skin prick responses, and atopic wheeze at age 5 in English children: A cohort study
    • P Cullinan, SJ MacNeill, JM Harris Early allergen exposure, skin prick responses, and atopic wheeze at age 5 in English children: a cohort study Thorax 59 2004 855 861
    • (2004) Thorax , vol.59 , pp. 855-861
    • Cullinan, P.1    MacNeill, S.J.2    Harris, J.M.3
  • 82
    • 11944263820 scopus 로고    scopus 로고
    • Relationship between exposure to domestic allergens and bronchial hyperresponsiveness in non-sensitised, atopic asthmatic subjects
    • SJ Langley, S Goldthorpe, M Craven, A Woodcock, A Custovic Relationship between exposure to domestic allergens and bronchial hyperresponsiveness in non-sensitised, atopic asthmatic subjects Thorax 60 2005 17 21
    • (2005) Thorax , vol.60 , pp. 17-21
    • Langley, S.J.1    Goldthorpe, S.2    Craven, M.3    Woodcock, A.4    Custovic, A.5
  • 83
    • 34447254241 scopus 로고    scopus 로고
    • Bronchial responsiveness in atopic adults increases with exposure to cat allergen
    • S Chinn, J Heinrich, JM Antó Bronchial responsiveness in atopic adults increases with exposure to cat allergen Am J Respir Crit Care Med 176 2007 20 26
    • (2007) Am J Respir Crit Care Med , vol.176 , pp. 20-26
    • Chinn, S.1    Heinrich, J.2    Antó, J.M.3
  • 84
    • 0034675203 scopus 로고    scopus 로고
    • The role of acute and chronic stress in asthma attacks in children
    • S Sandberg, JY Paton, S Ahola The role of acute and chronic stress in asthma attacks in children Lancet 356 2000 982 987
    • (2000) Lancet , vol.356 , pp. 982-987
    • Sandberg, S.1    Paton, J.Y.2    Ahola, S.3
  • 86
    • 9644260543 scopus 로고    scopus 로고
    • Asthma exacerbations in children immediately following stressful life events: A Cox's hierarchical regression
    • S Sandberg, S Järvenpää, A Penttinen, JY Paton, DC McCann Asthma exacerbations in children immediately following stressful life events: a Cox's hierarchical regression Thorax 59 2004 1046 1051
    • (2004) Thorax , vol.59 , pp. 1046-1051
    • Sandberg, S.1    Järvenpää, S.2    Penttinen, A.3    Paton, J.Y.4    McCann, D.C.5
  • 88
    • 36749010093 scopus 로고    scopus 로고
    • The association between gastro-oesophageal reflux disease and asthma: A systematic review
    • BD Havemann, CA Henderson, HB El-Serag The association between gastro-oesophageal reflux disease and asthma: a systematic review Gut 56 2007 1654 1664
    • (2007) Gut , vol.56 , pp. 1654-1664
    • Havemann, B.D.1    Henderson, C.A.2    El-Serag, H.B.3
  • 91
    • 69349097543 scopus 로고    scopus 로고
    • Unmet needs in severe chronic upper airway disease (SCUAD)
    • Extended Global Allergy and Asthma European Network, World Allergy Organization and Allergic Rhinitis and its Impact on Asthma Study Group G.W.
    • J Bousquet, C Bachert, GW Canonica Extended Global Allergy and Asthma European Network, World Allergy Organization and Allergic Rhinitis and its Impact on Asthma Study Group Unmet needs in severe chronic upper airway disease (SCUAD) J Allergy Clin Immunol 124 2009 428 433
    • (2009) J Allergy Clin Immunol , vol.124 , pp. 428-433
    • Bousquet, J.1    Bachert, C.2    Canonica3
  • 92
    • 62649093035 scopus 로고    scopus 로고
    • Rhinosinusitis, symptomatology & absence of polyposis in children with primary ciliary dyskinesia
    • M Rollin, K Seymour, M Hariri, J Harcourt Rhinosinusitis, symptomatology & absence of polyposis in children with primary ciliary dyskinesia Rhinology 47 2009 75 78
    • (2009) Rhinology , vol.47 , pp. 75-78
    • Rollin, M.1    Seymour, K.2    Hariri, M.3    Harcourt, J.4
  • 93
    • 15444379385 scopus 로고    scopus 로고
    • Exercise induced dyspnea in children and adolescents: If not asthma then what?
    • M Abu-Hassan, B Tannous, M Weinberger Exercise induced dyspnea in children and adolescents: if not asthma then what? Ann Allergy Asthma Immunol 94 2005 366 371
    • (2005) Ann Allergy Asthma Immunol , vol.94 , pp. 366-371
    • Abu-Hassan, M.1    Tannous, B.2    Weinberger, M.3
  • 94
    • 24144500823 scopus 로고    scopus 로고
    • How accurate is the diagnosis of exercise-induced asthma among Vancouver schoolchildren?
    • M Seear, D Wensley, N West How accurate is the diagnosis of exercise-induced asthma among Vancouver schoolchildren? Arch Dis Child 90 2005 898 902
    • (2005) Arch Dis Child , vol.90 , pp. 898-902
    • Seear, M.1    Wensley, D.2    West, N.3
  • 95
    • 0021866314 scopus 로고
    • Efficacy of Nijmegen questionnaire in recognition of the hyperventilation syndrome
    • DJ Van Dixhoorn, HJ Duivendorm Efficacy of Nijmegen questionnaire in recognition of the hyperventilation syndrome J Psychosom Res 29 1985 199 206
    • (1985) J Psychosom Res , vol.29 , pp. 199-206
    • Van Dixhoorn, D.J.1    Duivendorm, H.J.2
  • 96
    • 0033808407 scopus 로고    scopus 로고
    • Children's perception of breathlessness in acute asthma
    • I Male, H Richter, P Seddon Children's perception of breathlessness in acute asthma Arch Dis Child 83 2000 325 329
    • (2000) Arch Dis Child , vol.83 , pp. 325-329
    • Male, I.1    Richter, H.2    Seddon, P.3
  • 99
    • 0038342586 scopus 로고    scopus 로고
    • Food allergy as a risk factor for life-threatening asthma in childhood: A case-controlled study
    • G Roberts, N Patel, F Levi-Schaffer, P Habibi, G Lack Food allergy as a risk factor for life-threatening asthma in childhood: a case-controlled study J Allergy Clin Immunol 112 2003 168 174
    • (2003) J Allergy Clin Immunol , vol.112 , pp. 168-174
    • Roberts, G.1    Patel, N.2    Levi-Schaffer, F.3    Habibi, P.4    Lack, G.5
  • 101
    • 0033510680 scopus 로고    scopus 로고
    • A randomized clinical trial to reduce asthma morbidity among inner-city children: Results of the National Cooperative Inner-City Asthma Study
    • R Evans 3rd, PJ Gergen, H Mitchell A randomized clinical trial to reduce asthma morbidity among inner-city children: results of the National Cooperative Inner-City Asthma Study J Pediatr 135 1999 332 338
    • (1999) J Pediatr , vol.135 , pp. 332-338
    • Iii, E.R.1    Gergen, P.J.2    Mitchell, H.3
  • 102
    • 4444358501 scopus 로고    scopus 로고
    • Results of a home-based environmental intervention among urban children with asthma
    • Inner-City Asthma Study Group R.S.
    • WJ Morgan, EF Crain, RS Gruchalla Inner-City Asthma Study Group Results of a home-based environmental intervention among urban children with asthma N Engl J Med 351 2004 1068 1080
    • (2004) N Engl J Med , vol.351 , pp. 1068-1080
    • Morgan, W.J.1    Crain, E.F.2    Gruchalla3
  • 103
    • 27644596223 scopus 로고    scopus 로고
    • Cost-effectiveness of a home-based environmental intervention for inner-city children with asthma
    • M Kattan, SC Stearns, EF Crain Cost-effectiveness of a home-based environmental intervention for inner-city children with asthma J Allergy Clin Immunol 116 2005 1058 1063
    • (2005) J Allergy Clin Immunol , vol.116 , pp. 1058-1063
    • Kattan, M.1    Stearns, S.C.2    Crain, E.F.3
  • 104
    • 77956386016 scopus 로고    scopus 로고
    • A systematic review to examine the impact of psycho-educational interventions on health outcomes and costs in adults and children with difficult asthma
    • JR Smith, M Mugford, R Holland A systematic review to examine the impact of psycho-educational interventions on health outcomes and costs in adults and children with difficult asthma Int Soc Technol Assess Health Care Meet 19 2005 172
    • (2005) Int Soc Technol Assess Health Care Meet , vol.19 , pp. 172
    • Smith, J.R.1    Mugford, M.2    Holland, R.3
  • 105
    • 0025895418 scopus 로고
    • Individualised asthma self-management: A beginning
    • H Kotses, C Stout, JK Wigal Individualised asthma self-management: a beginning J Asthma 28 1991 287 289
    • (1991) J Asthma , vol.28 , pp. 287-289
    • Kotses, H.1    Stout, C.2    Wigal, J.K.3
  • 107
    • 0031913720 scopus 로고    scopus 로고
    • Corticosteroid unresponsiveness in asthma: Primary or acquired?
    • DN Payne, M Hubbard, SA McKenzie Corticosteroid unresponsiveness in asthma: primary or acquired? Pediatr Pulmonol 25 1998 59 61
    • (1998) Pediatr Pulmonol , vol.25 , pp. 59-61
    • Payne, D.N.1    Hubbard, M.2    McKenzie, S.A.3
  • 108
    • 0028079557 scopus 로고
    • Steroid-resistant asthma. Cellular mechanisms contributing to inadequate response to glucocorticoid therapy
    • ER Sher, DYM Leung, W Surs Steroid-resistant asthma. Cellular mechanisms contributing to inadequate response to glucocorticoid therapy J Clin Invest 93 1994 33 39
    • (1994) J Clin Invest , vol.93 , pp. 33-39
    • Sher, E.R.1    Leung, D.Y.M.2    Surs, W.3
  • 109
    • 49449089908 scopus 로고    scopus 로고
    • Molecular mechanisms of corticosteroid resistance
    • IM Adcock, PJ Barnes Molecular mechanisms of corticosteroid resistance Chest 134 2008 394 401
    • (2008) Chest , vol.134 , pp. 394-401
    • Adcock, I.M.1    Barnes, P.J.2
  • 110
    • 0035888740 scopus 로고    scopus 로고
    • Relationship between exhaled nitric oxide and mucosal eosinophilic inflammation in children with difficult asthma, after treatment with oral prednisolone
    • DNR Payne, IM Adcock, NM Wilson, T Oates, M Scallan, A Bush Relationship between exhaled nitric oxide and mucosal eosinophilic inflammation in children with difficult asthma, after treatment with oral prednisolone Am J Respir Crit Care Med 164 2001 1376 1381
    • (2001) Am J Respir Crit Care Med , vol.164 , pp. 1376-1381
    • Payne, D.N.R.1    Adcock, I.M.2    Wilson, N.M.3    Oates, T.4    Scallan, M.5    Bush, A.6
  • 113
    • 33644764664 scopus 로고    scopus 로고
    • Asthma Control Test: Reliability, validity, and responsiveness in patients not previously followed by asthma specialists
    • M Schatz, CA Sorkness, JT Li Asthma Control Test: reliability, validity, and responsiveness in patients not previously followed by asthma specialists J Allergy Clin Immunol 117 2006 549 556
    • (2006) J Allergy Clin Immunol , vol.117 , pp. 549-556
    • Schatz, M.1    Sorkness, C.A.2    Li, J.T.3
  • 114
    • 0036260794 scopus 로고    scopus 로고
    • Exhaled nitric oxide correlates with airway eosinophils in childhood asthma
    • TJ Warke, PS Fitch, V Brown Exhaled nitric oxide correlates with airway eosinophils in childhood asthma Thorax 57 2002 383 387
    • (2002) Thorax , vol.57 , pp. 383-387
    • Warke, T.J.1    Fitch, P.S.2    Brown, V.3
  • 115
    • 0031778830 scopus 로고    scopus 로고
    • Persistence of sputum eosinophilia in children with controlled asthma when compared with healthy children
    • Y Cai, K Carty, RL Henry, PG Gibson Persistence of sputum eosinophilia in children with controlled asthma when compared with healthy children Eur Respir J 11 1998 848 853
    • (1998) Eur Respir J , vol.11 , pp. 848-853
    • Cai, Y.1    Carty, K.2    Henry, R.L.3    Gibson, P.G.4
  • 116
    • 18844402394 scopus 로고    scopus 로고
    • Is a two-week trial of oral prednisolone predictive of target lung function in pediatric asthma?
    • C Lex, DN Payne, A Zacharasiewicz Is a two-week trial of oral prednisolone predictive of target lung function in pediatric asthma? Pediatr Pulmonol 39 2005 521 527
    • (2005) Pediatr Pulmonol , vol.39 , pp. 521-527
    • Lex, C.1    Payne, D.N.2    Zacharasiewicz, A.3
  • 117
    • 77956368298 scopus 로고    scopus 로고
    • Noninvasive markers of inflammation as a measurement of corticosteroid responsiveness in children with severe asthma (sa)
    • C Bossley, S Saglani, L Fleming Noninvasive markers of inflammation as a measurement of corticosteroid responsiveness in children with severe asthma (sa) Eur Respir J 34 suppl 53 2009 566S
    • (2009) Eur Respir J , vol.34 , Issue.SUPPL. 53
    • Bossley, C.1    Saglani, S.2    Fleming, L.3
  • 119
    • 1842370350 scopus 로고    scopus 로고
    • Effect of inhaled formoterol and budesonide on exacerbations of asthma. Formoterol and Corticosteroids Establishing Therapy (FACET) International Study Group
    • RA Pauwels, CG Löfdahl, DS Postma Effect of inhaled formoterol and budesonide on exacerbations of asthma. Formoterol and Corticosteroids Establishing Therapy (FACET) International Study Group N Engl J Med 337 1997 1405 1411
    • (1997) N Engl J Med , vol.337 , pp. 1405-1411
    • Pauwels, R.A.1    Löfdahl, C.G.2    Postma, D.S.3
  • 120
    • 33845928663 scopus 로고    scopus 로고
    • Budesonide/formoterol maintenance plus reliever therapy: A new strategy in pediatric asthma
    • H Bisgaard, P Le Roux, D Bjmer, A Dymek, JH Vermeulen, C Hultquist Budesonide/formoterol maintenance plus reliever therapy: a new strategy in pediatric asthma Chest 130 2006 1733 1743
    • (2006) Chest , vol.130 , pp. 1733-1743
    • Bisgaard, H.1    Le Roux, P.2    Bjmer, D.3    Dymek, A.4    Vermeulen, J.H.5    Hultquist, C.6
  • 121
    • 66549115675 scopus 로고    scopus 로고
    • Combination formoterol and inhaled steroid versus beta2-agonist as relief medication for chronic asthma in adults and children
    • CJ Cates, TJ Lasserson Combination formoterol and inhaled steroid versus beta2-agonist as relief medication for chronic asthma in adults and children Cochrane Database Syst Rev 2 2009 CD007085.
    • (2009) Cochrane Database Syst Rev , vol.2
    • Cates, C.J.1    Lasserson, T.J.2
  • 123
    • 20044362008 scopus 로고    scopus 로고
    • Benefits of omalizumab as add-on therapy in patients with severe persistent asthma who are inadequately controlled despite best available therapy (GINA 2002 step 4 treatment): INNOVATE
    • M Humbert, R Beasley, J Ayres Benefits of omalizumab as add-on therapy in patients with severe persistent asthma who are inadequately controlled despite best available therapy (GINA 2002 step 4 treatment): INNOVATE Allergy 60 2005 309 316
    • (2005) Allergy , vol.60 , pp. 309-316
    • Humbert, M.1    Beasley, R.2    Ayres, J.3
  • 124
    • 70349322996 scopus 로고    scopus 로고
    • Adding omalizumab to the therapy of adolescents with persistent uncontrolled moderate - Severe allergic asthma
    • M Massanari, H Milgrom, S Pollard Adding omalizumab to the therapy of adolescents with persistent uncontrolled moderate - severe allergic asthma Clin Pediatr 48 2009 859 865
    • (2009) Clin Pediatr , vol.48 , pp. 859-865
    • Massanari, M.1    Milgrom, H.2    Pollard, S.3
  • 125
    • 71249102935 scopus 로고    scopus 로고
    • Omalizumab for the treatment of exacerbations in children with inadequately controlled allergic (IgE-mediated) asthma
    • B Lanier, T Bridges, M Kulus, AF Taylor, I Berhane, CF Vidaurre Omalizumab for the treatment of exacerbations in children with inadequately controlled allergic (IgE-mediated) asthma J Allergy Clin Immunol 124 2009 1210 1216
    • (2009) J Allergy Clin Immunol , vol.124 , pp. 1210-1216
    • Lanier, B.1    Bridges, T.2    Kulus, M.3    Taylor, A.F.4    Berhane, I.5    Vidaurre, C.F.6
  • 126
    • 0031470655 scopus 로고    scopus 로고
    • The use of cyclosporin in corticosteroid dependent asthma
    • ME Coren, M Rosenthal, A Bush The use of cyclosporin in corticosteroid dependent asthma Arch Dis Child 77 1997 522 523
    • (1997) Arch Dis Child , vol.77 , pp. 522-523
    • Coren, M.E.1    Rosenthal, M.2    Bush, A.3
  • 127
    • 10144255093 scopus 로고    scopus 로고
    • A placebo-controlled multi-center study of auranofin in the treatment of patients with corticosteroid-dependent asthma. Auranofin Multicenter Drug Trial
    • IL Bernstein, DI Bernstein, JW Dubb, I Faiferman, B Wallin A placebo-controlled multi-center study of auranofin in the treatment of patients with corticosteroid-dependent asthma. Auranofin Multicenter Drug Trial J Allergy Clin Immunol 98 1996 317 324
    • (1996) J Allergy Clin Immunol , vol.98 , pp. 317-324
    • Bernstein, I.L.1    Bernstein, D.I.2    Dubb, J.W.3    Faiferman, I.4    Wallin, B.5
  • 129
    • 71749120427 scopus 로고    scopus 로고
    • Recent asthma exacerbations predict future exacerbations in children with severe or difficult-to-treat asthma
    • T Haselkorn, RS Zeiger, BE Chipps Recent asthma exacerbations predict future exacerbations in children with severe or difficult-to-treat asthma J Allergy Clin Immunol 124 2009 921 927
    • (2009) J Allergy Clin Immunol , vol.124 , pp. 921-927
    • Haselkorn, T.1    Zeiger, R.S.2    Chipps, B.E.3
  • 130
    • 58849162826 scopus 로고    scopus 로고
    • Acute exacerbations of asthma: Epidemiology, biology and the exacerbation-prone phenotype
    • RH Dougherty, JV Fahy Acute exacerbations of asthma: epidemiology, biology and the exacerbation-prone phenotype Clin Exp Allergy 39 2009 193 202
    • (2009) Clin Exp Allergy , vol.39 , pp. 193-202
    • Dougherty, R.H.1    Fahy, J.V.2
  • 131
    • 33748446393 scopus 로고    scopus 로고
    • Role of deficient type III interferon-lambda production in asthma exacerbations
    • M Contoli, SD Message, V Laza-Stanca Role of deficient type III interferon-lambda production in asthma exacerbations Nat Med 12 2006 1023 1026
    • (2006) Nat Med , vol.12 , pp. 1023-1026
    • Contoli, M.1    Message, S.D.2    Laza-Stanca, V.3
  • 132
    • 60849114033 scopus 로고    scopus 로고
    • Respiratory virus induction of alpha-, beta- and lambda-interferons in bronchial epithelial cells and peripheral blood mononuclear cells
    • MR Khaitov, V Laza-Stanca, MR Edwards Respiratory virus induction of alpha-, beta- and lambda-interferons in bronchial epithelial cells and peripheral blood mononuclear cells Allergy 64 2009 375 386
    • (2009) Allergy , vol.64 , pp. 375-386
    • Khaitov, M.R.1    Laza-Stanca, V.2    Edwards, M.R.3
  • 133
    • 71749107897 scopus 로고    scopus 로고
    • Consistently very poorly controlled asthma, as defined by the impairment domain of the Expert Panel Report 3 guidelines, increases risk for future severe asthma exacerbations in the Epidemiology and Natural History of Asthma: Outcomes and Treatment Regimens (TENOR) study
    • TENOR Study Group R.S.
    • T Haselkorn, JE Fish, RS Zeiger TENOR Study Group Consistently very poorly controlled asthma, as defined by the impairment domain of the Expert Panel Report 3 guidelines, increases risk for future severe asthma exacerbations in The Epidemiology and Natural History of Asthma: Outcomes and Treatment Regimens (TENOR) study J Allergy Clin Immunol 124 2009 895 902 e1-4.
    • (2009) J Allergy Clin Immunol , vol.124 , pp. 895-902
    • Haselkorn, T.1    Fish, J.E.2    Zeiger3
  • 134
    • 33846176158 scopus 로고    scopus 로고
    • Recent asthma exacerbations: A key predictor of future exacerbations
    • TENOR Study Group S.E.
    • MK Miller, JH Lee, DP Miller, SE Wenzel TENOR Study Group Recent asthma exacerbations: a key predictor of future exacerbations Respir Med 101 2007 481 489
    • (2007) Respir Med , vol.101 , pp. 481-489
    • Miller, M.K.1    Lee, J.H.2    Miller, D.P.3    Wenzel4
  • 135
    • 1542313825 scopus 로고    scopus 로고
    • Risk factors for an intensive care unit admission in children with asthma
    • Y Belessis, S Dixon, A Thomsen Risk factors for an intensive care unit admission in children with asthma Pediatr Pulmonol 37 2004 201 209
    • (2004) Pediatr Pulmonol , vol.37 , pp. 201-209
    • Belessis, Y.1    Dixon, S.2    Thomsen, A.3
  • 136
    • 0027216415 scopus 로고
    • Sudden-onset fatal asthma. A distinct entity with few eosinophils and relatively more neutrophils in the airway submucosa?
    • S Sur, TB Crotty, GM Kephart Sudden-onset fatal asthma. A distinct entity with few eosinophils and relatively more neutrophils in the airway submucosa? Am Rev Respir Dis 148 1993 713 719
    • (1993) Am Rev Respir Dis , vol.148 , pp. 713-719
    • Sur, S.1    Crotty, T.B.2    Kephart, G.M.3
  • 137
    • 0029893414 scopus 로고    scopus 로고
    • Airway structure and inflammatory cells in fatal attacks of asthma
    • NE Carroll, S Carello, C Cooke, A James Airway structure and inflammatory cells in fatal attacks of asthma Eur Respir J 9 1996 709 715
    • (1996) Eur Respir J , vol.9 , pp. 709-715
    • Carroll, N.E.1    Carello, S.2    Cooke, C.3    James, A.4
  • 138
    • 0032833536 scopus 로고    scopus 로고
    • Pattern of airway inflammation and its determinants in children with acute severe asthma
    • PG Gibson, MZ Norzila, K Fakes, J Simpson, RL Henry Pattern of airway inflammation and its determinants in children with acute severe asthma Pediatr Pulmonol 28 1999 261 270
    • (1999) Pediatr Pulmonol , vol.28 , pp. 261-270
    • Gibson, P.G.1    Norzila, M.Z.2    Fakes, K.3    Simpson, J.4    Henry, R.L.5
  • 139
    • 0034995560 scopus 로고    scopus 로고
    • Thunderstorm outflows preceding epidemics of asthma during spring and summer
    • GB Marks, JR Colquhoun, ST Girgis Thunderstorm outflows preceding epidemics of asthma during spring and summer Thorax 56 2001 468 471
    • (2001) Thorax , vol.56 , pp. 468-471
    • Marks, G.B.1    Colquhoun, J.R.2    Girgis, S.T.3
  • 140
    • 0033558138 scopus 로고    scopus 로고
    • Asthma visits to emergency rooms and soybean unloading in the harbors of Valencia and A Coruña, Spain
    • F Ballester, JB Soriano, I Otero Asthma visits to emergency rooms and soybean unloading in the harbors of Valencia and A Coruña, Spain Am J Epidemiol 149 1999 315 322
    • (1999) Am J Epidemiol , vol.149 , pp. 315-322
    • Ballester, F.1    Soriano, J.B.2    Otero, I.3
  • 142
    • 61849086181 scopus 로고    scopus 로고
    • Mepolizumab and exacerbations of refractory eosinophilic asthma
    • P Haldar, CE Brightling, B Hargadon Mepolizumab and exacerbations of refractory eosinophilic asthma N Engl J Med 360 2009 973 984
    • (2009) N Engl J Med , vol.360 , pp. 973-984
    • Haldar, P.1    Brightling, C.E.2    Hargadon, B.3
  • 143
    • 61849155730 scopus 로고    scopus 로고
    • Mepolizumab for prednisone-dependent asthma with sputum eosinophilia
    • P Nair, MM Pizzichini, M Kjarsgaard Mepolizumab for prednisone-dependent asthma with sputum eosinophilia N Engl J Med 360 2009 985 993
    • (2009) N Engl J Med , vol.360 , pp. 985-993
    • Nair, P.1    Pizzichini, M.M.2    Kjarsgaard, M.3
  • 144
    • 84921431253 scopus 로고    scopus 로고
    • Inhaled steroids for episodic viral wheeze of childhood
    • M McKean, F Ducharme Inhaled steroids for episodic viral wheeze of childhood Cochrane Database Syst Rev 2 2000 CD001107.
    • (2000) Cochrane Database Syst Rev , vol.2
    • McKean, M.1    Ducharme, F.2
  • 145
    • 33847056975 scopus 로고    scopus 로고
    • Short-course montelukast for intermittent asthma in children: A randomized controlled trial
    • CF Robertson, D Price, R Henry Short-course montelukast for intermittent asthma in children: a randomized controlled trial Am J Respir Crit Care Med 175 2007 323 329
    • (2007) Am J Respir Crit Care Med , vol.175 , pp. 323-329
    • Robertson, C.F.1    Price, D.2    Henry, R.3
  • 147
    • 64749116304 scopus 로고    scopus 로고
    • Risks of long-acting beta-agonists in achieving asthma control
    • JM Drazen, PM O'Byrne Risks of long-acting beta-agonists in achieving asthma control N Engl J Med 360 2009 1671 1672
    • (2009) N Engl J Med , vol.360 , pp. 1671-1672
    • Drazen, J.M.1    O'Byrne, P.M.2
  • 148
    • 73449095250 scopus 로고    scopus 로고
    • Meta-analysis of the risk of mortality with salmeterol and the effect of concomitant inhaled corticosteroid therapy
    • M Weatherall, M Wijesinghe, K Perrin, M Harwood, R Beasley Meta-analysis of the risk of mortality with salmeterol and the effect of concomitant inhaled corticosteroid therapy Thorax 65 2010 39 43
    • (2010) Thorax , vol.65 , pp. 39-43
    • Weatherall, M.1    Wijesinghe, M.2    Perrin, K.3    Harwood, M.4    Beasley, R.5
  • 149
    • 15744368346 scopus 로고    scopus 로고
    • Sputum induction in children with difficult asthma: Safety, feasibility, and inflammatory cell profiles
    • C Lex, DN Payne, A Zacharasiewicz Sputum induction in children with difficult asthma: safety, feasibility, and inflammatory cell profiles Pediatr Pulmonol 39 2005 318 324
    • (2005) Pediatr Pulmonol , vol.39 , pp. 318-324
    • Lex, C.1    Payne, D.N.2    Zacharasiewicz, A.3
  • 150
    • 0033864739 scopus 로고    scopus 로고
    • Theophylline induces neutrophil apoptosis through adenosine A2A receptor antagonism
    • K Yasui, K Agematsu, K Shinozaki Theophylline induces neutrophil apoptosis through adenosine A2A receptor antagonism J Leukoc Biol 67 2000 529 535
    • (2000) J Leukoc Biol , vol.67 , pp. 529-535
    • Yasui, K.1    Agematsu, K.2    Shinozaki, K.3
  • 151
    • 0036185807 scopus 로고    scopus 로고
    • Effect of long term treatment with azithromycin on disease parameters in cystic fibrosis: A randomised controlled trial
    • J Wolter, S Seeney, S Bell Effect of long term treatment with azithromycin on disease parameters in cystic fibrosis: a randomised controlled trial Thorax 57 2002 212 216
    • (2002) Thorax , vol.57 , pp. 212-216
    • Wolter, J.1    Seeney, S.2    Bell, S.3
  • 152
    • 0037190575 scopus 로고    scopus 로고
    • Long term azithromycin in children with cystic fibrosis: A randomized, placebo-controlled crossover trial
    • A Equi, I Balfour-Lynn, A Bush, M Rosenthal Long term azithromycin in children with cystic fibrosis: a randomized, placebo-controlled crossover trial Lancet 360 2002 978 984
    • (2002) Lancet , vol.360 , pp. 978-984
    • Equi, A.1    Balfour-Lynn, I.2    Bush, A.3    Rosenthal, M.4
  • 153
    • 0141816759 scopus 로고    scopus 로고
    • Azithromycin in patients with cystic fibrosis chronically infected with Pseudomonas aeruginosa: A randomized controlled trial
    • L Saiman, BC Marshall, N Meyer-Hamblett Azithromycin in patients with cystic fibrosis chronically infected with Pseudomonas aeruginosa: a randomized controlled trial JAMA 290 2003 1749 1756
    • (2003) JAMA , vol.290 , pp. 1749-1756
    • Saiman, L.1    Marshall, B.C.2    Meyer-Hamblett, N.3
  • 154
    • 33749984264 scopus 로고    scopus 로고
    • Long term effects of azithromycin in patients with cystic fibrosis: A double blind, placebo controlled trial
    • A Clement, A Tamalet, E Leroux, S Ravilly, B Fauroux, JP Jais Long term effects of azithromycin in patients with cystic fibrosis: a double blind, placebo controlled trial Thorax 61 2006 895 902
    • (2006) Thorax , vol.61 , pp. 895-902
    • Clement, A.1    Tamalet, A.2    Leroux, E.3    Ravilly, S.4    Fauroux, B.5    Jais, J.P.6
  • 155
    • 0031807730 scopus 로고    scopus 로고
    • Improvement of survival in patients with diffuse panbronchiolitis treated with low-dose erythromycin
    • S Kudoh, A Azuma, M Yamamoto, T Izumi, M Ando Improvement of survival in patients with diffuse panbronchiolitis treated with low-dose erythromycin Am J Respir Crit Care Med 157 1998 1829 1832
    • (1998) Am J Respir Crit Care Med , vol.157 , pp. 1829-1832
    • Kudoh, S.1    Azuma, A.2    Yamamoto, M.3    Izumi, T.4    Ando, M.5
  • 158
    • 17644441986 scopus 로고    scopus 로고
    • Clarithromycin suppresses bronchial hyperresponsiveness associated with eosinophilic inflammation in patients with asthma
    • H Amayasu, S Yoshida, S Ebana Clarithromycin suppresses bronchial hyperresponsiveness associated with eosinophilic inflammation in patients with asthma Ann Allergy Asthma Immunol 84 2000 594 598
    • (2000) Ann Allergy Asthma Immunol , vol.84 , pp. 594-598
    • Amayasu, H.1    Yoshida, S.2    Ebana, S.3
  • 159
    • 0029972142 scopus 로고    scopus 로고
    • Opposing effects of glucocorticoids on the rate of apoptosis in neutrophilic and eosinophilic granulocytes
    • LC Meagher, JM Cousin, JR Seckl, C Haslett Opposing effects of glucocorticoids on the rate of apoptosis in neutrophilic and eosinophilic granulocytes J Immunol 156 1996 4422 4428
    • (1996) J Immunol , vol.156 , pp. 4422-4428
    • Meagher, L.C.1    Cousin, J.M.2    Seckl, J.R.3    Haslett, C.4
  • 160
    • 0025978793 scopus 로고
    • Exposure to aeroallergen as a possible precipitating factor in respiratory arrest in young patients with asthma
    • MT O'Hallaren, JW Yunginger, KP Offord Exposure to aeroallergen as a possible precipitating factor in respiratory arrest in young patients with asthma N Engl J Med 324 1991 359 363
    • (1991) N Engl J Med , vol.324 , pp. 359-363
    • O'Hallaren, M.T.1    Yunginger, J.W.2    Offord, K.P.3
  • 161
  • 162
    • 0034058643 scopus 로고    scopus 로고
    • Sensitivity to fungal allergens is a risk factor for life-threatening asthma
    • PN Black, AA Udy, SM Brodie Sensitivity to fungal allergens is a risk factor for life-threatening asthma Allergy 55 2000 501 504
    • (2000) Allergy , vol.55 , pp. 501-504
    • Black, P.N.1    Udy, A.A.2    Brodie, S.M.3
  • 164
    • 0041846937 scopus 로고    scopus 로고
    • Rapidly developing Cushing syndrome in a 4-year-old patient during combined treatment with itraconazole and inhaled budesonide
    • E De Wachter, J Vanbesien, I De Schutter, A Malfroot, J De Schepper Rapidly developing Cushing syndrome in a 4-year-old patient during combined treatment with itraconazole and inhaled budesonide Eur J Pediatr 162 2003 488 489
    • (2003) Eur J Pediatr , vol.162 , pp. 488-489
    • De Wachter, E.1    Vanbesien, J.2    De Schutter, I.3    Malfroot, A.4    De Schepper, J.5
  • 165
    • 74949090750 scopus 로고    scopus 로고
    • Effectiveness and safety of bronchial thermoplasty in the treatment of severe asthma: A multicenter, randomized, double-blind, sham-controlled clinical trial
    • AIR2 Trial Study Group M.
    • M Castro, AS Rubin, M Laviolette AIR2 Trial Study Group Effectiveness and safety of bronchial thermoplasty in the treatment of severe asthma: a multicenter, randomized, double-blind, sham-controlled clinical trial Am J Respir Crit Care Med 181 2010 116 124
    • (2010) Am J Respir Crit Care Med , vol.181 , pp. 116-124
    • Castro, M.1    Rubin, A.S.2    Laviolette3
  • 166
    • 77953039047 scopus 로고    scopus 로고
    • A randomized, controlled, phase 2 study of AMG 317, an IL-4Ralpha antagonist, in patients with asthma
    • J Corren, W Busse, EO Meltzer A randomized, controlled, phase 2 study of AMG 317, an IL-4Ralpha antagonist, in patients with asthma Am J Respir Crit Care Med 181 2010 788 796
    • (2010) Am J Respir Crit Care Med , vol.181 , pp. 788-796
    • Corren, J.1    Busse, W.2    Meltzer, E.O.3
  • 167
    • 0034878193 scopus 로고    scopus 로고
    • On the functional consequences of bronchial basement membrane thickening
    • M Milanese, E Crimi, A Scordamaglia, A Riccio On the functional consequences of bronchial basement membrane thickening J Appl Physiol 91 2001 1035 1040
    • (2001) J Appl Physiol , vol.91 , pp. 1035-1040
    • Milanese, M.1    Crimi, E.2    Scordamaglia, A.3    Riccio, A.4
  • 168
    • 0037438424 scopus 로고    scopus 로고
    • In vivo and in vitro effects of SAR 943, a rapamycin analogue, on airway inflammation and remodeling
    • Y Fujitani, A Trifilieff In vivo and in vitro effects of SAR 943, a rapamycin analogue, on airway inflammation and remodeling Am J Respir Crit Care Med 167 2003 193 198
    • (2003) Am J Respir Crit Care Med , vol.167 , pp. 193-198
    • Fujitani, Y.1    Trifilieff, A.2
  • 169
    • 0344084189 scopus 로고    scopus 로고
    • Usefulness of monitoring lung function in asthma
    • PL Brand, RJ Roorda Usefulness of monitoring lung function in asthma Arch Dis Child 88 2003 1021 1025
    • (2003) Arch Dis Child , vol.88 , pp. 1021-1025
    • Brand, P.L.1    Roorda, R.J.2
  • 170
    • 18644373492 scopus 로고    scopus 로고
    • Clinical use of non-invasive measurements of airway inflammation in steroid reduction in children
    • A Zacharasiewicz, N Wilson, C Lex Clinical use of non-invasive measurements of airway inflammation in steroid reduction in children Am J Respir Crit Care Med 177 2005 1077 1082
    • (2005) Am J Respir Crit Care Med , vol.177 , pp. 1077-1082
    • Zacharasiewicz, A.1    Wilson, N.2    Lex, C.3
  • 171
    • 14944353086 scopus 로고    scopus 로고
    • Exhaled nitric oxide predicts asthma relapse in children with clinical asthma remission
    • MW Pijnenburg, W Hofhuis, WC Hop, JC De Jongste Exhaled nitric oxide predicts asthma relapse in children with clinical asthma remission Thorax 60 2005 215 218
    • (2005) Thorax , vol.60 , pp. 215-218
    • Pijnenburg, M.W.1    Hofhuis, W.2    Hop, W.C.3    De Jongste, J.C.4
  • 172
    • 24644519265 scopus 로고    scopus 로고
    • Titrating steroids on exhaled nitric oxide in children with asthma: A randomized controlled trial
    • MW Pijnenburg, EM Bakker, WC Hop, JC De Jongste Titrating steroids on exhaled nitric oxide in children with asthma: a randomized controlled trial Am J Respir Crit Care Med 172 2005 831 836
    • (2005) Am J Respir Crit Care Med , vol.172 , pp. 831-836
    • Pijnenburg, M.W.1    Bakker, E.M.2    Hop, W.C.3    De Jongste, J.C.4
  • 173
    • 77956391610 scopus 로고    scopus 로고
    • The use of non-invasive markers of inflammation to guide management in children with severe asthma
    • L Fleming, N Wilson, N Regamey, A Bush The use of non-invasive markers of inflammation to guide management in children with severe asthma Am J Respir Crit Care Med 179 suppl 2009 A1305
    • (2009) Am J Respir Crit Care Med , vol.179 , Issue.SUPPL. , pp. 1305
    • Fleming, L.1    Wilson, N.2    Regamey, N.3    Bush, A.4
  • 174
    • 44149108461 scopus 로고    scopus 로고
    • Are inflammatory phenotypes in children with severe asthma stable?
    • L Fleming, N Wilson, N Regamey, A Bush Are inflammatory phenotypes in children with severe asthma stable? Eur Respir J 30 suppl 51 2007 483S
    • (2007) Eur Respir J , vol.30 , Issue.SUPPL. 51
    • Fleming, L.1    Wilson, N.2    Regamey, N.3    Bush, A.4
  • 175
    • 71549161831 scopus 로고    scopus 로고
    • Discordance between sputum eosinophils and exhaled nitric oxide in children with asthma
    • L Fleming, L Tsartsali, N Wilson, N Regamey, C Bossley, A Bush Discordance between sputum eosinophils and exhaled nitric oxide in children with asthma Thorax 63 suppl V11 2008 A34
    • (2008) Thorax , vol.63 , Issue.SUPPL. V11 , pp. 34
    • Fleming, L.1    Tsartsali, L.2    Wilson, N.3    Regamey, N.4    Bossley, C.5    Bush, A.6
  • 176
    • 0037202790 scopus 로고    scopus 로고
    • Asthma exacerbations and sputum eosinophil counts: A randomised controlled trial
    • RH Green, CE Brightling, S McKenna Asthma exacerbations and sputum eosinophil counts: a randomised controlled trial Lancet 360 2002 1715 1721
    • (2002) Lancet , vol.360 , pp. 1715-1721
    • Green, R.H.1    Brightling, C.E.2    McKenna, S.3
  • 177
  • 178
    • 33845490811 scopus 로고    scopus 로고
    • Airway eosinophilia in children with severe asthma: Predictive values of non-invasive tests
    • C Lex, F Ferreira, A Zacharasiewicz Airway eosinophilia in children with severe asthma: predictive values of non-invasive tests Am J Respir Crit Care Med 174 2006 1286 1291
    • (2006) Am J Respir Crit Care Med , vol.174 , pp. 1286-1291
    • Lex, C.1    Ferreira, F.2    Zacharasiewicz, A.3
  • 182
    • 0031928989 scopus 로고    scopus 로고
    • A two-compartment model of pulmonary nitric oxide exchange dynamics
    • NM Tsoukias, SC George A two-compartment model of pulmonary nitric oxide exchange dynamics J Appl Physiol 85 1998 653 666
    • (1998) J Appl Physiol , vol.85 , pp. 653-666
    • Tsoukias, N.M.1    George, S.C.2
  • 183
    • 0034972684 scopus 로고    scopus 로고
    • A single-breath technique with variable flow rate to characterize nitric oxide exchange dynamics in the lungs
    • NM Tsoukias, HW Shin, AF Wilson, SC George A single-breath technique with variable flow rate to characterize nitric oxide exchange dynamics in the lungs J Appl Physiol 91 2001 477 487
    • (2001) J Appl Physiol , vol.91 , pp. 477-487
    • Tsoukias, N.M.1    Shin, H.W.2    Wilson, A.F.3    George, S.C.4
  • 184
    • 33746619130 scopus 로고    scopus 로고
    • Measurement of bronchial and alveolar nitric oxide production in normal children and children with asthma
    • E Paraskakis, C Brindicci, L Fleming Measurement of bronchial and alveolar nitric oxide production in normal children and children with asthma Am J Respir Crit Care Med 174 2006 260 267
    • (2006) Am J Respir Crit Care Med , vol.174 , pp. 260-267
    • Paraskakis, E.1    Brindicci, C.2    Fleming, L.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.