Glutamate carboxypeptidase II: An overview of structural studies and their importance for structure-based drug design and deciphering the reaction mechanism of the enzyme

Current Medicinal Chemistry

Volumn 19, Issue 9, 2012, Pages 1300-1309

  Pavlicek J ^a   Ptacek J ^a   Barinka C ^a  

^a INSTITUTE OF BIOTECHNOLOGY   (Czech Republic)

Author keywords

folate hydrolase; Glutamate carboxypeptidase II; metallopeptidase; prostate specific membrane antigen; X ray crystallography

Indexed keywords

ARGININE; GAMMA GLUTAMYL HYDROLASE; GAMMA GLUTAMYL HYDROLASE III; GLUTAMATE CARBOXYPEPTIDASE II; GLUTAMATE CARBOXYPEPTIDASE II INHIBITOR; GLYCAN DERIVATIVE; ION; POLYCYCLIC AROMATIC HYDROCARBON; UNCLASSIFIED DRUG; ZINC BINDING PROTEIN;

BINDING SITE; ENZYME ACTIVE SITE; ENZYME MECHANISM; ENZYME STRUCTURE; ENZYME SUBSTRATE; ENZYME SUBSTRATE COMPLEX; HUMAN; IC 50; PHARMACOPHORE; PROTEIN FUNCTION; REVIEW; SINGLE NUCLEOTIDE POLYMORPHISM;

ANIMALS; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; ENZYME INHIBITORS; GLUTAMATE CARBOXYPEPTIDASE II; HUMANS; MODELS, MOLECULAR; POLYMORPHISM, GENETIC; PROTEIN CONFORMATION;

EID: 84858136101     PISSN: 09298673     EISSN: 1875533X     Source Type: Journal    
DOI: 10.2174/092986712799462667     Document Type: Review

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