Substrate specificity, inhibition and enzymological analysis of recombinant human glutamate carboxypeptidase II

Journal of Neurochemistry

Volumn 80, Issue 3, 2002, Pages 477-487

  Barinka, Cyril ^a   Rinnová, Markéta ^a   Šácha, Pavel ^a   Rojas, Camilo ^b   Majer, Pavel ^b   Slusher, Barbara S ^b   Konvalinka, Jan ^a  

^a INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY   (Czech Republic)

^b GUILFORD PHARMACEUTICALS INC   (United States)

Author keywords

Enzyme glycosylation; Glutamate carboxypeptidase II; NAALADase; Neuroprotection; Zinc metallopeptidase

Indexed keywords

ACETYLALANYLGLUTAMIC ACID; ACETYLALANYLMETHIONINE; ACETYLASPARTYLMETHIONINE; ACETYLGLUTAMYLMETHIONINE; ALPHA AMINO ACID; DIPEPTIDE; DIPEPTIDYL PEPTIDASE IV; GAMMA GLUTAMYL HYDROLASE; GAMMA GLUTAMYL HYDROLASE II; GLUTAMIC ACID; METALLOPROTEINASE; N ACETYLASPARTYLGLUTAMIC ACID; PEPTIDASE; RECOMBINANT ENZYME; UNCLASSIFIED DRUG;

AMINO ACID METABOLISM; ANIMAL CELL; ARTICLE; BRAIN; CONTROLLED STUDY; DROSOPHILA; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME GLYCOSYLATION; ENZYME INHIBITION; ENZYME SPECIFICITY; FLUOROMETRY; HYDROLYSIS; KINETICS; NERVE CELL NECROSIS; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ANIMALS; ANTIGENS, CD26; ANTIGENS, SURFACE; BRAIN; CARBOXYPEPTIDASES; DROSOPHILA; ENZYME ACTIVATION; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GLUTAMATE CARBOXYPEPTIDASE II; GLYCOSYLATION; HUMANS; HYDROGEN-ION CONCENTRATION; HYDROLYSIS; PEPTIDE FRAGMENTS; RECOMBINANT PROTEINS; SUBSTRATE SPECIFICITY; TUMOR CELLS, CULTURED;

ANIMALIA;

EID: 0036488137     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.0022-3042.2001.00715.x     Document Type: Article

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