The extracellular regions of PSMA and the transferrin receptor contain an aminopeptidase domain: Implications for drug design

Protein Science

Volumn 8, Issue 11, 1999, Pages 2546-2549

  Mahadevan, Daruka ^a   Saldanha, José W ^a,b  

^a UNIVERSITY OF LONDON   (United Kingdom)

^b NATIONAL INSTITUTE FOR MEDICAL RESEARCH   (United Kingdom)

Author keywords

Aminopeptidase; Catalytic pocket; Folate hydrolase; Prostate specific membrane antigen; Specificity pocket; Transferrin receptor

Indexed keywords

AMINOPEPTIDASE; ANTINEOPLASTIC AGENT; ENZYME INHIBITOR; FOLIC ACID; IRON; PROSTATE SPECIFIC ANTIGEN; TRANSFERRIN; TRANSFERRIN RECEPTOR;

AEROMONAS; ARTICLE; DRUG DESIGN; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN STRUCTURE; PSEUDOMONAS; SEQUENCE ANALYSIS; STREPTOMYCES; STRUCTURE ANALYSIS;

AEROMONAS; BACTERIA (MICROORGANISMS); PSEUDOMONAS; PSEUDOMONAS SP.; STREPTOMYCES; STREPTOMYCES GRISEUS; VIBRIO PROTEOLYTICUS;

EID: 0032697048     PISSN: 09618368     EISSN: None     Source Type: Journal    
DOI: 10.1110/ps.8.11.2546     Document Type: Article

References (24)

1. Altschul SF, Madden TL, Achaffer AA, Zhang J, Zhang Z, Miller W, Lipman DJ. 1997. Gapped BLAST and PSI-BLAST: A new generation of protein database search programs. Nucleic Acids Res 25:3389-3402.
2. Bayliss MA, Prescott JM. 1986. Modified activity of Aeromonas aminopeptidase: Metal ion substitution and role of substrates. Biochemistry 25:8113-8117.
3. Burley SK, David PR, Sweet RM, Taylor A, Lipscomb WN. 1992. Structure determination and refinement of bovine lens leucine aminopeptidase and its complex with bestatin. J Mol Biol 224:113-140.
4. Burley SK, David PR, Taylor A, Lipscomb WN. 1990. Leucine aminopeptidase: Bestatin inhibition and a model for enzyme catalyzed peptide hydrolysis. Proc Natl Acad Sci 87:6878-6882.
5. Bzdega T, Turi T, Wroblewska B, She D, Chung HS, Neale JH. 1997. Molecular cloning of a peptidase against N-acetlyaspartylglutamate from a rat hippocampal cDNA library. J Neurochem 69:2270-2277.
6. Carter RE, Feldman AR, Coyle JT. 1996. PSMA is a hydrolase with substrate and pharmacologic characteristics of a neuropeptidase. Proc Natl Acad Sci 93:749-753.
7. Chevrier B, D'Orchymont H, Schalk C, Tarnus C, Moras D. 1996. The structure of the AMP complexed with a hydroxamate inhibitor. Eur J Biochem 237:393-398.
8. Chevrier B, Schalk C, D'Orchymont H, Rondeau J-M, Moras D, Tarnus C. 1994. Crystal structure of AMP: A prototypical member of the cocatalytic zinc enzyme family. Structure 2:283-291.
9. Greenblat HM, Almog O, Maras B, Spungin-Bailik A, Barra D, Blumberg S, Shoham G. 1997. Streptomyces griseus aminopeptidase: X-ray crystallographic structure at 1.75 Å resolution. J Mol Biol 265:620-636.
10. Heston WD. 1996. Significance of PSMA. A neurocarboxypeptidase and membrane folate hydrolase. Urologe A 35:400-407.
11. Israeli RS, Powell CT, Fair WR, Heston WD. 1993. Molecular cloning of a complementary DNA encoding a PMSA. Cancer Res 53:227-230.
12. Jones DT. 1999. GenTHREADER: An efficient and reliable protein fold recognition method for genomic sequences. J Mol Biol 287:797-815.
13. Lebron JA, Bennett MJ, Vaughn DE, Chirino AJ, Snow PM, Mintier GA, Feder JN, Bjorkman PJ. 1998. Crystal structure of the hemachromatosis protein HFE and characterization of its interaction with transferrin receptor. Cell 93:111-123.
14. Melton RG, Sherwood RF. 1996. Antibody-enzyme conjugates for cancer therapy. J Natl Cancer Inst 88:153-165.
15. Newman R, Domingo D, Trotter J, Trowbridge I. 1983. Selection and properties of a mouse L-cell transformant expressing human transferrin receptor. Nature 304:643-645.
16. O'Keefe DS, Su SL, Bacich DJ, Horiguchi Y, Luo Y, Powell CT, Zandvliet D, Russell PJ, Molloy PL, Nowak NJ, et al. 1998. Mapping, genomic organization, and promoter analysis of the human prostate-specific membrane antigen gene. Biochim Biophys Acta 1443:113-127.
17. Pinto JT, Suffoletto BP, Berzin TM, Qiao CH, Lin S, Tong WP, May F, Mukherjee B, Heston WD. 1996. PSMA: A novel folate hydrolase in human prostate carcinoma cells. Clin Cancer Res 2:1445-1451.
18. Rinker-Schaeffer CW, Hawkins AL, Su S, Israeli RS, Griffin CA, Issacs JT, Heston WD. 1995. Localization and physical mapping of the prostate-specific membrane antigen (PSM) gene to chromosome 11. Genomics 30: 105-108.
19. Rowsell S, Pauptit RA, Tucker AC, Melton RG, Blow DM, Brick P. 1997. Crystal structure of carboxypeptidase G2, a bacterial enzyme with application in cancer therapy. Structure 5:337-347.
20. Schneider C, Williams JG. 1985. Molecular dissection of the human transferrin receptor. J Cell Sci Suppl 3:139-149.
21. Simpson A, Moss D, Slingsby C. 1995. The avian eye lens protein delta-crystallin shows a novel packing arrangement of tetramers in a supramolecular helix. Structure 3:403-412.
22. Su SL, Huang I-P, Fair WR, Powell CT, Heston WD. 1995. Alternatively spliced variants of prostate-specific membrane RNA: Ratio of expression as a potential measurement of progression. Cancer Res 55:1441-1443.
23. Taylor WR, Orengo CA. 1989. Protein structure alignment. J Mol Biol 208: 1-22.
24. Thompson JD, Gibson TJ, Plewniak F, Jeanmougin F, Higgins DG. 1997. The Clustal_X windows interface: Flexible strategies for multiple sequence alignment aided by quality analysis tools. Nucleic Acids Res 25:4876-4882.