Human glutamate carboxypeptidase II inhibition: Structures of GCPII in complex with two potent inhibitors, quisqualate and 2-PMPA

Acta Crystallographica Section D: Biological Crystallography

Volumn 63, Issue 4, 2007, Pages 508-513

  Mesters, Jeroen R ^a   Henning, Karen ^a   Hilgenfeld, Rolf ^a  

^a UNIVERSITY OF LÜBECK   (Germany)

Author keywords

Drug design; Excitotoxic neurotransmitters; NAALADase; Neurodegenerative disease; Prostate cancer; PSMA

Indexed keywords

2 (PHOSPHONOMETHYL)PENTANEDIOIC ACID; 2-(PHOSPHONOMETHYL)PENTANEDIOIC ACID; AMINO ACID RECEPTOR STIMULATING AGENT; ENZYME INHIBITOR; GLUTAMATE CARBOXYPEPTIDASE II; GLUTAMATE CARBOXYPEPTIDASE II, HUMAN; MEMBRANE ANTIGEN; ORGANOPHOSPHORUS COMPOUND; QUISQUALIC ACID; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; CHEMICAL STRUCTURE; CHEMISTRY; DRUG ANTAGONISM; HUMAN; HYDROGEN BOND; PROTEIN CONFORMATION;

ANTIGENS, SURFACE; BINDING SITES; ENZYME INHIBITORS; EXCITATORY AMINO ACID AGONISTS; GLUTAMATE CARBOXYPEPTIDASE II; HUMANS; HYDROGEN BONDING; MODELS, MOLECULAR; ORGANOPHOSPHORUS COMPOUNDS; PROTEIN CONFORMATION; QUISQUALIC ACID;

EID: 33947541693     PISSN: 09074449     EISSN: 13990047     Source Type: Journal    
DOI: 10.1107/S090744490700902X     Document Type: Article

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