Widdrol activates DNA damage checkpoint through the signaling Chk2-p53-Cdc25A-p21-MCM4 pathway in HT29 cells

Molecular and Cellular Biochemistry

Volumn 363, Issue 1-2, 2012, Pages 281-289

  Yun, Hee Jung ^a   Hyun, Sook Kyung ^a,b   Park, Jung Ha ^c   Kim, Byung Woo ^a,b   Kwon, Hyun Ju ^a,b  

^a Dong Eui University   (South Korea)

^b Blue Bio Industry RIC   (South Korea)

^c UNIVERSITY OF TOKYO   (Japan)

Author keywords

DNA damage checkpoint pathway; G1 cell cycle arrest; MCM; p21; Widdrol

Indexed keywords

ANTINEOPLASTIC AGENT; CELL DIVISION CYCLE 25A PROTEIN; CELL PROTEIN; CHECKPOINT KINASE 2; CYCLIN DEPENDENT KINASE 2; CYCLIN E; DOUBLE STRANDED DNA; HISTONE H2AX; MINICHROMOSOME MAINTENANCE PROTEIN 4; PLANT EXTRACT; PROTEIN P21; PROTEIN P53; UNCLASSIFIED DRUG; WIDDROL;

ANIMAL CELL; ARTICLE; CELL STRAIN HT29; CONTROLLED STUDY; DNA DAMAGE; DNA STRAND BREAKAGE; DOWN REGULATION; DRUG MECHANISM; G1 PHASE CELL CYCLE CHECKPOINT; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION;

ADENOCARCINOMA; ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; BENZOCYCLOHEPTENES; CDC25 PHOSPHATASES; CELL CYCLE PROTEINS; COLONIC NEOPLASMS; CYCLIN-DEPENDENT KINASE INHIBITOR P21; DNA BREAKS, DOUBLE-STRANDED; DNA-BINDING PROTEINS; FIBROBLASTS; G1 PHASE CELL CYCLE CHECKPOINTS; HISTONES; HT29 CELLS; HUMANS; MICE; NUCLEAR PROTEINS; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; SIGNAL TRANSDUCTION; TIME FACTORS; TUMOR SUPPRESSOR PROTEIN P53;

EUKARYOTA; JUNIPERUS CHINENSIS;

EID: 84857897864     PISSN: 03008177     EISSN: 15734919     Source Type: Journal    
DOI: 10.1007/s11010-011-1180-z     Document Type: Article

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