Widdrol from Juniperus chinensis induces apoptosis in human colon adenocarcinoma HT29 cells

Biotechnology and Bioprocess Engineering

Volumn 15, Issue 1, 2010, Pages 167-172

  Kwon, Hyun Ju ^a   Lee, Eun Woo ^a   Hong, Yun Kyung ^a   Yun, Hee Jung ^a   Kim, Byung Woo ^a  

^a Dong Eui University   (South Korea)

Author keywords

Anti cancer; Anti proliferative activity; Apoptosis; HT29 cell; Juniperus chinensis; Plant widdrol

Indexed keywords

ADENOCARCINOMA CELLS; ANTI-BACTERIAL; ANTI-FUNGAL; ANTI-PROLIFERATIVE; ANTI-PROLIFERATIVE ACTIVITY; ANTI-TUMORS; ANTICANCER DRUG; ANTIPROLIFERATIVE EFFECT; APOPTOSIS; APOPTOTIC MECHANISMS; CASPASES; CELL VIABILITY; CHROMATIN CONDENSATION; CYTOCHROME C; CYTOSOLS; CYTOTOXIC ACTIVITIES; DOSE-DEPENDENT MANNER; HUMAN COLON; INDUCED APOPTOSIS; INHIBITED GROWTH; PROTEOLYTIC CLEAVAGE; WESTERN-BLOT ANALYSIS;

ACTIVATION ANALYSIS; CELL CULTURE;

CELL DEATH;

ANTINEOPLASTIC AGENT; CASPASE 3; CASPASE 8; CASPASE 9; CYTOCHROME C; JUNIPERUS CHINENSIS EXTRACT; PLANT EXTRACT; PLANT WIDDROL; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CELL CYCLE G1 PHASE; CELL STRAIN HT29; CELL VIABILITY; CHEMICAL STRUCTURE; CHROMATIN CONDENSATION; COLON ADENOCARCINOMA; CYTOTOXICITY; DRUG ISOLATION; HUMAN; HUMAN CELL; JUNIPERUS; JUNIPERUS CHINENSIS;

BACTERIA (MICROORGANISMS); JUNIPERUS CHINENSIS;

EID: 77953597072     PISSN: 12268372     EISSN: None     Source Type: Journal    
DOI: 10.1007/s12257-009-0154-4     Document Type: Article

References (30)

1. Kaufmann, S. H. and M. O. Hengartner (2001) Programmed cell death: alive and well in the new millennium. Trends Cell Biol. 11: 526-534.
2. Kaufmann, S. H. and W. C. Earnshaw (2000) Induction of apoptosis by cancer chemotherapy. Exp. Cell Res. 256: 42-49.
3. Salvesen, G. S. and V. M. Dixit (1997) Caspases: intracellular signaling by proteolysis. Cell 91: 443-446.
4. Shi, Y. (2002) Mechanisms of caspase activation and inhibition during apoptosis. Mol. Cell 9: 459-470.
5. Denecker, G., D. Vercammen, W. Declercq, and P. Vandenabeele (2001) Apoptotic and necrotic cell death induced by death domain receptors. Cell Mol. Life Sci. 58: 356-370.
6. Wilson, S. E. (1999) Stimulus-specific and cell typespecific cascades: emerging principles relating to control of apoptosis in the eye. Exp. Eye Res. 69: 255-266.
7. Kelekar, A. and C. B. Thompson (1998) Bcl-2 family proteins: the role of the BH3 domain in apoptosis. Trends Cell Biol. 8: 324-330.
8. Newmeyer, D. D. and S. Ferguson-Miller (2003) Mitochondria: releasing power for life and unleashing the machineries of death. Cell 112: 481-490.
9. Chandra, J., A. Samali, and S. Orrenius (2000) Triggering and modulation of apoptosis by oxidative stress. Free Rad. Biol. Med. 29: 323-333.
10. Germain, M., E. B. Affar, D. D'Amours, V. M. Dixit, G. S. Salvesen, and G. G. Poirier (1999) Cleavage of automodified poly(ADP-ribose) polymerase during apoptosis. Evidence for involvement of caspase-7. J. Biol. Chem. 274: 28379-28384.
11. Dirr, M. A. (1977) Manual of woody landscape plants: their identification, ornamental characteristics, culture, propagation, and uses. 4th ed., p. 1007. Stipes Publishing Company, Champaign, IL, USA.
12. Corner, E. J. H. (1988) Wayside Trees of Malaya. 3rd ed., pp. 396-446. Malayan Nature Society, Kuala Lumpur, Malaysia.
13. Kuo, Y. H. and W. C. Chen (1994) Three new diterpenes, 1,3-dioxototarol, isototarolenone, and 1-oxo-3β-hydroxytotarol from the roots of Juniperus chine-nsis Linn. Chem. Pharm. Bull. 42: 1774-1776.
14. Perry, L. M. (1980) Medicinal Plants of East and Southeast Asia. pp. 240-241. MIT Press, Cambridge, MA, USA.
15. Ohashi, H., T. Asai, and S. Kawai (1994) Screening of main Japanese conifers for antifungal leaf components, sesquiterpenes of Juniperus chinensis var. pyramidalis. Holzforschung 48: 193-198.
16. Clark, A. M., J. D. McChesney, and R. P. Adams (1988) Antimicrobial properties of heartwood, bark/ sapwood, and leaves of Juniperus species. Phytother. Res. 4: 15-19.
17. Johnson, A. E., L. F. James, and J. Spiller (1976) The abortifacient and toxic effects of big sagebrush (Artemisia tridentata) and juniper (Juniperus osteosperma) on domestic sheep. J. Range Manag. 29: 278-280.
18. Appel, A. G. and T. P. Mack (1989) Repellency of milled aromatic eastern red cedar to domiciliary cockroaches (Dictyoptera: Blattellidae and Blattidae). J. Econ. Entomol. 82: 152-155.
19. Agrawal, O. P., S. Bharadwaj, and R. Mathur (1980) Antifertility effects of fruits of Juniperus communis. Planta Med. 32: 98-101.
20. Teng, C. M., C. H. Lin, Y. H. Kuo, Y. L. Lin, and T. F. Huang (1994) Antiplatelet and vasorelaxing action of the acetoxy derivative of cedranediol isolated from Juniperus squamata. Planta Med. 60: 209-213.
21. Feliciano, A. S., M. Gordaliza, J. M. M. del-Corral, M. A. Castro, M. D. G. Gravalos, and P. R. Lazaro(1993) Antineoplastic and antiviral activities of some cyclolignans. Planta Med. 59: 246-249.
22. Tammami, B., S. J. Torrance, and J. R. Cole (1977) Antitumor agent from Juniperus bermudiana (Pinaceae): deoxypodophyllotoxin. Phytochemistry 16: 1100-1101.
23. Yarelis, O. N., S. S. Iraida, G. C. Isidro, and H. G. Rosario (2006) The antifungal activity of widdrol and its biotransformation by Colletotrichum gloeosporioides (penz.) Penz. & Sacc. and Botrytis cinerea Pers. J. Agric. Food Chem. 54: 7517-7521.
24. Enzell, C. (1962) The chemistry of the natural order cupressales 47. The structures and absolute configurations of widdrol and widdrol-α-epoxide. Acta Chem. Scand. 16: 1552-1568.
25. Hu, W. and J. J. Kavanagh (2003) Anticancer therapy targeting the apoptotic pathway. Lancet Oncol. 4: 721-729.
26. Tan, M. L., S. F. Suaiman, N. Najimuddin, M. R. Smian, and T. S. Tengku Muhammad (2005) Methanolic extract of Pereskia bleo(Kunth) DC. (Cactaceae) induces apoptosis in breast carcinama, T47-D cell line. J. Ethnopharmacol. 96: 287-294.
27. Korsmeyer, S. J., M. C. Wei, M. Saito, S. Weiler, J. Oh, and P. H. Schlesinger (2000) Pro-apoptotic cascade activates BID, which oligomerized BAK or BAX into pores that result in the release of cytochrome C. Cell Death Differ. 7: 1166-1173.
28. Luo, X., I. Budihardjo, H. Zou, C. Slaughter, and X. Wang (1998) Bid, a Bcl2 interacting protein, mediates cytochrome C release from mitochondria in response to activation of cell death receptors. Cell 94: 481-490.
29. Liu, X., C. N. Kim, J. Yang, R. Jemmerson, and X. Wang (1996) Induction of apoptotic program in cell-freeextracts: requirement for dATP and cytochrome C. Cell 86: 147-157.
30. Janicke, R. U., M. L. Sprengart, M. R. Wati, and A. G. Porter (1998) Caspase-3 is required for DNA fragmentation and morphological changes associated with apoptosis. J. Biol. Chem. 273: 9357-9360.