Approaches targeting KV10.1 open a novel window for cancer diagnosis and therapy

Current Medicinal Chemistry

Volumn 19, Issue 5, 2012, Pages 675-682

  Pardo, L A ^a   Gomez Varela D ^a   Major, F ^b   Sansuk, K ^c   Leurs, R ^c   Downie, B R ^a   Tietze, L F ^b   Stuhmer W ^a  

^a MAX PLANCK INSTITUTE OF EXPERIMENTAL MEDICINE   (Germany)

^b UNIVERSITY OF GÖTTINGEN   (Germany)

^c VU UNIVERSITY AMSTERDAM   (Netherlands)

Author keywords

ADEPT; Astemizole; Cancer diagnosis; Cancer prognosis; Eag1; Ether go go; Imipramine; Immunotargeted therapy; Immunotherapy; KCNH1; KV10.1; Potassium channel; Tumor therapy

Indexed keywords

AMIODARONE; ANTIARRHYTHMIC AGENT; ASTEMIZOLE; DOFETILIDE; DRONEDARONE; IMIPRAMINE; N METHYL ASTEMIZOLE; N METHYL IMIPRAMINE; POTASSIUM CHANNEL; POTASSIUM CHANNEL BLOCKING AGENT; POTASSIUM CHANNEL KV10.1; POTASSIUM CHANNEL KV10.1 BLOCKING AGENT; SOLTALOL; UNCLASSIFIED DRUG; KCNH1 PROTEIN, HUMAN; POTASSIUM CHANNEL HERG;

CANCER DIAGNOSIS; CANCER THERAPY; DRUG BINDING; DRUG CYTOTOXICITY; DRUG DESIGN; DRUG MECHANISM; DRUG STRUCTURE; DRUG SYNTHESIS; HEART ARRHYTHMIA; HUMAN; IC 50; NONHUMAN; PROTEIN EXPRESSION; PROTEIN FUNCTION; REVIEW; TUMOR GROWTH; MOLECULARLY TARGETED THERAPY; NEOPLASM;

ETHER-A-GO-GO POTASSIUM CHANNELS; HUMANS; MOLECULAR TARGETED THERAPY; NEOPLASMS;

EID: 84857725208     PISSN: 09298673     EISSN: 1875533X     Source Type: Journal    
DOI: 10.2174/092986712798992011     Document Type: Review

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