-
1
-
-
38549117309
-
The HGNC Database in 2008: A resource for the human genome
-
Bruford EA, Lush MJ, Wright MW, Sneddon TP, Povey S, et al. (2008) The HGNC Database in 2008: a resource for the human genome. Nucleic Acids Res 36: D445-448.
-
(2008)
Nucleic Acids Res
, vol.36
-
-
Bruford, E.A.1
Lush, M.J.2
Wright, M.W.3
Sneddon, T.P.4
Povey, S.5
-
2
-
-
0028292927
-
A family of potassium channel genes related to eag in Drosophila and mammals
-
Warmke JW, Ganetzky B (1994) A family of potassium channel genes related to eag in Drosophila and mammals. Proc Natl Acad Sci U S A 91: 3438-3442.
-
(1994)
Proc Natl Acad Sci U S A
, vol.91
, pp. 3438-3442
-
-
Warmke, J.W.1
Ganetzky, B.2
-
3
-
-
0028109116
-
Functional expression of a rat homologue of the voltage gated either a go-go potassium channel reveals differences in selectivity and activation kinetics between the Drosophila channel and its mammalian counterpart
-
Ludwig J, Terlau H, Wunder F, Bruggemann A, Pardo LA, et al. (1994) Functional expression of a rat homologue of the voltage gated either a go-go potassium channel reveals differences in selectivity and activation kinetics between the Drosophila channel and its mammalian counterpart. Embo J 13: 4451-4458.
-
(1994)
Embo J
, vol.13
, pp. 4451-4458
-
-
Ludwig, J.1
Terlau, H.2
Wunder, F.3
Bruggemann, A.4
Pardo, L.A.5
-
4
-
-
32244436422
-
Ether a go-go potassium channels and cancer
-
Camacho J (2006) Ether a go-go potassium channels and cancer. Cancer Lett 233: 1-9.
-
(2006)
Cancer Lett
, vol.233
, pp. 1-9
-
-
Camacho, J.1
-
5
-
-
4944252457
-
Ether a go-go potassium channels as human cervical cancer markers
-
Farias LM, Ocana DB, Diaz L, Larrea F, Avila-Chavez E, et al. (2004) Ether a go-go potassium channels as human cervical cancer markers. Cancer Res 64: 6996-7001.
-
(2004)
Cancer Res
, vol.64
, pp. 6996-7001
-
-
Farias, L.M.1
Ocana, D.B.2
Diaz, L.3
Larrea, F.4
Avila-Chavez, E.5
-
6
-
-
0033567462
-
Identification of ether a go-go and calcium-activated potassium channels in human melanoma cells
-
Meyer R, Schonherr R, Gavrilova-Ruch O, Wohlrab W, Heinemann SH (1999) Identification of ether a go-go and calcium-activated potassium channels in human melanoma cells. J Membr Biol 171: 107-115.
-
(1999)
J Membr Biol
, vol.171
, pp. 107-115
-
-
Meyer, R.1
Schonherr, R.2
Gavrilova-Ruch, O.3
Wohlrab, W.4
Heinemann, S.H.5
-
7
-
-
33847389726
-
Expression of voltage-gated potassium channels in human and mouse colonic carcinoma
-
Ousingsawat J, Spitzner M, Puntheeranurak S, Terracciano L, Tornillo L, et al. (2007) Expression of voltage-gated potassium channels in human and mouse colonic carcinoma. Clin Cancer Res 13: 824-831.
-
(2007)
Clin Cancer Res
, vol.13
, pp. 824-831
-
-
Ousingsawat, J.1
Spitzner, M.2
Puntheeranurak, S.3
Terracciano, L.4
Tornillo, L.5
-
8
-
-
0033570146
-
Oncogenic potential of EAG K(+) channels
-
Pardo LA, del Camino D, Sanchez A, Alves F, Bruggemann A, et al. (1999) Oncogenic potential of EAG K(+) channels. EMBO J 18: 5540-5547.
-
(1999)
EMBO J
, vol.18
, pp. 5540-5547
-
-
Pardo, L.A.1
del Camino, D.2
Sanchez, A.3
Alves, F.4
Bruggemann, A.5
-
9
-
-
0037098907
-
Effects of imipramine on ion channels and proliferation of IGR1 melanoma cells
-
Gavrilova-Ruch O, Schonherr K, Gessner G, Schonherr R, Klapperstuck T, et al. (2002) Effects of imipramine on ion channels and proliferation of IGR1 melanoma cells. J Membr Biol 188: 137-149.
-
(2002)
J Membr Biol
, vol.188
, pp. 137-149
-
-
Gavrilova-Ruch, O.1
Schonherr, K.2
Gessner, G.3
Schonherr, R.4
Klapperstuck, T.5
-
10
-
-
34547636154
-
Monoclonal antibody blockade of the human Eag1 potassium channel function exerts antitumor activity
-
Gomez-Varela D, Zwick-Wallasch E, Knotgen H, Sanchez A, Hettmann T, et al. (2007) Monoclonal antibody blockade of the human Eag1 potassium channel function exerts antitumor activity. Cancer Res 67: 7343-7349.
-
(2007)
Cancer Res
, vol.67
, pp. 7343-7349
-
-
Gomez-Varela, D.1
Zwick-Wallasch, E.2
Knotgen, H.3
Sanchez, A.4
Hettmann, T.5
-
11
-
-
33750419308
-
Ether a go-go potassium channel expression in soft tissue sarcoma patients
-
Mello de Queiroz F, Suarez-Kurtz G, Stuhmer W, Pardo LA (2006) Ether a go-go potassium channel expression in soft tissue sarcoma patients. Mol Cancer 5: 42.
-
(2006)
Mol Cancer
, vol.5
, pp. 42
-
-
de Queiroz, F.M.1
Suarez-Kurtz, G.2
Stuhmer, W.3
Pardo, L.A.4
-
12
-
-
33744961342
-
Silencing the activity and proliferative properties of the human EagI Potassium Channel by RNA Interference
-
Weber C, Mello de Queiroz F, Downie BR, Suckow A, Stuhmer W, et al. (2006) Silencing the activity and proliferative properties of the human EagI Potassium Channel by RNA Interference. J Biol Chem 281: 13030-13037.
-
(2006)
J Biol Chem
, vol.281
, pp. 13030-13037
-
-
Weber, C.1
de Queiroz, F.M.2
Downie, B.R.3
Suckow, A.4
Stuhmer, W.5
-
13
-
-
0032567106
-
Crystal structure and functional analysis of the HERG potassium channel
-
Morais Cabral JH, Lee A, Cohen SL, Chait BT, Li M, et al. (1998) Crystal structure and functional analysis of the HERG potassium channel N terminus: a eukaryotic PAS domain. Cell 95: 649-655.
-
(1998)
N Terminus: A Eukaryotic PAS Domain. Cell
, vol.95
, pp. 649-655
-
-
Morais, J.H.C.1
Lee, A.2
Cohen, S.L.3
Chait, B.T.4
Li, M.5
-
14
-
-
0032990441
-
PAS domains: Internal sensors of oxygen, redox potential, and light
-
Taylor BL, Zhulin IB (1999) PAS domains: internal sensors of oxygen, redox potential, and light. Microbiol Mol Biol Rev 63: 479-506.
-
(1999)
Microbiol Mol Biol Rev
, vol.63
, pp. 479-506
-
-
Taylor, B.L.1
Zhulin, I.B.2
-
15
-
-
0026347866
-
Similarities in amino acid sequences of Drosophila eag and cyclic nucleotide-gated channels
-
Guy HR, Durell SR, Warmke J, Drysdale R, Ganetzky B (1991) Similarities in amino acid sequences of Drosophila eag and cyclic nucleotide-gated channels. Science 254: 730.
-
(1991)
Science
, vol.254
, pp. 730
-
-
Guy, H.R.1
Durell, S.R.2
Warmke, J.3
Drysdale, R.4
Ganetzky, B.5
-
16
-
-
70350514521
-
Absence of direct cyclic nucleotide modulation of mEAG1 and hERG1 channels revealed with fluorescence and electrophysiological methods
-
Brelidze TI, Carlson AE, Zagotta WN (2009) Absence of direct cyclic nucleotide modulation of mEAG1 and hERG1 channels revealed with fluorescence and electrophysiological methods. J Biol Chem 284: 27989-27997.
-
(2009)
J Biol Chem
, vol.284
, pp. 27989-27997
-
-
Brelidze, T.I.1
Carlson, A.E.2
Zagotta, W.N.3
-
18
-
-
68549132502
-
Discovery of leukotriene A4 hydrolase inhibitors using metabolomics biased fragment crystallography
-
Davies DR, Mamat B, Magnusson OT, Christensen J, Haraldsson MH, et al. (2009) Discovery of leukotriene A4 hydrolase inhibitors using metabolomics biased fragment crystallography. J Med Chem 52: 4694-4715.
-
(2009)
J Med Chem
, vol.52
, pp. 4694-4715
-
-
Davies, D.R.1
Mamat, B.2
Magnusson, O.T.3
Christensen, J.4
Haraldsson, M.H.5
-
20
-
-
0032199006
-
Binding, gating, affinity and efficacy: The interpretation of structure-activity relationships for agonists and of the effects of mutating receptors
-
Colquhoun D (1998) Binding, gating, affinity and efficacy: the interpretation of structure-activity relationships for agonists and of the effects of mutating receptors. Br J Pharmacol 125: 924-947.
-
(1998)
Br J Pharmacol
, vol.125
, pp. 924-947
-
-
Colquhoun, D.1
-
22
-
-
34147210060
-
Bioluminescent assays for high-throughput screening
-
Fan F, Wood KV (2007) Bioluminescent assays for high-throughput screening. Assay Drug Dev Technol 5: 127-136.
-
(2007)
Assay Drug Dev Technol
, vol.5
, pp. 127-136
-
-
Fan, F.1
Wood, K.V.2
-
23
-
-
13344261467
-
High-throughput screening: Searching for higher productivity
-
Fox S, Farr-Jones S, Sopchak L, Boggs A, Comley J (2004) High-throughput screening: searching for higher productivity. J Biomol Screen 9: 354-358.
-
(2004)
J Biomol Screen
, vol.9
, pp. 354-358
-
-
Fox, S.1
Farr-Jones, S.2
Sopchak, L.3
Boggs, A.4
Comley, J.5
-
24
-
-
27844463050
-
Improving success rates for lead generation using affinity binding technologies
-
Makara GM, Athanasopoulos J (2005) Improving success rates for lead generation using affinity binding technologies. Curr Opin Biotechnol 16: 666-673.
-
(2005)
Curr Opin Biotechnol
, vol.16
, pp. 666-673
-
-
Makara, G.M.1
Athanasopoulos, J.2
-
25
-
-
34447517392
-
Scaffold composition and biological relevance of screening libraries
-
Shelat AA, Guy RK (2007) Scaffold composition and biological relevance of screening libraries. Nat Chem Biol 3: 442-446.
-
(2007)
Nat Chem Biol
, vol.3
, pp. 442-446
-
-
Shelat, A.A.1
Guy, R.K.2
-
26
-
-
0033863669
-
High-throughput screening: New technology for the 21st century
-
Hertzberg RP, Pope AJ (2000) High-throughput screening: new technology for the 21st century. Curr Opin Chem Biol 4: 445-451.
-
(2000)
Curr Opin Chem Biol
, vol.4
, pp. 445-451
-
-
Hertzberg, R.P.1
Pope, A.J.2
-
27
-
-
10244264821
-
High throughput assay technologies for ion channel drug discovery
-
Zheng W, Spencer RH, Kiss L (2004) High throughput assay technologies for ion channel drug discovery. Assay Drug Dev Technol 2: 543-552.
-
(2004)
Assay Drug Dev Technol
, vol.2
, pp. 543-552
-
-
Zheng, W.1
Spencer, R.H.2
Kiss, L.3
-
28
-
-
35649000334
-
Green tea flavonoid epigallocatechin-3-gallate (EGCG) inhibits cardiac hERG potassium channels
-
Kelemen K, Kiesecker C, Zitron E, Bauer A, Scholz E, et al. (2007) Green tea flavonoid epigallocatechin-3-gallate (EGCG) inhibits cardiac hERG potassium channels. Biochem Biophys Res Commun 364: 429-435.
-
(2007)
Biochem Biophys Res Commun
, vol.364
, pp. 429-435
-
-
Kelemen, K.1
Kiesecker, C.2
Zitron, E.3
Bauer, A.4
Scholz, E.5
-
29
-
-
24044536663
-
Inhibition of cardiac HERG channels by grapefruit flavonoid naringenin: Implications for the influence of dietary compounds on cardiac repolarisation
-
Scholz EP, Zitron E, Kiesecker C, Luck S, Thomas D, et al. (2005) Inhibition of cardiac HERG channels by grapefruit flavonoid naringenin: implications for the influence of dietary compounds on cardiac repolarisation. Naunyn Schmiede-bergs Arch Pharmacol 371: 516-525.
-
(2005)
Naunyn Schmiede-bergs Arch Pharmacol
, vol.371
, pp. 516-525
-
-
Scholz, E.P.1
Zitron, E.2
Kiesecker, C.3
Luck, S.4
Thomas, D.5
-
30
-
-
35348862332
-
Orange flavonoid hesperetin modulates cardiac hERG potassium channel via binding to amino acid F656
-
Scholz EP, Zitron E, Kiesecker C, Thomas D, Kathofer S, et al. (2007) Orange flavonoid hesperetin modulates cardiac hERG potassium channel via binding to amino acid F656. Nutr Metab Cardiovasc Dis 17: 666-675.
-
(2007)
Nutr Metab Cardiovasc Dis
, vol.17
, pp. 666-675
-
-
Scholz, E.P.1
Zitron, E.2
Kiesecker, C.3
Thomas, D.4
Kathofer, S.5
-
31
-
-
20044393294
-
QTc prolongation by grapefruit juice and its potential pharmacological basis: HERG channel blockade by flavonoids
-
Zitron E, Scholz E, Owen RW, Luck S, Kiesecker C, et al. (2005) QTc prolongation by grapefruit juice and its potential pharmacological basis: HERG channel blockade by flavonoids. Circulation 111: 835-838.
-
(2005)
Circulation
, vol.111
, pp. 835-838
-
-
Zitron, E.1
Scholz, E.2
Owen, R.W.3
Luck, S.4
Kiesecker, C.5
-
32
-
-
68749097147
-
Voltage-dependent opening of HCN channels: Facilitation or inhibition by the phytoestrogen, genistein, is determined by the activation status of the cyclic nucleotide gating ring
-
Rozario AO, Turbendian HK, Fogle KJ, Olivier NB, Tibbs GR (2009) Voltage-dependent opening of HCN channels: Facilitation or inhibition by the phytoestrogen, genistein, is determined by the activation status of the cyclic nucleotide gating ring. Biochim Biophys Acta 1788: 1939-1949.
-
(2009)
Biochim Biophys Acta
, vol.1788
, pp. 1939-1949
-
-
Rozario, A.O.1
Turbendian, H.K.2
Fogle, K.J.3
Olivier, N.B.4
Tibbs, G.R.5
-
33
-
-
33845987008
-
The amiodarone derivative 2-methyl-3-(3,5-diiodo-4-carboxymethoxybenzyl)benzofuran (KB130015) opens large-conductance Ca2+-activated K+ channels and relaxes vascular smooth muscle
-
Gessner G, Heller R, Hoshi T, Heinemann SH (2007) The amiodarone derivative 2-methyl-3-(3,5-diiodo-4-carboxymethoxybenzyl)benzofuran (KB130015) opens large-conductance Ca2+-activated K+ channels and relaxes vascular smooth muscle. Eur J Pharmacol 555: 185-193.
-
(2007)
Eur J Pharmacol
, vol.555
, pp. 185-193
-
-
Gessner, G.1
Heller, R.2
Hoshi, T.3
Heinemann, S.H.4
-
34
-
-
0035814943
-
Short-and long-term effects of amiodarone on the two components of cardiac delayed rectifier K(+) current
-
Kamiya K, Nishiyama A, Yasui K, Hojo M, Sanguinetti MC, et al. (2001) Short-and long-term effects of amiodarone on the two components of cardiac delayed rectifier K(+) current. Circulation 103: 1317-1324.
-
(2001)
Circulation
, vol.103
, pp. 1317-1324
-
-
Kamiya, K.1
Nishiyama, A.2
Yasui, K.3
Hojo, M.4
Sanguinetti, M.C.5
-
35
-
-
0030058762
-
Class III antiarrhythmic drugs block HERG, a human cardiac delayed rectifier K+ channel. Open-channel block by methanesulfonanilides
-
Spector PS, Curran ME, Keating MT, Sanguinetti MC (1996) Class III antiarrhythmic drugs block HERG, a human cardiac delayed rectifier K+ channel. Open-channel block by methanesulfonanilides. Circ Res 78: 499-503.
-
(1996)
Circ Res
, vol.78
, pp. 499-503
-
-
Spector, P.S.1
Curran, M.E.2
Keating, M.T.3
Sanguinetti, M.C.4
-
36
-
-
17944387642
-
Design and synthesis of novel benzofurans as a new class of antifungal agents targeting fungal N-myristoyltransferase
-
Kawasaki K, Masubuchi M, Morikami K, Sogabe S, Aoyama T, et al. (2003) Design and synthesis of novel benzofurans as a new class of antifungal agents targeting fungal N-myristoyltransferase. Part 3. Bioorg Med Chem Lett 13: 87-91.
-
(2003)
Bioorg Med Chem Lett
, vol.13
, Issue.PART 3
, pp. 87-91
-
-
Kawasaki, K.1
Masubuchi, M.2
Morikami, K.3
Sogabe, S.4
Aoyama, T.5
-
38
-
-
0033637140
-
The effects of plant flavonoids on mammalian cells: Implications for inflammation, heart disease, and cancer
-
Middleton E, Jr., Kandaswami C, Theoharides TC (2000) The effects of plant flavonoids on mammalian cells: implications for inflammation, heart disease, and cancer. Pharmacol Rev 52: 673-751.
-
(2000)
Pharmacol Rev
, vol.52
, pp. 673-751
-
-
Middleton Jr., E.1
Kandaswami, C.2
Theoharides, T.C.3
-
39
-
-
1842317695
-
Gating of single Shaker potassium channels in Drosophila muscle and in Xenopus oocytes injected with Shaker mRNA
-
Zagotta WN, Hoshi T, Aldrich RW (1989) Gating of single Shaker potassium channels in Drosophila muscle and in Xenopus oocytes injected with Shaker mRNA. Proc Natl Acad Sci U S A 86: 7243-7247.
-
(1989)
Proc Natl Acad Sci U S A
, vol.86
, pp. 7243-7247
-
-
Zagotta, W.N.1
Hoshi, T.2
Aldrich, R.W.3
-
40
-
-
0019441262
-
Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches
-
Hamill OP, Marty A, Neher E, Sakmann B, Sigworth FJ (1981) Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches. Pflugers Arch 391: 85-100.
-
(1981)
Pflugers Arch
, vol.391
, pp. 85-100
-
-
Hamill, O.P.1
Marty, A.2
Neher, E.3
Sakmann, B.4
Sigworth, F.J.5
-
41
-
-
0031437768
-
Reduction of membrane protein hydrophobicity by site-directed mutagenesis: Introduction of multiple polar residues in helix D of bacteriorhodopsin
-
Chen GQ, Gouaux E (1997) Reduction of membrane protein hydrophobicity by site-directed mutagenesis: introduction of multiple polar residues in helix D of bacteriorhodopsin. Protein Eng 10: 1061-1066.
-
(1997)
Protein Eng
, vol.10
, pp. 1061-1066
-
-
Chen, G.Q.1
Gouaux, E.2
-
42
-
-
0141831003
-
Structural basis for modulation and agonist specificity of HCN pacemaker channels
-
Zagotta WN, Olivier NB, Black KD, Young EC, Olson R, et al. (2003) Structural basis for modulation and agonist specificity of HCN pacemaker channels. Nature 425: 200-205.
-
(2003)
Nature
, vol.425
, pp. 200-205
-
-
Zagotta, W.N.1
Olivier, N.B.2
Black, K.D.3
Young, E.C.4
Olson, R.5
|