Neutralization of macrophage migration inhibitory factor (MIF) by fully human antibodies correlates with their specificity for the β-sheet structure of MIF

Journal of Biological Chemistry

Volumn 287, Issue 10, 2012, Pages 7446-7455

  Kerschbaumer, Randolf J ^a   Rieger, Manfred ^a   Völkel, Dirk ^a   Roy, Didier Le ^b   Roger, Thierry ^b   Garbaraviciene, Jurate ^c   Boehncke, Wolf Henning ^c   Müllberg, Jürgen ^d   Hoet, Rene M ^d   Wood, Clive R ^d   Antoine, Gerhard ^a   Thiele, Michael ^a   Savidis Dacho, Helga ^a   Dockal, Michael ^a   Ehrlich, Hartmut ^a   Calandra, Thierry ^b   Scheiflinger, Friedrich ^a  

^a BAXTER INNOVATIONS GMBH   (Austria)

^b LAUSANNE UNIVERSITY HOSPITAL   (Switzerland)

^c GOETHE UNIVERSITY   (Germany)

^d Dyax Corp   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY THERAPY; BINDING EPITOPES; CONTACT HYPERSENSITIVITY; EPITOPE MAPPING; EXPERIMENTAL ANIMALS; HUMAN ANTIBODIES; IN-VITRO; MIGRATION INHIBITORY FACTORS; OXIDOREDUCTASES; PHAGE DISPLAY LIBRARIES; PROINFLAMMATORY CYTOKINES; PROTECTIVE EFFECTS; SHEET STRUCTURE; THERAPEUTIC TARGETS;

AMINO ACIDS; ANTIGENS; MACROPHAGES;

ANTIBODIES;

MACROPHAGE MIGRATION INHIBITION FACTOR; OXIDOREDUCTASE;

AMINO ACID SEQUENCE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY SPECIFICITY; ANTIGEN BINDING; ARTICLE; BETA SHEET; CONTACT ALLERGY; CONTROLLED STUDY; CRYSTAL STRUCTURE; EPITOPE MAPPING; HISTOPATHOLOGY; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; PHAGE DISPLAY; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN MOTIF;

AMINO ACID MOTIFS; ANIMALS; ANTIBODIES, MONOCLONAL; ANTIBODIES, NEUTRALIZING; DERMATITIS, CONTACT; DISEASE MODELS, ANIMAL; HUMANS; INTRAMOLECULAR OXIDOREDUCTASES; MACROPHAGE MIGRATION-INHIBITORY FACTORS; MICE; SEPSIS;

ANIMALIA;

EID: 84857697372     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.329664     Document Type: Article

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