Identification and characterization of novel classes of macrophage migration inhibitory factor (MIF) inhibitors with distinct mechanisms of action

Journal of Biological Chemistry

Volumn 285, Issue 34, 2010, Pages 26581-26598

  Ouertatani Sakouhi, Hajer ^a   El Turk, Farah ^a   Fauvet, Bruno ^a   Cho, Min Kyu ^b   Karpinar, Damla Pinar ^b   Le Roy, Didier ^c   Dewor, Manfred ^d   Roger, Thierry ^c   Bernhagen, Jürgen ^d   Calandra, Thierry ^c   Zweckstetter, Markus ^b   Lashuel, Hilal A ^a  

^a EPFL   (Switzerland)

^b MAX PLANCK INSTITUTE FOR BIOPHYSICAL CHEMISTRY   (Germany)

^c LAUSANNE UNIVERSITY HOSPITAL   (Switzerland)

^d RWTH AACHEN UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVITY-BASED; AKT PHOSPHORYLATION; AUTOIMMUNE DISORDER; BIOLOGIC ACTIVITIES; BIOLOGICAL ACTIVITIES; BIOLOGICALLY ACTIVE COMPOUNDS; BIOPHYSICAL METHODS; CATALYTIC ACTIVITY; CATALYTIC SITES; CHEMICAL CLASS; CHEMICAL STRUCTURE; EBSELEN; IN-VITRO; IN-VIVO; INTERACTION SITE; MECHANISM OF ACTION; MECHANISTIC PROBES; MIGRATION INHIBITORY FACTORS; N-TERMINALS; PHARMACOKINETIC PROPERTIES; PROINFLAMMATORY CYTOKINES; PROLINE RESIDUES; SMALL MOLECULES; STRUCTURE-ACTIVITY STUDIES; STRUCTURE-FUNCTION RELATIONSHIP; TAUTOMERASE; THERAPEUTIC TARGETS; TRIMERIC STRUCTURE;

BIOACTIVITY; ELECTROCHEMICAL SENSORS; MACROPHAGES; MOLECULES; OLIGOMERIZATION; PHOSPHORYLATION;

CATALYST ACTIVITY;

1,4 DIOXO 1,4 DIHYDRONAPHTHALEN 2 YL 4 METHYLBENZOIC ACID; 2 (2,3 DIHYDRO 1,3 BENZOTHIAZOL 2 YLIDEN) 3 (2 FURYL) 3 OXOPROPANENITRILE; 2 CHLORO 3 OXOCYCLOHEX 1 ENYL 3 (TRIFLUOROMETHYL)BENZOIC ACID; 2 OXO 1 PHENYL 1,2 DIHYDROQUINOLIN 4 YL BENZOIC ACID; 3 (4 METHOXYPHENYL) 3 OXOPROP 1 ENYL 4 CHLOROBENZOIC ACID; 3 CYANO 4,6 DIMETHYL 2 PYRIDYL THIOPENE 2 CARBOXYLIC ACID; 5 OXO 2,3 DIHYDRO 1H,5H PYRIDO[3,2,1 IJ]QUINOLIN 7 YL BENZOIC ACID; 5,5 DIMETHYL 3 OXOCYCLOHEX 1 ENYL 4 CHLOROBENZOIC ACID; 6 [MORPHOLINO[4 (TRIFLUOROMETHYL)PHENYL]METHYL] 1,3 BENZODIOXOL 5 OL; 7,10 DIOXO 4,5 DIHYDRO 7H,10H PYRANO[3,2 C]PYRROLO[3,2,1 IJ]QUINOLIN 8 YL 4 FLUOROBENZOIC ACID; BENZYL ISOTHIOCYANATE; BTB 09588; DFP 00129; DOPACHROME TAUTOMERASE; DP 00477; EBSELEN; HEXACHLOROPHENE; HTS 11308; HTS 12696; JFD 03186; JFD 03990; KM 05004; MACROPHAGE MIGRATION INHIBITION FACTOR; MACROPHAGE MIGRATION INHIBITION FACTOR INHIBITOR; ML 05004; N (2 CHLOROPHENYL) N' [(5 NITRO 3 HIENYL)CARBONYL]THIOUREA; N (2,4 DINITROPHENOXY)THIOPENE 2 CARBOXAMIDE; N 1 [3 (TRIFLUOROMETHYL)PHENYL] 3 (2 CHLOROANILINO) 2 CYANO 3 THIOXOPROPANAMIDE; N' [(3 ACETYL 1,3 THIAZOLAN 2 YL)CARBONYL] 1,3 BENZODIOXOLE 5 CARBOHYDRAZIDE; N'',N DI(4 HYDROXYBENZYLIDENE)CARBONIC DIHYDRAZIDE; NRB 04242; PROTEIN INHIBITOR; PROTEIN KINASE B; RDR 03785; RF 00032; RJC 02246; RJC 04082; S 07438; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG DETERMINATION; DRUG SCREENING; DRUG STRUCTURE; ENZYME ACTIVITY; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; OLIGOMERIZATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INTERACTION; PROTEIN MODIFICATION; PROTEIN PHOSPHORYLATION; PROTEIN PURIFICATION; STRUCTURE ACTIVITY RELATION;

CHEMOTAXIS; GLUCOCORTICOIDS; HUMANS; INHIBITORY CONCENTRATION 50; MACROPHAGE MIGRATION-INHIBITORY FACTORS; MUTATION; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; SMALL MOLECULE LIBRARIES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 77956212412     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.113951     Document Type: Article

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