Structure activity studies of the cytokine macrophage migration inhibitory factor (MIF) reveal a critical role for its carboxy terminus

FEBS Letters

Volumn 414, Issue 2, 1997, Pages 226-232

  Mischke, Ralf ^a   Gessner, André ^b   Kapurniotu, Aphrodite ^c   Jüttner, Stefan ^b   Kleemann, Robert ^a   Brunner, Herwig ^a   Bernhagen, Jürgen ^a  

^a UNIVERSITY OF STUTTGART   (Germany)

^b UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^c UNIVERSITY OF TÜBINGEN   (Germany)

Author keywords

Cytokine; Macrophage migration inhibitor factor; Mutagenesis; Protein structure; Structure activity study

Indexed keywords

MACROPHAGE MIGRATION INHIBITION FACTOR;

ARTICLE; CIRCULAR DICHROISM; ENZYME ACTIVITY; IMMUNITY; MUTAGENESIS; PRIORITY JOURNAL; PROTEIN QUATERNARY STRUCTURE; PROTEIN STRUCTURE; STRUCTURE ACTIVITY RELATION;

AMINO ACID SEQUENCE; ANIMALS; ANTIPROTOZOAL AGENTS; BIOLOGICAL ASSAY; CIRCULAR DICHROISM; DNA PRIMERS; GUANIDINE; GUANIDINES; HUMANS; JURKAT CELLS; LEISHMANIA MAJOR; MACROMOLECULAR SUBSTANCES; MACROPHAGE MIGRATION-INHIBITORY FACTORS; MODELS, STRUCTURAL; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; NADP TRANSHYDROGENASE; PEPTIDE FRAGMENTS; POLYMERASE CHAIN REACTION; PROTEIN CONFORMATION; PROTEIN DENATURATION; PROTEIN STRUCTURE, SECONDARY; RECOMBINANT PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP; THERMODYNAMICS;

EID: 0031559878     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-5793(97)01039-9     Document Type: Article

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